Pregnancy zone protein (PZP) (NM_002864) Human Untagged Clone

CAT#: SC309018

PZP (untagged)-Human pregnancy-zone protein (PZP)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PZP
• Synonyms: CPAMD6
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_002864, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGCGGAAAGACAGACTTCTTCATTTATGTCTTGTGCTACTTCTTATCCTGCTTTCTGCCAGTGACTCAA
  ACTCTACAGAACCGCAGTATATGGTGCTGGTCCCCTCCCTGCTCCACACTGAGGCCCCTAAGAAGGGCTG
  TGTCCTTCTGAGCCACCTGAATGAGACAGTGACTGTAAGTGCTTCCTTGGAGTCTGGCAGGGAAAACAGG
  AGCCTCTTCACTGACCTGGTGGCGGAGAAGGACTTATTCCACTGTGTCTCCTTCACTCTCCCAAGGATCT
  CAGCCTCTTCAGAGGTGGCATTCCTTAGCATCCAGATAAAGGGGCCTACGCAAGATTTCAGGAAGAGGAA
  CACAGTTCTGGTACTGAACACCCAAAGTCTGGTCTTTGTCCAGACAGACAAACCCATGTATAAACCAGGA
  CAGACAGTAAGATTCCGTGTTGTCTCCGTGGATGAAAATTTTCGCCCTCGAAATGAACTGATTCCACTGA
  TATACCTTGAGAACCCAAGAAGAAATCGAATTGCACAATGGCAGAGTCTCAAGCTAGAAGCTGGCATCAA
  TCAGTTGTCCTTTCCCCTCTCATCAGAGCCCATTCAGGGCTCCTACAGGGTGGTGGTACAGACAGAATCA
  GGTGGAAGGATACAGCACCCCTTCACCGTGGAGGAATTTGTGCTTCCCAAGTTTGAGGTCAAAGTTCAGG
  TGCCAAAGATAATCAGTATCATGGATGAAAAAGTGAACATAACAGTCTGTGGAGAATACACTTATGGGAA
  GCCTGTCCCAGGACTTGCAACTGTGAGCCTGTGTAGAAAATTATCTCGTGTTCTTAATTGTGACAAGCAG
  GAGGTCTGTGAGGAATTCAGTCAACAGCTTAACAGCAATGGCTGCATCACCCAACAAGTACACACCAAAA
  TGCTCCAGATTACAAATACGGGCTTTGAAATGAAGCTTAGAGTGGAAGCCAGGATCAGAGAAGAGGGGAC
  AGACCTGGAAGTCACTGCAAACAGGATCAGTGAAATCACAAACATTGTATCCAAACTCAAATTCGTGAAA
  GTGGATTCACACTTTAGACAAGGAATCCCCTTTTTTGCACAGGTGCTTCTGGTGGATGGAAAAGGTGTGC
  CCATCCCCAATAAACTCTTCTTCATCTCTGTGAATGACGCCAATTATTACTCCAATGCAACCACCAATGA
  GCAGGGTCTTGCACAGTTTTCAATCAATACTACCAGTATCTCGGTTAATAAACTTTTTGTCCGGGTTTTC
  ACTGTGCATCCCAACTTGTGTTTTCACTATTCATGGGTAGCAGAAGACCACCAGGGTGCTCAGCACACTG
  CAAATCGTGTTTTCTCCTTAAGTGGAAGTTACATTCACCTGGAGCCTGTGGCTGGTACCCTGCCCTGTGG
  CCACACGGAGACTATCACGGCACACTATACACTGAATAGACAGGCCATGGGAGAGTTATCGGAGCTCAGT
  TTCCATTACCTGATCATGGCTAAGGGAGTCATCGTCAGATCTGGAACCCACACTCTGCCTGTGGAGTCAG
  GAGACATGAAAGGCAGTTTTGCCTTATCCTTCCCTGTGGAGTCAGACGTTGCCCCCATTGCACGAATGTT
  CATCTTTGCCATTTTACCAGATGGAGAAGTTGTTGGAGACTCTGAAAAATTTGAGATTGAAAACTGTCTA
  GCCAACAAGGTGGATTTGAGCTTCAGCCCAGCACAAAGTCCCCCAGCCTCACATGCCCACCTGCAAGTAG
  CAGCTGCTCCGCAGTCCCTCTGTGCCCTTCGTGCTGTGGACCAAAGTGTGCTGCTCATGAAGCCTGAGGC
  TGAGCTCTCTGTGTCCTCAGTATATAATCTGCTAACTGTGAAGGATCTCACCAATTTTCCTGACAATGTG
  GACCAGCAGGAGGAAGAACAAGGACACTGTCCCCGTCCTTTCTTCATTCATAATGGAGCCATCTATGTTC
  CCTTATCAAGTAATGAAGCAGATATTTATAGCTTCCTCAAGGGGATGGGATTGAAGGTGTTCACTAACTC
  AAAAATCCGAAAACCAAAGTCGTGTTCAGTCATCCCTTCCGTGTCTGCAGGAGCAGTAGGTCAAGGATAC
  TATGGAGCAGGTCTAGGAGTAGTAGAGAGACCATATGTTCCTCAATTAGGCACATATAATGTGATACCCT
  TAAATAATGAACAAAGTTCAGGGCCAGTCCCTGAAACGGTGCGAAGCTATTTTCCTGAGACTTGGATCTG
