DUOX1 (NM_175940) Human Untagged Clone

CAT#: SC307058

DUOX1 (untagged)-Human dual oxidase 1 (DUOX1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DUOX1
• Synonyms: LNOX1; NOXEF1; THOX1
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_175940, the custom clone sequence may differ by one or more nucleotides
  ATGGGCTTCTGCCTGGCTCTAGCATGGACACTTCTGGTTGGGGCATGGACCCCTCTGGGA
  GCTCAGAACCCCATTTCGTGGGAGGTGCAGCGATTTGATGGGTGGTACAACAACCTCATG
  GAGCACAGATGGGGCAGCAAAGGCTCCCGGCTGCAGCGCCTGGTCCCAGCCAGCTATGCA
  GATGGCGTGTACCAGCCCTTGGGAGAACCCCACCTGCCCAACCCCCGAGACCTTAGCAAC
  ACCATCTCAAGGGGCCCTGCAGGGCTGGCCTCCCTGAGAAACCGCACAGTGTTGGGGGTC
  TTCTTTGGCTATCACGTGCTTTCAGACCTGGTGAGCGTGGAAACTCCCGGCTGCCCCGCC
  GAGTTCCTCAACATTCGCATCCCGCCCGGAGACCCCATGTTCGACCCCGACCAGCGCGGG
  GACGTGGTGCTGCCCTTCCAGAGAAGCCGCTGGGACCCCGAGACCGGACGGAGTCCCAGC
  AATCCCCGGGACCCGGCCAACCAGGTGACGGGCTGGCTGGACGGCAGCGCCATCTATGGT
  TCCTCGCATTCCTGGAGCGACGCGCTGCGGAGCTTCTCCAGGGGACAGCTGGCGTCGGGG
  CCCGACCCCGCTTTTCCCCGAGACTCGCAGAACCCCCTGCTCATGTGGGCGGCGCCCGAC
  CCCGCCACCGGGCAGAACGGGCCCCGGGGGCTGTACGCCTTCGGGGCAGAGAGAGGGAAC
  CGGGAACCCTTCCTGCAGGCGCTGGGCCTGCTCTGGTTCCGCTACCACAACCTGTGGGCG
  CAGAGGCTGGCCCGCCAGCACCCAGACTGGGAGGACGAGGAGCTGTTCCAGCACGCACGC
  AAGAGGGTCATCGCCACCTACCAGAACATCGCTGTGTATGAGTGGCTGCCCAGCTTCCTG
  CAGAAAACACTCCCGGAGTATACAGGATACCGGCCATTTCTGGACCCCAGCATCTCCTCA
  GAGTTCGTGGCGGCCTCTGAGCAGTTCCTGTCCACCATGGTGCCCCCTGGCGTCTACATG
  AGAAATGCCAGCTGCCACTTCCAGGGGGTCATCAATCGGAACTCAAGTGTCTCCAGAGCT
  CTCCGGGTCTGCAACAGCTACTGGAGCCGTGAGCACCCAAGCCTACAAAGTGCTGAAGAT
  GTGGATGCACTGCTGCTGGGCATGGCCTCCCAGATCGCAGAGCGAGAGGACCATGTGTTG
  GTTGAAGATGTGCGGGATTTCTGGCCTGGGCCACTGAAGTTTTCCCGCACAGACCACCTG
  GCCAGCTGCCTGCAGCGGGGCCGGGATCTGGGCCTGCCCTCTTACACCAAGGCCAGGGCA
  GCACTGGGCTTGTCTCCCATTACCCGCTGGCAGGACATCAACCCTGCACTCTCCCGGAGC
  AATGACACTGTACTGGAGGCCACAGCTGCCCTGTACAACCAGGACTTATCCTGGCTAGAG
