NFAT5 (NM_006599) Human Untagged Clone

CAT#: SC309614

NFAT5 (untagged)-Human nuclear factor of activated T-cells 5, tonicity-responsive (NFAT5), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NFAT5
• Synonyms: NF-AT5; NFATL1; NFATZ; OREBP; TONEBP
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_006599, the custom clone sequence may differ by one or more nucleotides
  ATGCCCTCGGACTTCATCTCATTGCTCAGCGCGGACCTAGACCTGGAATCGCCCAAGTCC
  CTCTACTCGCGAGAATCTGTCTATGATCTTCTCCCAAAGGAGTTACAGTTACCTCCATCT
  AGAGAAACATCTGTAGCATCAATGAGTCAGACAAGCGGTGGTGAGGCAGGCTCGCCTCCT
  CCAGCTGTTGTTGCTGCTGATGCTTCTTCAGCTCCCTCCTCTTCCTCCATGGGCGGTGCT
  TGCAGCTCCTTTACCACCTCTTCCAGCCCTACCATTTATTCTACCTCAGTCACCGACAGC
  AAGGCTATGCAAGTGGAGAGCTGCTCCTCAGCCGTGGGGGTAAGTAACAGAGGGGTAAGT
  GAAAAGCAGTTAACCAGTAACACAGTTCAGCAGCATCCATCAACACCGAAGAGGCACACA
  GTCTTGTACATCTCACCACCACCTGAGGACTTGCTGGATAACAGTCGGATGTCCTGCCAG
  GATGAGGGGTGTGGATTGGAATCTGAGCAGAGCTGCAGTATGTGGATGGAGGATTCCCCC
  TCCAACTTCAGTAACATGAGCACCAGTTCCTACAATGATAACACTGAGGTACCTCGTAAA
  TCACGAAAACGAAATCCAAAGCAGAGGCCGGGGGTCAAACGACGAGATTGTGAAGAATCT
  AATATGGATATATTTGATGCCGACAGTGCCAAAGCACCTCACTATGTGCTTTCTCAGCTT
  ACCACGGACAACAAAGGCAACTCAAAAGCGGGAAATGGAACATTGGAAAACCAAAAAGGA
  ACTGGAGTAAAGAAGAGCCCTATGTTGTGTGGACAATATCCTGTTAAAAGTGAGGGAAAG
  GAGCTGAAGATAGTTGTACAACCTGAGACACAGCACCGAGCTCGGTACCTGACTGAGGGC
  AGCCGTGGCTCAGTGAAAGATAGAACACAGCAAGGCTTTCCTACAGTAAAGCTGGAAGGC
  CATAATGAACCTGTAGTGTTGCAAGTGTTTGTGGGCAACGACTCTGGACGAGTGAAACCA
  CATGGATTTTATCAGGCCTGCAGAGTAACTGGACGAAATACAACTCCTTGCAAAGAAGTG
  GACATTGAAGGCACTACTGTTATAGAAGTCGGCCTTGATCCTAGCAACAACATGACACTG
  GCGGTGGACTGCGTAGGGATATTGAAATTGAGGAATGCTGATGTCGAAGCCAGAATAGGA
  ATTGCTGGTTCCAAGAAGAAAAGCACTCGTGCCAGATTGGTTTTTCGAGTTAATATCATG
  AGGAAAGATGGCTCCACTTTGACACTGCAAACACCCTCTTCTCCAATTTTGTGTACTCAG
  CCAGCAGGAGTGCCAGAAATCTTAAAGAAAAGCTTGCATAGCTGTTCAGTGAAAGGAGAA
  GAAGAAGTGTTTTTAATCGGCAAGAACTTTCTGAAAGGAACTAAAGTTATTTTCCAAGAA
  AATGTTTCTGATGAAAACTCTTGGAAGTCAGAAGCTGAAATTGATATGGAACTATTTCAT
  CAGAATCATCTTATTGTGAAGGTTCCTCCCTATCATGACCAACATATAACTTTGCCTGTG
  TCAGTGGGAATATATGTAGTGACAAATGCTGGAAGATCTCATGATGTTCAACCATTCACT
  TACACTCCAGACCCAGCAGCAGCTGGTGCTTTGAATGTAAATGTGAAGAAGGAAATATCT
  AGTCCAGCAAGACCTTGCTCTTTTGAAGAGGCCATGAAAGCAATGAAAACTACTGGATGT
  AATTTAGATAAGGTAAATATTATCCCTAATGCCCTGATGACTCCACTCATACCAAGCAGT
  ATGATTAAGAGTGAAGATGTTACTCCAATGGAAGTAACAGCAGAAAAAAGATCTTCCACT
  ATTTTTAAGACTACAAAGTCTGTTGGATCAACTCAGCAAACATTAGAAAACATCTCAAAC
  ATAGCAGGAAATGGCTCTTTTTCATCACCATCATCTTCCCACCTACCTTCTGAAAATGAA
  AAACAGCAGCAGATTCAGCCCAAGGCATACAACCCAGAGACCCTGACAACTATTCAAACC
  CAGGACATCTCACAGCCTGGTACTTTTCCAGCAGTTTCTGCTTCTAGTCAGCTGCCCAAC
  AGCGATGCACTATTGCAGCAGGCTACACAGTTTCAGACAAGAGAAACTCAGTCTAGAGAG
  ATATTACAGTCAGATGGTACAGTGGTTAATTTGTCACAACTGACTGAGGCATCACAACAA
  CAGCAGCAGTCACCACTACAAGAACAAGCACAGACTTTACAGCAGCAGATTTCATCAAAT
  ATTTTTCCATCACCAAATAGTGTGAGTCAGCTTCAGAATACTATTCAGCAGCTGCAAGCA
  GGGAGTTTCACAGGCAGTACTGCTAGTGGCAGCAGTGGAAGTGTTGACTTGGTCCAACAA
  GTTTTAGAGGCACAGCAGCAGTTATCTTCAGTTTTATTTTCTGCTCCAGATGGTAATGAG