  GGAGTTGGTGGCAGTGAACTCATCAGGTGTGGCTGAGGTAGGAGTAACAGTCCCTGACACCATCACCGAG
  TGGAAGGCAGGGGCCTTCTGCCTGTCCGAAGATGCTGGACTTGGTATCTCTTCCACTGCCTCTCTCCGAG
  CCTTCCAGCCCTTCTTTGTGGAGCTCACAATGCCTTACTCTGTGATTCGTGGAGAGGTCTTCACACTCAA
  GGCCACGGTCCTAAACTACCTTCCCAAATGCATCCGGGTCAGTGTGCAGCTGAAAGCCTCTCCAGCCTTC
  CTAGCTTCCCAAAATACAAAGGGAGAAGAATCCTATTGTATCTGTGGAAATGAGAGACAAACCTTGTCTT
  GGACAGTGACTCCTAAAACTCTGGGGAATGTGAACTTCTCAGTGAGTGCAGAGGCAATGCAGTCCTTAGA
  ACTCTGTGGAAATGAGGTTGTTGAGGTCCCTGAGATTAAAAGAAAAGACACAGTCATCAAAACCCTGTTG
  GTGGAGGCTGAAGGTATTGAGCAAGAAAAGACTTTCAGTTCTATGACCTGTGCCTCAGGTGCTAATGTGT
  CTGAGCAGTTGTCCTTGAAGCTCCCATCAAATGTGGTCAAAGAATCTGCCAGAGCTTCTTTCTCAGTTCT
  GGGTGACATATTAGGTTCTGCTATGCAAAATATACAAAATCTCCTCCAGATGCCATATGGCTGTGGAGAA
  CAGAACATGGTCCTATTTGCTCCTAACATCTATGTCTTGAACTATCTGAATGAAACCCAGCAGCTGACGC
  AGGAGATCAAGGCCAAGGCCGTTGGCTATCTCATCACTGGTTACCAGAGACAGCTGAACTACAAACACCA
  AGATGGCTCCTACAGCACCTTTGGGGAACGATATGGCAGGAACCAGGGCAACACTTGGCTCACAGCTTTT
  GTACTGAAGACTTTCGCCCAGGCTCGATCCTACATCTTCATTGATGAAGCACACATTACCCAATCTCTCA
  CGTGGCTCTCCCAGATGCAGAAGGACAATGGCTGTTTCAGGAGCTCTGGGTCACTGCTCAACAATGCCAT
  AAAGGGAGGTGTAGAAGATGAAGCGACCCTCTCCGCCTATGTTACTATTGCCCTTCTGGAAATTCCTCTC
  CCAGTCACTAACCCTATTGTTCGCAATGCCCTGTTCTGCCTGGAGTCAGCCTGGAATGTAGCAAAGGAGG
  GGACCCATGGGAGCCATGTCTACACCAAGGCATTGCTGGCCTATGCTTTTTCCCTACTGGGAAAGCAAAA
  TCAGAATAGAGAAATACTGAACTCACTTGATAAGGAAGCTGTGAAAGAAGACAACCTCGTCCATTGGGAG
  CGCCCTCAGAGACCCAAGGCACCAGTGGGGCATCTTTACCAAACCCAGGCTCCCTCTGCTGAGGTGGAGA
  TGACATCCTATGTGCTCCTCGCTTATCTCACGGCCCAGCCAGCCCCCACCTCAGGGGACCTGACCTCTGC
  AACTAACATTGTGAAGTGGATCATGAAGCAGCAGAACGCCCAAGGTGGTTTCTCCTCCACCCAGGACACA
  GTGGTGGCTCTCCATGCCCTGTCCAGGTATGGAGCAGCCACTTTCACCAGAACTGAGAAAACTGCACAGG
  TCACCGTTCAGGATTCACAGACCTTTTCTACAAATTTCCAAGTAGACAACAACAACCTCCTATTACTGCA
  GCAGATCTCATTGCCAGAGCTCCCTGGAGAATATGTCATAACAGTAACTGGGGAAAGATGTGTGTATCTT
  CAGACATCCATGAAATACAATATTCTTCCAGAGAAAGAGGACTCCCCATTTGCTTTAAAAGTGCAGACTG
  TGCCCCAAACTTGCGATGGACACAAAGCCCACACCAGCTTTCAGATCTCACTGACCATCAGTTACACAGG
  AAACCGTCCTGCTTCCAATATGGTGATTGTTGATGTAAAGATGGTATCTGGTTTTATTCCCCTGAAACCA
  ACAGTAAAAATGCTTGAAAGATCTAGCTCTGTGAGCCGGACAGAAGTGAGCAACAACCATGTCCTCATTT
  ATGTGGAACAGGTGACAAATCAGACGCTAAGTTTTTCCTTCATGGTTCTGCAAGACATCCCAGTAGGAGA
  CTTGAAGCCAGCAATTGTTAAAGTCTATGATTACTATGAGACAGATGAGTCTGTGGTTGCTGAGTATATC
  GCCCCCTGCAGCACAGATACAGAGCATGGAAATGTTTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_002864
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002864.2, NP_002855.2
• RefSeq Size: 4615 bp
• RefSeq ORF: 4449 bp
• Locus ID: 5858
• Cytogenetics: 12p13.31
• Domains: A2M, A2M_N
• Protein Families: Druggable Genome
• Gene Summary: 'The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients. [provided by RefSeq, Dec 2016]'