LAMA3 (NM_198129) Human Untagged Clone

CAT#: SC309364

LAMA3 (untagged)-Human laminin, alpha 3 (LAMA3), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LAMA3
• Synonyms: BM600; E170; LAMNA; LOCS
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_198129, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCGGCGGCCGCGCGGCCTCGGGGTCGGGCACTGGGGCCAGTACTGCCGCCGACGCCGCTGCTCCTGC
  TGGTACTGCGGGTGCTGCCAGCCTGCGGGGCGACCGCTCGGGATCCCGGGGCCGCGGCCGGGCTCAGCCT
  TCACCCGACTTACTTCAACCTGGCCGAGGCGGCGAGGATTTGGGCCACCGCCACCTGCGGGGAGAGGGGA
  CCCGGCGAGGGGAGGCCCCAGCCCGAGCTCTACTGCAAGTTGGTCGGGGGCCCCACCGCCCCAGGCAGCG
  GCCACACCATCCAGGGCCAGTTCTGTGACTATTGCAATTCTGAAGACCCCAGGAAAGCACATCCTGTCAC
  CAATGCCATCGATGGATCTGAACGTTGGTGGCAAAGCCCTCCCCTGTCCTCAGGCACACAGTACAACAGA
  GTCAACCTCACCTTGGATCTGGGGCAGCTCTTCCATGTGGCCTATATTTTAATCAAATTTGCAAATTCTC
  CTCGCCCTGATCTTTGGGTCTTGGAAAGATCTGTAGACTTTGGAAGCACCTACTCACCATGGCAATATTT
  TGCTCATTCTAAAGTAGACTGTTTAAAAGAATTTGGGCGGGAGGCAAATATGGCTGTCACCCGGGATGAT
  GATGTACTTTGTGTTACTGAATATTCCCGTATTGTACCTTTGGAAAATGGTGAGGTTGTGGTGTCCTTGA
  TAAACGGTCGTCCAGGTGCAAAAAATTTTACTTTCTCTCACACCCTGAGGGAGTTTACCAAGGCAACAAA
  CATCCGCTTGCGTTTTCTTAGAACCAATACGCTTCTTGGACACCTCATCTCCAAAGCCCAGCGAGATCCA
  ACTGTCACTCGGCGGTATTATTACAGCATAAAGGACATCAGCATTGGTGGGCAGTGTGTTTGCAATGGCC
  ATGCTGAAGTGTGCAATATAAACAATCCTGAAAAACTGTTTCGGTGTGAATGCCAGCACCACACCTGTGG
  GGAGACGTGTGATCGCTGCTGCACAGGGTACAATCAGAGGCGCTGGCGGCCCGCCGCTTGGGAGCAGAGC
  CACGAGTGTGAAGCATGCAACTGCCACGGCCATGCCAGCAACTGTTACTATGATCCAGATGTTGAGCGGC
  AGCAGGCAAGCTTGAATACCCAGGGCATCTATGCTGGTGGAGGGGTCTGCATTAACTGTCAGCACAACAC
  AGCTGGAGTAAACTGTGAACAGTGTGCTAAGGGCTATTACCGCCCTTATGGGGTTCCAGTGGATGCCCCT
  GATGGCTGCATCCCCTGCAGCTGTGACCCTGAGCATGCGGATGGCTGTGAACAGGGTTCAGGCCGCTGTC
  ACTGCAAGCCAAATTTCCACGGAGACAACTGTGAGAAGTGTGCAATTGGATACTACAATTTCCCATTTTG
  CTTGAGAATTCCCATTTTTCCTGTTTCTACACCAAGTTCAGAAGATCCAGTAGCTGGAGATATAAAAGGG
  TGTGACTGTAATCTGGAAGGTGTTCTCCCTGAAATATGTGATGCCCACGGACGGTGCCTGTGCCGCCCTG
