MRP5 (ABCC5) (NM_005688) Human Untagged Clone

CAT#: SC308972

ABCC5 (untagged)-Human ATP-binding cassette, sub-family C (CFTR/MRP), member 5 (ABCC5), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ABCC5
• Synonyms: ABC33; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_005688 edited
  ATGAAGGATATCGACATAGGAAAAGAGTATATCATCCCCAGTCCTGGGTATAGAAGTGTG
  AGGGAGAGAACCAGCACTTCTGGGACGCACAGAGACCGTGAAGATTCCAAGTTCAGGAGA
  ACTCGACCGTTGGAATGCCAAGATGCCTTGGAAACAGCAGCCCGAGCCGAGGGCCTCTCT
  CTTGATGCCTCCATGCATTCTCAGCTCAGAATCCTGGATGAGGAGCATCCCAAGGGAAAG
  TACCATCATGGCTTGAGTGCTCTGAAGCCCATCCGGACTACTTCCAAACACCAGCACCCA
  GTGGACAATGCTGGGCTTTTTTCCTGTATGACTTTTTCGTGGCTTTCTTCTCTGGCCCGT
  GTGGCCCACAAGAAGGGGGAGCTCTCAATGGAAGACGTGTGGTCTCTGTCCAAGCACGAG
  TCTTCTGACGTGAACTGCAGAAGACTAGAGAGACTGTGGCAAGAAGAGCTGAATGAAGTT
  GGGCCAGACGCTGCTTCCCTGCGAAGGGTTGTGTGGATCTTCTGCCGCACCAGGCTCATC
  CTGTCCATCGTGTGCCTGATGATCACGCAGCTGGCTGGCTTCAGTGGACCAGCCTTCATG
  GTGAAACACCTCTTGGAGTATACCCAGGCAACAGAGTCTAACCTGCAGTACAGCTTGTTG
  TTAGTGCTGGGCCTCCTCCTGACGGAAATCGTGCGGTCTTGGTCGCTTGCACTGACTTGG
  GCATTGAATTACCGAACCGGTGTCCGCTTGCGGGGGGCCATCCTAACCATGGCATTTAAG
  AAGATCCTTAAGTTAAAGAACATTAAAGAGAAATCCCTGGGTGAGCTCATCAACATTTGC
  TCCAACGATGGGCAGAGAATGTTTGAGGCAGCAGCCGTTGGCAGCCTGCTGGCTGGAGGA
  CCCGTTGTTGCCATCTTAGGCATGATTTATAATGTAATTATTCTGGGACCAACAGGCTTC
  CTGGGATCAGCTGTTTTTATCCTCTTTTACCCAGCAATGATGTTTGCATCACGGCTCACA
  GCATATTTCAGGAGAAAATGCGTGGCCGCCACGGATGAACGTGTCCAGAAGATGAATGAA
  GTTCTTACTTACATTAAATTTATCAAAATGTATGCCTGGGTCAAAGCATTTTCTCAGAGT
  GTTCAAAAAATCCGCGAGGAGGAGCGTCGGATATTGGAAAAAGCCGGGTACTTCCAGAGC
  ATCACTGTGGGTGTGGCTCCCATTGTGGTGGTGATTGCCAGCGTGGTGACCTTCTCTGTT
  CATATGACCCTGGGCTTCGATCTGACAGCAGCACAGGCTTTCACAGTGGTGACAGTCTTC
  AATTCCATGACTTTTGCTTTGAAAGTAACACCGTTTTCAGTAAAGTCCCTCTCAGAAGCC
  TCAGTGGCTGTTGACAGATTTAAGAGTTTGTTTCTAATGGAAGAGGTTCACATGATAAAG
  AACAAACCAGCCAGTCCTCACATCAAGATAGAGATGAAAAATGCCACCTTGGCATGGGAC
  TCCTCCCACTCCAGTATCCAGAACTCGCCCAAGCTGACCCCCAAAATGAAAAAAGACAAG
  AGGGCTTCCAGGGGCAAGAAAGAGAAGGTGAGGCAGCTGCAGCGCACTGAGCATCAGGCG
  GTGCTGGCAGAGCAGAAAGGCCACCTCCTCCTGGACAGTGACGAGCGGCCCAGTCCCGAA
  GAGGAAGAAGGCAAGCACATCCACCTGGGCCACCTGCGCTTACAGAGGACACTGCACAGC
  ATCGATCTGGAGATCCAAGAGGGTAAACTGGTTGGAATCTGCGGCAGTGTGGGAAGTGGA
  AAAACCTCTCTCATTTCAGCCATTTTAGGCCAGATGACGCTTCTAGAGGGCAGCATTGCA
  ATCAGTGGAACCTTCGCTTATGTGGCCCAGCAGGCCTGGATCCTCAATGCTACTCTGAGA
  GACAACATCCTGTTTGGGAAGGAATATGATGAAGAAAGATACAACTCTGTGCTGAACAGC
  TGCTGCCTGAGGCCTGACCTGGCCATTCTTCCCAGCAGCGACCTGACGGAGATTGGAGAG
  CGAGGAGCCAACCTGAGCGGTGGGCAGCGCCAGAGGATCAGCCTTGCCCGGGCCTTGTAT
  AGTGACAGGAGCATCTACATCCTGGACGACCCCCTCAGTGCCTTAGATGCCCATGTGGGC
  AACCACATCTTCAATAGTGCTATCCGGAAACATCTCAAGTCCAAGACAGTTCTGTTTGTT
