Neurofascin (NFASC) (NM_015090) Human Untagged Clone

CAT#: SC304227

NFASC (untagged)-Human neurofascin (NFASC), transcript variant 4

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NFASC
• Synonyms: NEDCPMD; NF; NRCAML
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_015090, the custom clone sequence may differ by one or more nucleotides
  ATGGCCAGGCAGCCACCGCCGCCCTGGGTCCATGCAGCCTTCCTCCTCTGCCTCCTCAGT
  CTTGGCGGAGCCATCGAAATTCCTATGGATCTGACGCAGCCGCCAACCATCACCAAGCAG
  TCAGCGAAGGATCACATCGTGGACCCCCGTGATAACATCCTGATTGAGTGTGAAGCAAAA
  GGGAACCCTGCCCCCAGCTTCCACTGGACACGAAACAGCAGATTCTTCAACATCGCCAAG
  GACCCCCGGGTGTCCATGAGGAGGAGGTCTGGGACCCTGGTGATTGACTTCCGCAGTGGC
  GGGCGGCCGGAGGAATATGAGGGGGAATATCAGTGCTTCGCCCGCAACAAATTTGGCACG
  GCCCTGTCCAATAGGATCCGCCTGCAGGTGTCTAAATCTCCTCTGTGGCCCAAGGAAAAC
  CTAGACCCTGTCGTGGTCCAAGAGGGCGCTCCTTTGACGCTCCAGTGCAACCCCCCGCCT
  GGACTTCCATCCCCGGTCATCTTCTGGATGAGCAGCTCCATGGAGCCCATCACCCAAGAC
  AAACGTGTCTCTCAGGGCCATAACGGAGACCTATACTTCTCCAACGTGATGCTGCAGGAC
  ATGCAGACCGACTACAGTTGTAACGCCCGCTTCCACTTCACCCACACCATCCAGCAGAAG
  AACCCTTTCACCCTCAAGGTCCTCACCAACCACCCTTATAATGACTCGTCCTTAAGAAAC
  CACCCTGACATGTACAGTGCCCGAGGAGTTGCAGAAAGAACACCAAGCTTCATGTATCCC
  CAGGGCACCGCGAGCAGCCAGATGGTGCTTCGTGGCATGGACCTCCTGCTGGAATGCATC
  GCCTCCGGGGTCCCAACACCAGACATCGCATGGTACAAGAAAGGTGGGGACCTCCCATCT
  GATAAGGCCAAGTTTGAGAACTTTAATAAGGCCCTGCGTATCACAAATGTCTCTGAGGAA
  GACTCCGGGGAGTATTTCTGCCTGGCCTCCAACAAGATGGGCAGCATCCGGCACACGATC
  TCGGTGAGAGTAAAGGCTGCTCCCTACTGGCTGGACGAACCCAAGAACCTTATTCTGGCT
  CCTGGCGAGGATGGGAGACTGGTGTGTCGAGCCAATGGAAACCCCAAACCCACTGTCCAG
  TGGATGGTGAATGGGGAACCTTTGCAATCGGCACCACCTAACCCAAACCGTGAGGTGGCC
  GGAGACACCATCATCTTCCGGGACACCCAGATCAGCAGCAGGGCTGTGTACCAGTGCAAC
  ACCTCCAACGAGCATGGCTACCTGCTGGCCAACGCCTTTGTCAGTGTGCTGGATGTGCCG
  CCTCGGATGCTGTCGCCCCGGAACCAGCTCATTCGAGTGATTCTTTACAACCGGACGCGG
  CTGGACTGCCCTTTCTTTGGGTCTCCCATCCCCACACTGCGATGGTTTAAGAATGGGCAA
  GGAAGCAACCTGGATGGTGGCAACTACCATGTTTATGAGAACGGCAGTCTGGAAATTAAG
  ATGATCCGCAAAGAGGACCAGGGCATCTACACCTGTGTCGCCACCAACATCCTGGGCAAA
  GCTGAAAACCAAGTCCGCCTGGAGGTCAAAGACCCCACCAGGATCTACCGGATGCCCGAG
  GACCAGGTGGCCAGAAGGGGCACCACGGTGCAGCTGGAGTGTCGGGTGAAGCACGACCCC
  TCCCTGAAACTCACCGTCTCCTGGCTGAAGGATGACGAGCCGCTCTATATTGGAAACAGG
  ATGAAGAAGGAAGACGACTCCCTGACCATCTTTGGGGTGGCAGAGCGGGACCAGGGCAGT
  TACACGTGTGTCGCCAGCACCGAGCTAGACCAAGACCTGGCCAAGGCCTACCTCACCGTG
  CTAGGACGGCCAGACCGGCCCCGGGACCTGGAGCTGACCGACCTGGCCGAGAGGAGCGTG
