DKK2 (NM_014421) Human Untagged Clone

CAT#: SC304099

DKK2 (untagged)-Human dickkopf homolog 2 (Xenopus laevis) (DKK2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DKK2
• Synonyms: DKK-2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_014421 edited
  CTCCCTCCCTTTGCATTCCCACCCCTCCGGGCTTTGCGTCTTCCTGGGGACCCCCTCGCC
  GGGAGATGGCCGCGTTGATGCGGAGCAAGGATTCGTCCTGCTGCCTGCTCCTACTGGCCG
  CGGTGCTGATGGTGGAGAGCTCACAGATCGGCAGTTCGCGGGCCAAACTCAACTCCATCA
  AGTCCTCTCTGGGCGGGGAGACGCCTGGTCAGGCCGCCAATCGATCTGCGGGCATGTACC
  AAGGACTGGCATTCGGCGGCAGTAAGAAGGGCAAAAACCTGGGGCAGGCCTACCCTTGTA
  GCAGTGATAAGGAGTGTGAAGTTGGGAGGTATTGCCACAGTCCCCACCAAGGATCATCGG
  CCTGCATGGTGTGTCGGAGAAAAAAGAAGCGCTGCCACCGAGATGGCATGTGCTGCCCCA
  GTACCCGCTGCAATAATGGCATCTGTATCCCAGTTACTGAAAGCATCTTAACCCCTCACA
  TCCCGGCTCTGGATGGTACTCGGCACAGAGATCGAAACCACGGTCATTACTCAAACCATG
  ACTTGGGATGGCAGAATCTAGGAAGACCACACACTAAGATGTCACATATAAAAGGGCATG
  AAGGAGACCCCTGCCTACGATCATCAGACTGCATTGAAGGGTTTTGCTGTGCTCGTCATT
  TCTGGACCAAAATCTGCAAACCAGTGCTCCATCAGGGGGAAGTCTGTACCAAACAACGCA
  AGAAGGGTTCTCATGGGCTGGAAATTTTCCAGCGTTGCGACTGTGCGAAGGGCCTGTCTT
  GCAAAGTATGGAAAGATGCCACCTACTCCTCCAAAGCCAGACTCCATGTGTGTCAGAAAA
  TTTGATCACCATTGAGGAACATCATCAATTGCAGACTGTGAAGTTGTGTATTTAATGCAT
  TATAGCATGGTGGAAAATAAGGTTCAGATGCAGAAGAATGG
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_014421 unedited
  GTGGAGTTCAAAATTTGTATACGACTCATATAGGGCGGCCGCGATTCGCCCTTCTCCCTC
  CCTTTGCATTCCCACCCCTCCGGGCTTTGCGTCTTCCTGGGGACCCCCTCGCCGGGAGAT
  GGCCGCGTTGATGCGGAGCAAGGATTCGTCCTGCTGCCTGCTCCTACTGGCCGCGGTGCT
  GATGGTGGAGAGCTCACAGATCGGCAGTTCGCGGGCCAAACTCAACTCCATCAAGTCCTC
  TCTGGGCGGGGAGACGCCTGGTCAGGCCGCCAATCGATCTGCGGGCATGTACCAAGGACT
  GGCATTCGGCGGCAGTAAGAAGGGCAAAAACCTGGGGCAGGCCTACCCTTGTAGCAGTGA
  TAAGGAGTGTGAAGTTGGGAGGTATTGCCACAGTCCCCACCAAGGATCATCGGCCTGCAT
  GGTGTGTCGGAGAAAAAAGAAGCGCTGCCACCGAGATGGCATGTGCTGCCCCAGTACCCG
  CTGCAATAATGGCATCTGTATCCCAGTTACTGAAAGCATCTTAACCCCTCACATCCCGGC
  TCTGGATGGTACTCGGCACAGAGATCGAAACCACGGTCATTACTCAAACCATGACTTGGG
  ATGGCAGAATCTAGGAAGACCACACACTAAGATGTCACATATAAAAGGGCATGAAGGAGA
  CCCCTGCCTACGATCATCAGACTGCATTGAAGGGTTTTGCTGTGCTCGTCATTTCTGGAC
  CAAAATCTGCAAACCAGTGCTCCATCAGGGGGAAGTCTGTACCAAACAACGCAAGAAGGG
  TTCTCATGGGCTGGAAATTTTCCAGCGTTGCGACTGTGCGAAGGGCCTGTCTTGCAAGTA
  TGGAAAGATGCCACCTACTCCTCCCAAGCCAGACTCCATGTGTGTCAGAAAATTTG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_014421 unedited
  NGGCCCTGGNGATGGCACTTCCAGGNCCAGNAAAGCACTGGGGNAGGGTCACAGGATGCC
  ACCCGGGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGACAAGCTT
  GATATCGGTACCAGATCTGAATTCGCCCTTCCCATTCTTCTGCATCTGAACCTTATTTTC
  CACCATGCTATAATGCATTAAATACACAACTTCACAGTCTGCAATTGATGATGTTCCTCA
  ATGGTGATCAAATTTTCTGACACACATGGAGTCTGGCTTTGGAGGAGTAGGTGGCATCTT
  TCCATACTTTGCAAGACAGGCCCTTCGCACAGTCGCAACGCTGGAAAATTTCCAGCCCAT
  GAGAACCCTTCTTGCGTTGTTTGGTACAGACTTCCCCCTGATGGAGCACTGGTTTGCAGA
  TTTTGGTCCAGAAATGACGAGCACAGCAAAACCCTTCAATGCAGTCTGATGATCGTAGGC
  AGGGGTCTCCTTCATGCCCTTTTATATGTGACATCTTAGTGTGTGGTCTTCCTAGATTCT
  GCCATCCCAAGTCATGGTTTGAGTAATGACCGTGGTTTCGATCTCTGTGCCGAGTACCAT
  CCAGAGCCGGGATGTGAGGGGTTAAGATGCTTTCAGTAACTGGGATACAGATGCCATTAT
  TGCAGCGGGTACTGGGGCAGCACATGCCATCTCGGTGGCAGCGCTTCTTTTTTCTCCGAC
  ACACCATGCAGGCCGATGATCCTTGGTGGGGACTGTGGCAATACCTCCCAACTTCACACT
  CCTTATCACTGCTACAAGGGTAGGCCTGCCCCANGTTTTTGCCCTTCTTACTGCCGCCGA
  ATGCCAGTCCTTGGTACATGCCCGCAGATCGATTGGCGGCCTGACCAGGCGTCTCCCCGC
  CG
  
• Restriction Sites: Please inquire
• ACCN: NM_014421
• ORF Size: 780 bp
• Insert Size: 950
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.

Reference Data

• RefSeq: NM_014421.2, NP_055236.1
• RefSeq Size: 3659
• RefSeq ORF: 780
• Locus ID: 27123
• Protein Families: Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Stem cell relevant signaling - Wnt Signaling pathway
• Protein Pathways: Wnt signaling pathway
• Gene Summary: This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]