RAGE (AGER) (NM_172197) Human Untagged Clone

CAT#: SC306735

AGER (untagged)-Human advanced glycosylation end product-specific receptor (AGER), transcript variant 7


  "NM_172197" in other vectors (4)

Reconstitution Protocol

USD 580.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol AGER
Synonyms RAGE; SCARJ1
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_172197 edited
GGTCCCTGGAAGGAAGCAGGATGGCAGCCGGAACAGCAGTTGGAGCCTGGGTGCTGGTCC
TCAGTCTGTGGGGGGCAGTAGTAGGTGCTCAAAACATCACAGCCCGGATTGGCGAGCCAC
TGGTGCTGAAGTGTAAGGGGGCCCCCAAGAAACCACCCCAGCGGCTGGAATGGAAACTGG
GAGGAGGCCCCTGGGACAGTGTGGCTCGTGTCCTTCCCAACGGCTCCCTCTTCCTTCCGG
CTGTCGGGATCCAGGATGAGGGGATTTTCCGGTGCCAGGCAATGAACAGGAATGGAAAGG
AGACCAAGTCCAACTACCGAGTCCGTGTCTACCAGATTCCTGGGAAGCCAGAAATTGTAG
ATTCTGCCTCTGAACTCACGGCTGGTGTTCCCAATAAGGTGGGGACATGTGTGTCAGAGG
GAAGCTACCCTGCAGGGACTCTTAGCTGGCACTTGGATGGGAAGCCCCTGGTGCCTAATG
AGAAGGGAGTATCTGTGAAGGAACAGACCAGGAGACACCCTGAGACAGGGCTCTTCACAC
TGCAGTCGGAGCTAATGGTGACCCCAGCCCGGGGAGGAGATCCCCGTCCCACCTTCTCCT
GTAGCTTCAGCCCAGGCCTTCCCCGACACCGGGCCTTGCGCACAGCCCCCATCCAGCCCC
GTGTCTGGGAGCCTGTGCCTCTGGAGGAGGTCCAATTGGTGGTGGAGCCAGAAGGTGGAG
CAGTAGCTCCTGGTGGAACCGTAACCCTGACCTGTGAAGTCCCTGCCCAGCCCTCTCCTC
AAATCCACTGGATGAAGGATGTGAGTGACCTGGAGAGAGGGGCTGGGAGAACCAGGCGAG
GAGGGGCCAACTGCAGGCTCTGTGGGAGGATCAGGGCTGGGAACTCTAGCCCTGGCCCTG
GGGATCCTGGGAGGCCTGGGGACAGCCGCCCTGCTCATTGGGGTCATCTTGTGGCAAAGG
CGGCAACGCCGAGGAGAGGAGAGGAAGGCCCCAGAAAACCAGGAGGAAGAGGAGGAGCGT
GCAGAACTGAATCAGTCGGAGGAACCTGAGGCAGGCGAGAGTAGTACTGGAGGGCCTTGA
GGGGCCCACAGACAGATCCCATCCATCAGCTCCCTTTTCTTTTTCCCTTGAACTGTTCTG
GCCTCAGACCAACTCTCTCCTGTATAATCTCTCTCCTGTATAACCCCACCTTGCCAAGCT
TTCTTCTACAACCAGAGCCCCCACAATGATGATTAAACACCTGACACATCTCAAAAAAAA
AAAAAAAAAAAAAAAAAAA
>OriGene 5' read for NM_172197 unedited
GGTGCTATATGTATACGACTCCTATAGGGCGGCCGCGAATTCGGCCATTACGGCCGGGGG
TCCCTGGAAGGAAGCAGGATGGCAGCCGGAACAGCAGTTGGAGCCTGGGTGCTGGTCCTC
AGTCTGTGGGGGGCAGTAGTAGGTGCTCAAAACATCACAGCCCGGATTGGCGAGCCACTG
GTGCTGAAGTGTAAGGGGGCCCCCAAGAAACCACCCCAGCGGCTGGAATGGAAACTGGGA
GGAGGCCCCTGGGACAGTGTGGCTCGTGTCCTTCCCAACGGCTCCCTCTTCCTTCCGGCT
GTCGGGATCCAGGATGAGGGGATTTTCCGGTGCCAGGCAATGAACAGGAATGGAAAGGAG
ACCAAGTCCAACTACCGAGTCCGTGTCTACCAGATTCCTGGGAAGCCAGAAATTGTAGAT
TCTGCCTCTGAACTCACGGCTGGTGTTCCCAATAAGGTGGGGACATGTGTGTCAGAGGGA
AGCTACCCTGCAGGGACTCTTAGCTGGCACTTGGATGGGAAGCCCCTGGTGCCTAATGAG
AAGGGAGTATCTGTGAAGGAACAGACCAGGAGACACCCTGAGACAGGGCTCTTCACACTG
CAGTCGGAGCTAATGGTGACCCCAGCCCGGGGAGGAGATCCCCGTCCCACCTTCTCCTGT
AGCTTTCAGCCCCAGGCCCTTCCCCGACACCGGGCCTTGCGCACAGCCCCCCATCCAGCC
