KDM2B (NM_032590) Human Untagged Clone

CAT#: SC305484

KDM2B (untagged)-Human lysine (K)-specific demethylase 2B (KDM2B), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: KDM2B
• Synonyms: CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC305484 sequence for NM_032590 edited (data generated by NextGen Sequencing)
  
  
  ATGGCGGGTCCGCAAATGGGGGGATCTGCAGAGGATCACCCCCCACGAAAAAGACATGCAGCAGAAAAGC
  AAAAAAAGAAAACAGTTATATATACAAAATGCTTTGAATTTGAGTCGGCCACACAGCGCCCGATTGACCG
  CCAGCGATACGACGAGAACGAGGACTTGTCGGACGTGGAGGAGATCGTCAGCGTCCGCGGCTTCAGCCTG
  GAGGAGAAGCTTCGCAGCCAGCTGTACCAGGGGGACTTCGTGCACGCCATGGAGGGCAAAGATTTCAACT
  ATGAGTACGTACAGAGAGAAGCTCTCAGGGTTCCCCTGATATTTCGAGAAAAGGATGGACTGGGAATTAA
  GATGCCTGACCCTGATTTCACAGTCCGAGACGTCAAACTCCTAGTGGGGAGCCGGCGGCTTGTGGACGTG
  ATGGATGTGAACACCCAGAAGGGCACGGAGATGAGCATGTCCCAGTTTGTGCGTTACTACGAGACGCCCG
  AGGCCCAGCGGGACAAGCTGTACAACGTCATCAGCCTAGAGTTCAGCCACACCAAGCTGGAGCACTTGGT
  CAAGCGTCCGACTGTGGTAGACCTGGTGGACTGGGTGGACAACATGTGGCCCCAGCATCTGAAGGAGAAG
  CAGACAGAAGCCACGAACGCCATTGCAGAGATGAAGTACCCGAAAGTGAAAAAGTACTGTCTGATGAGCG
  TGAAAGGTTGTTTCACCGACTTCCACATCGACTTTGGAGGCACTTCCGTTTGGTACCATGTTTTCCGGGG
  TGGGAAGATTTTTTGGCTGATTCCTCCAACGCTGCACAATTTGGCGCTGTACGAGGAGTGGGTGCTGTCA
  GGCAAACAGAGTGACATCTTTCTGGGAGACCGTGTGGAACGATGCCAAAGAATTGAGCTGAAGCAGGGCT
  ACACATTTTTCATCCCTTCCGGTTGGATCCATGCCGTCTACACCCCTGTAGACTCTTTGGTGTTCGGCGG
  AAACATCCTGCACAGCTTTAACGTGCCCATGCAGCTGCGGATCTACGAGATCGAGGACAGGACGCGGGTG
  CAGCCCAAATTCCGTTACCCCTTCTACTATGAGATGTGCTGGTATGTCCTGGAGAGATACGTGTACTGTG
  TGACCCAGCGCTCCCACCTCACTCAGGAATACCAGAGGGAGTCGATGCTTATTGATGCCCCGAGGAAGCC
  CAGCATAGACGGCTTCTCTTCGGATTCCTGGCTGGAGATGGAGGAGGAGGCCTGTGATCAGCAGCCTCAG
  GAGGAGGAGGAGAAGGACGAGGAGGGCGAGGGCAGGGACAGGGCACCCAAACCGCCCACCGATGGCTCCA
  CTTCACCCACCAGCACGCCCTCTGAGGACCAGGAGGCCCTCGGGAAGAAGCCCAAAGCACCTGCCCTGCG
  ATTCCTCAAAAGGACTTTGTCTAATGAGTCGGAGGAAAGTGTGAAGTCCACCACATTGGCCGTAGACTAC
  CCCAAGACCCCCACCGGCTCTCCCGCCACGGAGGTCTCTGCCAAATGGACCCATCTCACTGAGTTTGAAC
  TGAAGGGCCTGAAAGCTCTGGTGGAGAAACTGGAATCCCTCCCGGAGAACAAGAAGTGTGTCCCCGAGGG
  CATCGAGGACCCCCAGGCACTCCTGGAGGGTGTGAAGAACGTCCTGAAGGAGCACGCAGATGATGACCCT
  AGTCTGGCCATCACTGGGGTCCCTGTGGTGACTTGGCCAAAGAAGACTCCAAAGAACCGGGCTGTGGGTC
  GGCCCAAGGGGAAGCTGGGCCCGGCCTCCGCGGTGAAGTTGGCCGCCAACCGGACAACGGCAGGAGCTCG
  GCGGCGCCGGACGCGATGCCGCAAGTGCGAGGCCTGCCTGCGGACCGAGTGCGGAGAGTGCCACTTCTGC
  AAGGACATGAAGAAGTTCGGGGGCCCCGGGCGCATGAAGCAGAGCTGCATCATGCGGCAGTGCATCGCGC
  CAGTGCTGCCCCACACCGCCGTGTGCCTTGTGTGTGGCGAGGCGGGGAAGGAAGACACGGTGGAAGAGGA
  GGAAGGCAAGTTTAACCTCATGCTCATGGAGTGCTCCATCTGCAATGAAATCATCCACCCTGGATGCCTT
