PTPN13 (NM_080684) Human Untagged Clone

CAT#: SC309552

PTPN13 (untagged)-Human protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) (PTPN13), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PTPN13
• Synonyms: FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL; PTP1E; PTPL1; PTPLE
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_080684, the custom clone sequence may differ by one or more nucleotides
  ATGCACGTGTCACTAGCTGAGGCCCTGGAGGTTCGGGGTGGACCACTTCAGGAGGAAGAA
  ATATGGGCTGTATTAAATCAAAGTGCTGAAAGTCTCCAAGAATTATTCAGAAAAGTAAGC
  CTAGCTGATCCTGCTGCCCTTGGCTTCATCATTTCTCCATGGTCTCTGCTGTTGCTGCCA
  TCTGGTAGTGTGTCATTTACAGATGAAAATATTTCCAATCAGGATCTTCGAGCATTCACT
  GCACCAGAGGTTCTTCAAAATCAGTCACTAACTTCTCTCTCAGATGTTGAAAAGATCCAC
  ATTTATTCTCTTGGAATGACACTGTATTGGGGGGCTGATTATGAAGTGCCTCAGAGCCAA
  CCTATTAAGCTTGGAGATCATCTCAACAGCATACTGCTTGGAATGTGTGAGGATGTTATT
  TACGCTCGAGTTTCTGTTCGGACTGTGCTGGATGCTTGCAGTGCCCACATTAGGAATAGC
  AATTGTGCACCCTCATTTTCCTACGTGAAACACTTGGTAAAACTGGTTCTGGGAAATCTT
  TCTGGGACAGATCAGCTTTCCTGTAACAGTGAACAAAAGCCTGATCGAAGCCAGGCTATT
  CGAGATCGATTGCGAGGAAAAGGATTACCAACAGGAAGAAGCTCTACTTCTGATGTACTA
  GACATACAAAAGCCTCCACTCTCTCATCAGACCTTTCTTAACAAAGGGCTTAGTAAATCT
  ATGGGATTTCTGTCCATCAAAGATACACAAGATGAGAATTATTTCAAGGACATTTTATCA
  GATAATTCTGGACGTGAAGATTCTGAAAATACATTCTCCCCTTACCAGTTCAAAACTAGT
  GGCCCAGAAAAAAAACCCATCCCTGGCATTGATGTGCTTTCTAAGAAGAAGATCTGGGCT
  TCATCCATGGACTTGCTTTGTACAGCTGACAGAGACTTCTCTTCAGGAGAGACTGCCACA
  TATCGTCGTTGTCACCCTGAGGCAGTAACAGTGCGGACTTCAACTACTCCTAGAAAAAAG
  GAGGCAAGATACTCAGATGGAAGTATAGCCTTGGATATCTTTGGCCCTCAGAAAATGGAT
  CCAATATATCACACTCGAGAATTGCCCACCTCCTCAGCAATATCAAGTGCTTTGGACCGA
  ATCCGAGAGAGACAAAAGAAACTTCAGGTTCTGAGGGAAGCCATGAATGTAGAAGAACCA
  GTTCGAAGATACAAAACTTATCATGGTGATGTCTTTAGTACCTCCAGTGAAAGTCCATCT
  ATTATTTCCTCTGAATCAGATTTCAGACAAGTGAGAAGAAGTGAAGCCTCAAAGAGGTTT
  GAATCCAGCAGTGGTCTCCCAGGGGTAGATGAAACCTTAAGTCAAGGCCAGTCACAGAGA
  CCGAGCAGACAATATGAAACACCCTTTGAAGGCAACTTAATTAATCAAGAGATCATGCTA
  AAACGGCAAGAGGAAGAACTGATGCAGCTACAAGCCAAAATGGCCCTTAGACAGTCTCGG
  TTGAGCCTATATCCAGGAGACACAATCAAAGCGTCCATGCTTGACATCACCAGGGATCCG
