IL19 (NM_013371) Human Untagged Clone

CAT#: SC304003

IL19 (untagged)-Human interleukin 19 (IL19), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: IL19
• Synonyms: IL-10C; MDA1; NG.1; ZMDA1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_013371 edited
  ATTTCCTCTTATCCACCTGAATAAAAATGACCAGCCCTTTCCAAATGGCAGAGAGCACTG
  AGAGGAGACACAAGGAGCAGCCCGCAAGCACCAAGTGAGAGGCATGAAGTTACAGTGTGT
  TTCCCTTTGGCTCCTGGGTACAATACTGATATTGTGCTCAGTAGACAACCACGGTCTCAG
  GAGATGTCTGATTTCCACAGACATGCACCATATAGAAGAGAGTTTCCAAGAAATCAAAAG
  AGCCATCCAAGCTAAGGACACCTTCCCAAATGTCACTATCCTGTCCACATTGGAGACTCT
  GCAGATCATTAAGCCCTTAGATGTGTGCTGCGTGACCAAGAACCTCCTGGCGTTCTACGT
  GGACAGGGTGTTCAAGGATCATCAGGAGCCAAACCCCAAAATCTTGAGAAAAATCAGCAG
  CATTGCCAACTCTTTCCTCTACATGCAGAAAACTCTGCGGCAATGTCAGGAACAGAGGCA
  GTGTCACTGCAGGCAGGAAGCCACCAATGCCACCAGAGTCATCCATGACAACTATGATCA
  GCTGGAGGTCCACGCTGCTGCCATTAAATCCCTGGGAGAGCTCGACGTCTTTCTAGCCTG
  GATTAATAAGAATCATGAAGTAATGTTCTCAGCTTGATGACAAGGAACCTGTATAGTGAT
  CCAGGGATGAACACCCCCTGTGCGGTTTACTGTGGGAGACAGCCCAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_013371 unedited
  NAGGTCACATTTGTATACGACTCATATAGGGCGGCCGCGATTCAAATCTGGTACCGAGCT
  CGGATCCACTAGTAACGGCCGCCAGTGTGCTGGAATTCGCCCTTAGCATTTCCTCTTATC
  CACCTGAATAAAAATGACCAGCCCTTTCCAAATGGCAGAGAGCACTGAGAGGAGACACAA
  GGAGCAGCCCGCAAGCACCAAGTGAGAGGCATGAAGTTACAGTGTGTTTCCCTTTGGCTC
  CTGGGTACAATACTGATATTGTGCTCAGTAGACAACCACGGTCTCAGGAGATGTCTGATT
  TCCACAGACATGCACCATATAGAAGAGAGTTTCCAAGAAATCAAAAGAGCCATCCAAGCT
  AAGGACACCTTCCCAAATGTCACTATCCTGTCCACATTGGAGACTCTGCAGATCATTAAG
  CCCTTAGATGTGTGCTGCGTGACCAAGAACCTCCTGGCGTTCTACGTGGACAGGGTGTTC
  AAGGATCATCAGGAGCCAAACCCCAAAATCTTGAGAAAAATCAGCAGCATTGCCAACTCT
  TTCCTCTACATGCAGAAAACTCTGCGGCAATGTCAGGAACAGAGGCAGTGTCACTGCAGG
  CAGGAAGCCACCAATGCCACCAGAGTCATCCATGACAACTATGATCAGCTGGAGGTCCAC
  GCTGCTGCCATTAAATCCCTGGGAGAGCTCGACGTCTTTCTAGCCTGGATTAATAAGAAT
  CATGAAGTAATGTTCTCAGCTTGATGACAAGGAACCTGTATAGTGATCCAGGGATGAACA
  CCCNCTGTGCGGTTTACTGTGGGAGACAGCCCACAGGGGCGAATTCTGCAGATATCCATC
  ACACTGGGCGGCCGCTCGACTCTAGATTGCNGGCCGCGTCATAGCTGTTTCCCTGACAC
  
• Restriction Sites: Please inquire
• ACCN: NM_013371
• ORF Size: 534 bp
• Insert Size: 700
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This construct is a cloned PCR fragment that was fully sequenced. There are no nucleotide differences between the OriGene clone and the NCBI reference ORF.

Reference Data

• RefSeq: NM_013371.2, NP_037503.2
• RefSeq Size: 1831
• RefSeq ORF: 534
• Locus ID: 29949
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
• Gene Summary: The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) contains two alternate 5' non-coding exons, resulting in translation initiation from an in-frame downstream AUG start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.