Capicua (CIC) (NM_015125) Human Untagged Clone

CAT#: SC304239

CIC (untagged)-Human capicua homolog (Drosophila) (CIC)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CIC
• Synonyms: MRD45
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_015125, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGTATTCGGCCCACAGGCCCCTGATGCCCGCGTCCAGCGCGGCCTCCCGTGGCCTCGGCATGTTCGTGT
  GGACGAATGTGGAACCTCGCTCTGTGGCTGTGTTCCCTTGGCACTCCTTAGTCCCCTTCCTGGCACCCAG
  CCAGCCTGACCCCTCCGTGCAGCCGAGCGAGGCCCAGCAACCTGCCAGCCACCCAGTGGCCTCCAACCAG
  AGCAAAGAACCTGCTGAGTCGGCAGCTGTTGCTCATGAACGGCCACCAGGTGGGACAGGGAGTGCTGACC
  CTGAGCGGCCCCCTGGAGCCACATGCCCTGAGAGCCCAGGACCCGGACCCCCACACCCTTTGGGGGTGGT
  GGAATCTGGTAAGGGTCCGCCTCCCACCACGGAGGAGGAGGCCTCCGGCCCCCCAGGAGAGCCCCGGCTG
  GACAGTGAGACAGAGAGTGACCATGATGATGCCTTCCTCTCCATCATGTCTCCTGAGATCCAGTTGCCTC
  TACCGCCCGGAAAACGTCGGACCCAGTCCCTCAGTGCCCTACCCAAGGAACGGGACTCATCTTCTGAGAA
  GGATGGACGCAGCCCCAACAAGCGGGAGAAGGACCACATCCGGCGGCCCATGAATGCCTTCATGATCTTC
  AGCAAGCGGCACCGGGCCCTGGTCCACCAGCGTCATCCCAACCAGGACAACCGGACCGTCAGCAAGATCC
  TGGGCGAGTGGTGGTATGCCCTGGGGCCCAAGGAGAAGCAGAAGTACCACGACCTGGCCTTCCAGGTGAA
  GGAGGCCCACTTCAAGGCCCACCCAGATTGGAAGTGGTGCAACAAGGACCGAAAGAAGTCCAGCTCAGAG
  GCCAAGCCCACGAGCCTGGGGCTGGCAGGAGGGCACAAGGAGACGCGGGAGCGGAGCATGTCGGAGACGG
  GCACTGCTGCTGCCCCTGGGGTGTCCTCTGAGCTCCTGTCCGTTGCAGCCCAGACACTCCTGAGCTCAGA
  CACCAAGGCTCCGGGGAGCAGCTCCTGTGGGGCAGAACGGCTACACACAGTTGGGGGACCTGGCTCAGCC
  CGGCCCCGAGCTTTCTCCCACAGCGGGGTACACAGCCTGGACGGCGGAGAAGTAGACAGTCAGGCGCTAC
  AGGAACTGACGCAGATGGTGTCTGGCCCTGCATCGTACTCTGGCCCAAAGCCTTCTACCCAGTATGGAGC
  TCCAGGACCCTTTGCAGCCCCTGGTGAGGGAGGTGCCTTGGCGGCCACTGGGCGGCCCCCGCTGCTGCCC
  ACCCGAGCTTCTCGTTCTCAGCGTGCGGCCAGTGAGGACATGACGAGTGATGAGGAGCGCATGGTCATCT
  GTGAGGAGGAAGGGGATGATGATGTCATTGCTGACGATGGCTTCGGCACCACTGACATTGATCTCAAGTG
  CAAGGAGCGGGTGACCGACAGCGAGAGTGGGGACAGCTCTGGGGAGGACCCAGAGGGCAACAAGGGCTTT
  GGTCGGAAGGTGTTTTCACCTGTGATCCGTTCCTCCTTTACCCACTGCCGCCCCCCACTGGACCCTGAGC