  TTAAGAGAAATTGCCCTAGAAACAGCCATGACTCAAAGAAAACTGAGGAATTTCTTTGGC
  CCTGAGTTTGTGAAAATGACAATTGAACCATTTATATCTTTGGATTTGCCACGGTCTATT
  CTTACTAAGAAAGGGAAGAATGAGGATAACCGAAGGAAAGTAAACATAATGCTTCTGAAC
  GGGCAAAGACTGGAACTGACCTGTGATACCAAAACTATATGTAAAGATGTGTTTGATATG
  GTTGTGGCACATATTGGCTTAGTAGAGCATCATTTGTTTGCTTTAGCTACCCTCAAAGAT
  AATGAATATTTCTTTGTTGATCCTGACTTAAAATTAACCAAAGTGGCCCCAGAGGGATGG
  AAAGAAGAACCAAAGAAAAAGACCAAAGCCACTGTTAATTTTACTTTGTTTTTCAGAATT
  AAATTTTTTATGGATGATGTTAGTCTAATACAACATACTCTGACGTGTCATCAGTATTAC
  CTTCAGCTTCGAAAAGATATTTTGGAGGAAAGGATGCACTGTGATGATGAGACTTCCTTA
  TTGCTGGCATCCTTGGCTCTCCAGGCTGAGTATGGAGATTATCAACCAGAGGTTCATGGT
  GTGTCTTACTTTAGAATGGAGCACTATTTGCCCGCCAGAGTGATGGAGAAACTTGATTTA
  TCCTATATCAAAGAAGAGTTACCCAAATTGCATAATACCTATGTGGGAGCTTCTGAAAAA
  GAGACAGAGTTAGAATTTTTAAAGGTCTGCCAAAGACTGACAGAATATGGAGTTCATTTT
  CACCGAGTGCACCCTGAGAAGAAGTCACAAACAGGAATATTGCTTGGAGTCTGTTCTAAA
  GGTGTCCTTGTGTTTGAAGTTCACAATGGAGTGCGCACATTGGTCCTTCGCTTTCCATGG
  AGGGAAACCAAGAAAATATCTTTTTCTAAAAAGAAAATCACATTGCAAAATACATCAGAT
  GGAATAAAACATGGCTTCCAGACAGACAACAGTAAGATATGCCAGTACCTGCTGCACCTC
  TGCTCTTACCAGCATAAGTTCCAGCTACAGATGAGAGCAAGACAGAGCAACCAAGATGCC
  CAAGATATTGATGTGCTACACAAAAGATGGAGCATAGTATCTTCACCAGAAAGGGAGATC
  ACCTTAGTGAACCTGAAAAAAGATGCAAAGTATGGCTTGGGATTTCAAATTATTGGTGGG
  GAGAAGATGGGAAGACTGGACCTAGGCATATTTATCAGTTCAGTTGCCCCTGGAGGACCA
  GCTGACTTGGATGGATGCTTGAAGCCAGGAGACCGTTTGATATCTGTGAATAGTGTGAGT
  CTGGAGGGAGTCAGCCACCATGCTGCAATTGAAATTTTGCAAAATGCACCTGAAGATGTG
  ACACTTGTTATCTCTCAGCCAAAAGAAAAGATATCCAAAGTGCCTTCTACTCCTGTGCAT
  CTCACCAATGAGATGAAAAACTACATGAAGAAATCTTCCTACATGCAAGACAGTGCTATA
  GATTCTTCTTCCAAGGATCACCACTGGTCACGTGGTACCCTGAGGCACATCTCGGAGAAC
  TCCTTTGGGCCATCTGGGGGCCTGCGGGAAGGAAGCCTGAGTTCTCAAGATTCCAGGACT
  GAGAGTGCCAGCTTGTCTCAAAGCCAGGTCAATGGTTTCTTTGCCAGCCATTTAGGTGAC
  CAAACCTGGCAGGAATCACAGCATGGCAGCCCTTCCCCATCTGTAATATCCAAAGCCACC
  GAGAAAGAGACTTTCACTGATAGTAACCAAAGCAAAACTAAAAAGCCAGGCATTTCTGAT
  GTAACTGATTACTCAGACCGTGGAGATTCAGACATGGATGAAGCCACTTACTCCAGCAGT
  CAGGATCATCAAACACCAAAACAGGAATCTTCCTCTTCAGTGAATACATCCAACAAGATG
  AATTTTAAAACTTTTTCTTCATCACCTCCTAAGCCTGGAGATATCTTTGAGGTTGAACTG
