TRPM7 (NM_017672) Human Untagged Clone

CAT#: SC304505

TRPM7 (untagged)-Human transient receptor potential cation channel, subfamily M, member 7 (TRPM7)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TRPM7
• Synonyms: ALSPDC; CHAK; CHAK1; LTrpC-7; LTRPC7; TRP-PLIK
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_017672 edited
  ATGTCCCAGAAATCCTGGATAGAAAGCACTTTGACCAAGAGGGAATGTGTATATATTATA
  CCAAGTTCCAAGGACCCTCACAGATGCCTTCCAGGATGTCAAATTTGTCAGCAACTCGTC
  AGGTGTTTTTGTGGTCGCTTGGTCAAGCAACATGCTTGTTTTACTGCAAGTCTTGCCATG
  AAATACTCAGATGTGAAATTGGGTGACCATTTTAATCAGGCAATAGAAGAATGGTCTGTG
  GAAAAGCATACAGAACAGAGCCCAACGGATGCTTATGGAGTCATAAATTTTCAAGGGGGT
  TCTCATTCCTACAGAGCTAAGTATGTGAGGCTATCATATGACACCAAACCTGAAGTCATT
  CTGCAACTTCTGCTTAAAGAATGGCAAATGGAGTTACCCAAACTTGTTATCTCTGTACAT
  GGGGGCATGCAGAAATTTGAGCTTCACCCACGAATCAAGCAGTTGCTTGGAAAAGGTCTT
  ATTAAAGCTGCAGTTACAACTGGAGCCTGGATTTTAACTGGAGGAGTAAACACAGGTGTG
  GCAAAACATGTTGGAGATGCCCTCAAAGAACATGCTTCCAGATCATCTCGAAAGATTTGC
  ACTATCGGAATAGCTCCATGGGGAGTGATTGAAAACAGAAATGATCTTGTTGGGAGAGAT
  GTGGTTGCTCCTTATCAAACCTTATTGAACCCCCTGAGCAAATTGAATGTTTTGAATAAT
  CTGCATTCCCATTTCATATTGGTGGATGATGGCACTGTTGGAAAGTATGGGGCGGAAGTC
  AGACTGAGAAGAGAACTTGAAAAAACTATTAATCAGCAAAGAATTCATGCTAGGATTGGC
  CAGGGTGTCCCTGTGGTGGCACTTATATTTGAGGGTGGGCCAAATGTTATCCTCACAGTT
  CTTGAATACCTTCAGGAAAGCCCCCCTGTTCCAGTAGTTGTGTGTGAAGGAACAGGCAGA
  GCTGCAGATCTGCTAGCGTATATTCATAAACAAACAGAAGAAGGAGGGAATCTTCCTGAT
  GCAGCAGAGCCCGATATTATTTCCACTATCAAAAAAACATTTAACTTTGGCCAGAATGAA
  GCACTTCATTTATTTCAAACACTGATGGAGTGCATGAAAAGAAAGGAGCTTATCACTGTT
  TTCCATATTGGGTCAGATGAACATCAAGATATAGATGTAGCAATACTTACTGCACTGCTA
  AAAGGTACTAATGCATCTGCATTTGACCAGCTTATCCTTACATTGGCATGGGATAGAGTT
  GACATTGCCAAAAATCATGTATTTGTTTATGGACAGCAGTGGCTGGTTGGATCCTTGGAA
  CAAGCTATGCTTGATGCTCTTGTAATGGATAGAGTTGCATTTGTAAAACTTCTTATTGAA
  AATGGAGTAAGCATGCATAAATTCCTTACCATTCCGAGACTGGAAGAACTTTACAACACT
  AAACAAGGTCCAACTAATCCAATGCTGTTTCATCTTGTTCGAGACGTCAAACAGGGAAAT
  CTTCCTCCAGGATATAAGATCACTCTGATTGATATAGGACTTGTTATTGAATATCTCATG
  GGAGGAACCTACAGATGCACCTATACTAGGAAACGTTTTCGATTAATATATAATAGTCTT
  GGTGGAAATAATCGGAGGTCTGGCCGAAATACCTCCAGCAGCACTCCTCAGTTGCGAAAG
  AGTCATGAATCTTTTGGCAATAGGGCAGATAAAAAGGAAAAAATGAGGCATAACCATTTC
  ATTAAGACAGCACAGCCCTACCGACCAAAGATTGATACAGTTATGGAAGAAGGAAAGAAG
  AAAAGAACCAAAGATGAAATTGTAGACATTGATGATCCAGAAACCAAGCGCTTTCCTTAT