  GGGTTGAGGGCCCTCGATGTGATACCTGCCGCTCTGGTTTCTACTCATTCCCTATTTGCCAAGCCTGCTG
  GTGTTCAGCCCTTGGATCCTACCAGATGCCCTGCAGCTCAGTGACTGGACAGTGTGAATGTCGGCCAGGA
  GTTACAGGACAGCGGTGTGACAGGTGTCTCTCAGGAGCTTATGATTTCCCCCACTGCCAAGGTTCCAGCA
  GTGCTTGTGACCCAGCTGGTACCATCAACTCCAATTTGGGGTATTGCCAATGCAAGCTTCATGTTGAAGG
  TCCTACTTGTAGCCGCTGCAAACTGTTATATTGGAATCTGGACAAAGAAAACCCCAGTGGATGTTCAGAA
  TGCAAGTGCCATAAGGCGGGAACAGTGAGTGGAACTGGAGAGTGTAGGCAGGGAGATGGTGACTGTCACT
  GCAAGTCCCATGTGGGTGGCGATTCCTGCGACACCTGTGAAGATGGATATTTTGCTTTGGAAAAGAGCAA
  TTACTTTGGGTGTCAAGGGTGTCAGTGTGACATTGGTGGGGCATTGTCCTCCATGTGCAGTGGGCCCTCG
  GGAGTGTGCCAGTGCCGAGAGCATGTCGTGGGAAAGGTGTGCCAGCGGCCTGAAAACAACTACTATTTCC
  CAGATTTGCATCATATGAAGTATGAGATTGAAGACGGCAGCACACCTAATGGGAGAGACCTTCGATTTGG
  ATTTGATCCGCTGGCATTTCCTGAGTTTAGCTGGAGAGGATATGCCCAAATGACCTCAGTACAGAATGAT
  GTAAGAATAACATTGAATGTAGGGAAGTCAAGTGGCTCCTTGTTTCGTGTTATTCTGAGATACGTTAACC
  CTGGAACTGAAGCAGTATCTGGCCATATAACTATTTATCCATCCTGGGGTGCTGCTCAAAGCAAAGAGAT
  CATCTTCCTGCCGAGTAAGGAGCCAGCCTTTGTCACTGTCCCTGGAAATGGTTTTGCAGACCCATTTTCA
  ATCACACCAGGAATATGGGTTGCTTGTATTAAGGCAGAAGGAGTCCTTCTGGATTACCTGGTGCTGCTCC
  CCAGGGACTACTATGAAGCCTCTGTACTGCAGCTGCCAGTCACAGAACCATGTGCCTACGCAGGACCTCC
  CCAAGAAAATTGCTTACTCTACCAGCATTTGCCAGTGACCAGATTCCCCTGTACCCTGGCTTGTGAGGCC
  AGACACTTCCTGCTTGATGGGGAGCCAAGACCCGTGGCAGTGAGGCAGCCCACACCTGCACACCCTGTCA
  TGGTGGACCTCAGCGGGAGAGAGGTGGAATTGCATCTGCGGCTGCGCATCCCACAGGTTGGCCACTACGT
  GGTTGTGGTCGAGTATTCCACGGAGGCAGCTCAGCTGTTTGTGGTTGATGTGAATGTGAAGAGCTCCGGG
  TCTGTTCTGGCAGGCCAGGTGAACATTTACAGCTGCAACTACAGTGTTCTCTGCCGGAGTGCTGTGATTG
  ATCACATGAGCCGCATCGCCATGTATGAGCTATTGGCAGATGCAGACATTCAGCTCAAGGGACACATGGC
  CCGATTCCTTCTGCATCAAGTTTGTATCATACCTATTGAAGAATTCTCAGCTGAGTATGTGAGACCACAA
  GTCCACTGCATTGCCAGTTATGGGCGATTTGTCAATCAAAGTGCCACCTGTGTCTCCTTGGCCCATGAAA
  CTCCTCCAACAGCATTAATTTTGGATGTTCTAAGTGGCAGGCCTTTCCCTCACCTGCCCCAGCAGTCGTC
  ACCTTCTGTTGATGTTCTTCCTGGGGTCACCTTGAAGGCACCGCAGAATCAAGTGACCCTGAGAGGACGT
