PACE4 (PCSK6) (NM_138321) Human Untagged Clone

CAT#: SC309110

PCSK6 (untagged)-Human proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 8

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PCSK6
• Synonyms: PACE4; SPC4
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_138321, the custom clone sequence may differ by one or more nucleotides
  ATGCCTCCGCGCGCGCCGCCTGCGCCCGGGCCCCGGCCGCCGCCCCGGGCCGCCGCCGCC
  ACCGACACCGCCGCGGGCGCGGGGGGCGCGGGGGGCGCGGGGGGCGCCGGCGGGCCCGGG
  TTCCGGCCGCTCGCGCCGCGTCCCTGGCGCTGGCTGCTGCTGCTGGCGCTGCCTGCCGCC
  TGCTCCGCGCCCCCGCCGCGCCCCGTCTACACCAACCACTGGGCGGTGCAAGTGCTGGGC
  GGCCCGGCCGAGGCGGACCGCGTGGCGGCGGCGCACGGGTACCTCAACTTGGGCCAGATT
  GGAAACCTGGAAGATTACTACCATTTTTATCACAGCAAAACCTTTAAAAGATCAACCTTG
  AGTAGCAGAGGCCCTCACACCTTCCTCAGAATGGACCCCCAGGTGAAATGGCTCCAGCAA
  CAGGAAGTGAAACGAAGGGTGAAGAGACAGGTGCGAAGTGACCCGCAGGCCCTTTACTTC
  AACGACCCCATTTGGTCCAACATGTGGTACCTGCATTGTGGCGACAAGAACAGTCGCTGC
  CGGTCGGAAATGAATGTCCAGGCAGCGTGGAAGAGGGGCTACACAGGAAAAAACGTGGTG
  GTCACCATCCTTGATGATGGCATAGAGAGAAATCACCCTGACCTGGCCCCAAATTATGAT
  TCCTACGCCAGCTACGACGTGAACGGCAATGATTATGACCCATCTCCACGATATGATGCC
  AGCAATGAAAATAAACACGGCACTCGTTGTGCGGGAGAAGTTGCTGCTTCAGCAAACAAT
  TCCTACTGCATCGTGGGCATAGCGTACAATGCCAAAATAGGAGGCATCCGCATGCTGGAC
  GGCGATGTCACAGATGTGGTCGAGGCAAAGTCGCTGGGCATCAGACCCAACTACATCGAC
  ATTTACAGTGCCAGCTGGGGGCCGGACGACGACGGCAAGACGGTGGACGGGCCCGGCCGA
  CTGGCTAAGCAGGCTTTCGAGTATGGCATTAAAAAGGGCCGGCAGGGCCTGGGCTCCATT
  TTCGTCTGGGCATCTGGGAATGGCGGGAGAGAGGGGGACTACTGCTCGTGCGATGGCTAC
  ACCAACAGCATCTACACCATCTCCGTCAGCAGCGCCACCGAGAATGGCTACAAGCCCTGG
  TACCTGGAAGAGTGTGCCTCCACCCTGGCCACCACCTACAGCAGTGGGGCCTTTTATGAG
  CGAAAAATCGTCACCACGGATCTGCGTCAGCGCTGTACCGATGGCCACACTGGGACCTCA
  GTCTCTGCCCCCATGGTGGCGGGCATCATCGCCTTGGCTCTAGAAGCAAACAGCCAGTTA
  ACCTGGAGGGACGTCCAGCACCTGCTAGTGAAGACATCCCGGCCGGCCCACCTGAAAGCG
  AGCGACTGGAAAGTGAACGGCGCGGGTCATAAAGTTAGCCATTTCTATGGATTTGGTTTG
  GTGGACGCAGAAGCTCTCGTTGTGGAGGCAAAGAAGTGGACAGCAGTGCCATCGCAGCAC
  ATGTGTGTGGCCGCCTCGGACAAGAGACCCAGGAGCATCCCCTTAGTGCAGGTGCTGCGG
  ACTACGGCCCTGACCAGCGCCTGCGCGGAGCACTCGGACCAGCGGGTGGTCTACTTGGAG
