MACC1 (NM_182762) Human Untagged Clone

CAT#: SC307508

MACC1 (untagged)-Human metastasis associated in colon cancer 1 (MACC1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MACC1
• Synonyms: 7A5; SH3BP4L
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_182762 edited
  GCTTGGGCTCACTTCCACAAATGTGGAAAAATGCTAATCACTGAAAGAAAACATTTTCGG
  TCAGGAAGAATTGCACAAAGTATGTCTGAAGCAAATTTGATTGACATGGAAGCTGGAAAA
  CTCTCAAAAAGTTGCAATATTACAGAATGCCAGGACCCAGACTTGCTTCACAATTGGCCG
  GATGCTTTCACCCTTCGTGGTAATAATGCTTCCAAAGTTGCAAATCCATTCTGGAATCAA
  CTGTCTGCTTCTAACCCATTTTTGGATGACATAACTCAACTAAGAAATAACAGGAAGAGA
  AATAATATTTCCATCTTAAAGGAAGATCCTTTTCTTTTCTGTAGAGAAATAGAAAATGGA
  AATTCTTTTGATTCCTCCGGTGATGAACTTGATGTGCATCAGTTACTTAGGCAGACTTCC
  TCAAGAAATTCTGGAAGATCTAAAAGTGTTTCAGAACTTCTGGACATTTTAGACGACACA
  GCACATGCCCATCAGAGTATACATAACTCTGACCAGATCCTACTACACGACTTAGAGTGG
  CTTAAAAATGATCGGGAGGCTTATAAAATGGCTTGGTTAAGTCAACGCCAGCTGGCCCGC
  TCCTGCCTTGATTTGAATACAATTAGTCAGAGCCCTGGATGGGCCCAGACACAACTTGCG
  GAGGTCACCATAGCTTGCAAAGTAAACCATCAAGGAGGGTCAGTACAATTACCTGAATCA
  GACATCACTGTTCATGTGCCCCAAGGTCATGTGGCTGTGGGAGAATTCCAAGAGGTGTCT
  CTAAGGGCTTTCCTTGATCCGCCACACATGCTTAACCATGATCTTTCGTGCACTGTGAGC
  CCGTTGTTGGAAATCATGTTAGGCAACCTCAATACAATGGAAGCCCTTTTGCTGGAGATG
  AAAATTGGGGCTGAAGTAAGAAAGGATCCTTTCAGCCAAGTCATGACAGAAATGGTGTGT
  TTACACAGCTTGGGTAAAGAAGGCCCTTTTAAAGTTTTAAGCAACTGCTACATTTATAAA
  GACACCATCCAAGTCAAGCTAATCGACTTGAGTCAGGTAATGTATCTAGTGGTTGCTGCA
  CAAGCTAAAGCTCTTCCGTCACCAGCTGCCACCATTTGGGATTATATCCACAAAACCACC
  TCAATTGGAATTTATGGACCCAAATATATCCATCCCAGTTTTACTGTTGTTTTAACAGTT
  TGTGGACACAATTATATGCCAGGACAGCTTACAATTTCTGATATTAAGAAGGGTGGAAAA
  AACATATCTCCAGTTGTGTTTCAGCTCTGGGGGAAGCAGTCATTTTTACTTGACAAGCCA
  CAAGATTTAAGTATTTCTATTTTTTCCTGTGATCCTGATTTTGAAGTAAAGACAGAAGGA
  GAAAGGAAAGAAATTAAACAAAAGCAGTTGGAAGCAGGTGAAGTAGTTCATCAACAATTT
  TTATTTTCTTTAGTTGAGCACAGAGAGATGCACTTGTTTGATTTTTGTGTTCAAGTGGAG
  CCTCCCAATGGTGAACCAGTTGCACAGTTCTCTATCACTACTCCTGATCCAACCCCAAAC
  CTAAAAAGACTCTCGAATCTGCCAGGCTATTTGCAGAAGAAGGAGGAAATCAAGTCTGCT
  CCTTTATCACCAAAAATTCTTGTTAAATATCCTACATTTCAAGATAAAACATTGAACTTT
  AGCAACTATGGGGTAACCCTGAAGGCAGTGCTAAGACAAAGCAAGATTGATTACTTCCTT
  GAATATTTCAAAGGGGACACAATAGCTCTCCTCGGGGAAGGTAAGGTAAAAGCTATTGGT
  CAGTCCAAAGTGAAAGAATGGTATGTAGGAGTCCTCAGAGGTAAGATTGGACTTGTACAC
  TGCAAAAATGTCAAGGTGATTTCAAAGGAGCAAGTAATGTTTATGTCAGATAGTGTCTTT
  ACAACCAGAAATCTTCTTGAACAGATTGTCCTGCCTTTAAAAAAATTGACTTATATCTAC
  TCAGTTGTATTAACCTTGGTGTCAGAAAAAGTTTATGATTGGAAAGTTTTAGCTGATGTC
  CTGGGTTACTCACATCTGTCCCTGGAAGATTTTGATCAAATTCAAGCAGACAAAGAATCA
  GAGAAAGTTTCTTATGTTATAAAGAAGTTAAAGGAAGATTGCCACACAGAGAGAAATACA
  AGGAAGTTTCTGTATGAACTTATTGTGGCTCTTCTGAAAATGGATTGCCAAGAGTTAGTC
  GCACGTCTCATCCAAGAAGCTGCTGTTCTGACTTCAGCTGTCAAGCTTGGAAAAGGCTGG
  AGGGAACTAGCTGAAAAGTTAGTACGACTCACAAAGCAACAAATGGAGGCATATGAAATT
  CCTCATCGAGGAAACACTGGAGATGTTGCTGTTGAGATGATGTGGAAACCTGCCTATGAT
  TTTCTGTATACCTGGAGTGCTCACTATGGAAATAACTACAGAGATGTGTTACAAGACCTT
  CAGTCAGCTTTGGACAGAATGAAAAACCCTGTGACTAAACACTGGAGAGAATTAACTGGA
  GTTTTAATACTAGTAAATTCTTTGGAGGTTTTGAGAGTAACTGCATTCTCCACTTCTGAG
  GAAGTATAGAAACAAAGCGTGTGTTTTTGATGGGAGGG
  
• Restriction Sites: Please inquire
• ACCN: NM_182762
• ORF Size: 2559 bp
• Insert Size: 2600
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: The ORF of this clone has been fully sequenced and found to contain 6 SNPs compared with NM_182762.2.

Reference Data

• RefSeq: NM_182762.2, NP_877439.2
• RefSeq Size: 3188
• RefSeq ORF: 2559
• Locus ID: 346389
• Gene Summary: MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]). [supplied by OMIM, Mar 2009]