PIK3R5 (NM_014308) Human Untagged Clone

CAT#: SC308923

PIK3R5 (untagged)-Human phosphoinositide-3-kinase, regulatory subunit 5 (PIK3R5), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PIK3R5
• Synonyms: F730038I15Rik; FOAP-2; p101; P101-PI3K
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_014308 edited
  ATGCAGCCAGGGGCCACGACATGCACGGAGGACCGCATCCAGCATGCCCTGGAACGCTGC
  CTGCATGGACTCAGCCTCAGCCGCCGCTCCACCTCCTGGTCAGCTGGGCTGTGTCTGAAC
  TGCTGGAGCCTSCAGGAGCTGGTCAGCAGGGACCCGGGCCACTTCCTTATCCTCCTTGAG
  CAGATCCTGCAGAAGACCCGAGAGGTCCAGGAGAAGGGCACCTACGACCTGCTCACCCCG
  CTGGCCCTGCTCTTCTATTCCACTGTTCTTTGTACACCACACTTCCCACCAGACTCGGAT
  CTCCTTCTGAAGGCAGCCAGCACCTACCACCGGTTCCTGACCTGGCCTGTTCCTTACTGC
  AGCATCTGCCAGGAGCTGCTCACCTTCATTGATGCTGAACTCAAGGCCCCAGGGATCTCC
  TACCAGAGACTGGTGAGGGCTGAGCAGGGCCTGCCCATCAGGAGTCACCGCAGCTCCACC
  GTCACCGTGCTGCTGCTGAACCCAGTGGAAGTGCAGGCCGAGTTCCTTGCTGTAGCCAAT
  AAGCTGAGTACGCCCGGACACTCGCCTCACAGTGCCTACACCACCCTGCTCCTGCACGCC
  TTCCAGGCCACCTTTGGGGCCCACTGTGACGTCCCGGGCCTGCACTGCAGGCTACAGGCC
  AAGACCCTGGCAGAGCTTGAGGACATCTTCACGGAGACCGCAGAGGCACAGGAGCTGGCA
  TCTGGCATCGGGGATGCTGCAGAGGCCCGGCGGTGGCTCAGGACCAAGCTGCAGGCGGTG
  GGAGAAAAAGCTGGCTTCCCTGGGGTGTTAGACACTGCAAAACCAGGGAAGCTCCACACC
  ATCCCCATCCCTGTCGCCAGGTGCTACACCTACAGCTGGAGCCAGGACAGCTTTGACATC
  CTGCAGGAAATCCTGCTCAAGGAACAGGAGCTGCTCCAGCCAGGGATCCTGGGAGATGAT
  GAAGAGGAGGAAGAGGAGGAGGAGGAGGTGGAGGAGGACTTGGAAACTGATGGGCACTGT
  GCCGAGAGAGATTCCCTGCTCTCCACCAGCTCTTTGGCGTCCCATGACTCCACCCTGTCC
  CTTGCATCCTCCCAGGCCTCAGGGCCGGCCCTCTCGCGCCATCTGCTGACTTCCTTTGTC
  TCAGGCCTCTCTGATGGCATGGACAGCGGCTACGTGGAGGACAGCGAGGAGAGCTCCTCC
  GAGTGGCCTTGGAGGCGTGGCAGCCAGGAACGCCGAGGCCACCGCAGGCCTGGGCAGAAG
  TTCATCAGGATCTATAAACTCTTCAAGAGCACCAGCCAGCTGGTACTGCGGAGGGACTCT
  CGGAGCCTGGAGGGCAGCTCGGACACGGCCCTGCCCCTGAGGCGGGCAGGGAGCCTCTGC
  AGCCCCCTGGACGAACCAGTATCACCCCCTTCCCGGGCCCAGCGCTCCCGCTCCCTGCCC
  CAGCCCAAACTCGGTACCCAGCTGCCCAGCTGGCTTCTGGCCCCTGCTTCACGCCCCCAG
  CGCCGCCGCCCCTTCCTGAGTGGAGATGAGGATCCCAAGGCTTCCACGCTACGTGTTGTG
  GTCTTTGGCTCCGATCGGATTTCAGGGAAGGTGGCTCGGGCGTACAGCAACCTTCGGCGG
  CTGGAGAACAATCGCCCACTCCTCACACGGTTCTTCAAACTTCAGTTCTTCTACGTGCCT
  GTGAAGCGAAGTCATGGGACCAGCCCTGGTGCCTGTCCACCCCCTCGGAGCCAGACGCCC
  TCACCCCCGACAGACTCCCCTAGGCACGCCAGCCCTGGAGAGCTGGGCACCACCCCATGG
