PTPRU (NM_133178) Human Untagged Clone

CAT#: SC305932

PTPRU (untagged)-Human protein tyrosine phosphatase, receptor type, U (PTPRU), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PTPRU
• Synonyms: FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI; PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_133178, the custom clone sequence may differ by one or more nucleotides
  ATGGCCCGTGCCCAGGCGCTCGTGCTGGCACTCACCTTCCAGCTCTGCGCGCCGGAGACC
  GAGACTCCGGCAGCTGGCTGCACCTTCGAGGAGGCAAGTGACCCAGCAGTGCCCTGCGAG
  TACAGCCAGGCCCAGTACGATGACTTCCAGTGGGAGCAAGTGCGAATCCACCCTGGCACC
  CGGGCACCTGCGGACCTGCCCCACGGCTCCTACTTGATGGTCAACACTTCCCAGCATGCC
  CCAGGCCAGCGAGCCCATGTCATCTTCCAGAGCCTGAGCGAGAATGATACCCACTGTGTG
  CAGTTCAGCTACTTCCTGTACAGCCGGGACGGGCACAGCCCGGGCACCCTGGGCGTCTAC
  GTGCGCGTTAATGGGGGCCCCCTGGGCAGTGCTGTGTGGAATATGACTGGATCCCACGGC
  CGTCAGTGGCACCAGGCTGAGCTGGCTGTCAGCACTTTCTGGCCCAATGAATATCAGGTG
  CTGTTTGAGGCCCTCATCTCCCCAGACCGCAGGGGCTACATGGGCCTAGATGACATCCTG
  CTTCTCAGCTACCCCTGCGCAAAGGCCCCACACTTCTCCCGCCTGGGCGACGTGGAGGTC
  AACGCGGGCCAGAACGCGTCGTTCCAGTGCATGGCCGCGGGCAGAGCGGCCGAGGCCGAA
  CGCTTCCTCTTGCAACGGCAGAGCGGGGCGCTGGTGCCGGCGGCGGGCGTGCGGCACATC
  AGCCACCGGCGCTTCCTGGCCACTTTCCCGCTGGCTGCCGTGAGCCGCGCCGAGCAGGAC
  CTGTACCGCTGTGTGTCCCAGGCCCCGCGCGGCGCGGGCGTCTCTAACTTCGCGGAGCTC
  ATCGTCAAGGAGCCCCCAACTCCCATCGCGCCCCCACAGCTGCTGCGTGCTGGCCCCACC
  TACCTCATCATCCAGCTCAACACCAACTCCATCATTGGCGACGGGCCGATCGTGCGCAAG
  GAGATTGAGTACCGCATGGCGCGCGGGCCCTGGGCTGAGGTGCACGCCGTCAGCCTGCAG
  ACCTACAAGCTGTGGCACCTCGACCCCGACACAGAGTATGAGATCAGCGTGCTGCTCACG
  CGTCCCGGAGACGGCGGCACTGGCCGCCCTGGGCCACCCCTCATCAGCCGCACCAAATGC
  GCAGAGCCCATGAGGGCCCCCAAAGGCCTGGCTTTTGCTGAGATCCAGGCCCGTCAGCTG
  ACCCTGCAGTGGGAACCACTGGGCTACAACGTGACGCGTTGCCACACCTATACTGTGTCG
  CTGTGCTATCACTACACCCTGGGCAGCAGCCACAACCAGACCATCCGAGAGTGTGTGAAG
  ACAGAGCAAGGTGTCAGCCGCTACACCATCAAGAACCTGCTGCCCTATCGGAACGTTCAC
  GTGAGGCTTGTCCTCACTAACCCTGAGGGGCGCAAAGAGGGCAAGGAGGTCACTTTCCAG
  ACGGATGAGGATGTGCCCAGTGGGATTGCAGCCGAGTCCCTGACCTTCACTCCACTGGAG
  GACATGATCTTCCTCAAGTGGGAGGAGCCCCAGGAGCCCAATGGTCTCATCACCCAGTAT
  GAGATCAGCTACCAGAGCATCGAGTCATCAGACCCGGCAGTGAACGTGCCAGGCCCACGA
  CGTACCATCTCCAAGCTCCGCAATGAGACCTACCATGTCTTCTCCAACCTGCACCCAGGC
  ACCACCTACCTGTTCTCCGTGCGGGCCCGCACAGGCAAAGGCTTCGGCCAGGCGGCACTC
  ACTGAGATAACCACTAACATCTCTGCTCCCAGCTTTGATTATGCCGACATGCCGTCACCC
  CTGGGCGAGTCTGAGAACACCATCACCGTGCTGCTGAGGCCGGCACAGGGCCGCGGTGCG
  CCCATCAGTGTGTACCAGGTGATTGTGGAGGAGGAGCGGGCGCGGAGGCTGCGGCGGGAG
  CCAGGTGGACAGGACTGCTTCCCAGTGCCATTGACCTTCGAGGCGGCGCTGGCCCGAGGC
  CTGGTGCACTACTTCGGGGCCGAACTGGCGGCCAGCAGTCTACCTGAGGCCATGCCCTTT
  ACCGTGGGTGACAACCAGACCTACCGAGGCTTCTGGAACCCACCACTTGAGCCTAGGAAG
  GCCTATCTCATCTACTTCCAGGCAGCAAGCCACCTGAAGGGGGAGACCCGGCTGAATTGC
