ASXL1 (NM_015338) Human Untagged Clone

CAT#: SC309230

ASXL1 (untagged)-Human additional sex combs like 1 (Drosophila) (ASXL1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ASXL1
• Synonyms: BOPS; MDS
• Vector: PCMV6-Neo
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_015338 edited
  CGTCGGTCCTGTCTCAGTCCCTCAGCAGAGCGGGAAAGCGGAGGCCGGAGCCGTGACCTC
  TGACCCCGTGGTTATGCGGAGCCGCCGCATTCCTTAGCGATCGCGGGGCAGCCGCCGCTG
  CCGCCGTGGGCGACTGACGCAGCGCGGGCGCGTGGAGCCGCCGCCGCCCCTCCCCCACCG
  CCGCCGGGGAGAAGGATGAAGGACAAACAGAAGAAGAAGAAGGAGCGCACGTGGGCCGAG
  GCCGCGCGCCTGGTATTAGAAAACTACTCGGATGCTCCAATGACACCAAAACAGATTCTG
  CAGGTCATAGAGGCAGAAGGACTAAAGGAAATGAGAAGTGGGACTTCCCCTCTCGCATGC
  CTCAATGCTATGCTACATTCCAATTCAAGAGGAGGAGAGGGGTTGTTTTATAAACTGCCT
  GGCCGAATCAGCCTTTTCACGCTCAAGAAGGATGCCCTGCAGTGGTCTCGCCATCCAGCT
  ACAGTGGAGGGAGAGGAGCCAGAGGACACGGCTGATGTGGAGAGCTGTGGGTCTAATGAA
  GCCAGCACTGTGAGTGGTGAAAACGATGTATCTCTTGATGAAACATCTTCGAACGCATCC
  TGTTCTACAGAATCTCAGAGTCGACCTCTTTCCAATCCCAGGGACAGCTACAGAGCTTCC
  TCACAGGCGAACAAACAAAAGAAAAAGACTGGGGTGATGCTGCCTCGAGTTGTCCTGACT
  CCTCTGAAGGTAAACGGGGCCCACGTGGAATCTGCATCAGGGTTCTCGGGCTGCCACGCC
  GATGGCGAGAGCGGCAGCCCGTCCAGCAGCAGCAGCGGCTCTCTGGCCCTGGGCAGCGCT
  GCTATTCGTGGCCAGGCCGAGGTCACCCAGGACCCTGCCCCGCTCCTGAGAGGCTTCCGG
  AAGCCAGCCACAGGTCAAATGAAGCGCAACAGAGGGGAAGAAATAGATTTTGAGACACCT
  GGGTCCATTCTTGTCAACACCAACCTCCGTGCCCTGATCAACTCTCGGACCTTCCATGCC
  TTACCATCACACTTCCAGCAGCAGCTCCTCTTCCTCCTGCCTGAAGTAGACAGACAGGTG
  GGGACGGATGGCCTGTTGCGTCTCAGCAGCAGTGCACTAAATAACGAGTTTTTTACCCAT
  GCGGCTCAGAGCTGGCGGGAGCGCCTGGCTGATGGTGAATTTACTCATGAGATGCAAGTC
  AGGATACGACAGGAAATGGAGAAGGAAAAGAAGGTGGAACAATGGAAAGAAAAGTTCTTT
  GAAGACTACTATGGACAGAAGCTGGGTTTGACCAAAGAAGAGTCATTGCAGCAGAACGTG
  GGCCAGGAGGAGGCTGAAATCAAAAGTGGCTTGTGTGTCCCAGGAGAATCAGTGCGTATA
  CAGCGTGGTCCAGCCACCCGACAGCGAGATGGGCATTTTAAGAAACGCTCTCGGCCAGAT
  CTCCGAACCAGAGCCAGAAGGAATCTGTACAAAAAACAGGAGTCAGAACAAGCAGGGGTT
  GCTAAGGATGCAAAATCTGTGGCCTCAGATGTTCCCCTCTACAAGGATGGGGAGGCTAAG
  ACTGACCCAGCAGGGCTGAGCAGTCCCCATCTGCCAGGCACATCCTCTGCAGCACCCGAC
  CTGGAGGGTCCCGAATTCCCAGTTGAGTCTGTGGCTTCTCGGATCCAGGCTGAGCCAGAC
  AACTTGGCACGTGCCTCTGCATCTCCAGACAGAATTCCTAGCCTGCCTCAGGAAACTGTG