  GAGGAGAGCACCAATGACATCTCCCACTACCTCGGCATGCTGGACCCCTGGTATGAGCGC
  AATGTACTGGGCCTCATGCACCTGCCCCCTGAAGTCCTGTGCCAGCAGTCCCTGAAGGCT
  GAAGCCCAGGCCCTGGAGGGCTCCCCAACCCAGCTGCCCATCCTGGCTGACATGCTACTC
  TACTACTGCCGCTTTGCCGCCAGACCGGTGCTGCTGCAAGTCTATCAGACCGAGCTGACC
  TTCATCACTGGGGAGAAGACGACAGAGATCTTCATCCACTCCTTGGAGCTGGGTCACTCC
  GCTGCCACACGTGCCATCAAGGCGTCAGGTCCTGGCAGCAAGCGGCTGGGCATCGATGGC
  GACCGGGAGGCTGTTCCTCTAACACTACAGATTATTTACAGCAAGGGGGCCATCAGTGGA
  CGAAGTCGCTGGAGCAACCTGGAGAAGGTCTGTACCTCCGTGAACCTCAACAAGGCCTGC
  CGGAAGCAGGAGGAGCTGGATTCCAGCATGGAGGCCCTGACGCTAAACCTGACAGAAGTG
  GTGAAAAGGCAGAACTCCAAATCCAAGAAGGGCTTTAACCAGATTAGCACATCGCAGATC
  AAAGTGGACAAGGTGCAGATCATCGGCTCCAACAGCTGCCCCTTTGCTGTGTGCCTGGAC
  CAGGATGAGAGAAAGATCCTGCAGAGTGTAGTCAGATGTGAGGTCTCACCGTGCTACAAG
  CCAGAGAAGAGCGACCTCTCCTCACCACCCCAGACGCCTCCTGACCTGCCGGCCCAGGCC
  GCACCTGATCTCTGCTCCCTTCTCTGCCTGCCCATCATGACTTTCAGTGGAGCTCTGCCC
  TAGTGTGGGCCCAGCGCCAGACTGGACAGAAGCCCTGGGGCAACCTCCTCGGCCACCCCT
  CCAGGACAGTCCCTCTCTGTGGAGAACTGAATGGCCCTGTGCAGAGCCATAGTCCCACTG
  TGGGTCCTGCAATGAGCAGGGGCTGGGAGTAGAGGGTTTCTGGGGCCTCAGGGTTCTGGG
  AAAGCAACAGCTATCAGAGAGAGAAGGGCCAGACCCCATAGCCTCTTAGATTCCTGGCAG
  TAGAAGGAGAAGGATGGGTAAATTGACCTCTGAAGTCCCTGACCATTAGCATGGTCTAGG
  ATCCTTTCTAGA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_014308 unedited
  GGTCAGATTTGTATACGACTCATATAGGCGGCCGCGNATTCATGCAGCCAGGGGCCACGA
  CATGCACGGAGGACCGCATCCAGCATGCCCTGGAACGCTGCCTGCATGGACTCAGCCTCA
  GCCGCCGCTCCACCTCCTGGTCAGCTGGGCTGTGTCTGAACTGCTGGAGCCTCCAGGAGC
  TGGTCAGCAGGGACCCGGGCCACTTCCTTATCCTCCTTGAGCAGATCCTGCAGAAGACCC
  GAGAGGTCCAGGAGAAGGGCACCTACGACCTGCTCACCCCGCTGGCCCTGCTCTTCTATT
  CCACTGTTCTTTGTACACCACACTTCCCACCAGACTCGGATCTCCTTCTGAAGGCAGCCA
  GCACCTACCACCGGTTCCTGACCTGGCCTGTTCCTTACTGCAGCATCTGCCAGGAGCTGC
  TCACCTTCATTGATGCTGAACTCAAGGCCCCAGGGATCTCCTACCAGAGACTGGTGAGGG
  CTGAGCAGGGCCTGCCCATCAGGAGTCACCGCAGCTCCACCGTCACCGTGCTGCTGCTGA
  ACCCAGTGGAAGTGCAGGCCGAGTTCCTTGCTGTAGCCAATAAGCTGAGTACGCCCGGAC
  ACTCGCCTCACAGTGCCTACACCACCCTGCTCCTGCACGCCTTCCAGGCCACCTTTGGGG
  CCCACTGTGACGTCCCGGGCCTGCACTGCAGGCTACAGGCCAAGACCCTGGCAGAGCTTG
  ANGACATCTTCACGGAGACCGCAGAGCACAGGAGCTGGCATCTGGCATCGGGGATGCTGC
  AGAGGCCCGGGCGTGGCTCANGACCAAGCTGCNAGCNGTGGGAGAAAAAGCTGGCTTTTC
  CTGGGGTGTAGACACTGCAAACCAGGAAGCTNCACACATCCCCTNCCTNNGTCGCAGTGC