  ACCCACCAGTTACAGTACCTGGTTGACTGTGATGAAGTGATCTTCATGAAAGAGGGCTGT
  ATTACGGAAAGAGGCACCCATGAGGAACTGATGAATTTAAATGGTGACTATGCTACCATT
  TTTAATAACCTGTTGCTGGGAGAGACACCGCCAGTTGAGATCAATTCAAAAAAGGAAACC
  AGTGGTTCACAGAAGAAGTCACAAGACAAGGGTCCTAAAACAGGATCAGTAAAGAAGGAA
  AAAGCAGTAAAGCCAGAGGAAGGGCAGCTTGTGCAGCTGGAAGAGAAAGGGCAGGGTTCA
  GTGCCCTGGTCAGTATATGGTGTCTACATCCAGGCTGCTGGGGGCCCCTTGGCATTCCTG
  GTTATTATGGCCCTTTTCATGCTGAATGTAGGCAGCACCGCCTTCAGCACCTGGTGGTTG
  AGTTACTGGATCAAGCAAGGAAGCGGGAACACCACTGTGACTCGAGGGAACGAGACCTCG
  GTGAGTGACAGCATGAAGGACAATCCTCATATGCAGTACTATGCCAGCATCTACGCCCTC
  TCCATGGCAGTCATGCTGATCCTGAAAGCCATTCGAGGAGTTGTCTTTGTCAAGGGCACG
  CTGCGAGCTTCCTCCCGGCTGCATGACGAGCTTTTCCGAAGGATCCTTCGAAGCCCTATG
  AAGTTTTTTGACACGACCCCCACAGGGAGGATTCTCAACAGGTTTTCCAAAGACATGGAT
  GAAGTTGACGTGCGGCTGCCGTTCCAGGCCGAGATGTTCATCCAGAACGTTATCCTGGTG
  TTCTTCTGTGTGGGAATGATCGCAGGAGTCTTCCCGTGGTTCCTTGTGGCAGTGGGGCCC
  CTTGTCATCCTCTTTTCAGTCCTGCACATTGTCTCCAGGGTCCTGATTCGGGAGCTGAAG
  CGTCTGGACAATATCACGCAGTCACCTTTCCTCTCCCACATCACGTCCAGCATACAGGGC
  CTTGCCACCATCCACGCCTACAATAAAGGGCAGGAGTTTCTGCACAGATACCAGGAGCTG
  CTGGATGACAACCAAGCTCCTTTTTTTTTGTTTACGTGTGCGATGCGGTGGCTGGCTGTG
  CGGCTGGACCTCATCAGCATCGCCCTCATCACCACCACGGGGCTGATGATCGTTCTTATG
  CACGGGCAGATTCCCCCAGCCTATGCGGGTCTCGCCATCTCTTATGCTGTCCAGTTAACG
  GGGCTGTTCCAGTTTACGGTCAGACTGGCATCTGAGACAGAAGCTCGATTCACCTCGGTG
  GAGAGGATCAATCACTACATTAAGACTCTGTCCTTGGAAGCACCTGCCAGAATTAAGAAC
  AAGGCTCCCTCCCCTGACTGGCCCCAGGAGGGAGAGGTGACCTTTGAGAACGCAGAGATG
  AGGTACCGAGAAAACCTCCCTCTTGTCCTAAAGAAAGTATCCTTCACGATCAAACCTAAA
  GAGAAGATTGGCATTGTGGGGCGGACAGGATCAGGGAAGTCCTCGCTGGGGATGGCCCTC
  TTCCGTCTGGTGGAGTTATCTGGAGGCTGCATCAAGATTGATGGAGTGAGAATCAGTGAT
  ATTGGCCTTGCCGACCTCCGAAGCAAACTCTCTATCATTCCTCAAGAGCCGGTGCTGTTC
  AGTGGCACTGTCAGATCAAATTTGGACCCCTTCAACCAGTACACTGAAGACCAGATTTGG
  GATGCCCTGGAGAGGACACACATGAAAGAATGTATTGCTCAGCTACCTCTGAAACTTGAA
  TCTGAAGTGATGGAGAATGGGGATAACTTCTCAGTGGGGGAACGGCAGCTCTTGTGCATA
  GCTAGAGCCCTGCTCCGCCACTGTAAGATTCTGATTTTAGATGAAGCCACAGCTGCCATG
  GACACAGAGACAGACTTATTGATTCAAGAGACCATCCGAGAAGCATTTGCAGACTGTACC
  ATGCTGACCATTGCCCATCGCCTGCACACGGTTCTAGGCTCCGATAGGATTATGGTGCTG
  GCCCAGGGACAGGTGGTGGAGTTTGACACCCCATCGGTCCTTCTGTCCAACGACAGTTCC
  CGATTCTATGCCATGTTTGCTGCTGCAGAGAACAAGGTCGCTGTCAAGGGCTGA
  
• Restriction Sites: Please inquire
• ACCN: NM_005688
• ORF Size: 4314 bp
• Insert Size: 4300
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_005688.2, NP_005679.2
• RefSeq Size: 5851
• RefSeq ORF: 4314
• Locus ID: 10057
• Domains: ABC_membrane, ABC_tran, AAA
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: ABC transporters
• Gene Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
  Transcript Variant: This variant (1) encodes the longest isoform (1).