  GATCAGGAACCCAAGGATCAGAAGAGGAAATCCTTTGAGCAGGCGGCCTCTGCATCCTTT
  CCCGAAAAGAAGCCCCGGCTTGAAGATCGTCAGTCCTTTCGTAACACAATTGAAAGTGTT
  CACACCGAAAAGCCACAGCCCACTAAAGAGGAGCCCAAAGTCCCGCCCATCCGGATTCAA
  CTTTCACGTATCAAACCACCCTGGGTGGTTAAAGGTCAGCCCACTTACCAGATATGCCCC
  CGGATCATCCCCACCACGGAGTCCTCCTGCCGGGGTTGGACTGGCGCCAGGACCCTCGCA
  GACATTAAAGCCCGTGCTCTGCAGGTCCGAGGGGCGAGAGGTCACCACTGCCATAGAGAG
  GCGGCCACCACTGCCATCGGAGGGGGGGGTGGCCCGGGTGGAGGTGGCGGCGGGGCCACC
  GATGAGGGAGGTGGCAGAGGCAGCAGCAGTGGTGATGGTGGTGAGGCCTGTGGCCACCCT
  GAGCCCAGGGGAGGCCCGAGCACCCCTGGAAAGTGTACGTCAGATCTACAGCGAACACAA
  CTACTGCCGCCTTATCCTCTAAATGGGGAGCATACCCAGGCCGGAACTGCCATGTCCAGA
  GCTAGGAGAGAGGACCTGCCTTCTCTGAGAAAGGAGGAAAGCTGCCTACTACAGAGGGCT
  ACAGTTGGACTCACAGATGGGCTAGGAGATGCCTCCCAACTCCCCGTTGCTCCCACTGGG
  GACCAGCCATGCCAGGCCTTGCCCCTACTGTCCTCCCAAACCTCAGTAGCTGAGAGATTA
  GTGGAGCAGCCTCAGTTGCATCCGGATGTTAGAACTGAATGTGAGTCTGGCACCACTTCC
  TGGGAAAGTGATGATGAGGAGCAAGGACCCACCGTTCCTGCAGACAATGGTCCCATTCCG
  TCTCTAGTGGGAGATGATACATTAGAGAAAGGAACTGGCCAAGCTCTTGACAGTCATCCC
  ACTATGAAGGATCCTGTAAATGTGACCCCCAGTTCCACACCTGAATCCTCACCGACTGAT
  TGCCTGCAGAACAGAGCATTTGATGACGAATTAGGGCTTGGTGGCTCATGCCCTCCTATG
  AGGGAAAGTGATACTAGACAAGAAAACTTGAAAACCAAGGCTCTCGTTTCTAACAGTTCT
  TTGCATTGGATACCCATCCCATCGAATGATGAGGTAGTGAAACAGCCCAAACCAGAATCC
  AGAGAACACATACCATCTGTTGAGCCCCAGGTTGGAGAGGAGTGGGAGAAAGCTGCTCCC
  ACCCCTCCTGCATTGCCTGGGGATTTGACAGCTGAGGAGGGTCTAGATCCTCTTGACAGC
  CTTACTTCACTCTGGACTGTGCCATCTCGAGGAGGCAGTGACAGCAATGGCAGTTACTGT
  CAACAGGTGGACATTGAAAAGCTGAAAATCAACGGAGACTCTGAAGCACTGAGTCCTCAC
  GGTGAGTCCACGGATACAGCCTCTGACTTTGAAGGTCACCTCACGGAGGACAGCAGTGAG
  GCTGACACTAGAGAAGCTGCAGTGACAAAGGGATCTTCGGTGGACAAGGATGAGAAACCC
  AATTGGAACCAATCTGCCCCACTGTCCAAGGTGAATGGTGACATGCGTCTGGTTACAAGG
  ACAGATGGGATGGTTGCTCCTCAGAGCTGGGTGTCTCGAGTATGTGCGGTCCGCCAAAAG
  ATCCCAGATTCCCTACTGCTGGCCAGTACTGAGTACCAGCCAAGAGCCGTGTGCCTGTCC
  ATGCCTGGGTCCTCAGTGGAGGCCACTAACCCACTTGTGATGCAGTTGCTGCAGGGTAGC
  TTGCCCCTAGAGAAGGTTCTTCCACCAGCCCACGATGACAGCATGTCAGAATCCCCACAA
  GTACCACTTACAAAAGACCAGAGCCATGGCTCGCTACGCATGGGATCTTTACATGGTCTT
  GGAAAAAACAGTGGCATGGTTGATGGAAGCAGCCCCAGTTCTTTAAGGGCTTTGAAGGAG
  CCTCTTCTGCCAGATAGCTGTGAAACAGGCACTGGTCTTGCCAGGATTGAGGCCACCCAG