  AATGTTCAAGAGCAGCTTAGTGCAGATATTTTTCAACAAGTCAGTCAAATTCAGAGTGGT
  GTAAGCCCTGGAATGTTTTCCTCAACAGAGCCAACAGTCCATACCAGACCAGATAATTTA
  TTACCTGGAAGAGCTGAAAGTGTTCATCCACAGTCTGAAAACACGTTATCTAATCAACAG
  CAGCAGCAGCAGCAGCAACAGCAAGTGATGGAATCTTCAGCCGCAATGGTGATGGAGATG
  CAACAGAGTATCTGCCAGGCAGCTGCCCAGATTCAGTCAGAGTTATTCCCTTCAACTGCT
  TCAGCAAATGGAAACCTTCAGCAATCGCCAGTTTACCAGCAGACTTCTCACATGATGAGT
  GCATTGTCTACCAATGAGGATATGCAAATGCAGTGTGAATTGTTTTCTTCTCCTCCTGCA
  GTTTCTGGAAATGAAACTTCTACAACTACCACACAGCAGGTTGCAACCCCTGGCACTACC
  ATGTTTCAGACATCAAGTTCAGGAGATGGAGAAGAAACTGGAACACAAGCAAAACAGATT
  CAGAACAGTGTCTTTCAGACCATGGTCCAAATGCAACATAGTGGGGACAATCAACCTCAA
  GTTAACCTTTTTTCATCCACAAAAAGTATGATGAGTGTTCAGAATAGTGGTACCCAACAA
  CAAGGTAATGGTTTATTCCAGCAAGGGAATGAGATGATGTCACTTCAATCTGGAAATTTT
  TTGCAGCAGTCTTCTCATTCACAGGCCCAACTTTTTCATCCTCAAAATCCTATTGCCGAT
  GCTCAGAACCTTTCCCAGGAAACTCAAGGTTCTCTCTTTCATAGTCCAAATCCTATTGTC
  CACAGTCAGACTTCTACAACCTCCTCTGAACAAATGCAGCCTCCAATGTTTCACTCTCAA
  AGTACCATTGCTGTGTTACAGGGCTCTTCAGTTCCTCAAGACCAGCAGTCAACCAACATA
  TTTCTTTCCCAGAGTCCCATGAATAATCTTCAGACTAACACAGTAGCCCAAGAAGCATTT
  TTTGCAGCACCGAACTCAATTTCTCCACTTCAGTCAACATCAAACAGTGAACAACAAGCT
  GCTTTCCAACAGCAAGCTCCAATATCACACATCCAGACTCCTATGCTTTCCCAAGAACAG
  GCACAACCCCCGCAGCAGGGTTTATTTCAGCCTCAGGTGGCCCTGGGCTCCCTTCCACCT
  AATCCAATGCCTCAAAGCCAACAAGGAACCATGTTCCAGTCACAGCACTCAATAGTTGCC
  ATGCAGAGTAACTCTCCATCCCAGGAACAGCAGCAGCAGCAGCAACAGCAGCAGCAACAG
  CAGCAGCAACAACAACAGAGCATTTTATTCAGTAATCAGAATACCATGGCTACAATGGCG
  TCTCCAAAGCAACCACCACCAAACATGATATTCAACCCAAATCAAAATCCAATGGCTAAT
  CAGGAGCAACAGAACCAGTCAATTTTTCACCAACAAAGTAACATGGCCCCAATGAATCAA
  GAGCAACAGCCCATGCAATTTCAGAGTCAGTCCACAGTTTCCTCACTTCAGAACCCAGGT
  CCTACCCAGTCGGAATCATCACAGACCCCCTTGTTCCATAGCTCTCCTCAGATTCAGTTG
  GTACAAGGGTCACCTAGTTCTCAAGAGCAGCAAGTAACTCTCTTCTTATCTCCAGCATCC
  ATGTCTGCCTTGCAGACCAGTATAAATCAACAAGATATGCAACAGTCTCCTCTTTATTCC
  CCTCAGAACAACATGCCTGGAATTCAAGGAGCCACATCTTCGCCTCAACCACAGGCTACT
  TTATTTCACAACACAGCAGGAGGCACAATGAACCAACTGCAGAATTCTCCTGGCTCATCT
  CAGCAGACATCAGGAATGTTCTTATTTGGCATTCAAAATAACTGTAGTCAGCTTTTAACC
  TCTGGACCAGCTACATTGCCTGATCAGTTGATGGCCATAAGTCAGCCAGGCCAACCACAA
  AACGAGGGCCAGCCACCTGTGACAACACTTCTTTCTCAGCAAATGCCAGAGAATTCTCCA
  CTGGCATCCTCTATAAACACCAACCAGAACATCGAAAAGATTGATTTGCTTGTTTCATTG
  CAAAACCAAGGGAACAACTTGACTGGCTCCTTTTAA
  
• Restriction Sites: Please inquire
• ACCN: NM_006599
• ORF Size: 4596 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_006599.2, NP_006590.1
• RefSeq Size: 14123
• RefSeq ORF: 4596
• Locus ID: 10725
• Domains: IPT
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Axon guidance, B cell receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, VEGF signaling pathway, Wnt signaling pathway
• Gene Summary: The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (3) lacks two exons in the 5' region, compared to variant 1. This difference causes translation initiation at an upstream start codon and results in an isoform (c) with a longer N-terminus compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.