NLRP7 (NM_139176) Human Untagged Clone

CAT#: SC306130

NLRP7 (untagged)-Human NLR family, pyrin domain containing 7 (NLRP7), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NLRP7
• Synonyms: CLR19.4; HYDM; NALP7; NOD12; PAN7; PYPAF3
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_139176, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGACATCGCCCCAGCTAGAGTGGACTCTGCAGACCCTTCTGGAGCAGCTGAACGAGGATGAATTAAAGA
  GTTTCAAATCCCTTTTATGGGCTTTTCCCCTCGAAGACGTGCTACAGAAGACCCCATGGTCTGAGGTGGA
  AGAGGCTGATGGCAAGAAACTGGCAGAAATTCTGGTCAACACCTCCTCAGAAAATTGGATAAGGAATGCG
  ACTGTGAACATCTTGGAAGAGATGAATCTCACGGAATTGTGTAAGATGGCAAAGGCTGAGATGATGGAGG
  ACGGACAGGTGCAAGAAATAGATAATCCTGAGCTGGGAGATGCAGAAGAAGACTCGGAGTTAGCAAAGCC
  AGGTGAAAAGGAAGGATGGAGAAATTCAATGGAGAAACAGTCTTTGGTCTGGAAGAACACCTTTTGGCAA
  GGAGACATTGACAATTTCCATGACGACGTCACTCTGAGAAACCAACGGTTCATTCCATTCTTGAATCCCA
  GAACACCCAGGAAGCTAACACCTTACACGGTGGTGCTGCACGGCCCCGCAGGCGTGGGGAAAACCACGCT
  GGCCAAAAAGTGTATGCTGGACTGGACAGACTGCAACCTCAGCCCGACGCTCAGATACGCGTTCTACCTC
  AGCTGCAAGGAGCTCAGCCGCATGGGCCCCTGCAGTTTTGCAGAGCTGATCTCCAAAGACTGGCCTGAAT
  TGCAGGATGACATTCCAAGCATCCTAGCCCAAGCACAGAGAATCCTGTTCGTGGTCGATGGCCTTGATGA
  GCTGAAAGTCCCACCTGGGGCGCTGATCCAGGACATCTGCGGGGACTGGGAGAAGAAGAAGCCGGTGCCC
  GTCCTCCTGGGGAGTTTGCTGAAGAGGAAGATGTTACCCAGGGCAGCCTTGCTGGTCACCACGCGGCCCA
  GGGCACTGAGGGACCTCCAGCTCCTGGCGCAGCAGCCGATCTACGTAAGGGTGGAGGGCTTCCTGGAGGA
  GGACAGGAGGGCCTATTTCCTGAGACACTTTGGAGACGAGGACCAAGCCATGCGTGCCTTTGAGCTAATG
  AGGAGCAACGCGGCCCTGTTCCAGCTGGGCTCGGCCCCCGCGGTGTGCTGGATTGTGTGCACGACTCTGA
  AGCTGCAGATGGAGAAGGGGGAGGACCCGGTCCCCACCTGCCTCACCCGCACGGGGCTGTTCCTGCGTTT
  CCTCTGCAGCCGGTTCCCGCAGGGCGCACAGCTGCGGGGCGCGCTGCGGACGCTGAGCCTCCTGGCCGCG
  CAGGGCCTGTGGGCGCAGATGTCCGTGTTCCACCGAGAGGACCTGGAAAGGCTCGGGGTGCAGGAGTCCG
  ACCTCCGTCTGTTCCTGGACGGAGACATCCTCCGCCAGGACAGAGTCTCCAAAGGCTGCTACTCCTTCAT
  CCACCTCAGCTTCCAGCAGTTTCTCACTGCCCTGTTCTACGCCCTGGAGAAGGAGGAGGGGGAGGACAGG
  GACGGCCACGCCTGGGACATCGGGGACGTACAGAAGCTGCTTTCCGGAGAAGAAAGACTCAAGAACCCCG