CCCGTGTCTGGGAGCCTGTGCCTCTGGAGGAGGTCCAATTGGTGGTGGAGCCAGAAGTGG
AGCAGTAGCTCCTGGTGGAACCGTAACCCTGACCTGTGAAGTCCCTGCCCAGCCCTCTCC
TCAATCCACTGATGAAGATGTGAGTGACCTGGAGAGAGGGGCTGGGAGACCAGCGAGAGG
GCCAACTGCAGCCTCTGTGGGAGGATCAGGGCCTGGGAACCTTCTAGCCCTGG
>OriGene 3' read for NM_172197 unedited
ATGACGTATGCACCCTCAGGGCCGGAAGGCACCTGGGGTAGTGTTGTCACAGGGCACTGC
CACCCGGGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGAGGCC
GAGGCGGCCGACATGTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGATGTGTCAGGTGTTT
AATCATCATTGTGGGGGCTCTGGTTGTAGAAGAAAGCTTGGCAAGGTGGGGTTATACAGG
AGAGAGATTATACAGGAGAGAGTTGGTCTGAGGCCAGAACAGTTCAAGGGAAAAAGAAAA
GGGAGCTGATGGATGGGATCTGTCTGTGGGCCCCTCAAGGCCCTCCAGTACTACTCTCGC
CTGCCTCAGGTTCCTCCGACTGATTCAGTTCTGCACGCTCCTCCTCTTCCTCCTGGTTTT
CTGGGGCCTTCCTCTCCTCTCCTCGGCGTTGCCGCCTTTGCCACAAGATGACCCCAATGA
GCAGGGCGGCTGTCCCCAGGCCTCCCAGGATCCCCAGGGCCAGGGCTAGAGTTCCCAGCC
CTGATCCTCCCACAGAGCCTGCAGTTGGCCCCTCCTCGCCTGGTTCTCCCAGCCCCTCTC
TCCAGGTCACTCACATCCTTCATCCAGTGGATTTGAGGAGAGGGCTGGGCAGGGACTTCA
CAGGTCAGGGTTACGGTTCCACCAGGAGCTACTGCTCCACCTTCTGGCTCCACCACCAAT
TGGACCTCCTCCAGAGGCACAGGCTCCCAGACACGGGGCTGGATGGGGGCTGTGCGCAAG
GCCCGGTGTCGGGGAAGGCCTGGGCTGAAGCTACAGGAGAAGTGGGACGGGGATCTCCTC
CCCGGGCTGGGGTCACCATTAGCTCCGACTGCAGTGTGAAGAGCCTGTCTCAGGTGTCTC
TGTCTGTCTCACAGATACTCCTCTCATAGGCACCAGGCTTCCATCCAGTGCCAGCTAAAA
AGTT
Restriction Sites Please inquire     
ACCN NM_172197
Insert Size 1300 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_172197.1, NP_751947.1
RefSeq Size 1259 bp
RefSeq ORF 1029 bp
Locus ID 177
Cytogenetics 6p21.32
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Gene Summary 'The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]'
Transcript Variant: This variant (7, also known as RAGE_v16) uses alternate splice sites at several internal coding exons compared to variant 1. This results in a frame-shift and a shorter isoform (7, also known as hRAGEsec) with a distinct C-terminus compared to isoform 1. Sequence Note: This Refseq, containing two in-frame translation initiation codons (at nt 8-10 and nt 101-103), is annotated with a CDS starting from the downstream AUG (dAUG) because the AGE receptor encoded by this gene is a known type 1 transmembrane protein requiring signal peptide for its function, and a signal peptide of 22 aa is predicted for the dAUG initiated protein. Translation initiation from the upstream AUG (uAUG) will add an extra 31 aa to the N-terminus, and no signal peptide is predicted for the uAUG initiated protein.

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