  CTGCTCCCTGGGGGACTCCTGGAGAGCCACCGGGACCCTGGACCTCTGTTCAGCACCATC
  GTCCTTGAACAATTTGTGCGGCTACGGGATGGTGACCGCTACTGGTTTGAGAACACCAGG
  AATGGGCTGTTCTCCAAGAAGGAGATTGAAGAAATCCGAAATACCACCCTGCAGGACGTG
  CTGGTCGCTGTTATCAACATTGACCCCAGTGCTCTGCAGCCCAATGTCTTTGTCTGGCAT
  AAAGGAGACCCCTGTCCGCAGCCGAGACAGCTCAGCACTGAAGGCCTGCCAGCGTGTGCT
  CCCTCTGTTGTTCGTGACTATTTTGAGGGCAGTGGATTTGGCTTCGGGGTCACCATCGGG
  ACCCTCTGTTGCTTCCCTTTGGTGAGCCTGCTCAGTGCCTGGATTGTTGCCCGGCTCCGG
  ATGAGAAATTTCAAGAGGCTCCAGGGCCAGGACCGCCAGAGCATCGTGTCTGAGAAGCTC
  GTGGGAGGCATGGAAGCTTTGGAATGGCAAGGCCACAAGGAGCCCTGCCGGCCCGTGCTT
  GTGTACCTGCAGCCCGGGCAGATCCGTGTGGTAGATGGCAGGCTCACCGTGCTCCGCACC
  ATCCAGCTGCAGCCTCCACAGAAGGTCAACTTCGTCCTGTCCAGCAACCGTGGACGCCGC
  ACTCTGCTGCTCAAGATCCCCAAGGAGTATGACCTGGTGCTGCTGTTTAACTTGGAGGAA
  GAGCGGCAGGCGCTGGTGGAAAATCTCCGGGGAGCTCTGAAGGAGAGCGGGTTGAGCATC
  CAGGAGTGGGAGCTGCGGGAGCAGGAGCTGATGAGAGCAGCTGTGACACGGGAGCAGCGG
  AGGCACCTCCTGGAGACCTTTTTCAGGCACCTTTTCTCCCAGGTGCTGGACATCAACCAG
  GCCGACGCAGGGACCCTGCCCCTGGACTCCTCCCAGAAGGTGCGGGAGGCCCTGACCTGT
  GAGCTGAGCAGGGCCGAGTTTGCCGAGTCCCTGGGCCTCAAGCCCCAGGACATGTTTGTG
  GAGTCCATGTTCTCTCTGGCTGACAAGGATGGCAATGGCTACCTGTCCTTCCGAGAGTTC
  CTGGACATCCTGGTGGTCTTCATGAAAGGCTCTCCTGAGGAAAAGTCTCGCCTTATGTTC
  CGCATGTACGACTTTGATGGGAATGGCCTCATTTCCAAGGATGAGTTCATCAGGATGCTG
  AGATCCTTCATCGAGATCTCCAACAACTGCCTGTCCAAGGCCCAGCTGGCTGAGGTGGTG
  GAGTCCATGTTCCGGGAGTCGGGATTCCAGGACAAGGAGGAACTGACATGGGAAGATTTT
  CACTTCATGCTGCGGGACCACAATAGCGAGCTCCGCTTCACGCAGCTCTGTGTCAAAGGG
  GTGGAGGTGCCTGAAGTCATCAAGGACCTCTGCCGGCGAGCCTCCTACATCAGCCAGGAT
  ATGATCTGTCCCTCTCCCAGAGTGAGTGCCCGCTGTTCCCGCAGCGACATTGAGACTGAG
  TTGACACCTCAGAGACTGCAGTGCCCCATGGACACAGACCCTCCCCAGGAGATTCGGCGG
  AGGTTTGGCAAGAAGGTAACGTCATTCCAGCCCTTGCTGTTCACTGAGGCGCACCGAGAG
  AAGTTCCAACGCAGCTGTCTCCACCAGACGGTGCAACAGTTCAAGCGCTTCATTGAGAAC
  TACCGGCGCCACATCGGCTGCGTGGCCGTGTTCTACGCCATCGCTGGGGGGCTTTTCCTG
