DC SIGN (CD209) (NM_021155) Human Untagged Clone

CAT#: SC304915

CD209 (untagged)-Human CD209 molecule (CD209), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CD209
• Synonyms: CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_021155 edited
  GCCCTTTGGGGTGACATGAGTGACTCCAAGGAACCAAGACTGCAGCAGCTGGGCCTCCTG
  GAGGAGGAACAGCTGAGAGGCCTTGGATTCCGACAGACTCGAGGATACAAGAGCTTAGCA
  GGGTGTCTTGGCCATGGTCCCCTGGTGCTGCAACTCCTCTCCTTCACGCTCTTGGCTGGG
  CTCCTTGTCCAAGTGTCCAAGGTCCCCAGCTCCATAAGTCAGGAACAATCCAGGCAAGAC
  GCGATCTACCAGAACCTGACCCAGCTTAAAGCTGCAGTGGGTGAGCTCTCAGAGAAATCC
  AAGCTGCAGGAGATCTACCAGGAGCTGACCCAGCTGAAGGCTGCAGTGGGTGAGCTTCCA
  GAGAAATCTAAGCTGCAGGAGATCTACCAGGAGCTGACCCGGCTGAAGGCTGCAGTGGGT
  GAGCTTCCAGAGAAATCTAAGCTGCAGGAGATCTACCAGGAGCTGACCTGGCTGAAGGCT
  GCAGTGGGTGAGCTTCCAGAGAAATCTAAGATGCAGGAGATCTACCAGGAGCTGACTCGG
  CTGAAGGCTGCAGTGGGTGAGCTTCCAGAGAAATCTAAGCAGCAGGAGATCTACCAGGAG
  CTGACCCGGCTGAAGGCTGCAGTGGGTGAGCTTCCAGAGAAATCTAAGCAGCAGGAGATC
  TACCAGGAGCTGACCCGGCTGAAGGCTGCAGTGGGTGAGCTTCCAGAGAAATCTAAGCAG
  CAGGAGATCTACCAGGAGCTGACCCAGCTGAAGGCTGCAGTGGAACGCCTGTGCCACCCC
  TGTCCCTGGGAATGGACATTCTTCCAAGGAAACTGTTACTTCATGTCTAACTCCCAGCGG
  AACTGGCACGACTCCATCACCGCCTGCAAAGAAGTGGGGGCCCAGCTCGTCGTAATCAAA
  AGTGCTGAGGAGCAGAACTTCCTACAGCTGCAGTCTTCCAGAAGTAACCGCTTCACCTGG
  ATGGGACTTTCAGATCTAAATCAGGAAGGCACGTGGCAATGGGTGGACGGCTCACCTCTG
  TTGCCCAGCTTCAAGCAGTATTGGAACAGAGGAGAGCCCAACAACGTTGGGGAGGAAGAC
  TGCGCGGAATTTAGTGGCAATGGCTGGAACGACGACAAATGTAATCTTGCCAAATTCTGG
  ATCTGCAAAAAGTCCGCAGCCTCCTGCTCCAGGGATGAAGAACAGTTTCTTTCTCCAGCC
  CCTGCCACCCCAAACCCCCCTCCTGCGTAGCAGAACTTCACCCCCTTTTAAGCTACAGTT
  CCTTCTCTCCATCCTTCGACCTTCACAAAATCTCTGGGACTGTTCTTTGTCAGATTCTTC
  CTCCTTTAGAAGGCTGGGTCCCATTCTGTCCTTCTTGTCATGCCTCCAATTTCCCCTGGT
  GTAGAGCTTGTTTTTCTGGCCCATCCTTGGAGCTTTATG
  
• Restriction Sites: Please inquire
• ACCN: NM_021155
• ORF Size: 1215 bp
• Insert Size: 1400
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The ORF of this clone has been fully sequenced and found to be a perfect match to NM_021155.2.

Reference Data

• RefSeq: NM_021155.2, NP_066978.1
• RefSeq Size: 4266
• RefSeq ORF: 1215
• Locus ID: 30835
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants. [provided by RefSeq, Feb 2009]
  Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: This record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.