  ATCCGCATTGCCAGGAAAGCTGCCTGCAAGGAAAGCAAGCGGCCCCTGGAGGTGTCCCAG
  AGATCGGAGGAGATGGGGCTTATCCTGGGCATCTGTGCAGGGGGGCTTGCTGTCCTCATC
  CTTCTCCTGGGTGCCATCATTGTCATCATCCGCAAAGGGAAGCCGGTGAACATGACCAAG
  GCCACCGTCAACTACCGCCAGGAGAAGACACACATGATGAGCGCCGTGGACCGCAGCTTC
  ACAGACCAGAGCACCCTGCAGGAGGACGAGCGGCTGGGCCTGTCCTTCATGGACACCCAT
  GGCTACAGCACCCGGGGAGACCAGCGCAGCGGTGGGGTCACTGAGGCCAGCAGCCTCCTG
  GGGGGCTCCCCGAGGCGTCCCTGTGGCCGGAAGGGCTCCCCATACCACACGGGGCAGCTG
  CACCCTGCGGTGCGTGTCGCAGACCTTCTGCAGCACATCAACCAGATGAAGACGGCCGAG
  GGTTACGGCTTCAAGCAGGAGTATGAGAGCTTCTTTGAAGGCTGGGACGCCACAAAGAAG
  AAAGACAAGGTCAAGGGCAGCCGGCAGGAGCCAATGCCTGCCTATGATCGGCACCGAGTG
  AAACTGCACCCGATGCTGGGAGACCCCAATGCCGACTACATTAATGCCAACTACATAGAT
  GGTTACCACAGGTCAAACCACTTCATAGCCACTCAAGGGCCGAAGCCTGAGATGGTCTAT
  GACTTCTGGCGTATGGTGTGGCAGGAGCACTGTTCCAGCATCGTCATGATCACCAAGCTG
  GTCGAGGTGGGCAGGGTGAAATGCTCACGGTACTGGCCGGAGGACTCAGACACCTACGGG
  GACATCAAGATTATGCTGGTGAAGACAGAGACCCTGGCTGAGTATGTCGTGCGCACTTTT
  GCCCTGGAGCGGAGAGGCTACTCTGCCCGGCACGAGGTCCGCCAGTTCCACTTCACAGCG
  TGGCCAGAGCATGGCGTCCCCTACCATGCCACGGGGCTGCTGGCTTTCATCCGGCGCGTG
  AAGGCCTCCACCCCACCTGATGCCGGGCCCATTGTCATCCACTGCAGCGCGGGCACCGGC
  CGCACAGGTTGCTATATCGTCCTGGATGTGATGCTGGACATGGCAGAGTGTGAGGGCGTC
  GTGGACATTTACAACTGTGTGAAGACTCTCTGCTCCCGGCGTGTCAACATGATCCAGACT
  GAGGAGCAGTACATCTTCATTCATGATGCAATCCTGGAGGCCTGCCTGTGTGGGGAGACC
  ACCATCCCTGTCAGTGAGTTCAAGGCCACCTACAAGGAGATGATCCGCATTGATCCTCAG
  AGTAATTCCTCCCAGCTGCGGGAAGAGTTCCAGACGCTGAACTCGGTCACCCCGCCGCTG
  GACGTGGAGGAGTGCAGCATCGCCCTGTTGCCCCGGAACCGCGACAAGAACCGCAGCATG
  GACGTCCTGCCGCCCGACCGCTGCCTGCCCTTCCTCATCTCCACTGATGGGGACTCCAAC
  AACTACATTAATGCAGCCCTGACTGACAGCTACACACGGAGTGCGGCCTTCATCGTGACC
  CTGCACCCGCTGCAGAGCACCACGCCCGACTTCTGGCGGCTGGTCTACGATTACGGGTGC
  ACCTCCATCGTCATGCTCAACCAGCTGAACCAGTCCAACTCCGCCTGGCCCTGCCTGCAG
  TACTGGCCAGAGCCAGGCCGGCAGCAATATGGCCTCATGGAGGTGGAGTTTATGTCGGGC
  ACAGCTGATGAAGACTTAGTGGCTCGAGTCTTCCGGGTGCAGAACATCTCTCGGTTGCAG
  GAGGGGCACCTGCTGGTGCGGCACTTCCAGTTCCTGCGCTGGTCTGCATACCGGGACACA
  CCTGACTCCAAGAAGGCCTTCTTGCACCTGCTGGCTGAGGTGGACAAGTGGCAGGCCGAG
  AGTGGGGATGGGCGCACCATCGTGCACTGCCTAAACGGGGGAGGACGCAGCGGCACCTTC
  TGCGCCTGCGCCACGGTCCTGGAGATGATCCGCTGCCACAACTTGGTGGACGTTTTCTTT
  GCTGCCAAAACCCTCCGGAACTACAAACCCAACATGGTGGAGACCATGGATCAGTACCAC
  TTTTGCTACGATGTGGCCCTGGAGTACTTGGAGGGGCTGGAGTCAAGATAG
  
• Restriction Sites: Please inquire
• ACCN: NM_133178
• ORF Size: 4311 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_133178.1, NP_573439.1
• RefSeq Size: 5607
• RefSeq ORF: 4311
• Locus ID: 10076
• Protein Families: Transmembrane
• Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010]
  Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is 10 aa shorter than isoform 3.