  GCTAAAAATGATAACAGCTTGGGGATAAGTGTCACGGGAGGTGTGAATACGAGTGTCAGA
  CATGGTGGCATTTATGTGAAAGCTGTTATTCCCCAGGGAGCAGCAGAGTCTGATGGTAGA
  ATTCACAAAGGTGATCGCGTCCTAGCTGTCAATGGAGTTAGTCTAGAAGGAGCCACCCAT
  AAGCAAGCTGTGGAAACACTGAGAAATACAGGACAGGTGGTTCATCTGTTATTAGAAAAG
  GGACAATCTCCAACATCTAAAGAACATGTCCCGGTAACCCCACAGTGTACCCTTTCAGAT
  CAGAATGCCCAAGGTCAAGGCCCAGAAAAAGTGAAGAAAACAACTCAGGTCAAAGACTAC
  AGCTTTGTCACTGAAGAAAATACATTTGAGGTAAAATTATTTAAAAATAGCTCAGGTCTA
  GGATTCAGTTTTTCTCGAGAAGATAATCTTATACCGGAGCAAATTAATGCCAGCATAGTA
  AGGGTTAAAAAGCTCTTTCCTGGACAGCCAGCAGCAGAAAGTGGAAAAATTGATGTAGGA
  GATGTTATCTTGAAAGTGAATGGAGCCTCTTTGAAAGGACTATCTCAGCAGGAAGTCATA
  TCTGCTCTCAGGGGAACTGCTCCAGAAGTATTCTTGCTTCTCTGCAGACCTCCACCTGGT
  GTGCTACCGGAAATTGATACTGCGCTTTTGACCCCACTTCAGTCTCCAGCACAAGTACTT
  CCAAACAGCAGTAAAGACTCTTCTCAGCCATCATGTGTGGAGCAAAGCACCAGCTCAGAT
  GAAAATGAAATGTCAGACAAAAGCAAAAAACAGTGCAAGTCCCCATCCAGAAGAGACAGT
  TACAGTGACAGCAGTGGGAGTGGAGAAGATGACTTAGTGACAGCTCCAGCAAACATATCA
  AATTCGACCTGGAGTTCAGCTTTGCATCAGACTCTAAGCAACATGGTATCACAGGCACAG
  AGTCATCATGAAGCACCCAAGAGTCAAGAAGATACCATTTGTACCATGTTTTACTATCCT
  CAGAAAATTCCCAATAAACCAGAGTTTGAGGACAGTAATCCTTCCCCTCTACCACCGGAT
  ATGGCTCCTGGGCAGAGTTATCAACCCCAATCAGAATCTGCTTCCTCTAGTTCGATGGAT
  AAGTATCATATACATCACATTTCTGAACCAACTAGACAAGAAAACTGGACACCTTTGAAA
  AATGACTTGGAAAATCACCTTGAAGACTTTGAACTGGAAGTAGAACTCCTCATTACCCTA
  ATTAAATCAGAAAAAGGAAGCCTGGGTTTTACAGTAACCAAAGGCAATCAGAGAATTGGT
  TGTTATGTTCATGATGTCATACAGGATCCAGCCAAAAGTGATGGAAGGCTAAAACCTGGG
  GACCGGCTCATAAAGGTTAATGATACAGATGTTACTAATATGACTCATACAGATGCAGTT
  AATCTGCTCCGGGCTGCATCCAAAACAGTCAGATTAGTTATTGGACGAGTTCTAGAATTA
  CCCAGAATACCAATGTTGCCTCATTTGCTACCGGACATAACACTAACGTGCAACAAAGAG
  GAGTTGGGTTTTTCCTTATGTGGAGGTCATGACAGCCTTTATCAAGTGGTATATATTAGT
  GATATTAATCCAAGGTCCGTCGCAGCCATTGAGGGTAATCTCCAGCTATTAGATGTCATC
  CATTATGTGAACGGAGTCAGCACACAAGGAATGACCTTGGAGGAAGTTAACAGAGCATTA
  GACATGTCACTTCCTTCATTGGTATTGAAAGCAACAAGAAATGATCTTCCAGTGGTCCCC
  AGCTCAAAGAGGTCTGCTGTTTCAGCTCCAAAGTCAACCAAAGGCAATGGTTCCTACAGT
  GTGGGGTCTTGCAGCCAGCCTGCCCTCACTCCTAATGATTCATTCTCCACGGTTGCTGGG