  CCCCAGGGCCCCCGGATCCTCCTGTAGCCTTTGGCAAAGGCTATGGTTCCGCCCCATCCTCCTCTGCGTC
  CTCGCCTGCTTCCTCCTCAGCCTCGGCAGCCACCTCCTTCTCACTGGGCTCAGGAACCTTCAAGGCCCAG
  GAGTCTGGTCAGGGCAGCACAGCGGGCCCCCTACGGCCCCCACCCCCTGGGGCTGGGGGTCCAGCGACAC
  CTTCCAAGGCAACCCGGTTCCTCCCAATGGATCCTGCCACCTTCCGGCGCAAGAGACCCGAAAGTGTGGG
  TGGCCTGGAGCCACCAGGCCCCTCAGTCATCGCGGCCCCTCCCAGCGGAGGAGGAAACATCCTGCAGACA
  CTGGTGCTGCCCCCAAACAAGGAGGAGCAAGAGGGCGGCGGAGCCAGAGTGCCCTCCGCCCCCGCCCCAT
  CACTGGCCTATGGGGCCCCAGCAGCTCCCCTGTCCCGTCCTGCCGCCACCATGGTCACCAATGTGGTGCG
  GCCTGTCAGCAGCACTCCTGTGCCCATCGCCTCTAAGCCCTTCCCCACCTCTGGCCGGGCTGAGGCGTCT
  CCAAATGACACAGCAGGTGCCAGGACTGAAATGGGCACTGGGTCTCGGGTGCCTGGGGGCTCCCCGCTGG
  GTGTCAGCTTAGTGTATTCGGACAAGAAGTCGGCAGCAGCCACCTCACCAGCCCCACACTTGGTGGCTGG
  ACCCCTGCTGGGCACTGTGGGGAAGGCGCCTGCCACTGTCACTAACCTACTGGTGGGCACCCCGGGGTAT
  GGGGCCCCTGCGCCCCCTGCTGTCCAGTTCATTGCCCAGGGGGCCCCTGGTGGTGGGACCACTGCGGGCT
  CAGGAGCAGGTGCTGGGAGTGGCCCCAATGGGCCAGTACCCCTGGGCATCCTGCAACCAGGTGCCCTGGG
  CAAGGCTGGGGGAATCACCCAGGTACAGTACATCCTGCCCACGCTGCCCCAGCAGCTTCAGGTGGCACCT
  GCCCCAGCACCAGCCCCTGGGACCAAGGCAGCGGCTCCCAGCGGCCCTGCACCCACCACCAGCATCCGTT
  TCACCCTCCCACCGGGCACTTCCACCAACGGCAAAGTCCTGGCTGCCACTGCACCCACTCCTGGCATCCC
  CATCCTGCAGTCTGTACCCTCCGCCCCACCCCCCAAAGCCCAGTCAGTTTCTCCCGTGCAGGCCCCGCCC
  CCGGGTGGCTCAGCCCAGCTGCTGCCTGGGAAGGTCCTAGTGCCTCTGGCCGCCCCTAGCATGTCAGTGC
  GGGGTGGAGGGGCCGGCCAGCCACTGCCACTGGTGAGCCCGCCCTTCTCAGTACCTGTGCAGAATGGTGC
  CCAGCCCCCCAGCAAGATCATCCAGCTGACCCCGGTGCCTGTGAGCACACCCAGCGGCCTGGTGCCGCCC
  CTGAGCCCAGCCACACTCCCTGGACCCACCTCTCAGCCTCAGAAGGTCCTGTTGCCCTCCTCCACCAGAA
  TCACCTATGTGCAGTCAGCGGGCGGGCACGCGCTGCCCCTGGGTACCAGCCCTGCGTCCAGCCAGGCTGG
  AACAGTCACCTCGTACGGGCCCACGAGCTCTGTAGCTCTAGGCTTCACCTCGCTGGGGCCCAGCGGCCCC
  GCCTTCGTGCAGCCCCTGCTCTCAGCAGGCCAAGCCCCACTGCTGGCTCCCGGTCAGGTGGGCGTGTCAC
  CTGTGCCCAGTCCCCAGCTGCCGCCTGCCTGTGCAGCCCCCGGAGGTCCTGTCATAACAGCATTTTACTC
  TGGCAGCCCTGCACCCACCTCCTCAGCACCCCTGGCCCAGCCATCCCAGGCCCCCCCAAGCCTGGTCTAC