  ACCTGATTCAAGTAGGACACTTCTTATTCGGCCTCGCTAACGAGAAGAGAGCCAAGGAGTTGGAGGCCAC
  TTTTGGCTGCCGGATGTCACCGGACATCAAACAGGAATTGCTGCAATGCAAAGCACATCTTCATGCAAAT
  AAGCCCTTATCCGTGACCGACCTGAAGGAGGTCTTGGGCTGCCTGTATGAGTCTCAGGAGGAGGAGCTGG
  CGAAGGTGGTGGTGGCCCCGTTCAAGGAAATTTCTATTCACCTGACAAATACTTCTGAAGTGATGCATTG
  TTCCTTCAGCCTGAAGCATTGTCAAGACTTGCAGAAACTCTCACTGCAGGTAGCAAAGGGGGTGTTCCTG
  GAGAATTACATGGATTTTGAACTGGACATTGAATTTGAAAGCTCAAACAGCAACCTCAAGTTTCTGGAAG
  TGAAACAAAGCTTCCTGAGTGACTCTTCTGTGCGGATTCTTTGTGACCACGTAACCCGTAGCACCTGTCA
  TCTGCAGAAAGTGGAGATTAAAAACGTCACCCCTGACACCGCGTACCGGGACTTCTGTCTTGCTTTCATT
  GGGAAGAAGACCCTCACGCACCTGACCCTGGCAGGGCACATCGAGTGGGAACGCACGATGATGCTGATGC
  TGTGTGACCTGCTCAGAAATCATAAATGCAACCTGCAGTACCTGAGGTTGGGAGGTCACTGTGCCACCCC
  GGAGCAGTGGGCTGAATTCTTCTATGTCCTCAAAGCCAACCAGTCCCTGAAGCACCTGCGTCTCTCAGCC
  AATGTGCTCCTGGATGAGGGTGCCATGTTGCTGTACAAGACCATGACACGCCCAAAACACTTCCTGCAGA
  TGTTGTCGTTGGAAAACTGTCGTCTTACAGAAGCCAGTTGCAAGGACCTTGCTGCTGTCTTGGTTGTCAG
  CAAGAAGCTGACACACCTGTGCTTGGCCAAGAACCCCATTGGGGATACAGGGGTGAAGTTTCTGTGTGAG
  GGCTTGAGTTACCCTGATTGTAAACTGCAGACCTTGGTGTTACAGCAATGCAGCATAACCAAGCTTGGCT
  GTAGATATCTCTCAGAGGCGCTCCAAGAAGCCTGCAGCCTCACAAACCTGGACTTGAGTATCAACCAGAT
  AGCTCGTGGATTGTGGATTCTCTGTCAGGCATTAGAGAATCCAAACTGTAACCTAAAACACCTACGCCTC
  TGGAGCTGCTCCCTCATGCCTTTCTATTGTCAGCATCTTGGATCTGCTCTCCTCAGCAATCAGAAGCTTG
  AAACTCTGGACCTGGGCCAGAATCATTTGTGGAAGAGTGGCATAATTAAGCTCTTTGGGGTTCTAAGACA
  AAGAACTGGATCCTTGAAGATACTCAGGTTGAAGACCTATGAAACTAATTTGGAAATCAAGAAGCTGTTG
  GAGGAAGTGAAAGAAAAGAATCCCAAGCTGACTATTGATTGCAATGCTTCCGGGGCAACGGCACCTCCGT
  GCTGTGACTTTTTTTGCTGA
  
  
• Restriction Sites: SgfI-RsrII
• ACCN: NM_139176
• ORF Size: 3030 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_139176.3, NP_631915.2
• RefSeq Size: 3337
• RefSeq ORF: 3030
• Locus ID: 199713
• Gene Summary: This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 5' coding region, compared to variant 3, resulting in a shorter protein (isoform 1), compared to isoform 3.