Nogo A (RTN4) (NM_207520) Human Untagged Clone

CAT#: SC308607

RTN4 (untagged)-Human reticulon 4 (RTN4), transcript variant 4

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RTN4
• Synonyms: ASY; Nbla00271; Nbla10545; NI220/250; NOGO; NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_207520 edited
  CGGCGGCAACTGGGGACAGGGCGGGTGGCGCATCACCGGCGCGGAGGCAGGAGGAGCAGT
  CTCATTGTTCCGGGAGCCGTCACCACAGTAGGTCCCTCGGCTCAGTCGGCCCAGCCCCTC
  TCAGTCCTCCCCAACCCCCACAACCGCCCGCGGCTCTGAGACGCGGCCCCGGCGGCGGCG
  GCAGCAGCTGCAGCATCATCTCCACCCTCCAGCCATGGAAGACCTGGACCAGTCTCCTCT
  GGTCTCGTCCTCGGACAGCCCACCCCGGCCGCAGCCCGCGTTCAAGTACCAGTTCGTGAG
  GGAGCCCGAGGACGAGGAGGAAGAAGAGGAGGAGGAAGAGGAGGACGAGGACGAAGACCT
  GGAGGAGCTGGAGGTGCTGGAGAGGAAGCCCGCCGCCGGGCTGTCCGCGGCCCCAGTGCC
  CACCGCCCCTGCCGCCGGCGCGCCCCTGATGGACTTCGGAAATGACTTCGTGCCGCCGGC
  GCCCCGGGGACCCCTGCCGGCCGCTCCCCCCGTCGCCCCGGAGCGGCAGCCGTCTTGGGA
  CCCGAGCCCGGTGTCGTCGACCGTGCCCGCGCCATCCCCGCTGTCTGCTGCCGCAGTCTC
  GCCCTCCAAGCTCCCTGAGGACGACGAGCCTCCGGCCCGGCCTCCCCCTCCTCCCCCGGC
  CAGCGTGAGCCCCCAGGCAGAGCCCGTGTGGACCCCGCCAGCCCCGGCTCCCGCCGCGCC
  CCCCTCCACCCCGGCCGCGCCCAAGCGCAGGGGCTCCTCGGGCTCAGTGGATGAGACCCT
  TTTTGCTCTTCCTGCTGCATCTGAGCCTGTGATACGCTCCTCTGCAGTTGTTGACCTCCT
  GTATTGGAGAGACATTAAGAAGACTGGAGTGGTGTTTGGTGCCAGCCTATTCCTGCTGCT
  TTCATTGACAGTATTCAGCATTGTGAGCGTAACAGCCTACATTGCCTTGGCCCTGCTCTC
  TGTGACCATCAGCTTTAGGATATACAAGGGTGTGATCCAAGCTATCCAGAAATCAGATGA
  AGGCCACCCATTCAGGGCATATCTGGAATCTGAAGTTGCTATATCTGAGGAGTTGGTTCA
  GAAGTACAGTAATTCTGCTCTTGGTCATGTGAACTGCACGATAAAGGAACTCAGGCGCCT
  CTTCTTAGTTGATGATTTAGTTGATTCTCTGAAGTTTGCAGTGTTGATGTGGGTATTTAC
  CTATGTTGGTGCCTTGTTTAATGGTCTGACACTACTGATTTTGGCTCTCATTTCACTCTT
  CAGTGTTCCTGTTATTTATGAACGGCATCAGGCACAGATAGATCATTATCTAGGACTTGC
  AAATAAGAATGTTAAAGATGCTATGGCTAAAATCCAAGCAAAAATCCCTGGATTGAAGCG
  CAAAGCTGAATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTC
  ATTTGATTATACGGGGGAGGGTCAGGGAAGAACGAACCTTGACGTTGCAGTGCAGTTTCA
  CAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGGAAAAATTACCTGTC
  TTGACTGCCATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCG
  TAATCATATCTTTTTCCTATCTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTT
  ACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGATGGTGGAGCTAGAAA
  AAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_207520 unedited
  NNNNGGGGGGNNNGGGGGGGTTCAAATTTGTATACGACTCACTATAGGCGGCCGCGAATT
  CGCACGAGGCGGCGGCAACTGGGGACAGGGCGGGTGGCGCATCACCGGCGCGGAGGCAGG
  AGGAGCAGTCTCATTGTTCCGGGAGCCGTCACCACAGTAGGTCCCTCGGCTCAGTCGGCC
  CAGCCCCTCTCAGTCCTCCCCAACCCCCACAACCGCCCGCGGCTCTGAGACGCGGCCCCG
  GCGGCGGCGGCAGCAGCTGCAGCATCATCTCCACCCTCCAGCCATGGAAGACCTGGACCA
  GTCTCCTCTGGTCTCGTCCTCGGACAGCCCACCCCGGCCGCAGCCCGCGTTCAAGTACCA
  GTTCGTGAGGGAGCCCGAGGACGAGGAGGAAGAAGAGGAGGAGGAAGAGGAGGACGAGGA
  CGAAGACCTGGAGGAGCTGGAGGTGCTGGAGAGGAAGCCCGCCGCCGGGCTGTCCGCGGC
  CCCAGTGCCCACCGCCCCTGCCGCCGGCGCGCCCCTGATGGACTTCGGAAATGACTTCGT
  GCCGCCGGCGCCCCGGGGACCCCTGCCGGCCGCTCCCCCCGTCGCCCCGGAGCGGCAGCC
  GTCTTGGGACCCGAGCCCGGTGTCGTCGACCGTGCCCGCGCCATCCCCGCTGTCTGCTGC
  CGCAGTCTCGCCCTCCAAGCTCCCTGAGGACGACGAGCCTCCGGCCCGGCCTCCCCTCCT
  TCCCCGGNCAGNGTGAGCCCCCAGGCAGAGCCCGTGTGGACCCCGCCAGCCCCGGGTTCC
  CGGCGNGCCCCCCCTCCACCCCCGGCCGCCGCCCAAGCGCAGGGGCTCCTCGGGCCTCAT
  GGATGAGACCTTTTTGCTCTTCCTGCTGGATCTGAGCCTGTGATACT
  