  AAGATTAAGGAGTCAGAGGGTGTGGTCAACGACGAGCTTCCAAACTGCTGGGAGTGTCCGAAGTGTAACC
  ACGCCGGCAAGACCGGGAAACAAAAGCGTGGCCCTGGCTTTAAGTACGCCTCCAACCTGCCCGGCTCCCT
  GCTCAAGGAGCAGAAGATGAACCGGGACAACAAGGAAGGGCAGGAACCTGCCAAGCGGAGGAGTGAGTGT
  GAGGAGGCGCCCCGGCGCAGGTCGGATGAGCACTCGAAGAAGGTGCCGCCGGACGGCCTTCTGCGCAGAA
  AGTCTGACGACGTGCACCTGAGGAAGAAGCGGAAATATGAGAAGCCCCAGGAGCTGAGTGGACGCAAGCG
  GGCCTCATCGCTTCAAACGTCCCCCGGTTCCTCCTCTCACCTCTCGCCGAGGCCCCCTCTAGGCAGCAGC
  CTCAGCCCCTGGTGGAGATCCAGTCTCACTTACTTCCAGCAGCAGCTCAAACCTGGCAAAGAAGATAAGC
  TTTTCAGGAAAAAGCGGCGGTCCTGGAAGAACGCCGAGGACCGCATGGCGCTGGCCAACAAGCCCCTCCG
  GCGCTTCAAGCAGGAACCCGAGGACGAACTGCCCGAGGCGCCCCCCAAGACCAGGGAGAGCGATCACTCC
  CGCTCCAGCTCCCCCACCGCGGGACCCAGCACCGAAGGGGCCGAGGGCCCGGAGGAGAAGAAGAAGGTGA
  AGATGCGCCGGAAGCGGCGGCTTCCCAACAAGGAGCTGAGCAGGGAGCTGAGCAAGGAGCTCAACCACGA
  GATCCAGAGGACGGAGAACAGCCTGGCCAACGAGAACCAGCAGCCCATCAAGTCGGAGCCTGAGAGCGAG
  GGCGAGGAGCCCAAGCGGCCCCCGGGCATCTGCGAGCGTCCCCACCGCTTCAGCAAGGGGCTCAACGGCA
  CCCCCCGGGAGCTGCGGCACCAGCTGGGGCCCAGCCTGCGCAGCCCGCCCCGTGTCATCTCCCGGCCCCC
  ACCCTCCGTGTCCCCGCCCAAGTGTATCCAGATGGAGCGCCATGTGATCCGGCCACCCCCCATCAGCCCC
  CCGCCTGACTCGCTACCCCTGGACGATGGGGCAGCCCACGTCATGCACAGGGAGGTGTGGATGGCCGTCT
  TCAGCTACCTCAGCCACCAAGACCTGTGTGTGTGCATGCGGGTCTGCAGGACCTGGAACCGCTGGTGCTG
  CGATAAGCGGTTGTGGACCCGCATTGACCTGAACCACTGCAAGTCTATCACACCCCTGATGCTGAGTGGC
  ATCATCCGGCGACAGCCCGTCTCCCTCGACCTCAGCTGGACCAATATCTCCAAGAAGCAGCTGAGCTGGC
  TCATCAACCGGCTGCCTGGGCTCCGGGACTTGGTGCTGTCAGGCTGCTCATGGATCGCGGTCTCGGCCCT
  TTGCAGCTCCAGTTGTCCGCTGCTCCGGACCCTGGATGTCCAGTGGGTGGAGGGACTAAAGGATGCCCAA
  ATGCGGGATCTCCTGTCCCCGCCCACAGACAACAGGCCAGGTCAGATGGACAATCGGAGCAAGCTCCGGA
  ACATCGTGGAGCTGCGCCTGGCAGGCCTGGACATCACAGATGCCTCCCTGCGGCTCATCATCCGCCACAT
  GCCCCTGCTCTCCAAGCTCCACCTCAGTTACTGTAACCACGTCACCGACCAGTCTATCAACCTGCTCACT
  GCTGTTGGCACCACCACCCGAGACTCCTTAACCGAGATCAACCTGTCTGACTGCAATAAGGTCACTGATC
  AGTGCCTGTCCTTCTTCAAACGCTGTGGAAACATCTGTCATATTGACCTGAGGTACTGCAAGCAAGTCAC
  CAAGGAAGGCTGTGAGCAGTTCATAGCCGAGATGTCTGTGAGTGTCCAGTTTGGGCAAGTAGAAGAAAAA
  CTCCTGCAAAAACTGAGTTAG
  
  Clone variation with respect to NM_032590.4
  2418:t=>c 2724:t=>c 3570:a=>g
• Restriction Sites: Please inquire
• ACCN: NM_032590
• ORF Size: 4011 bp
• Insert Size: 4500
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone has been fully sequenced and found three SNPs within the protein associated with this reference, NM_032590.3. These three SNPs don't change amino acid.

Reference Data

• RefSeq: NM_032590.3, NP_115979.3
• RefSeq Size: 5318
• RefSeq ORF: 4011
• Locus ID: 84678
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).