  GAAGAAATAAATGAAATATCGTACCCCAAAGGAAAATGTTCTACTTATCAGATAAAGGGA
  TCACCAAACTTGACTCTGCCCAAAGAATCTTATATACAAGAAGATGACATTTATGATGAT
  TCCCAAGAAGCTGAAGTTATCCAGTCTCTGCTGGATGTTGTGGATGAGGAAGCCCAGAAT
  CTTTTAAACGAAAATAATGCAGCAGGATACTCCTGTGGTCCAGGTACATTAAAGATGAAT
  GGGAAGTTATCAGAAGAGAGAACAGAAGATACAGACTGCGATGGTTCACCTTTACCTGAG
  TATTTTACTGAGGCCACCAAAATGAATGGCTGTGAAGAATATTGTGAAGAAAAAGTAAAA
  AGTGAAAGCTTAATTCAGAAGCCACAAGAAAAGAAGACTGATGATGATGAAATAACATGG
  GGAAATGATGAGTTGCCAATAGAGAGAACAAACCATGAAGATTCTGATAAAGATCATTCC
  TTTCTGACAAACGATGAGCTCGCTGTACTCCCTGTCGTCAAAGTGCTTCCCTCTGGTAAA
  TACACGGGTGCCAACTTAAAATCAGTCATTCGAGTCCTGCGGGGTTTGCTAGATCAAGGA
  ATTCCTTCTAAGGAGCTGGAGAATCTTCAAGAATTAAAACCTTTGGATCAGTGTCTAATT
  GGGCAAACTAAGGAAAACAGAAGGAAGAACAGATATAAAAATATACTTCCCTATGATGCT
  ACAAGAGTGCCTCTTGGAGATGAAGGTGGCTATATCAATGCCAGCTTCATTAAGATACCA
  GTTGGGAAAGAAGAGTTCGTTTACATTGCCTGCCAAGGACCACTGCCTACAACTGTTGGA
  GACTTCTGGCAGATGATTTGGGAGCAAAAATCCACAGTGATAGCCATGATGACTCAAGAA
  GTAGAAGGAGAAAAAATCAAATGCCAGCGCTATTGGCCCAACATCCTAGGCAAAACAACA
  ATGGTCAGCAACAGACTTCGACTGGCTCTTGTGAGAATGCAGCAGCTGAAGGGCTTTGTG
  GTGAGGGCAATGACCCTTGAAGATATTCAGACCAGAGAGGTGCGCCATATTTCTCATCTG
  AATTTCACTGCCTGGCCAGACCATGATACACCTTCTCAACCAGATGATCTGCTTACTTTT
  ATCTCCTACATGAGACACATCCACAGATCAGGCCCAATCATTACGCACTGCAGTGCTGGC
  ATTGGACGTTCAGGGACCCTGATTTGCATAGATGTGGTTCTGGGATTAATCAGTCAGGAT
  CTTGATTTTGACATCTCTGATTTGGTGCGCTGCATGAGACTACAAAGACACGGAATGGTT
  CAGACAGAGGATCAATATATTTTCTGCTATCAAGTCATCCTTTATGTCCTGACACGTCTT
  CAAGCAGAAGAAGAGCAAAAACAGCAGCCTCAGCTTCTGAAGTGA
  
• Restriction Sites: Please inquire
• ACCN: NM_080684
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_080684.1, NP_542415.1
• RefSeq Size: 7546 bp
• RefSeq ORF: 6885 bp
• Locus ID: 5783
• Cytogenetics: 4q21.3
• Domains: Y_phosphatase, B41, PDZ
• Protein Families: Druggable Genome, Phosphatase
• Gene Summary: 'The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]'
  Transcript Variant: This variant (3) lacks multiple in-frame segments of the coding region, compared to variant 4. The encoded protein (isoform 3) lacks 191 internal amino acids, compared to isoform 4.