  CCACTTAATGAACTTTTAATTTGGGCTTGCCTTATGAAGAGGCAGGTCATGGCCCGTTTT
  TTATGGCAACATGGTGAAGAATCAATGGCTAAAGCATTAGTTGCCTGTAAGATCTATCGT
  TCAATGGCATATGAAGCAAAGCAGAGTGACCTGGTAGATGATACTTCAGAAGAACTAAAA
  CAGTATTCCAATGATTTTGGTCAGTTGGCCGTTGAATTATTAGAACAGTCCTTCAGACAA
  GATGAAACCATGGCTATGAAATTGCTCACTTATGAACTGAAGAACTGGAGTAATTCAACC
  TGCCTTAAGTTAGCAGTTTCTTCAAGACTTAGACCTTTTGTAGCTCACACCTGTACACAA
  ATGTTGTTATCTGATATGTGGATGGGAAGGCTGAATATGAGGAAAAATTCCTGGTACAAG
  GTCATACTAAGCATTTTAGTTCCACCTGCCATATTGCTGTTAGAGTATAAAACTAAGGCT
  GAAATGTCCCATATCCCACAATCTCAAGATGCTCATCAGATGACAATGGATGACAGCGAA
  AACAACTTTCAGAACATAACAGAAGAGATCCCCATGGAAGTGTTTAAAGAAGTACGGATT
  TTGGATAGTAATGAAGGAAAGAATGAGATGGAGATACAAATGAAATCAAAAAAGCTTCCA
  ATTACGCGAAAGTTTTATGCCTTTTATCATGCACCAATTGTAAAATTCTGGTTTAACACG
  TTGGCATATTTAGGATTTCTGATGCTTTATACATTTGTGGTTCTTGTACAAATGGAACAG
  TTACCTTCAGTTCAAGAATGGATTGTTATTGCTTATATTTTTACTTATGCCATTGAGAAA
  GTCCGTGAGATCTTTATGTCTGAAGCTGGGAAAGTAAACCAGAAGATTAAAGTATGGTTT
  AGTGATTACTTCAACATCAGTGATACAATTGCCATAATTTCTTTCTTCATTGGATTTGGA
  CTAAGATTTGGAGCAAAATGGAACTTTGCAAATGCATATGATAATCATGTTTTTGTGGCT
  GGAAGATTAATTTACTGTCTTAACATAATATTTTGGTATGTGCGTTTGCTAGATTTTCTA
  GCTGTAAATCAACAGGCAGGACCTTATGTAATGATGATTGGAAAAATGGTGGCCAATATG
  TTCTACATTGTAGTGATTATGGCTCTTGTATTACTTAGTTTTGGTGTTCCCAGAAAGGCA
  ATACTTTATCCTCATGAAGCACCATCTTGGACTCTTGCTAAAGATATAGTTTTTCACCCA
  TACTGGATGATTTTTGGTGAAGTTTATGCATACGAAATTGATGTGTGTGCAAATGATTCT
  GTTATCCCTCAAATCTGTGGTCCTGGGACGTGGTTGACTCCATTTCTTCAAGCAGTCTAC
  CTCTTTGTACAGTATATCATTATGGTTAATCTTCTTATTGCATTTTTCAACAATGTGTAT
  TTACAAGTGAAGGCAATTTCCAATATTGTATGGAAGTACCAGCGTTATCATTTTATTATG
  GCTTATCATGAGAAACCAGTTCTGCCTCCTCCACTTATCATTCTTAGCCATATAGTTTCT
  CTGTTTTGCTGCATATGTAAGAGAAGAAAGAAAGATAAGACTTCCGATGGACCAAAACTT
  TTCTTAACAGAAGAAGATCAAAAGAAACTTCATGATTTTGAAGAGCAGTGTGTTGAAATG
  TATTTCAATGAAAAAGATGACAAATTTCATTCTGGGAGTGAAGAGAGAATTCGTGTCACT
  TTTGAAAGAGTGGAACAGATGTGCATTCAGATTAAAGAAGTTGGAGATCGTGTCAACTAC
  ATAAAAAGATCATTACAATCATTAGATTCTCAAATTGGCCATTTGCAAGATCTTTCAGCC
  CTGACGGTAGATACATTAAAAACACTCACTGCCCAGAAAGCGTCGGAAGCTAGCAAAGTT
  CATAATGAAATCACACGAGAACTGAGCATTTCCAAACACTTGGCTCAAAACCTTATTGAT
  GATGGTCCTGTAAGACCTTCTGTATGGAAAAAGCATGGTGTTGTAAATACACTTAGCTCC
  TCTCTTCCTCAAGGTGATCTTGAAAGTAATAATCCTTTTCATTGTAATATTTTAATGAAA
  GATGACAAAGATCCCCAGTGTAATATATTTGGTCAAGACTTACCTGCAGTACCCCAGAGA
  AAAGAATTTAATTTTCCAGAGGCTGGTTCCTCTTCTGGTGCCTTATTCCCAAGTGCTGTT
