Siglec 7 (SIGLEC7) (NM_016543) Human Untagged Clone

CAT#: SC304431

SIGLEC7 (untagged)-Human sialic acid binding Ig-like lectin 7 (SIGLEC7), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SIGLEC7
• Synonyms: AIRM1; CD328; CDw328; D-siglec; p75; p75/AIRM1; QA79; SIGLEC-7; SIGLEC19P; SIGLECP2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_016543 edited
  TGAGAGAAGAACCCTGAGGAACAGACGTTCCCTCGCGGCCCTGGCACCTCCAACCCCAGA
  TATGCTGCTGCTGCTGCTGCTGCCCCTGCTCTGGGGGAGGGAGAGGGTGGAAGGACAGAA
  GAGTAACCGGAAGGATTACTCGCTGACGATGCAGAGTTCCGTGACCGTGCAAGAGGGCAT
  GTGTGTCCATGTGCGCTGCTCCTTCTCCTACCCAGTGGACAGCCAGACTGACTCTGACCC
  AGTTCATGGCTACTGGTTCCGGGCAGGGAATGATATAAGCTGGAAGGCTCCAGTGGCCAC
  AAACAACCCAGCTTGGGCAGTGCAGGAGGAAACTCGGGACCGATTCCACCTCCTTGGGGA
  CCCACAGACCAAAAATTGCACCCTGAGCATCAGAGATGCCAGAATGAGTGATGCGGGGAG
  ATACTTCTTTCGTATGGAGAAAGGAAATATAAAATGGAATTATAAATATGACCAGCTCTC
  TGTGAACGTGACAGACCCTCCTCAGAACTTGACTGTGACTGTCTTCCAAGGAGAAGGCAC
  AGCATCCACAGCTCTGGGGAACAGCTCATCTCTTTCAGTCCTAGAGGGCCAGTCTCTGCG
  CTTGGTCTGTGCTGTTGACAGCAATCCCCCTGCCAGGCTGAGCTGGACCTGGAGGAGTCT
  GACCCTGTACCCCTCACAGCCCTCAAACCCTCTGGTACTGGAGCTGCAAGTGCACCTGGG
  GGATGAAGGGGAATTCACCTGTCGAGCTCAGAACTCTCTGGGTTCCCAGCACGTTTCCCT
  GAACCTCTCCCTGCAACAGGAGTACACAGGCAAAATGAGGCCTGTATCAGGAGTGTTGCT
  GGGGGCGGTCGGGGGAGCTGGAGCCACAGCCCTGGTCTTCCTCTCCTTCTGTGTCATCTT
  CATTGTAGTGAGGTCCTGCAGGAAGAAATCGGCAAGGCCAGCAGCGGACGTGGGAGACAT
  AGGCATGAAGGATGCAAACACCATCAGGGGCTCAGCCTCTCAGGGTAACCTGACTGAGTC
  CTGGGCAGATGATAACCCCCGACACCATGGCCTGGCTGCCCACTCCTCAGGGGAGGAAAG
  AGAGATCCAGTATGCACCCCTCAGCTTTCATAAGGGGGAGCCTCAGGACCTATCAGGTCA
  AGAAGCCACCAACAATGAGTACTCAGAGATCAAGATCCCCAAGTAAGAAAATGCAGAGGC
  TCGGGCTTGTTTGAGGGTTCACGACCCCTCCAGCAAAGGAGTCTGAGGCTGATTCCAGTA
  GAATTAGCAGCCCTCAATGCTGTGCAACAAGACATCAGAACTTATTCCTCTTGTCTAACT
  GAAAATGCATGCCTGATGACCAAACTCTCCCTTTCCCCATCCAATCGGTCCACACTCCCC
  GCCCTGGCCTCTGGTACCCACCATTCTCCTCTGTACTTCTCTAAGGATGACTACTTTAGA
  TTCCGAATATAGTGAGATTGTAACGTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAA
  
• Restriction Sites: Please inquire
• ACCN: NM_016543
• ORF Size: 951 bp
• Insert Size: 1500
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The ORF of this clone is found to be a perfect match to NM_016543.1.

Reference Data

• RefSeq: NM_016543.1, NP_057627.1
• RefSeq Size: 1476
• RefSeq ORF: 951
• Locus ID: 27036
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Gene Summary: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (2) lacks an in-frame coding exon, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.