TLR4 (NM_138556) Human Untagged Clone

CAT#: SC306037

TLR4 (untagged)-Human toll-like receptor 4 (TLR4), transcript variant 2


Reconstitution Protocol

USD 660.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol TLR4
Synonyms ARMD10; CD284; homolog of Drosophila toll; hToll; OTTHUMP00000022807; TOLL; TOLL, hToll; toll-like receptor 4
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_138556 edited
GGACTCTGATCCCAGCCATGGCCTTCCTCTCCTGCGTGAGACCAGAAAGCTGGGAGCCCT
GCGTGGAGACTTGGCCCTAAACCACACAGAAGAGCTGGCATGAAACCCAGAGCTTTCAGA
CTCCGGAGCCTCAGCCCTTCACCCCGATTCCATTGCTTCTTGCTAAATGCTGCCGTTTTA
TCACGGAGGTGTGAAATCCAGACAATTGAAGATGGGGCATATCAGAGCCTAAGCCACCTC
TCTACCTTAATATTGACAGGAAACCCCATCCAGAGTTTAGCCCTGGGAGCCTTTTCTGGA
CTATCAAGTTTACAGAAGCTGGTGGCTGTGGAGACAAATCTAGCATCTCTAGAGAACTTC
CCCATTGGACATCTCAAAACTTTGAAAGAACTTAATGTGGCTCACAATCTTATCCAATCT
TTCAAATTACCTGAGTATTTTTCTAATCTGACCAATCTAGAGCACTTGGACCTTTCCAGC
AACAAGATTCAAAGTATTTATTGCACAGACTTGCGGGTTCTACATCAAATGCCCCTACTC
AATCTCTCTTTAGACCTGTCCCTGAACCCTATGAACTTTATCCAACCAGGTGCATTTAAA
GAAATTAGGCTTCATAAGCTGACTTTAAGAAATAATTTTGATAGTTTAAATGTAATGAAA
ACTTGTATTCAAGGTCTGGCTGGTTTAGAAGTCCATCGTTTGGTTCTGGGAGAATTTAGA
AATGAAGGAAACTTGGAAAAGTTTGACAAATCTGCTCTAGAGGGCCTGTGCAATTTGACC
ATTGAAGAATTCCGATTAGCATACTTAGACTACTACCTCGATGGTATTATTGACTTATTT
AATTGTTTGACAAATGTTTCTTCATTTTCCCTGGTGAGTGTGACTATTGAAAGGGTAAAA
GACTTTTCTTATAATTTCGGATGGCAACATTTAGAATTAGTTAACTGTAAATTTGGACAG
TTTCCCACATTGAAACTCAAATCTCTCAAAAGGCTTACTTTCACTTCCAACAAAGGTGGG
AATGCTTTTTCAGAAGTTGATCTACCAAGCCTTGAGTTTCTAGATCTCAGTAGAAATGGC
TTGAGTTTCAAAGGTTGCTGTTCTCAAAGTGATTTTGGGACAATCAGCCTAAAGTATTTA
GATCTGAGCTTCAATGGTGTTATTACCATGAGTTCAAACTTCTTGGGCTTAGAACAACTA
GAACATCTGGATTTCCAGCATTCCAATTTGAAACAAATGAGTGAGTTTTCAGTATTCCTA
TCACTCAGAAACCTCATTTACCTTGACATTTCTCATACTCACACCAGAGTTGCTTTCAAT
GGCATCTTCAATGGCTTGTCCAGTCTCGAAGTCTTGAAAATGGCTGGCAATTCTTTCCAG
GAAAACTTCCTTCCAGATATCTTCACAGAGCTGAGAAACTTGACCTTCCTGGACCTCTCT
CAGTGTCAACTGGAGCAGTTGTCTCCAACAGCATTTAACTCACTCTCCAGTCTTCAGGTA
CTAAATATGAGCCACAACAACTTCTTTTCATTGGATACGTTTCCTTATAAGTGTCTGAAC
TCCCTCCAGGTTCTTGATTACAGTCTCAATCACATAATGACTTCCAAAAAACAGGAACTA
CAGCATTTTCCAAGTAGTCTAGCTTTCTTAAATCTTACTCAGAATGACTTTGCTTGTACT
