CDC2L1 (CDK11B) (NM_033493) Human Untagged Clone

CAT#: SC309471

CDK11B (untagged)-Human cyclin-dependent kinase 11B (CDK11B), transcript variant 9

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CDK11B
• Synonyms: CDC2L1; CDK11; CDK11-p46; CDK11-p58; CDK11-p110; CLK-1; p58; p58CDC2L1; p58CLK-1; PK58
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_033493, the custom clone sequence may differ by one or more nucleotides
  ATGGGTGATGAAAAGGACTCTTGGAAAGTGAAAACTTTAGATGAAATTCTTCAGGAAAAG
  AAACGAAGGAAGGAACAAGAGGAGAAAGCAGAGATAAAACGCTTAAAAAATTCTGATGAC
  CGGGATTCCAAGCGGGATTCCCTTGAGGAGGGGGAGCTGAGAGATCACTGCATGGAGATC
  ACAATAAGGAACTCCCCGTATAGAAGAGAAGACTCTATGGAAGACAGAGGAGAAGAAGAT
  GATTCTTTGGCCATCAAACCACCCCAGCAAATGTCTCGGAAAGAAAAAGTTCATCACAGA
  AAAGATGAAAAGAGAAAAGAGAAAAAGCATGCTAGAGTGAAAGAAAAAGAAAGAGAGCAC
  GAACGTCGGAAACGACATCGAGAAGAACAGGATAAAGCTCGCCGGGAATGGGAAAGACAG
  AAGAGAAGGGAAATGGCAAGGGAGCATTCCAGGAGAGAAAGGGACCGCTTGGAGCAGTTA
  GAAAGGAAGCGGGAGCGGGAGCGCAAGATGCGGGAGCAGCAGAAGGAGCAGCGGGAGCAG
  AAGGAGCGCGAGCGGCGGGCGGAGGAGCGGCGCAAGGAGCGGGAGGCCCGCAGGGAAGTG
  TCTGCACATCACCGAACGATGAGAGAGGACTACAGCGACAAAGTGAAAGCCAGCCACTGG
  AGTCGCAGCCCGCCTCGGCCGCCGCGGGAGCGGTTCGAGTTGGGAGACGGCCGGAAGCCA
  GTAAAAGAAGAGAAAATGGAAGAAAGGGACCTGCTGTCCGACTTACAGGACATCAGCGAC
  AGCGAGAGGAAGACCAGCTCGGCCGAGTCCTCGTCAGCAGAATCAGGCTCAGGTTCTGAG
  GAAGAAGAGGAGGAGGAGGAAGAGGAGGAGGAGGAAGGGAGCACCAGTGAAGAATCAGAG
  GAGGAGGAGGAGGAAGAGGAAGAGGAGGAGGAGGAGACCGGCAGCAACTCTGAGGAGGCA
  TCAGAGCAGTCTGCCGAAGAAGTAAGTGAGGAAGAAATGAGTGAAGATGAAGAACGAGAA
  AATGAAAACCACCTCTTGGTTGTTCCAGAGTCACGGTTCGACCGAGATTCCGGGGAGAGT
  GAAGAAGCAGAGGAAGAAGTGGGTGAGGGAACGCCGCAGAGCAGCGCCCTGACAGAGGGC
  GACTATGTGCCCGACTCCCCTGCCCTGTCGCCCATCGAGCTCAAGCAGGAGCTGCCCAAG
  TACCTGCCGGCCCTGCAGGGCTGCCGGAGCGTCGAGGAGTTCCAGTGCCTGAACAGGATC
  GAGGAGGGCACCTATGGAGTGGTCTACAGAGCAAAAGACAAGAAAACAGATGAAATTGTG
  GCTCTAAAGCGGCTGAAGATGGAGAAGGAGAAGGAGGGCTTCCCGATCACGTCGCTGAGG
  GAGATCAACACCATCCTCAAGGCCCAGCATCCCAACATCGTCACCGTTAGAGAGATTGTG
  GTGGGCAGCAACATGGACAAGATCTACATCGTGATGAACTATGTGGAGCACGACCTCAAG
  AGCCTGATGGAGACCATGAAACAGCCCTTCCTGCCAGGGGAGGTGAAGACCCTGATGATC
  CAGCTGCTGCGTGGGGTGAAACACCTGCACGACAACTGGATCCTGCACCGTGACCTCAAG
  ACGTCCAACCTGCTGCTGAGCCACGCCGGCATCCTCAAGGTGGGTGACTTCGGGCTGGCG
  CGGGAGTACGGATCCCCTCTGAAGGCCTACACCCCGGTCGTGGTGACCCTGTGGTACCGC
  GCCCCAGAGCTGCTGCTTGGTGCCAAGGAATACTCCACGGCCGTGGACATGTGGTCAGTG
  GGTTGCATCTTCGGGGAGCTGCTGACTCAGAAGCCTCTGTTCCCCGGGAAGTCAGAAATC
  GATCAGATCAACAAGGTGTTCAAGGATCTGGGGACCCCTAGTGAGAAAATCTGGCCCGGC
  TACAGCGAGCTCCCAGCAGTCAAGAAGATGACCTTCAGCGAGCACCCCTACAACAACCTC
  CGCAAGCGCTTCGGGGCTCTGCTCTCAGACCAGGGCTTCGACCTCATGAACAAGTTCCTG
  ACCTACTTCCCCGGGAGGAGGATCAGCGCTGAGGACGGCCTCAAGCATGAGTATTTCCGC
  GAGACCCCCCTCCCCATCGACCCCTCCATGTTCCCCACGTGGCCCGCCAAGAGCGAGCAG
  CAGCGTGTGAAGCGGGGCACCAGCCCGAGGCCCCCTGAGGGAGGCCTGGGCTACAGCCAG
  CTGGGTGACGACGACCTGAAGGAGACGGGCTTCCACCTTACCACCACGAACCAGGGGGCC
  TCTGCCGCGGGCCCCGGCTTCAGCCTCAAGTTCTGA
  
• Restriction Sites: Please inquire
• ACCN: NM_033493
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_033493.1, NP_277028.1
• RefSeq Size: 2453 bp
• RefSeq ORF: 2316 bp
• Locus ID: 984
• Cytogenetics: 1p36.33
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: 'This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]'
  Transcript Variant: This variant (9) lacks two separated internal coding regions when compared to variant 1. The resulting protein thus lacks a 11 aa and a 14 aa internal fragment, as compared to isoform 1.