  GTACCACACCTGGGCCGATACGTCTTTGTCATCCATTTTTACCAAGCAGCGCACCCGACGTTTCCCGCGC
  AGGTGTCGGTGGATGGCGGGTGGCCACGGGCAGGCTCCTTCCATGCCTCTTTTTGCCCCCATGTGCTTGG
  CTGCCGGGATCAAGTGATTGCCGAAGGCCAGATTGAGTTTGACATCTCAGAGCCTGAAGTGGCCGCAACT
  GTGAAGGTTCCAGAAGGAAAGTCCTTGGTTTTGGTCCGTGTTCTAGTGGTGCCTGCAGAAAACTATGACT
  ACCAAATACTTCACAAAAAATCCATGGACAAGTCACTCGAGTTTATCACCAATTGTGGAAAAAACAGCTT
  TTACCTTGACCCCCAGACAGCCTCCAGATTCTGTAAGAATTCCGCCAGGTCCCTGGTGGCCTTTTACCAC
  AAGGGCGCCCTGCCTTGTGAGTGCCACCCCACTGGGGCCACCGGCCCTCACTGCAGCCCTGAGGGTGGGC
  AGTGCCCATGCCAGCCCAACGTCATCGGGCGGCAGTGCACCCGCTGTGCAACAGGCCACTACGGATTCCC
  ACGCTGCAAGCCGTGCAGCTGTGGTCGGCGCCTTTGTGAAGAGATGACGGGGCAGTGCCGCTGCCCTCCC
  CGCACGGTCAGGCCCCAGTGTGAGGTGTGTGAGACACACTCATTCAGCTTCCACCCCATGGCCGGCTGCG
  AAGGCTGCAACTGTTCCAGGAGGGGCACCATCGAGGCTGCCATGCCGGAGTGTGACCGGGACAGCGGGCA
  GTGCAGATGCAAGCCCAGAATCACAGGGCGGCAGTGTGACCGATGTGCTTCCGGGTTTTACCGCTTTCCT
  GAGTGTGTTCCCTGCAATTGCAACAGAGATGGGACTGAGCCAGGAGTGTGTGACCCAGGGACCGGGGCTT
  GCCTCTGCAAGGAAAATGTAGAAGGCACAGAGTGTAATGTGTGTCGAGAAGGCTCATTCCATTTGGACCC
  AGCCAATCTCAAGGGTTGTACCAGCTGTTTCTGTTTTGGAGTAAATAATCAATGTCACAGCTCACATAAG
  CGAAGGACTAAGTTTGTGGATATGCTGGGCTGGCACCTGGAGACAGCAGACAGAGTGGACATCCCTGTCT
  CTTTCAACCCAGGCAGCAACAGTATGGTGGCGGATCTCCAGGAGCTGCCCGCAACCATCCACAGCGCGTC
  CTGGGTCGCACCCACCTCCTACCTGGGGGACAAGGTTTCTTCATATGGTGGTTACCTCACTTACCAAGCC
  AAGTCCTTTGGCTTGCCTGGCGACATGGTTCTTCTGGAAAAGAAGCCGGATGTACAGCTCACTGGTCAGC
  ACATGTCCATCATCTATGAGGAGACAAACACCCCACGGCCAGACCGGCTGCATCATGGACGAGTGCACGT
  GGTCGAGGGAAACTTCAGACATGCCAGCAGCCGTGCCCCAGTGTCTAGGGAGGAGCTGATGACAGTGCTG
  TCTAGACTGGCAGATGTGCGCATCCAAGGCCTCTACTTCACAGAGACTCAAAGGCTCACCCTGAGCGAGG
  TGGGGCTAGAGGAAGCCTCTGACACAGGAAGTGGGCGCATAGCACTTGCTGTGGAAATCTGTGCCTGCCC
  CCCTGCCTACGCTGGTGACTCTTGTCAGGGTTGTAGCCCTGGATACTATCGGGATCATAAAGGCTTGTAT
  ACCGGACGGTGTGTTCCCTGCAATTGCAACGGACATTCAAATCAATGCCAGGATGGCTCAGGCATATGTG
  TTAACTGTCAGCACAACACCGCGGGAGAGCACTGTGAACGCTGCCAGGAGGGCTACTATGGCAACGCCGT
