Calpain 10 (CAPN10) (NM_023085) Human Untagged Clone

CAT#: SC309621

CAPN10 (untagged)-Human calpain 10 (CAPN10), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CAPN10
• Synonyms: CANP10; NIDDM1
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_023085, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGCGGGCGGGCCGGGGCGCGACGCCGGCGAGGGAGCTGTTCCGGGACGCCGCCTTCCCCGCCGCGGACT
  CCTCGCTCTTCTGCGACTTGTCTACGCCGCTGGCCCAGTTCCGCGAGGACATCACGTGGAGGCGGCCCCA
  GGAGATTTGTGCCACACCCCGGCTGTTTCCAGATGACCCACGGGAAGGGCAGGTGAAGCAGGGGCTGCTG
  GGGGATTGCTGGTTCCTGTGTGCCTGCGCCGCGCTGCAGAAGAGCAGGCACCTCCTGGACCAGGTCATTC
  CTCCGGGACAGCCGAGCTGGGCCGACCAGGAGTACCGGGGCTCCTTCACCTGTCGCATTTGGCAGTTTGG
  ACGCTGGGTGGAGGTGACCACAGATGACCGCCTGCCGTGCCTTGCAGGGAGACTCTGTTTCTCCCGCTGC
  CAGAGGGAGGATGTGTTCTGGCTCCCCTTACTGGAAAAGGTCTACGCCAAGGTCCATGGGTCCTACGAGC
  ACCTGTGGGCCGGGCAGGTGGCGGATGCCCTGGTGGACCTGACCGGCGGCCTGGCAGAAAGATGGAACCT
  GAAGGGCGTAGCAGGAAGCGGAGGCCAGCAGGACAGGCCAGGCCGCTGGGAGCACAGGACTTGTCGGCAG
  CTGCTCCACCTGAAGGACCAGTGTCTGATCAGCTGCTGCGTGCTCAGCCCCAGAGCAGGTGCCCGGGAGC
  TGGGGGAGTTCCATGCCTTCATTGTCTCGGACCTGCGGGAGCTCCAGGGTCAGGCGGGCCAGTGCATCCT
  GCTGCTGCGGATCCAGAACCCCTGGGGCCGGCGGTGCTGGCAGGGGCTCTGGAGAGAGGGGGGTGAAGGG
  TGGAGCCAGGTAGATGCAGCGGTAGCATCTGAGCTCCTGTCCCAGCTCCAGGAAGGGGAGTTCTGGGTGG
  AGGAGGAGGAGTTCCTCAGGGAGTTTGACGAGCTCACCGTTGGCTACCCGGTCACGGAGGCCGGCCACCT
  GCAGAGCCTCTACACAGAGAGGCTGCTCTGCCATACGCGGGCGCTGCCTGGGGCCTGGGTCAAGGGCCAG
  TCAGCAGGAGGCTGCCGGAACAACAGCGGCTTTCCCAGCAACCCCAAATTCTGGCTGCGGGTCTCAGAAC
  CGAGTGAGGTGTACATTGCCGTCCTGCAGAGATCCAGGCTGCACGCGGCGGACTGGGCAGGCCGGGCCCG
  GGCACTGGTGGGTGACAGTCATACTTCGTGGAGCCCAGCGAGCATCCCGGGCAAGCACTACCAGGCTGTG
  GGTCTGCACCTCTGGAAGGTCCCAGAGGGTGGAAGGAGCCAGGACGCACCCCCACTGCTGCTGCAGGAGC
  CGCTGCTGAGCTGCGTGCCACATCGCTACGCCCAGGAGGTGAGCCGGCTCTGCCTCCTGCCTGCGGGCAC
  CTACAAGGTTGTGCCCTCCACCTACCTGCCGGACACAGAGGGGGCCTTCACAGTGACCATCGCAACCAGG
  ATTGACAGGCCATCCATTCACAGCCAGGAGATGCTGGGCCAGTTCCTCCAAGAGGTCTCCGTCATGGCAG
  TGATGAAAACCTAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_023085
• ORF Size: 1554 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_023085.3, NP_075573.2
• RefSeq Size: 2197
• RefSeq ORF: 1554
• Locus ID: 11132
• Protein Families: Druggable Genome, Protease
• Gene Summary: Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]
  Transcript Variant: This variant (3, also known as CAPN10c) lacks two consecutive exons, resulting in the loss of an in-frame segment in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.