Repulsive Guidance Molecule C (HFE2) (NM_213653) Human Untagged Clone

CAT#: SC308698

HFE2 (untagged)-Human hemochromatosis type 2 (juvenile) (HFE2), transcript variant a

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: HFE2
• Synonyms: HFE2; HFE2A; JH; RGMC
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_213653 edited
  ATGGGGGAGCCAGGCCAGTCCCCTAGTCCCAGGTCCTCCCATGGCAGTCCCCCAACTCTA
  AGCACTCTCACTCTCCTGCTGCTCCTCTGTGGACATGCTCATTCTCAATGCAAGATCCTC
  CGCTGCAATGCTGAGTACGTATCGTCCACTCTGAGCCTTAGAGGTGGGGGTTCATCAGGA
  GCACTTCGAGGAGGAGGAGGAGGAGGCCGGGGTGGAGGGGTGGGCTCTGGCGGCCTCTGT
  CGAGCCCTCCGCTCCTATGCGCTCTGCACTCGGCGCACCGCCCGCACCTGCCGCGGGGAC
  CTCGCCTTCCATTCGGCGGTACATGGCATCGAAGACCTGATGATCCAGCACAACTGCTCC
  CGCCAGGGCCCTACAGCCCCTCCCCCGCCCCGGGGCCCCGCCCTTCCAGGCGCGGGCTCC
  GGCCTCCCTGCCCCGGACCCTTGTGACTATGAAGGCCGGTTTTCCCGGCTGCATGGTCGT
  CCCCCGGGGTTCTTGCATTGCGCTTCCTTCGGGGACCCCCATGTGCGCAGCTTCCACCAT
  CACTTTCACACATGCCGTGTCCAAGGAGCTTGGCCTCTACTGGATAATGACTTCCTCTTT
  GTCCAAGCCACCAGCTCCCCCATGGCGTTGGGGGCCAACGCTACCGCCACCCGGAAGCTC
  ACCATCATATTTAAGAACATGCAGGAATGCATTGATCAGAAGGTGTATCAGGCTGAGGTG
  GATAATCTTCCTGTAGCCTTTGAAGATGGTTCTATCAATGGAGGTGACCGACCTGGGGGA
  TCCAGTTTGTCGATTCAAACTGCTAACCCTGGGAACCATGTGGAGATCCAAGCTGCCTAC
  ATTGGCACAACTATAATCATTCGGCAGACAGCTGGGCAGCTCTCCTTCTCCATCAAGGTA
  GCAGAGGATGTGGCCATGGCCTTCTCAGCTGAACAGGACCTGCAGCTCTGTGTTGGGGGG
  TGCCCTCCAAGTCAGCGACTCTCTCGATCAGAGCGCAATCGTCGGGGAGCTATAACCATT
  GATACTGCCAGACGGCTGTGCAAGGAAGGGCTTCCAGTGGAAGATGCTTACTTCCATTCC
  TGTGTCTTTGATGTTTTAATTTCTGGTGATCCCAACTTTACCGTGGCAGCTCAGGCAGCA
  CTGGAGGATGCCCGAGCCTTCCTGCCAGACTTAGAGAAGCTGCATCTCTTCCCCTCAGAT
  GCTGGGGTTCCTCTTTCCTCAGCAACCCTCTTAGCTCCACTCCTTTCTGGGCTCTTTGTT
  CTGTGGCTTTGCATTCAGTAAGGGGACCATCAGTCCCATTACTAGTTTGGAAATGATTTG
  GAGATACAGATTGGCATAGAAGAATGTAAAGAATCATTAAAGGAAGCAGGGCCTAGGAGA
  CACGTGAAACAATGACATTATCCAGAGTCAGATGAGGCTGCAGTCCAGGGTTGAAATTAT
  CACAGAATAAGGATTCTGGGCAAGGTTACTGCATTCCGGATCTCTGTGGGGCTCTTCACC
  AATTTTTCCAGCCTCATTTATAGTAAACAAATTGTTCTAATCCATTTACTGCAGATTTCA
  CCCTTATAAGTTTAGAGGTCATGAAGGTTTTAATGATCAGTAAAGATTTAAGGGTTGAGA
  TTTTTAAGAGGCAAGAGCTGAAAGCAGAAGACATGATCATTAGCCATAAGAAACTCAAAG
  GAGGAAGACATAATTAGGGAAAGAAGTCTATTTGATGAATATGTGTGTGTAAGGTATGTT
  CTGCTTTCTTGATTCAAAAATGAAGCAGGCATTGTCTAGCTCTTAGGTGAAGGGAGTCTC
  TGCTTTTGAAGAATGGCACAGGTAGGACAGAAGTATCATCCCTACCCCCTAACTAATCTG
  TTATTAAAGCTACAAATTCTTCACACCAWMAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_213653 unedited
  NNNNGGGGCGTCAAATATTTGTATACGACTCACTATAGGGCGGCCGCGAATTCGCACGAG
  ATGGGGGAGCCAGGCCAGTCCCCTAGTCCCAGGTCCTCCCATGGCAGTCCCCCAACTCTA
  AGCACTCTCACTCTCCTGCTGCTCCTCTGTGGACATGCTCATTCTCAATGCAAGATCCTC
  CGCTGCAATGCTGAGTACGTATCGTCCACTCTGAGCCTTAGAGGTGGGGGTTCATCAGGA
  GCACTTCGAGGAGGAGGAGGAGGAGGCCGGGGTGGAGGGGTGGGCTCTGGCGGCCTCTGT
  CGAGCCCTCCGCTCCTATGCGCTCTGCACTCGGCGCACCGCCCGCACCTGCCGCGGGGAC
  CTCGCCTTCCATTCGGCGGTACATGGCATCGAAGACCTGATGATCCAGCACANACTGNCN
  NTCCCGCCAGGGCCCTACAGCCCCTCCCCCGCCCCNCNNGGGGCCCCCCNNGCCCTTCCA
  GGCGCGNGNNGCTCCGGCCTCCCTGCCCCGGACCCTTGTGACTATGAAGGCCGGTTTTCC
  CGGCTGCATGGTCGTCCCCCGGGGTTCTTGCATTGCGCTTCCTTCGGGGACCCCCATGTG
  CGCAGCTTCCACCATCACTTTCACACATGCCGTGTCCAAGGAGCTTGGCCTCTACTGGAT
  AATGACTTCCTCTTTGTCCAAGCCACCAGCTCCCCCATGGCGTTGGGGGCCAACGCTACC
  GCCACCCGGAAGCTCACCATCATATTTAAGAACATGCAGGAATGCATTGATCAGAAGGTG
  TATCANGCTGAGGTGGATAATCTTCCTGTAGCCTTTGAAGATGGTTCTATCAATGGAGGT
  GACCGACCTGGGGGATCCAGTTTGTCN
  