  CCACGGATCCTGCAGGGCCTGCCCATGTCCTCACACTAACAGCTTTGCCACTGGCTGTGTGGTGAATGGG
  GGAGACGTGCGGTGCTCCTGCAAAGCTGGGTACACAGGAACACAGTGTGAAAGGTGTGCACCGGGATATT
  TCGGGAATCCCCAGAAATTCGGAGGTAGCTGCCAACCATGCAGTTGTAACAGCAATGGCCAGCTGGGCAG
  CTGTCATCCCCTGACTGGAGACTGCATAAACCAAGAACCCAAAGATAGCAGCCCTGCAGAAGAATGTGAT
  GATTGCGACAGCTGTGTGATGACCCTCCTGAACGACCTGGCCACCATGGGCGAGCAGCTCCGCCTGGTCA
  AGTCTCAGCTGCAGGGCCTGAGTGCCAGCGCAGGGCTTCTGGAGCAGATGAGGCACATGGAGACCCAGGC
  CAAGGACCTGAGGAATCAGTTGCTCAACTACCGTTCTGCCATTTCAAATCATGGATCAAAAATAGAAGGC
  CTGGAAAGAGAACTGACTGATTTGAATCAAGAATTTGAGACTTTGCAAGAAAAGGCTCAAGTAAATTCCA
  GAAAAGCACAAACATTAAACAACAATGTTAATCGGGCAACACAAAGCGCAAAAGAACTGGATGTGAAGAT
  TAAAAATGTCATCCGGAATGTGCACATTCTTTTAAAGCAGATCTCTGGGACAGATGGAGAGGGAAACAAC
  GTGCCTTCAGGTGACTTTTCCAGAGAGTGGGCTGAAGCCCAGCGCATGATGAGGGAACTGCGGAACAGGA
  ACTTTGGAAAGCACCTCAGAGAAGCAGAAGCTGATAAAAGGGAGTCGCAGCTCTTGCTGAACCGGATAAG
  GACCTGGCAGAAAACCCACCAGGGGGAGAACAATGGGCTTGCTAACAGTATCCGGGATTCTTTAAATGAA
  TACGAAGCCAAACTCAGTGACCTTCGTGCTCGGCTGCAGGAGGCAGCTGCCCAAGCCAAGCAGGCAAATG
  GCTTGAACCAAGAAAACGAGAGAGCTTTGGGAGCCATTCAGAGACAAGTGAAAGAAATAAATTCCCTGCA
  GAGTGATTTCACCAAGTATCTAACCACTGCAGACTCATCTTTGTTGCAAACCAACATTGCGCTGCAGCTG
  ATGGAGAAAAGCCAGAAGGAATATGAAAAATTAGCTGCCAGTTTAAATGAAGCAAGACAAGAACTAAGTG
  ACAAAGTAAGAGAACTTTCCAGATCTGCTGGCAAAACATCCCTTGTGGAGGAGGCAGAAAAGCACGCGCG
  GTCCTTACAAGAGCTGGCAAAGCAGCTGGAAGAGATCAAGAGAAACGCCAGCGGGGATGAGCTGGTGCGC
  TGTGCTGTGGATGCCGCCACCGCCTACGAGAACATCCTCAATGCCATCAAAGCGGCCGAGGACGCAGCCA
  ACAGGGCTGCCAGTGCATCTGAATCTGCCCTCCAGACAGTGATAAAGGAAGATCTGCCAAGAAAAGCTAA
  AACCCTGAGTTCCAACAGTGATAAACTGTTAAATGAAGCCAAGATGACACAAAAGAAGCTAAAGCAAGAA
  GTCAGTCCAGCTCTCAACAACCTACAGCAAACCCTGAATATTGTGACAGTTCAGAAAGAAGTGATAGACA
  CCAATCTCACAACTCTCCGAGATGGTCTTCATGGGATACAGAGAGGTGATATTGATGCTATGATCAGTAG
  TGCAAAGAGCATGGTCAGAAAGGCCAACGACATCACAGATGAGGTTCTGGATGGGCTCAACCCCATCCAG
  ACAGATGTGGAAAGAATTAAGGACACCTATGGGAGGACACAGAACGAAGACTTCAAAAAGGCTCTGACTG