  GAGAGGGCCTACTACTACGCCTTTGCCGCACATCACACGGGCATCACAGACACCACCCGC
  GTGGGAATCATCCTGTCGCGGGGCACAGCAGCCAGCATCTCTTTCATGTTCTCCTACATC
  TTGCTCACCATGTGCCGCAACCTCATCACCTTCCTGCGAGAAACCTTCCTCAACCGCTAC
  GTGCCCTTCGACGCCGCCGTGGACTTCCATCGCCTCATTGCCTCCACCGCCATCGTCCTC
  ACAGTCTTACACAGTGTGGGCCATGTGGTGAATGTGTACCTGTTCTCCATCAGCCCCCTC
  AGCGTCCTCTCTTGCCTCTTTCCTGGCCTCTTCCATGATGATGGGTCTGAGCTCCCCCAG
  AAGTATTACTGGTGGTTCTTCCAGACCGTACCAGGCCTCACGGGGGTTGTGCTGCTCCTG
  ATCCTGGCCATCATGTATGTCTTTGCCTCCCACCACTTCCGCCGCCGCAGTTTCCGGGGC
  TTCTGGCTGACCCACCACCTCTACATCCTGCTCTATGTCCTGCTCATCATCCATGGTAGC
  TTTGCCCTGATCCAGCTGCCCCGTTTCCACATCTTCTTCCTGGTCCCAGCAATCATCTAT
  GGGGGCGACAAGCTGGTGAGCCTGAGCCGGAAGAAGGTGGAGATCAGCGTGGTGAAGGCG
  GAGCTGCTGCCCTCAGGAGTGACCCACCTGCGGTTCCAGCGGCCCCAGGGCTTTGAGTAC
  AAGTCAGGGCAGTGGGTGCGGATCGCTTGCCTGGCTCTGGGGACCACCGAGTACCACCCC
  TTCACACTGACCTCTGCGCCCCATGAGGACACGCTTAGCCTGCACATCCGGGCAGCAGGG
  CCCTGGACCACTCGCCTCAGGGAGATCTACTCAGCCCCGACGGGTGACAGATGTGCCAGA
  TACCCAAAGCTGTACCTTGATGGACCATTTGGAGAGGGCCACCAGGAGTGGCATAAGTTT
  GAGGTGTCAGTGTTAGTGGGAGGGGGCATTGGGGTCACCCCTTTTGCCTCCATCCTCAAA
  GACCTGGTCTTCAAGTCATCCGTCAGCTGCCAAGTGTTCTGTAAGAAGATCTACTTCATC
  TGGGTGACGCGGACCCAGCGTCAGTTTGAGTGGCTGGCTGACATCATCCGAGAGGTGGAG
  GAGAATGACCACCAGGACCTGGTGTCTGTGCACATCTACATCACCCAGCTGGCTGAGAAG
  TTCGACCTCAGGACCACTATGCTGTACATCTGTGAGCGGCACTTCCAGAAGGTTCTGAAC
  CGGAGTCTATTCACAGGCCTGCGCTCCATCACCCACTTTGGCCGTCCCCCCTTTGAGCCC
  TTCTTCAACTCCCTGCAGGAGGTCCACCCCCAGGTCCGGAAGATCGGGGTGTTTAGCTGT
  GGCCCCCCTGGCATGACCAAGAATGTGGAAAAGGCCTGTCAGCTCATCAACAGGCAGGAC
  CGGACTCACTTCTCCCACCATTATGAGAACTTCTAG
  
• Restriction Sites: Please inquire
• ACCN: NM_175940
• ORF Size: 4656 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_175940.1, NP_787954.1
• RefSeq Size: 5501
• RefSeq ORF: 4656
• Locus ID: 53905
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
  Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.