  TCCCCTCCAGAACTGCGACAGAGACTACATGGGGTAGAACTCTTAAAAATATTTAATAAA
  AATCAAAAATTAGGCAGTTCATCTACTAGCATACCACATCTGTCATCCCCACCAACCAAA
  TTTTTTGTTAGTACACCATCTCAGCCAAGTTGCAAAAGCCACTTGGAAACTGGAACCAAA
  GATCAAGAAACTGTTTGCTCTAAAGCTACAGAAGGAGATAATACAGAATTTGGAGCATTT
  GTAGGACACAGAGATAGCATGGATTTACAGAGGTTTAAAGAAACATCAAACAAGATAAAA
  ATACTATCCAATAACAATACTTCTGAAAACACTTTGAAACGAGTGAGTTCTCTTGCTGGA
  TTTACTGACTGTCACAGAACTTCCATTCCTGTTCATTCAAAACAAGCAGAAAAAATCAGT
  AGAAGGCCATCTACCGAAGACACTCATGAAGTAGATTCCAAAGCAGCTTTAATACCGGAT
  TGGTTACAAGATAGACCATCAAACAGAGAAATGCCATCTGAAGAAGGAACATTAAATGGT
  CTCACTTCTCCATTTAAGCCAGCTATGGATACAAATTACTATTATTCAGCTGTGGAAAGA
  AATAACTTGATGAGGTTATCACAGAGCATTCCATTTACACCTGTGCCTCCAAGAGGGGAG
  CCTGTCACAGTGTATCGTTTGGAAGAGAGTTCACCCAACATACTAAATAACAGCATGTCT
  TCTTGGTCACAACTAGGCCTCTGTGCCAAAATAGAGTTTTTAAGCAAAGAGGAGATGGGA
  GGAGGTTTACGAAGAGCTGTCAAAGTACAGTGTACCTGGTCAGAACATGATATCCTCAAA
  TCAGGGCATCTTTATATTATCAAATCTTTTCTTCCAGAGGTGGTTAATACATGGTCAAGT
  ATTTATAAAGAAGATACAGTTCTGCATCTCTGTCTGAGAGAAATTCAACAACAGAGAGCA
  GCACAAAAGCTTACGTTTGCCTTTAATCAAATGAAACCCAAATCCATACCATATTCTCCA
  AGGTTCCTTGAAGTTTTCCTGCTGTATTGCCATTCAGCAGGACAGTGGTTTGCTGTGGAA
  GAATGTATGACTGGAGAATTTAGAAAATACAACAATAATAATGGAGATGAGATTATTCCA
  ACTAATACTCTGGAAGAGATCATGCTAGCCTTTAGCCACTGGACTTACGAATATACAAGA
  GGGGAGTTACTGGTACTTGATTTGCAAGGTGTTGGTGAAAATTTGACTGACCCATCTGTG
  ATAAAAGCAGAAGAAAAGAGATCCTGTGATATGGTTTTTGGCCCAGCAAATCTAGGAGAA
  GATGCAATTAAAAACTTCAGAGCAAAACATCACTGTAATTCTTGCTGTAGAAAGCTTAAA
  CTTCCAGATCTGAAGAGGAATGATTATACGCCTGATAAAATTATATTTCCTCAGGATGAG
  CCTTCAGATTTGAATCTTCAGCCTGGAAATTCCACCAAAGAATCAGAATCAACTAATTCT
  GTTCGTCTGATGTTATAA
  
• Restriction Sites: Please inquire
• ACCN: NM_017672
• ORF Size: 5595 bp
• Insert Size: 7300
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone has been fully sequenced and found one SNP within the protein associated with this reference, NM_017672.2:At position 5250, a C to T change results in no amino acid change.

Reference Data

• RefSeq: NM_017672.2, NP_060142.2
• RefSeq Size: 7226
• RefSeq ORF: 5595
• Locus ID: 54822
• Protein Families: Druggable Genome, Ion Channels: Transient receptor potential, Protein Kinase, Transmembrane
• Gene Summary: This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function. [provided by RefSeq, Aug 2017]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.