TGTGAACACCAGAGTTTCCTGCAATGGATCAAGGACCAGAGGCAGCTCTTGGTGGAAGTT
GAACGAATGGAATGTGCAACACCTTCAGATAAGCAGGGCATGCCTGTGCTGAGTTTGAAT
ATCACCTGTCAGATGAATAAGACCATCATTGGTGTGTCGGTCCTCAGTGTGCTTGTAGTA
TCTGTTGTAGCAGTTCTGGTCTATAAGTTCTATTTTCACCTGATGCTTCTTGCTGGCTGC
ATAAAGTATGGTAGAGGTGAAAACATCTATGATGCCTTTGTTATCTACTCAAGCCAGGAT
GAGGACTGGGTAAGGAATGAGCTAGTAAAGAATTTAGAAGAAGGGGTGCCTCCATTTCAG
CTCTGCCTTCACTACAGAGACTTTATTCCCGGTGTGGCCATTGCTGCCAACATCATCCAT
GAAGGTTTCCATAAAAGCCGAAAGGTGATTGTTGCGGTGTCCCAGCACTTCATCCAGAGC
CGCTGGTGTATCTTTGAATATGAGATTGCTCAGACCTGGCAGTTTCTGAGCAGTCGTGCT
GGTATCATCTTCATTGTCCTGCAGAAGGTGGAGAAGACCCTGCTCAGGCAGCAGGTGGAG
CTGTACCGCCTTCTCAGCAGGAACACTTACCTGGAGTGGGAGGACAGTGTCCTGGGGCGG
CACATCTTCTGGAGACGACTCAGAAAAGCCCTGCTGGATGGTAAATCATGGAATCCAGAA
GGAACAGTGGGTACAGGATGCAATTGGCAGGAAGCAACATCTATCTGAAGAGGAAAAATA
AAAACCTCCTGAGGCATTTCTTGCCCAGCTGGGTCCAACACTTGTTCAGTTAATAAGTAT
TAAATGCTGCCACATGTCAGGCCTTATG
>OriGene 5' read for NM_138556 unedited
GGGGGGTTAAATTTGTATACGACTCATATAGGGCGGCCGCGAATTCGCACGAGGGCGAGC
CACGCATTCACAGGGCCACTGCTGCTCACAGAAGCAGTGAGGATGATGCCAGGATGATGT
CTGCCTCGCGCCTGGCTGGGACTCTGATCCCAGCCATGGCCTTCCTCTCCTGCGTGAGAC
CAGAAAGCTGGGAGCCCTGCGTGGAGACTTGGCCCTAAACCACACAGAAGAGCTGGCATG
AAACCCAGAGCTTTCAGACTCCGGAGCCTCAGCCCTTCACCCCGATTCCATTGCTTCTTG
CTAAATGCTGCCGTTTTATCACGGAGGTGTGAAATCCAGACAATTGAAGATGGGGCATAT
CAGAGCCTAAGCCACCTCTCTACCTTAATATTGACAGGAAACCCCATCCAGAGTTTAGCC
CTGGGAGCCTTTTCTGGACTATCAAGTTTACAGAAGCTGGTGGCTGTGGAGACAAATCTA
GCATCTCTAGAGAACTTCCCCATTGGACATCTCAAAACTTTGAAAGAACTTAATGTGGCT
CACAATCTTATCCAATCTTTCAAATTACCTGAGTATTTTTCTAATCTGACCAATCTAGAG
CACTTGGACCTTTCCAGCAACAAGATTCAAAGTATTTATTGCACAGACTTGCGGGTTCTA
CATCAAATGCCCCTACTCAATCTCTCTTTAGACCTGTCCCTGAACCCTATGAACTTTATC
CAACCAGGTGCATTTAAAGAAATTANGCTTCATAAGCTGACTTTAAGAAATAATTTTGAT
AGTTTAAATGTAATGAANACTTGTATTCANAGTCTGGCTGGTTTAGAAGTCCATCGTTTG
GTTCTGGGAGAATTTAGAAATGAANGAAACTTGGNAAAGTT
>OriGene 3' genomic read for NM_138556 unedited
NTTCTCATCGCACACGTTACAGAAGCTGGTGGCTGTGGAGACAATCTAGCATCTCTATAG
AACTTCGCCATTGGACATCTCAAAACTTTGAAAGAACTTAATGTGGCTCACAATCTTATC
CAATCTTTCAAATTACCTGAGTATTTTTCTAATCTGACCAATCTAGAGCACTTGGACCTT
TCCAGCAACAAGATTCAAAGTATTTATTGCACAGACTTGCGGGTTCTACATCAAATGCCC
