MCOLN2 (NM_153259) Human Untagged Clone

CAT#: SC306572

MCOLN2 (untagged)-Human mucolipin 2 (MCOLN2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MCOLN2
• Synonyms: TRP-ML2; TRPML2
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_153259 edited
  ATGGCCCGGCAGCCTTATCGTTTTCCCCAGGCAAGGATTCCGGAGAGAGGATCAGGTGTT
  TTCAGGTTAACCGTCAGAAACGCAATGGCACATCGTGATTCTGAGATGAAAGAAGAATGT
  CTAAGGGAAGACCTGAAGTTTTACTTCATGAGCCCTTGTGAAAAATACCGAGCCAGACGC
  CAGATTCCGTGGAAACTGGGTTTGCAGATTTTGAAGATAGTCATGGTCACCACACAGCTT
  GTTCGTTTTGGTTTAAGTAACCAGCTGGTGGTTGCTTTCAAAGAAGATAACACTGTTGCT
  TTTAAGCACTTGTTTTTGAAAGGATATTCTGGTACAGATGAAGATGACTACAGCTGCAGT
  GTATATACTCAAGAGGATGCCTATGAGAGCATCTTTTTTGCTATTAATCAGTATCATCAG
  CTAAAGGACATTACCCTGGGGACCCTTGGTTATGGAGAAAATGAAGACAATAGAATTGGC
  TTAAAAGTCTGTAAGCAGCATTACAAGAAAGGGACCATGTTTCCTTCTAATGAGACACTG
  AATATTGACAACGACGTTGAGCTCGATTGTGTTCAATTAGACCTTCAGGACCTCTCCAAG
  AAGCCTCCGGACTGGAAGAACTCATCATTCTTCAGACTGGAATTTTATCGGCTCTTACAG
  GTTGAAATCTCCTTTCATCTTAAAGGCATTGACCTACAGACAATTCATTCCCGTGAGTTA
  CCAGACTGTTATGTCTTTCAGAATACGATTATCTTTGACAATAAAGCTCACAGTGGCAAA
  ATCAAAATCTATTTTGACAGTGATGCCAAAATTGAAGAATGTAAAGACTTGAACATATTT
  GGATCTACTCAGAAAAATGCTCAGTATGTCCTGGTGTTTGATGCATTTGTCATTGTGATT
  TGCTTGGCATCTCTTATTCTGTGTACAAGATCCATTGTTCTTGCTCTAAGGTTACGGAAG
  AGATTTCTAAATTTCTTCCTGGAGAAGTACAAGCGGCCTGTGTGTGACACCGACCAGTGG
  GAGTTCATCAACGGCTGGTATGTCCTGGTGATTATCAGCGACCTAATGACAATCATTGGC
  TCCATATTAAAAATGGAAATCAAAGCAAAGAATCTCACAAACTATGATCTCTGCAGCATT
  TTTCTTGGAACCTCTACGCTCTTGGTTTGGGTTGGAGTCATCAGATACCTGGGTTATTTC
  CAGGCATATAATGTGCTGATTTTAACAATGCAGGCCTCACTGCCAAAAGTTCTTCGGTTT
  TGTGCTTGTGCTGGTATGATTTATCTGGGTTACACATTCTGTGGCTGGATTGTCTTAGGA
  CCATACCATGACAAGTTTGAAAATCTGAACACAGTTGCTGAGTGTCTGTTTTCTCTGGTC
  AACGGTGATGACATGTTTGCAACCTTTGCCCAAATCCAGCAGAAGAGCATCTTGGTGTGG
  CTGTTCAGTCGTCTGTATTTATATTCCTTCATCAGCCTTTTTATATATATGATTCTCAGT
  CTTTTTATTGCACTTATTACAGATTCTTATGACACCATTAAGAAATTCCAACAGAATGGG
  TTTCCTGAAACGGATTTGCAGGAATTCCTGAAGGAATGCAGTAGCAAAGAAGAGTATCAG
  AAAGAGTCCTCAGCCTTCCTGTCCTGCATCTGCTGTCGGAGGAGGAAAAGAAGTGATGAT
  CACTTGATACCTATTAGCTAA
  
• Restriction Sites: Please inquire
• ACCN: NM_153259
• ORF Size: 1701 bp
• Insert Size: 1700
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_153259.2, NP_694991.2
• RefSeq Size: 3060
• RefSeq ORF: 1701
• Locus ID: 255231
• Protein Families: Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane
• Gene Summary: Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]). [supplied by OMIM, Sep 2009]
  Transcript Variant: This variant (1) encodes the longer isoform (1).