  3' Read Nucleotide Sequence

  >Forward primer walk for NM_213653 unedited
  GCCCCCCCTGGCGTTGGGGGCCAACNCTACCGCCACCCGGNAAGCTCACCATCATATTTA
  AGAACATGCAGGAATGCATTGATCAGAAGGTGTATCAGGCTGAGGTGGATAATCTTCCTG
  TAGCCTTTGAAGATGGTTCTATCAATGGAGGTGACCGACCTGGGGGATCCAGTTTGTCGA
  TTCAAACTGCTAACCCTGGGAACCATGTGGAGATCCAAGCTGCCTACATTGGCACAACTA
  TAATCATTCGGCAGACAGCTGGGCAGCTCTCCTTCTCCATCAAGGTAGCAGAGGATGTGG
  CCATGGCCTTCTCAGCTGAACAGGACCTGCAGCTCTGTGTTGGGGGGTGCCCTCCAAGTC
  AGCGACTCTCTCGATCAGAGCGCAATCGTCGGGGAGCTATAACCATTGATACTGCCAGAC
  GGCTGTGCAAGGAAGGGCTTCCAGTGGAAGATGCTTACTTCCATTCCTGTGTCTTTGATG
  TTTTAATTTCTGGTGATCCCAACTTTACCGTGGCAGCTCANGCAGCACTGGAGGATGCCC
  GAGCCTTCCTGCCAGACTTAGAGAAGCTGCATCTCTTCCCCTCAGATGCTGGGGTTCCTC
  TTTCCTCAGCAACCCTCTTAGCTCCACTCCTTTCTGGGCTCTTTGTTCTGTGGCTTTGCA
  TTCAGTAAGGGGACCATCAGTCCCATTACTAGTTTGGAAATGATTTGGAGATACAGATTG
  GCATAGAAGAAATGTAAGAATCATTAAAGGAAGCAGGGCCTANGAGACACGTGAAACAAT
  GACATTATCCAGAGTCAGATGAAGCTGCAGTCCANGGGTGAAATTATCACAGAATAAGGA
  TTCTGGGNCAGGGTACTGCATTCCGNATCTCTGTGGGGCTCTTCACCAATTTTCCAGCCT
  CATTATAGTAAACAAATTGTCTN
  
• Restriction Sites: Please inquire
• ACCN: NM_213653
• ORF Size: 1281 bp
• Insert Size: 1900
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.

Reference Data

• RefSeq: NM_213653.2, NP_998818.1
• RefSeq Size: 2128
• RefSeq ORF: 1281
• Locus ID: 148738
• Protein Families: Transmembrane
• Gene Summary: The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq, Oct 2015]
  Transcript Variant: This variant (a) represents the longest transcript, and encodes the longest isoform (a).