NYX (NM_022567) Human Untagged Clone

CAT#: SC305034

NYX (untagged)-Human nyctalopin (NYX)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NYX
• Synonyms: CLRP; CSNB1; CSNB1A; CSNB4; NBM1
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_022567, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGAAAGGCCGAGGGATGTTGGTCCTGCTTCTGCATGCGGTGGTCCTCGGCCTGCCCAGCGCCTGGGCCG
  TGGGGGCCTGCGCCCGCGCTTGTCCCGCCGCCTGCGCCTGCAGCACCGTGGAGCGCGGCTGCTCGGTGCG
  CTGCGACCGCGCGGGCCTCCTGCGGGTGCCGGCCGAGCTCCCGTGCGAGGCGGTCTCCATCGACCTGGAC
  CGGAACGGCCTGCGCTTCCTGGGCGAGCGAGCCTTCGGCACGCTGCCGTCCTTGCGCCGCCTGTCGCTGC
  GCCACAACAACCTGTCCTTCATCACGCCCGGCGCCTTCAAGGGCCTGCCGCGCCTGGCTGAGCTGCGCCT
  GGCGCACAACGGCGACCTGCGCTACCTGCACGCGCGCACCTTCGCGGCGCTCAGCCGCCTGCGCCGCCTA
  GACCTAGCAGCCTGCCGCCTCTTCAGCGTGCCCGAGCGCCTCCTGGCCGAACTGCCGGCCCTGCGCGAAC
  TCGCCGCCTTCGACAACCTGTTCCGCCGCGTGCCGGGCGCGCTGCGCGGCCTGGCCAACCTGACGCACGC
  GCACCTGGAGCGCGGCCGCATCGAGGCGGTGGCCTCCAGCTCGCTGCAGGGCCTGCGCCGCCTGCGCTCG
  CTCAGCCTGCAGGCCAACCGCGTCCGTGCCGTGCACGCTGGCGCCTTCGGGGACTGTGGCGTCCTGGAGC
  ATCTGCTGCTCAACGACAACCTGCTGGCCGAGCTCCCGGCCGACGCCTTCCGCGGCCTGCGGCGCCTGCG
  CACGCTCAACCTGGGTGGCAACGCGCTGGACCGCGTGGCGCGCGCCTGGTTCGCTGACCTGGCCGAGCTC
  GAGCTGCTCTACCTGGACCGCAACAGCATCGCCTTCGTGGAGGAGGGCGCCTTCCAGAACCTCTCGGGTC
  TCCTCGCGCTGCACCTCAACGGCAACCGCCTCACCGTGCTCGCCTGGGTCGCCTTCCAGCCCGGCTTCTT
  CCTGGGCCGCCTCTTCCTCTTCCGCAACCCGTGGTGCTGCGACTGCCGTCTGGAGTGGCTGAGGGACTGG
  ATGGAGGGCTCCGGACGTGTCACCGACGTGCCGTGCGCCTCCCCGGGCTCCGTGGCCGGCCTGGACCTCA
  GCCAGGTGACCTTCGGGCGCTCCTCCGATGGCCTCTGTGTGGACCCCGAGGAGCTGAACCTCACCACGTC
  CAGTCCAGGCCCGTCCCCAGAACCAGCGGCCACCACCGTGAGCAGGTTCAGCAGCCTCCTCTCCAAGCTG
  CTGGCCCCGAGGGTCCCGGTGGAGGAGGCGGCCAACACCACTGGGGGGCTGGCCAACGCCTCCCTGTCCG
  ACAGCCTCTCCTCCCGTGGGGTGGGAGGCGCGGGCCGGCAGCCCTGGTTTCTCCTCGCCTCTTGTCTCCT
  GCCCAGCGTGGCCCAGCACGTGGTGTTTGGCCTGCAGATGGACTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_022567
• ORF Size: 1446 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_022567.2, NP_072089.1
• RefSeq Size: 2629
• RefSeq ORF: 1446
• Locus ID: 60506
• Protein Families: Secreted Protein, Transmembrane
• Gene Summary: The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital stationary night blindness (XLCSNB). CSNB1 is a rare inherited retinal disorder characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB. [provided by RefSeq, Oct 2008]