  3' Read Nucleotide Sequence

  >Forward primer walk for NM_207520 unedited
  CTGTGTCTCCGCTGCGCCGCGCCCCCCTCCCCCCGGCCGCGCCCAAGCGCAGGGGCTCCT
  CGGGCTCAGTGGATGAGACCCTTTTTGCTCTTCCTGCTGCATCTGAGCCTGTGATACGCT
  CCTCTGCAGTTGTTGACCTCCTGTATTGGAGAGACATTAAGAAGACTGGAGTGGTGTTTG
  GTGCCAGCCTATTCCTGCTGCTTTCATTGACAGTATTCAGCATTGTGAGCGTAACAGCCT
  ACATTGCCTTGGCCCTGCTCTCTGTGACCATCAGCTTTAGGATATACAAGGGTGTGATCC
  AAGCTATCCAGAAATCAGATGAAGGCCACCCATTCAGGGCATATCTGGAATCTGAAGTTG
  CTATATCTGAGGAGTTGGTTCAGAAGTACAGTAATTCTGCTCTTGGTCATGTGAACTGCA
  CGATAAAGGAACTCAGGCGCCTCTTCTTAGTTGATGATTTAGTTGATTCTCTGAAGTTTG
  CAGTGTTGATGTGGGTATTTACCTATGTTGGTGCCTTGTTTAATGGTCTGACACTACTGA
  TTTTGGCTCTCATTTCACTCTTCAGTGTTCCTGTTATTTATGAACGGCATCAGGCACAGA
  TAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAAAATCCAAG
  CAAAAATCCCTGGATTGAAGCGCAAAGCTGAATGAAAACGCCCAAAATAATTAGTAGGAG
  TTCATCTTTAAAGGGGATATTCATTTGATTATACGGGGAGGGTCAGGGAAGAACGAACCT
  TGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTTATTTTTAGCCATGCACTG
  TTGTGAGGAAAAATTACCTGTCTTGACTGCCATGTGTTCATCATCTTAAGTATTTGTAAG
  CTGCTATTGTTATGGATTTAACCCGTAATCAATATCC
  
• Restriction Sites: Please inquire
• ACCN: NM_207520
• ORF Size: 1179 bp
• Insert Size: 1800
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.

Reference Data

• RefSeq: NM_207520.1, NP_997403.1
• RefSeq Size: 2471
• RefSeq ORF: 1179
• Locus ID: 57142
• Protein Families: Transmembrane
• Gene Summary: This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (4), also known as Foocen-m2 and RTN4-B2, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (D), that is missing an internal segment, compared to isoform A.