  ATGCAGATAACTCGGTGAATAAGTTAACCAACAAACTACCTGATCTTTGGCGCAAGATTGAAAGTATCAA
  CCAACAGCTGTTGCCCTTGGGAAACATCTCTGACAACATGGACAGAATACGAGAACTAATTCAGCAGGCC
  AGAGATGCTGCCAGTAAGGTTGCTGTCCCCATGAGGTTCAATGGTAAATCTGGAGTCGAAGTCCGACTGC
  CAAATGACCTGGAAGATTTGAAAGGATATACATCTCTGTCCTTGTTTCTCCAAAGGCCCAACTCAAGAGA
  AAATGGGGGTACTGAGAATATGTTTGTGATGTACCTTGGAAATAAAGATGCCTCCCGGGACTACATCGGC
  ATGGCAGTTGTGGATGGCCAGCTCACCTGTGTCTACAACCTGGGGGACCGTGAGGCTGAACTCCAAGTGG
  ACCAGATCTTGACCAAGAGTGAGACTAAGGAGGCAGTTATGGATCGGGTGAAATTTCAGAGAATTTATCA
  GTTTGCAAGGCTTAATTACACCAAAGGAGCCACATCCAGTAAACCAGAAACACCCGGAGTCTATGACATG
  GATGGTAGAAATAGCAATACACTCCTTAATTTGGATCCTGAAAATGTTGTATTTTATGTTGGAGGTTACC
  CACCTGATTTTAAACTTCCCAGTCGACTAAGTTTCCCTCCATACAAAGGTTGTATTGAATTAGATGACCT
  CAATGAAAATGTTCTGAGCTTGTACAACTTCAAAAAAACATTCAATCTCAACACAACTGAAGTGGAGCCT
  TGTAGAAGGAGGAAGGAAGAGTCAGACAAAAATTATTTTGAAGGTACGGGCTATGCTCGAGTTCCAACTC
  AACCACATGCTCCCATCCCAACCTTTGGACAGACAATTCAGACCACCGTGGATAGAGGCTTGCTGTTCTT
  TGCAGAAAACGGGGATCGCTTCATATCTCTAAATATAGAAGATGGCAAGCTCATGGTGAGATACAAACTG
  AATTCAGAGCTACCAAAAGAGAGAGGAGTTGGAGACGCCATAAACAACGGCAGAGACCATTCGATTCAGA
  TCAAAATTGGAAAACTCCAAAAGCGTATGTGGATAAATGTGGACGTTCAAAACACTATAATTGATGGTGA
  AGTATTTGATTTCAGCACATATTATCTGGGAGGAATTCCAATTGCAATCAGGGAAAGATTTAACATTTCT
  ACGCCTGCTTTCCGAGGCTGCATGAAAAATTTGAAGAAAACCAGTGGTGTCGTTAGATTGAATGATACTG
  TGGGAGTAACCAAAAAGTGCTCGGAAGACTGGAAGCTTGTGCGATCTGCCTCATTCTCCAGAGGAGGACA
  ATTGAGTTTCACTGATTTGGGCTTACCACCTACTGACCACCTCCAGGCCTCATTTGGATTTCAGACCTTT
  CAACCCAGTGGCATATTATTAGATCATCAGACATGGACAAGGAACCTGCAGGTCACTCTGGAAGATGGTT
  ACATTGAATTGAGCACCAGCGATAGCGGCGGCCCAATTTTTAAATCTCCACAGACGTATATGGATGGTTT
  ACTGCATTATGTATCTGTAATAAGCGACAACTCTGGACTACGGCTTCTCATCGATGACCAGCTTCTGAGA
  AATAGCAAAAGGCTAAAACACATTTCAAGTTCCCGGCAGTCTCTGCGTCTGGGCGGGAGCAATTTTGAGG
  GTTGTATTAGCAATGTTTTTGTCCAGAGGTTATCACTGAGTCCTGAAGTCCTAGATTTGACCAGTAACTC
  TCTCAAGAGAGATGTGTCCCTGGGAGGCTGCAGTTTAAACAAACCACCTTTTCTAATGTTGCTTAAAGGT