  CGGCTGACCTGGATCCCCGGGGATGCTAACAACAGCCCCATCACAGACTACGTCGTCCAG
  TTTGAAGAAGACCAGTTCCAACCTGGGGTCTGGCATGACCATTCCAAGTACCCCGGCAGC
  GTTAACTCAGCCGTCCTCCGGCTGTCCCCGTATGTCAACTACCAGTTCCGTGTCATTGCC
  ATCAACGAGGTTGGGAGCAGCCACCCCAGCCTCCCATCCGAGCGCTACCGAACCAGTGGA
  GCACCCCCCGAGTCCAATCCTGGTGACGTGAAGGGAGAGGGGACCAGAAAGAACAACATG
  GAGATCACGTGGACGCCCATGAATGCCACCTCGGCCTTTGGCCCCAACCTGCGCTACATT
  GTCAAGTGGAGGCGGAGAGAGACTCGAGAGGCCTGGAACAACGTCACAGTGTGGGGCTCT
  CGCTACGTGGTGGGGCAGACCCCAGTCTACGTGCCCTATGAGATCCGAGTCCAGGCTGAA
  AATGACTTCGGGAAGGGCCCTGAGCCAGAGTCCGTCATCGGTTACTCCGGAGAAGATTAT
  CCCAGGGCTGCGCCCACTGAAGTTAAAGTCCGAGTCATGAACAGCACAGCCATCAGCCTT
  CAGTGGAACCGCGTCTACTCCGACACGGTCCAGGGCCAGCTCAGAGAGTACCGAGCCTAC
  TACTGGAGGGAGAGCAGCTTGCTGAAGAACCTGTGGGTGTCTCAGAAGAGACAGCAAGCC
  AGCTTCCCTGGTGACCGCCTCCGTGGCGTGGTGTCCCGCCTCTTCCCCTACAGTAACTAC
  AAGCTGGAGATGGTTGTGGTCAATGGGAGAGGTGATGGGCCTCGCAGTGAGACCAAGGAG
  TTCACCACCCCGGAAGGAGTACCCAGTGCCCCTAGGCGTTTCCGAGTCCGGCAGCCCAAC
  CTGGAGACAATCAACCTGGAATGGGATCATCCTGAGCATCCAAATGGGATCATGATTGGA
  TACACTCTCAAATATGTGGCCTTTAACGGGACCAAAGTAGGAAAGCAGATAGTGGAAAAC
  TTCTCTCCCAATCAGACCAAGTTCACGGTGCAAAGAACGGACCCCGTGTCACGCTACCGC
  TTTACCCTCAGCGCCAGGACGCAGGTGGGCTCTGGGGAAGCCGTCACAGAGGAGTCACCA
  GCACCCCCGAATGAAGCTTACACCAACAACCAAGCGGACATCGCCACCCAGGGCTGGTTC
  ATTGGGCTTATGTGCGCCATCGCCCTCCTGGTGCTGATCCTGCTCATCGTCTGTTTCATC
  AAGAGGAGTCGCGGCGGCAAGTACCCAGTACGAGAAAAGAAGGATGTTCCCCTTGGCCCT
  GAAGACCCCAAGGAAGAGGATGGCTCATTTGACTATAGTGATGAGGACAACAAGCCCCTG
  CAGGGCAGTCAGACATCTCTGGACGGCACCATCAAGCAGCAGGAGAGTGACGACAGCCTG
  GTGGACTATGGCGAGGGTGGCGAGGGTCAGTTCAATGAAGACGGCTCCTTCATCGGCCAG
  TACACGGTCAAAAAGGACAAGGAGGAAACAGAGGGCAACGAAAGCTCAGAGGCCACGTCA
  CCTGTCAATGCTATCTACTCTCTGGCCTAA
  
• Restriction Sites: Please inquire
• ACCN: NM_015090
• ORF Size: 3522 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_015090.1, NP_055905.1
• RefSeq Size: 9841
• RefSeq ORF: 3522
• Locus ID: 23114
• Protein Families: Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs)
• Gene Summary: This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined. [provided by RefSeq, May 2009]
  Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (4) includes the third fibronectin type 3 (FNIII) repeat, lacks the mucin-like domain, and has several differences in the N-terminal and central regions, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.