  TACACCTACAGCTGG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_014308 unedited
  CCATAGGNATGGCACTTCCAGGNCCAGNAAAGCACTGGGNGAGGGTCACAGGGATGCCAC
  CCGGGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAAAGGATCCTAGACC
  ATGCTAATGGTCAGGGACTTCAGAGGTCAATTTACCCATCCTTCTCCTTCTACTGCCAGG
  AATCTAAGAGGCTATGGGGTCTGGCCCTTCTCTCTCTGATAGCTGTTGCTTTCCCAGAAC
  CCTGAGGCCCCAGAAACCCTCTACTCCCAGCCCCTGCTCATTGCAGGACCCACAGTGGGA
  CTATGGCTCTGCACAGGGCCATTCAGTTCTCCACAGAGAGGGACTGTCCTGGAGGGGTGG
  CCGAGGAGGTTGCCCCAGGGCTTCTGTCCAGTCTGGCGCTGGGCCCACACTAGGGCAGAG
  CTCCACTGAAAGTCATGATGGGCAGGCAGAGAAGGGAGCAGAGATCAGGTGCGGCCTGGG
  CCGGCAGGTCAGGAGGCGTCTGGGGTGGTGAGGAGAGGTCGCTCTTCTCTGGCTTGTAGC
  ACGGTGAGACCTCACATCTGACTACACTCTGCAGGATCTTTCTCTCATCCTGGTCCAGGC
  ACACAGCAAAGGGGCAGCTGTTGGAGCCGATGATCTGCACCTTGTCCACTTTGATCTGCG
  ATGTGCTAATCTGGTTAAAGCCCTTCTTGGATTTGGAGTTCTGCCTTTTCACCACTTCTG
  TCANGTTTAGCGTCAGGGCCTCCATGCTGGAATCCAGCTNCTCCTGCTTTTCCGCAGCCT
  TTGTTGANGTTCACGGGAGTACAGACCTTCTNCAGNTTGCTCCAGCGACTTCGTCCACTG
  ATGGCCCCCTTGCTGNTAATATCTGTAGTGGTAGAGAACAGCCTNCCNGTCGCATCGATG
  CCAGCCGCTGCTGCCG
  
• Restriction Sites: Please inquire
• ACCN: NM_014308
• ORF Size: 2643 bp
• Insert Size: 3000
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: There is 1 nucleotide difference between the OriGene clone and the NCBI reference ORF. These result in the substitution of 1 aa.

Reference Data

• RefSeq: NM_014308.1, NP_055123.1
• RefSeq Size: 3255
• RefSeq ORF: 2643
• Locus ID: 23533
• Protein Families: Druggable Genome
• Protein Pathways: Acute myeloid leukemia, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Glioma, Insulin signaling pathway, Jak-STAT signaling pathway, Leukocyte transendothelial migration, Melanoma, mTOR signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Phosphatidylinositol signaling system, Progesterone-mediated oocyte maturation, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, Small cell lung cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, VEGF signaling pathway
• Gene Summary: Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]
  Transcript Variant: This variant (2) differs in the 5' UTR exon, compared to variant 1. Both variants 1 and 2 encode the same isoform 1.