GAB2 (NM_080491) Human Untagged Clone

CAT#: SC305788

GAB2 (untagged)-Human GRB2-associated binding protein 2 (GAB2), transcript variant 1


  "NM_080491" in other vectors (6)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol GAB2
Synonyms KIAA0571
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC305788 sequence for NM_080491 edited (data generated by NextGen Sequencing)
ATGAGCGGCGGCGGCGACGTGGTGTGCACCGGCTGGCTGAGGAAATCGCCTCCCGAGAAG
AAGTTGAGGCGCTATGCCTGGAAGAAACGCTGGTTTATCCTGCGGAGTGGCCGGATGAGC
GGTGACCCAGATGTTCTGGAATACTACAAGAACGATCACTCCAAGAAGCCTCTGCGGATC
ATCAACCTGAACTTCTGTGAGCAGGTAGATGCAGGCCTGACCTTTAACAAGAAGGAGCTG
CAGGATAGTTTTGTGTTTGACATCAAGACCAGTGAACGCACCTTTTACCTGGTGGCTGAG
ACAGAAGAGGACATGAATAAGTGGGTCCAGAGCATCTGCCAGATCTGTGGCTTCAATCAG
GCTGAGGAGAGCACAGACTCCCTGAGAAATGTTTCCTCAGCCGGTCATGGCCCCCGCTCT
TCTCCAGCTGAGCTCAGCAGCTCTAGCCAGCACCTTCTCCGAGAGCGCAAGTCCTCAGCC
CCATCACACTCCAGCCAGCCAACTCTGTTCACGTTTGAACCCCCTGTGTCAAACCACATG
CAGCCCACCTTGTCCACCAGCGCACCTCAGGAGTATCTCTACTTGCACCAGTGCATAAGC
CGAAGAGCAGAAAATGCAAGGAGTGCCAGCTTCTCTCAGGGCACCAGAGCCTCTTTTCTC
ATGAGGAGTGACACAGCTGTACAAAAACTTGCCCAGGGCAATGGACACTGTGTCAACGGG
ATCAGTGGTCAAGTCCATGGCTTCTATAGCCTTCCCAAGCCGAGCCGGCACAATACAGAA
TTCAGAGACAGTACCTACGACCTCCCCCGCAGCCTGGCCTCCCATGGCCACACCAAGGGC
AGCCTCACAGGCTCCGAGACAGATAATGAGGATGTGTACACCTTCAAGACGCCCAGCAAC
ACCCTGTGCAGGGAGTTTGGGGACCTCCTGGTAGACAATATGGATGTTCCGGCCACCCCA
CTCTCAGCCTACCAGATCCCTAGGACATTCACTCTGGACAAAAACCACAATGCCATGACA
GTGGCCACTCCTGGGGACTCAGCCATAGCTCCCCCACCCCGCCCCCCCAAGCCAAGTCAG
GCAGAAACACCTCGATGGGGCAGTCCTCAGCAGAGACCGCCAATCAGTGAAAATAGCAGA
TCTGTCGCTGCCACCATCCCCAGACGCAACACCCTCCCTGCAATGGACAACAGCCGACTT
CACCGAGCTTCTTCCTGTGAGACCTACGAGTACCCACAGCGTGGTGGAGAGAGTGCAGGC
CGGTCTGCTGAATCCATGAGTGATGGAGTCGGCTCTTTCCTGCCAGGGAAAATGATTGTG
GGCCGATCGGACAGCACCAATTCTGAAGACAACTATGTGCCCATGAATCCAGGTTCTTCC
ACCCTGTTGGCCATGGAACGAGCAGGTGATAATTCCCAGAGCGTCTACATCCCAATGAGC
CCAGGGGCCCATCACTTTGACTCACTTGGCTACCCATCAACAACCCTTCCTGTGCACCGA
GGCCCCAGCAGAGGAAGTGAGATTCAGCCACCCCCTGTCAACCGCAACCTCAAACCTGAT
CGGAAAGCAAAGCCAACACCACTTGACCTGAGGAACAACACCGTCATCGATGAACTCCCC
TTCAAGTCACCTATCACCAAGTCTTGGTCTAGGGCCAACCACACCTTCAACTCCAGCTCC
TCCCAGTACTGCCGCCCCATCTCCACCCAGAGCATCACCAGCACAGACTCAGGAGACAGC
GAAGAGAACTATGTCCCTATGCAAAACCCAGTGTCTGCATCTCCCGTTCCCAGTGGCACG
AACAGTCCTGCCCCTAAGAAGAGCACCGGCAGCGTTGATTATCTGGCCCTGGACTTCCAG
CCGAGCTCCCCAAGCCCCCACCGCAAGCCATCTACTTCATCCGTCACCTCTGATGAGAAG
GTGGACTACGTTCAGGTGGACAAGGAGAAGACCCAGGCCCTGCAGAACACCATGCAGGAG
TGGACAGACGTGCGGCAGTCCTCGGAGCCTTCCAAGGGTGCCAAGCTGTGA

Clone variation with respect to NM_080491.2
918 c=>t;1290 t=>c;2004 a=>g
Restriction Sites Please inquire     
ACCN NM_080491
ORF Size 2031 bp
Insert Size 2700
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation There are 4 nucleotide differences between the OriGene clone and the NCBI reference ORF. OriGene considers these to be polymorphisms and to reflect the natural differences between individuals. These
Reference Data
RefSeq NM_080491.1, NP_536739.1
RefSeq Size 6007
RefSeq ORF 2031
Locus ID 9846
Protein Families Druggable Genome
Protein Pathways Chronic myeloid leukemia, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis
Gene Summary This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

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