DUOX1 (NM_017434) Human Untagged Clone

CAT#: SC304464

DUOX1 (untagged)-Human dual oxidase 1 (DUOX1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DUOX1
• Synonyms: LNOX1; NOXEF1; THOX1
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_017434, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGGCTTCTGCCTGGCTCTAGCATGGACACTTCTGGTTGGGGCATGGACCCCTCTGGGAGCTCAGAACC
  CCATTTCGTGGGAGGTGCAGCGATTTGATGGGTGGTACAACAACCTCATGGAGCACAGATGGGGCAGCAA
  AGGCTCCCGGCTGCAGCGCCTGGTCCCAGCCAGCTATGCAGATGGCGTGTACCAGCCCTTGGGAGAACCC
  CACCTGCCCAACCCCCGAGACCTTAGCAACACCATCTCAAGGGGCCCTGCAGGGCTGGCCTCCCTGAGAA
  ACCGCACAGTGTTGGGGGTCTTCTTTGGCTATCACGTGCTTTCAGACCTGGTGAGCGTGGAAACTCCCGG
  CTGCCCCGCCGAGTTCCTCAACATTCGCATCCCGCCCGGAGACCCCATGTTCGACCCCGACCAGCGCGGG
  GACGTGGTGCTGCCCTTCCAGAGAAGCCGCTGGGACCCCGAGACCGGACGGAGTCCCAGCAATCCCCGGG
  ACCCGGCCAACCAGGTGACGGGCTGGCTGGACGGCAGCGCCATCTATGGTTCCTCGCATTCCTGGAGCGA
  CGCGCTGCGGAGCTTCTCCAGGGGACAGCTGGCGTCGGGGCCCGACCCCGCTTTTCCCCGAGACTCGCAG
  AACCCCCTGCTCATGTGGGCGGCGCCCGACCCCGCCACCGGGCAGAACGGGCCCCGGGGGCTGTACGCCT
  TCGGGGCAGAGAGAGGGAACCGGGAACCCTTCCTGCAGGCGCTGGGCCTGCTCTGGTTCCGCTACCACAA
  CCTGTGGGCGCAGAGGCTGGCCCGCCAGCACCCAGACTGGGAGGACGAGGAGCTGTTCCAGCACGCACGC
  AAGAGGGTCATCGCCACCTACCAGAACATCGCTGTGTATGAGTGGCTGCCCAGCTTCCTGCAGAAAACAC
  TCCCGGAGTATACAGGATACCGGCCATTTCTGGACCCCAGCATCTCCTCAGAGTTCGTGGCGGCCTCTGA
  GCAGTTCCTGTCCACCATGGTGCCCCCTGGCGTCTACATGAGAAATGCCAGCTGCCACTTCCAGGGGGTC
  ATCAATCGGAACTCAAGTGTCTCCAGAGCTCTCCGGGTCTGCAACAGCTACTGGAGCCGTGAGCACCCAA
  GCCTACAAAGTGCTGAAGATGTGGATGCACTGCTGCTGGGCATGGCCTCCCAGATCGCAGAGCGAGAGGA
  CCATGTGTTGGTTGAAGATGTGCGGGATTTCTGGCCTGGGCCACTGAAGTTTTCCCGCACAGACCACCTG
  GCCAGCTGCCTGCAGCGGGGCCGGGATCTGGGCCTGCCCTCTTACACCAAGGCCAGGGCAGCACTGGGCT
  TGTCTCCCATTACCCGCTGGCAGGACATCAACCCTGCACTCTCCCGGAGCAATGACACTGTACTGGAGGC
  CACAGCTGCCCTGTACAACCAGGACTTATCCTGGCTAGAGCTGCTCCCTGGGGGACTCCTGGAGAGCCAC
  CGGGACCCTGGACCTCTGTTCAGCACCATCGTCCTTGAACAATTTGTGCGGCTACGGGATGGTGACCGCT
  ACTGGTTTGAGAACACCAGGAATGGGCTGTTCTCCAAGAAGGAGATTGAAGAAATCCGAAATACCACCCT
  GCAGGACGTGCTGGTCGCTGTTATCAACATTGACCCCAGTGCTCTGCAGCCCAATGTCTTTGTCTGGCAT
  AAAGGAGACCCCTGTCCGCAGCCGAGACAGCTCAGCACTGAAGGCCTGCCAGCGTGTGCTCCCTCTGTTG
  TTCGTGACTATTTTGAGGGCAGTGGATTTGGCTTCGGGGTCACCATCGGGACCCTCTGTTGCTTCCCTTT
  GGTGAGCCTGCTCAGTGCCTGGATTGTTGCCCGGCTCCGGATGAGAAATTTCAAGAGGCTCCAGGGCCAG
  GACCGCCAGAGCATCGTGTCTGAGAAGCTCGTGGGAGGCATGGAAGCTTTGGAATGGCAAGGCCACAAGG
  AGCCCTGCCGGCCCGTGCTTGTGTACCTGCAGCCCGGGCAGATCCGTGTGGTAGATGGCAGGCTCACCGT
  GCTCCGCACCATCCAGCTGCAGCCTCCACAGAAGGTCAACTTCGTCCTGTCCAGCAACCGTGGACGCCGC
  ACTCTGCTGCTCAAGATCCCCAAGGAGTATGACCTGGTGCTGCTGTTTAACTTGGAGGAAGAGCGGCAGG
  CGCTGGTGGAAAATCTCCGGGGAGCTCTGAAGGAGAGCGGGTTGAGCATCCAGGAGTGGGAGCTGCGGGA
  GCAGGAGCTGATGAGAGCAGCTGTGACACGGGAGCAGCGGAGGCACCTCCTGGAGACCTTTTTCAGGCAC