  TCTACCAGGTTTAACAAGACCAAGACTTTTCGTATCAACCAGCTGTTGCAGGACACACCAGTGGCCTCCC
  CAAGGAGCGTGAAGGTGTGGCAAGATGCTTGCTCACCACTTCCCAAGACCCAGGCCAATCATGGAGCCCT
  CCAGTTTGGGGACATTCCCACCAGCCACTTGCTATTCAAGCTTCCTCAGGAGCTGCTGAAACCCAGGTCA
  CAGTTTGCTGTGGACATGCAGACAACATCCTCCAGAGGACTGGTGTTTCACACGGGCACTAAGAACTCCT
  TTATGGCTCTTTATCTTTCAAAAGGACGTCTGGTCTTTGCACTGGGGACAGATGGGAAAAAATTGAGGAT
  CAAAAGCAAGGAGAAATGCAATGATGGGAAATGGCACACGGTGGTGTTTGGCCATGATGGGGAAAAGGGG
  CGCTTGGTTGTGGATGGACTGAGGGCCCGGGAGGGAAGTTTGCCTGGAAACTCCACCATCAGCATCAGAG
  CGCCAGTTTACCTGGGATCACCTCCATCAGGGAAACCAAAGAGCCTCCCCACAAACAGCTTTGTGGGATG
  CCTGAAGAACTTTCAGCTGGATTCAAAACCCTTGTATACCCCTTCTTCAAGCTTCGGGGTGTCTTCCTGC
  TTGGGTGGTCCTTTGGAGAAAGGCATTTATTTCTCTGAAGAAGGAGGTCATGTCGTCTTGGCTCACTCTG
  TATTGTTGGGGCCAGAATTTAAGCTTGTTTTCAGCATCCGCCCAAGAAGTCTCACTGGGATCCTAATACA
  CATCGGAAGTCAGCCCGGGAAGCACTTATGTGTTTACCTGGAGGCAGGAAAGGTCACGGCCTCTATGGAC
  AGTGGGGCAGGTGGGACCTCAACGTCGGTCACACCAAAGCAGTCTCTGTGTGATGGACAGTGGCACTCGG
  TGGCAGTCACCATAAAACAACACATCCTGCACCTGGAACTGGACACAGACAGTAGCTACACAGCTGGACA
  GATCCCCTTCCCACCTGCCAGCACTCAAGAGCCACTACACCTTGGAGGTGCTCCAGCCAATTTGACGACA
  CTGAGGATCCCTGTGTGGAAATCATTCTTTGGCTGTCTGAGGAATATTCATGTCAATCACATCCCTGTCC
  CTGTCACTGAAGCCTTGGAAGTCCAGGGGCCTGTCAGTCTGAATGGTTGTCCTGACCAGTAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_198129
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_198129.2, NP_937762.2
• RefSeq Size: 10666 bp
• RefSeq ORF: 10002 bp
• Locus ID: 3909
• Cytogenetics: 18q11.2
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: ECM-receptor interaction, Focal adhesion, Pathways in cancer, Small cell lung cancer
• Gene Summary: 'The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014]'
  Transcript Variant: This variant (1, also known as b1) represents the longest transcript and encodes the longest isoform (1, also known as alpha3B1). Variants 1 and 3 encode 'b' isoforms.