RANKL (TNFSF11) (NM_033012) Human Untagged Clone

CAT#: SC305532

TNFSF11 (untagged)-Human tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TNFSF11
• Synonyms: CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TNLG6B; TRANCE
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_033012 edited
  CGCCTGGCCTATTGAAGGTTTTTAATCTTCAGAGTTTCGACTTTATCAACAACACTTAGA
  AGCCACCAAAGAATTGCAGATGGATCCTAATAGAATATCAGAAGATGGCACTCACTGCAT
  TTATAGAATTTTGAGACTCCATGAAAATGCAGATTTTCAAGACACAACTCTGGAGAGTCA
  AGATACAAAATTAATACCTGATTCATGTAGGAGAATTAAACAGGCCTTTCAAGGAGCTGT
  GCAAAAGGAATTACAACATATCGTTGGATCACAGCACATCAGAGCAGAGAAAGCGATGGT
  GGATGGCTCATGGTTAGATCTGGCCAAGAGGAGCAAGCTTGAAGCTCAGCCTTTTGCTCA
  TCTCACTATTAATGCCACCGACATCCCATCTGGTTCCCATAAAGTGAGTCTGTCCTCTTG
  GTACCATGATCGGGGTTGGGCCAAGATCTCCAACATGACTTTTAGCAATGGAAAACTAAT
  AGTTAATCAGGATGGCTTTTATTACCTGTATGCCAACATTTGCTTTCGACATCATGAAAC
  TTCAGGAGACCTAGCTACAGAGTATCTTCAACTAATGGTGTACGTCACTAAAACCAGCAT
  CAAAATCCCAAGTTCTCATACCCTGATGAAAGGAGGAAGCACCAAGTATTGGTCAGGGAA
  TTCTGAATTCCATTTTTATTCCATAAACGTTGGTGGATTTTTTAAGTTACGGTCTGGAGA
  GGAAATCAGCATCGAGGTCTCCAACCCCTCCTTACTGGATCCGGATCAGGATGCAACATA
  CTTTGGGGCTTTTAAAGTTCGAGATATAGATTGAGCCCCAGTTTTTGGAGT
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_033012 unedited
  CAGTTCACATTTGTATACGACTCATATAGGGCGGCCGCGATTCAAATCTGGTACCGAGCT
  CGGATCCACTAGTAACGGCCGCCAGTGTGCTGGAATTCGCCCTTCGCCTGGCCTATTGAA
  GGTTTTTAATCTTCAGAGTTTCGACTTTATCAACAACACTTAGAAGCCACCAAAGAATTG
  CAGATGGATCCTAATAGAATATCAGAAGATGGCACTCACTGCATTTATAGAATTTTGAGA
  CTCCATGAAAATGCAGATTTTCAAGACACAACTCTGGAGAGTCAAGATACAAAATTAATA
  CCTGATTCATGTAGGAGAATTAAACAGGCCTTTCAAGGAGCTGTGCAAAAGGAATTACAA
  CATATCGTTGGATCACAGCACATCAGAGCAGAGAAAGCGATGGTGGATGGCTCATGGTTA
  GATCTGGCCAAGAGGAGCAAGCTTGAAGCTCAGCCTTTTGCTCATCTCACTATTAATGCC
  ACCGACATCCCATCTGGTTCCCATAAAGTGAGTCTGTCCTCTTGGTACCATGATCGGGGT
  TGGGCCAAGATCTCCAACATGACTTTTAGCAATGGANAACTAATAGTTAATCAGGATGGC
  TTTTATTACCTGTATGCCAACATTTGCTTTCGACATCATGAAACTTCAGGAGACCTAGCT
  ACAGAGTATCTTCAACTAATGGTGTACGTCACTAANACCAGCATCAAAATCCCAGTTCTC
  ATACCCTGATGAAAGGAGAAGCACCAAGTATTGGTCAGGGAATTCTGAATTCCATTTTTA
  TTCCATAACGTTGGTGGATTTTTTAAGTTACGGTCTGGAGAGGAATCAGCATCGAGGTCT
  CCAACCCCTCCTTACTGGATNCGGATCANNGATGCACATACTTTGGNGCNTTTTAAAGTN
  CGAGATATAGATG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_033012 unedited
  GCATTGGNATGGCACTTCCAGGNCCAGNAAAGCACTGGGGNAGGGTCACAGGGATGCCAC
  CCGGGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGATGCATGCTCGAGCG
  GCCGCCAGTGTGATGGATATCTGCAGAATTCGCCCTTACTCCAAAAACTGGGGCTCAATC
  TATATCTCGAACTTTAAAAGCCCCAAAGTATGTTGCATCCTGATCCGGATCCAGTAAGGA
  GGGGTTGGAGACCTCGATGCTGATTTCCTCTCCAGACCGTAACTTAAAAAATCCACCAAC
  GTTTATGGAATAAAAATGGAATTCAGAATTCCCTGACCAATACTTGGTGCTTCCTCCTTT
  CATCAGGGTATGAGAACTTGGGATTTTGATGCTGGTTTTAGTGACGTACACCATTAGTTG
  AAGATACTCTGTAGCTAGGTCTCCTGAAGTTTCATGATGTCGAAAGCAAATGTTGGCATA
  CAGGTAATAAAAGCCATCCTGATTAACTATTAGTTTTCCATTGCTAANAGTCATGTTGGA
  GATCTTGGCCCAACCCCGATCATGGTACCAAGAGGACAGACTCACTTTATGGGAACCAGA
  TGGGATGTCGGTGGCATTAATAGTGAGATGAGCAAAAAGCTGAGCTTTCAGCTTGCTCCT
  CTTGGCCAGATCTAACCATGAGCCATCCACCATCGCTTTCTCTGCTCTGATGTGCTGTGA
  TCCCACGATATGTTGTATTCCCTTTTGCACAGCTCCTTGAAGGCCTGTTTAANTCTCCTA
  CATGAATCAGTATAATTTTGGATACTGACTCTCCAAAGTTGTGGTCTGGAAATCTGCATT
  TTCATGGAGTCTCAAATTCTATAATGCAGTGAGTGCCATCTTCTGAAATTCTATTAAGAT
  CCAT
  
• Restriction Sites: Please inquire
• ACCN: NM_033012
• ORF Size: 735 bp
• Insert Size: 800
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.

Reference Data

• RefSeq: NM_033012.2, NP_143026.1
• RefSeq Size: 1931
• RefSeq ORF: 735
• Locus ID: 8600
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction
• Gene Summary: This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (2) with a shorter N-terminus compared to isoform 1.