  CTTTTCTCCCAGGTGCTGGACATCAACCAGGCCGACGCAGGGACCCTGCCCCTGGACTCCTCCCAGAAGG
  TGCGGGAGGCCCTGACCTGTGAGCTGAGCAGGGCCGAGTTTGCCGAGTCCCTGGGCCTCAAGCCCCAGGA
  CATGTTTGTGGAGTCCATGTTCTCTCTGGCTGACAAGGATGGCAATGGCTACCTGTCCTTCCGAGAGTTC
  CTGGACATCCTGGTGGTCTTCATGAAAGGCTCTCCTGAGGAAAAGTCTCGCCTTATGTTCCGCATGTACG
  ACTTTGATGGGAATGGCCTCATTTCCAAGGATGAGTTCATCAGGATGCTGAGATCCTTCATCGAGATCTC
  CAACAACTGCCTGTCCAAGGCCCAGCTGGCTGAGGTGGTGGAGTCCATGTTCCGGGAGTCGGGATTCCAG
  GACAAGGAGGAACTGACATGGGAAGATTTTCACTTCATGCTGCGGGACCACAATAGCGAGCTCCGCTTCA
  CGCAGCTCTGTGTCAAAGGGGTGGAGGTGCCTGAAGTCATCAAGGACCTCTGCCGGCGAGCCTCCTACAT
  CAGCCAGGATATGATCTGTCCCTCTCCCAGAGTGAGTGCCCGCTGTTCCCGCAGCGACATTGAGACTGAG
  TTGACACCTCAGAGACTGCAGTGCCCCATGGACACAGACCCTCCCCAGGAGATTCGGCGGAGGTTTGGCA
  AGAAGGTAACGTCATTCCAGCCCTTGCTGTTCACTGAGGCGCACCGAGAGAAGTTCCAACGCAGCTGTCT
  CCACCAGACGGTGCAACAGTTCAAGCGCTTCATTGAGAACTACCGGCGCCACATCGGCTGCGTGGCCGTG
  TTCTACGCCATCGCTGGGGGGCTTTTCCTGGAGAGGGCCTACTACTACGCCTTTGCCGCACATCACACGG
  GCATCACAGACACCACCCGCGTGGGAATCATCCTGTCGCGGGGCACAGCAGCCAGCATCTCTTTCATGTT
  CTCCTACATCTTGCTCACCATGTGCCGCAACCTCATCACCTTCCTGCGAGAAACCTTCCTCAACCGCTAC
  GTGCCCTTCGACGCCGCCGTGGACTTCCATCGCCTCATTGCCTCCACCGCCATCGTCCTCACAGTCTTAC
  ACAGTGTGGGCCATGTGGTGAATGTGTACCTGTTCTCCATCAGCCCCCTCAGCGTCCTCTCTTGCCTCTT
  TCCTGGCCTCTTCCATGATGATGGGTCTGAGCTCCCCCAGAAGTATTACTGGTGGTTCTTCCAGACCGTA
  CCAGGCCTCACGGGGGTTGTGCTGCTCCTGATCCTGGCCATCATGTATGTCTTTGCCTCCCACCACTTCC
  GCCGCCGCAGTTTCCGGGGCTTCTGGCTGACCCACCACCTCTACATCCTGCTCTATGTCCTGCTCATCAT
  CCATGGTAGCTTTGCCCTGATCCAGCTGCCCCGTTTCCACATCTTCTTCCTGGTCCCAGCAATCATCTAT
  GGGGGCGACAAGCTGGTGAGCCTGAGCCGGAAGAAGGTGGAGATCAGCGTGGTGAAGGCGGAGCTGCTGC
  CCTCAGGAGTGACCCACCTGCGGTTCCAGCGGCCCCAGGGCTTTGAGTACAAGTCAGGGCAGTGGGTGCG
  GATCGCTTGCCTGGCTCTGGGGACCACCGAGTACCACCCCTTCACACTGACCTCTGCGCCCCATGAGGAC
  ACGCTTAGCCTGCACATCCGGGCAGCAGGGCCCTGGACCACTCGCCTCAGGGAGATCTACTCAGCCCCGA
  CGGGTGACAGATGTGCCAGATACCCAAAGCTGTACCTTGATGGACCATTTGGAGAGGGCCACCAGGAGTG
  GCATAAGTTTGAGGTGTCAGTGTTAGTGGGAGGGGGCATTGGGGTCACCCCTTTTGCCTCCATCCTCAAA
  GACCTGGTCTTCAAGTCATCCGTCAGCTGCCAAGTGTTCTGTAAGAAGATCTACTTCATCTGGGTGACGC
  GGACCCAGCGTCAGTTTGAGTGGCTGGCTGACATCATCCGAGAGGTGGAGGAGAATGACCACCAGGACCT
  GGTGTCTGTGCACATCTACATCACCCAGCTGGCTGAGAAGTTCGACCTCAGGACCACTATGCTGTACATC
  TGTGAGCGGCACTTCCAGAAGGTTCTGAACCGGAGTCTATTCACAGGCCTGCGCTCCATCACCCACTTTG
  GCCGTCCCCCCTTTGAGCCCTTCTTCAACTCCCTGCAGGAGGTCCACCCCCAGGTCCGGAAGATCGGGGT
  GTTTAGCTGTGGCCCCCCTGGCATGACCAAGAATGTGGAAAAGGCCTGTCAGCTCATCAACAGGCAGGAC
  CGGACTCACTTCTCCCACCATTATGAGAACTTCTAG
  
  
• Restriction Sites: Please inquire
• ACCN: NM_017434
• ORF Size: 4656 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_017434.3, NP_059130.2
• RefSeq Size: 5693
• RefSeq ORF: 4656
• Locus ID: 53905
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
  Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.