  GCTCCTGGAGCACCCCAAAAGAATTGCAAGGCAGTCCCAAGTTTTGACTCCCTCCATCCA
  GTGACAAATCCCATTACATCCTCTAGGAAACTGGAAGAAATGGATTCCAAAGAGCAGTTC
  TCTTCCTTTAGTTGTGAAGATCAGAAGGAAGTCCGTGCTATGTCACAGGACAGTAATTCA
  AATGCTGCTCCAGGAAAGAGCCCAGGAGATCTTACTACCTCGAGAACACCTCGTTTCTCA
  TCTCCAAATGTGATCTCCTTTGGTCCAGAGCAGACAGGTCGGGCCCTGGGTGATCAGAGC
  AATGTTACAGGCCAAGGGAAGAAGCTTTTTGGCTCTGGGAATGTGGCTGCAACCCTTCAG
  CGCCCCAGGCCTGCGGACCCGATGCCTCTTCCTGCTGAGATCCCTCCAGTTTTTCCCAGT
  GGGAAGTTGGGACCAAGCACAAACTCCATGTCTGGTGGGGTACAGACTCCAAGGGAAGAC
  TGGGCTCCAAAGCCACATGCCTTTGTTGGCAGCGTCAAGAATGAGAAGACTTTTGTGGGG
  GGTCCTCTTAAGGCAAATGCCGAGAACAGGAAAGCTACTGGGCATAGTCCCCTGGAACTG
  GTGGGTCACTTGGAAGGGATGCCCTTTGTCATGGACTTGCCCTTCTGGAAATTACCCCGA
  GAGCCAGGGAAGGGGCTCAGTGAGCCTCTGGAGCCTTCTTCTCTCCCCTCCCAACTCAGC
  ATCAAGCAGGCATTTTATGGGAAGCTTTCTAAACTCCAACTGAGTTCCACCAGCTTTAAT
  TATTCCTCTAGCTCTCCCACCTTTCCCAAAGGCCTTGCTGGAAGTGTGGTGCAGCTGAGC
  CACAAAGCAAACTTTGGTGCGAGCCACAGTGCATCACTTTCCTTGCAAATGTTCACTGAC
  AGCAGCACGGTGGAAAGCATCTCGCTCCAGTGTGCGTGCAGCCTGAAAGCCATGATCATG
  TGCCAAGGCTGCGGTGCGTTCTGTCACGATGACTGTATTGGACCCTCAAAGCTCTGTGTA
  TTGTGCCTTGTGGTGAGATAATAAATTATGGCCATGGGAAACATTGTATATTTAGTGTGT
  GTATTTTGATAATGATTGATCTTAAATCTGTATACAGAATATCATTGATATAATACTCTT
  TAGGCAGGAGCACTCTTGCCTTCCCCCAAAATTTACACTGCTAAAGCCCTCTGTCACTTG
  GCGACCCTTCTGGTCTTGCTGGAGGGGTTTCCTGGGTATAACCCATTGGGCTGCCCAAGG
  CCAGCCAGCCTGAGCTCTCCTGCAAGACAGAGCCTGATGTGGCACGGAGTGGGGTTGCGG
  GGGGTGGGGGGACTGCCTGACTCCCAGAGGGACTTGAAACTGAAGCAAGAAGGTTGCATT
  CTCCACCAAGGGAGTTAACCTACCTGAACTAAGTAGAAATGCCAGTCTTCCACTACCCCC
  TCCCTGCCATCTTTTCTTCTGCTACTTTGGGGAGTTGATGGCCAGGAAAGAAGCCAGCAC
  AGGGTTAAAGTAACTCCTGGCATTGCCCACCAGGGGGCTGGTGCACCTGCTGACCTCAGG
  GTCACAGTTGAGTCATTTGCCAGTTGACGGAGCA
  
• Restriction Sites: Please inquire
• ACCN: NM_015338
• ORF Size: 4626 bp
• Insert Size: 5400
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: The ORF of this clone has been fully sequenced and found to be a perfect match to NM_015338.3.

Reference Data

• RefSeq: NM_015338.3, NP_056153.2
• RefSeq Size: 7026
• RefSeq ORF: 4626
• Locus ID: 171023
• Gene Summary: This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).