  CACGTGGTGGTTCGCACCTCCATCTCACACCCACGCCGAGGAGACCTCCAGATCTACCTG
  GTTTCTCCCTCGGGAACCAAGTCTCAACTTCTGGCAAAGAGGTTGCTGGATCTTTCCAAT
  GAAGGGTTTACAAACTGGGAATTCATGACTGTCCACTGCTGGGGAGAAAAGGCTGAAGGG
  CAGTGGACCTTGGAAATCCAAGATCTGCCATCCCAGGTCCGCAACCCGGAGAAGCAAGGG
  AAGTTGAAAGAATGGAGCCTCATACTGTATGGCACAGCAGAGCACCCGTACCACACCTTC
  AGTGCCCATCAGTCCCGCTCGCGGATGCTGGAGCTCTCAGCCCCAGAGCTGGAGCCACCC
  AAGGCTGCCCTGTCACCCTCCCAGGTGGAAGTTCCTGAAGATGAGGAAGATTACACAGGT
  GTGTGCCATCCGGAGTGTGGTGACAAAGGCTGTGATGGCCCCAATGCAGACCAGTGCTTG
  AACTGCGTCCACTTCAGCCTGGGGAGTGTCAAGACCAGCAGGAAGTGCGTGAGTGTGTGC
  CCCTTGGGCTACTTTGGGGACACAGCAGCAAGACGCTGTCGCCGGTGCCACAAGGGGTGT
  GAGACCTGCTCCAGCAGAGCTGCGACGCAGTGCCTGTCTTGCCGCCGCGGGTTCTATCAC
  CACCAGGAGATGAACACCTGTGTGACCCTCTGTCCTGCAGGATTTTATGCTGATGAAAGT
  CAGAAAAATTGCCTTAAATGCCACCCAAGCTGTAAAAAGTGCGTGGATGAACCTGAGAAA
  TGTACTGTCTGTAAAGAAGGATTCAGCCTTGCACGGGGCAGCTGCATTCCTGACTGTGAG
  CCAGGCACCTACTTTGACTCAGAGCTGATCAGATGTGGGGAATGCCATCACACCTGCGGA
  ACCTGCGTGGGGCCAGGCAGAGAAGAGTGCATTCACTGTGCGAAAAACTTCCACTTCCAC
  GACTGGAAGTGTGTGCCAGCCTGTGGTGAGGGCTTCTACCCAGAAGAGATGCCGGGCTTG
  CCCCACAAAGTGTGTCGAAGGTACGGTCCTCCTGGCGGGGAACGGCAGGCAGCTGTGTCC
  AGCAAAGGAGTGCCTGGAGGGCAGAGTCTGGCAGCATCTTCCCCAGGGGCCGGGGAGGGC
  ATGTTGCATCACCCCACTGTGGACAGGAGCCCATTTACAGAGCTGCTGAGGGGCCTTCGT
  CCCTTTGTTCACTGGATGCATATTTGTTGGGTCCCTGCTGTGGGCAGACACCGTGCAGCA
  GCGGGATAA
  
• Restriction Sites: Please inquire
• ACCN: NM_138321
• ORF Size: 2889 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_138321.1, NP_612194.1
• RefSeq Size: 3333
• RefSeq ORF: 2889
• Locus ID: 5046
• Protein Families: Druggable Genome, Protease, Secreted Protein
• Gene Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014]
  Transcript Variant: This variant (8) has multiple differences in the 3' coding region, one of which is a frameshift, compared to variant 1. The resulting isoform (PACE4-EII) has a distinct C-terminus, compared to isoform PACE4-AI. The preproprotein is annotated since the cleavage sites are maintained as in isoform PACE4-AI.