  ACTGTGGCCACCAGCACAACCCCACCTGCAGCCACCATTCTGCCCAAGGGCCCGCCAGCCCCTGCCACTG
  CCACCCCAGCCCCGACTAGCCCTTTCCCCAGCGCCACAGCAGGTTCCATGACCTACAGCTTAGTGGCCCC
  CAAGGCCCAGCGGCCCAGCCCGAAGGCCCCCCAGAAAGTGAAGGCAGCCATCGCCAGCATTCCCGTGGGG
  TCCTTTGAGGCAGGTGCCTCTGGGCGGCCTGGCCCTGCACCCCGGCAGCCTCTGGAGCCTGGCCCAGTCC
  GAGAGCCAACTGCCCCAGAGTCTGAGCTTGAGGGGCAGCCCACACCACCAGCCCCTCCACCCCTGCCAGA
  GACCTGGACTCCCACGGCCCGGAGCAGCCCCCCACTGCCCCCACCTGCTGAGGAGCGGACCAGCGCCAAG
  GGCCCTGAGACCATGGCCAGCAAATTCCCCAGCTCATCTTCAGACTGGCGCGTCCCTGGGCAGGGCCTGG
  AGAATCGTGGGGAGCCTCCCACTCCTCCCAGCCCGGCCCCAGCTCCAGCTGTAGCCCCTGGTGGCAGCAG
  CGAGAGCAGCAGTGGGCGGGCAGCCGGGGACACCCCGGAGCGCAAGGAGGCGGCTGGTACTGGCAAGAAG
  GTGAAGGTGCGGCCCCCGCCCCTGAAGAAGACCTTTGACTCTGTGGACAACAGGGTCCTGTCAGAAGTGG
  ACTTCGAAGAGCGCTTTGCTGAGTTGCCTGAGTTTCGGCCTGAGGAGGTGCTGCCCTCCCCCACCCTGCA
  GTCTCTGGCCACCTCACCCCGGGCCATCCTGGGCTCTTACCGCAAGAAGAGGAAGAACTCCACGGACCTG
  GATTCAGCACCCGAGGACCCCACCTCGCCCAAGCGCAAGATGAGAAGACGCTCCAGCTGCAGCTCGGAGC
  CCAACACCCCCAAGAGTGCCAAGTGCGAGGGGGACATCTTCACCTTTGACCGTACAGGTACAGAAGCCGA
  GGACGTGCTTGGGGAGCTAGAGTATGACAAGGTGCCATACTCCTCCCTGCGGCGCACCCTGGACCAGCGC
  CGGGCCCTGGTCATGCAGCTCTTTCAGGACCATGGCTTCTTCCCGTCAGCCCAGGCCACAGCCGCCTTCC
  AGGCCCGCTATGCAGACATCTTTCCCTCCAAGGTTTGTCTGCAGTTGAAGATCCGTGAGGTGCGCCAGAA
  GATCATGCAGGCTGCCACTCCCACGGAGCAGCCCCCTGGAGCTGAGGCTCCTCTCCCTGTACCGCCCCCC
  ACTGGCACCGCTGCTGCCCCTGCCCCCACTCCCAGCCCCGCAGGGGGCCCTGACCCCACCTCACCCAGCT
  CGGACTCTGGCACGGCCCAGGCTGCCCCGCCACTGCCTCCACCCCCAGAGTCGGGGCCTGGACAGCCTGG
  CTGGGAGGGGGCTCCCCAGCCCTCCCCCCCACCCCCAGGTCCCTCCACAGCTGCCACAGGCAGGTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_015125
• ORF Size: 4827 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_015125.4, NP_055940.3
• RefSeq Size: 5490
• RefSeq ORF: 4827
• Locus ID: 23152
• Gene Summary: The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
  Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (CIC-S, PMID:17190598) has a distinct N-terminus and is shorter than isoform CIC-L.