CTACTCAATCTCTCTTTAGACCTGTCCCTGAACCCTATGAACTTTATCCAACCAGGTGCA
TTTAAAGAAATTAGGCTTCATAAGCTGACTTTAAGAAATAATTTTGATAGTTTAACCGTA
ATGAAAACTTGTATTCAAGGTCTGGCTGGTTTAGAAGTCCATCGTTTGGTTCTGGGAGAA
TTTAGAAATGAAGGAAACTTGGAAAAGTTTGACAAATCTGCTCTAGAGGGCCTGTGCAAT
TTGACCATTGAAGAATTCCGATTAGCATACTTAGACTACTACCTCGATGGTATTATTGAC
TTATTTAATTGTTTGACAAATGTTTCTTCATTTTCCCTGGTGAGTGTGACTATTGAAAGG
GTAAAAGACTTTTCTTATAATTTCGGATGGCAACATTTACAATTAGTTAACTGTAAATTT
GGACAGTTTCCCACATTGAAACTCAAATCTCTCAAAAGGCTTACTTTCACTTCCAACAAA
GGTGGGAATGCTTTTTCAGAAGTTGATCTACCAAGCCTTGAGTTTCTAGATCTCAGTACA
AATGGCTTGAGTTTCAAAGGTTGCTGTTCTCAAAGTGATTTTGGGACAATCAGCCTAAAG
TATTTAGATCTGAGCTTCAATGGTGTTATTACCATGAGTTCAAACTTCTTGGGCTTAGAA
CAACTAGAACATCTTAATTTCCAGCATTCCAATTTGAACAAATGAGTGAGTTTTCAGTAT
TCCTATCACTCAAAACCTCATTTACCTTGACATTTCTCTACTCACACCAGAATTGCTTTC
ATGGCATCTTCAATGGCTGTCCATCCCCAAGTCTGGAAATGGCTTGGCAATTCTTCCCGG
AAAACTTCCTTTCCAATTCCTTCCCGGAGCGGAAAAACTTGACCTTCCTGGACCCCTCCC
AAGGTCAATGGGAACAACTGGTCCCCCACGGCTTTTAATTCACCCCTCAGTCTTTCGGGT
TATAAGATATGAGACCCCAGAACCTTCTCTTTTTTGGTGAAACGCTTCCCTCCTTAAGGT
GAGTTAATAATCTCTCCTCGGAGTGGTTTGTAATGATGCCCTCGAGCGCCTCAAACGCCG
CTCTCAAACATATAAGGGATAGATNTTATGTTTTTCTNGTCGTGCTCTAACCTCTCTNTC
ACATTCGATGATGAAGAGAAT
Restriction Sites Please inquire     
ACCN NM_138556
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation There are 3 nucleotide differences between the OriGene clone and the NCBI reference ORF. OriGene considers these to be polymorphisms and to reflect the natural differences between individuals. These result in the substitution of 3 amino acids.
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_138556.1, NP_612566.1
RefSeq Size 3767 bp
RefSeq ORF 2349 bp
Locus ID 7099
Cytogenetics 9q33.1
Protein Families Druggable Genome, Transmembrane
Protein Pathways Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway
Gene Summary 'The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]'
Transcript Variant: This variant (2) uses an alternative exon 2 compared to transcript variant 1, and encodes an isoform (B) with a different N-terminus compared to that of isoform (A).

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