ASIC3 (NM_004769) Human Untagged Clone

CAT#: SC309761

ASIC3 (untagged)-Human amiloride-sensitive cation channel 3 (ACCN3), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ASIC3
• Synonyms: ACCN3; DRASIC; SLNAC1; TNaC1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_004769 edited
  GGGCGGCCGCGAATTCGGCACCAGCTGCCTTCCAACCTTGGCTTGTCTCCCACCCTCTCT
  TCTCCTCTCCTTGCCTGGCCTCCTGAATCCTATCTTAGCCTCCTTAGCCCCCTGACTGAC
  TCTCTCTCGCTTCTTCCAAGCCTCTGTAGCTGGTTCCGCTCCTGGGTTCTGGCCATGAAG
  CCCACCTCAGGCCCAGAGGAGGCCCGGCGGCCAGCCTCGGACATCCGCGTGTTCGCCAGC
  AACTGCTCGATGCACGGGCTGGGCCACGTCTTCGGGCCAGGCAGCCTGAGCCTGCGCCGG
  GGGATGTGGGCAGCGGCCGTGGTCCTGTCAGTGGCCACCTTCCTCTACCAGGTGGCTGAG
  AGGGTGCGCTACTACAGGGAGTTCCACCACCAGACTGCCCTGGATGAGCGAGAAAGCCAC
  CGGCTCATCTTCCCGGCTGTCACCCTGTGCAACATCAACCCACTGCGCCGCTCGCGCCTA
  ACGCCCAACGACCTGCACTGGGCTGGGTCTGCGCTGCTGGGCCTGGATCCCGCAGAGCAC
  GCCGCCTTCCTGCGCGCCCTGGGCCGGCCTCCTGCACCGCCCGGCTTCATGCCCAGTCCC
  ACCTTTGACATGGCGCAACTCTATGCCCGTGCTGGGCACTCCCTGGATGACATGCTGCTG
  GACTGTCGCTTCCGTGGCCAACCTTGTGGGCCTGAGAACTTCACCACGATCTTCACCCGG
  ATGGGAAAGTGCTACACATTTAACTCTGGCGCTGATGGGGCAGAGCTGCTCACCACTACT
  AGGGGTGGCATGGGCAATGGGCTGGACATCATGCTGGACGTGCAGCAGGAGGAATATCTA
  CCTGTGTGGAGGGACAATGAGGAGACCCCGTTTGAGGTGGGGATCCGAGTGCAGATCCAC
  AGCCAGGAGGAGCCGCCCATCATCGATCAGCTGGGCTTGGGGGTGTCCCCGGGCTACCAG
  ACCTTTGTTTCTTGCCAGCAGCAGCAGCTGAGCTTCCTGCCACCGCCCTGGGGCGATTGC
  AGTTCAGCATCTCTGAACCCCAACTATGAGCCAGAGCCCTCTGATCCCCTAGGCTCCCCC
  AGCCCCAGCCCCAGCCCTCCCTATACCCTTATGGGGTGTCGCCTGGCCTGCGAAACCCGC
  TACGTGGCTCGGAAGTGCGGCTGCCGAATGGTGTACATGCCAGGCGACGTGCCAGTGTGC
  AGCCCCCAGCAGTACAAGAACTGTGCCCACCCGGCCATAGATGCCATGCTTCGCAAGGAC
  TCGTGCGCCTGCCCCAACCCGTGCGCCAGCACGCGCTACGCCAAGGAGCTCTCCATGGTG
  CGGATCCCGAGCCGCGCCGCCGCGCGCTTCCTGGCCCGGAAGCTCAACCGCAGCGAGGCC
  TACATCGCGGAGAACGTGCTGGCCCTGGACATCTTCTTTGAGGCCCTCAACTATGAGACC
  GTGGAGCAGAAGAAGGCCTATGAGATGTCAGAGCTGCTTGGTGACATTGGGGGCCAGATG
  GGGCTGTTCATCGGGGCCAGCCTGCTCACCATCCTCGAGATCCTAGACTACCTCTGTGAG
  GTGTTCCGAGACAAGGTCCTGGGATATTTCTGGAACCGACAGCACTCCCAAAGGCACTCC
  AGCACCAATCTGCTTCAGGAAGGGCTGGGCAGCCATCGAACCCAAGTTCCCCACCTCAGC
  CTGGGCCCCAGACCTCCCACCCCTCCCTGTGCCGTCACCAAGACTCTCTCCGCCTCCCAC
  CGCACCTGCTACCTTGTCACACAGCTCTAGACCTGCTGTCTGTGTCCTCGGAGCCCCGCC
  CTGACATCCTGGACATGCCTAGCCTGCACGTAGCTTTTCCGTCTTCACCCCAAATAAAGT
  CCTAATGCATCAGCAAAAAAAAAAAAAAAAACTCGACTCTAGATTGCGGCCG
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004769 unedited
  NTATATCGCCGACCCCTTGTCCCAATGGGCGGTAGGCGTGTACAGTGGGCAGGTCTATAT
  AAGCAGAGCTTGTTTAGTGAACCGTCAGTATTTTGTAATACGACTCACTATAGGGCGGCT
  CGCGAATTCGGCACCAGCTGCCTTCCAACCTTGGCTTGTCTCCCACCCTCTCTTCTCCTC
  TCCTTGCCTGGCCTCCTGAATCCTATCTTAGCCTCCTTAGCCCCCTGACTGACTCTCTCT
  CGCTTCTTCCAAGCCTCTGTAGCTGGTTCCGCTCCTGGGTTCTGGCCATGAAGCCCACCT
  CAGGCCCAGAGGAGGCCCGGCGGCCAGCCTCGGACATCCGCGTGTTCGCCAGCAACTGCT
  CGATGCACGGGCTGGGCCACGTCTTCTGGCCAGGCATCCTGAGCCTGCGCCGGGGGATGT
  GGGCAGCGGCCGTGGTCCTGTCAGTGGCCACCTTCCTCTACCAGGTGGCTGAGAGGGTGC
  GCTACTACAGGGAGTTCCACCACCAGACTGCCCTGGATGAGCGAGAAAGCCACCGGCTCA
  TCTTCCCGGCTGTCACCCTGTGCAACATCAACCCACTGCGCCGCTCGCGCCTAACGCCCA
  ACGACCTGCACTGGGCTGGGTCTGCGCTGCTGGGCCTGGATCCCGCAGAGCACGCCGCCT
  TCCTGCGCGCCCTGGGCCGGCCTCCTGCACCGCCCGGCTTCATGCCCAGTCCCACCTTTG
  ACATGACGCAACTCTATGCCCGTGCTAGGCACTCCCTGNATGACATGCTGCTGGACTGTC
  GCTTACCGTGGCCAACCTTTGTGGGCCTGAGAACTTCACCACGATCTTCACCCGGATGGG
  GAAAGTGCTACACATTTTACTCCTGCGCTGATGGGGCAGAACTGCTCACACTCTAAGGGT
  GGCATGGGCA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004769 unedited
  NNTTGTTGCATTAGGACTTTTTTGGGGTNGAANCGGNAAAACTACGTGCAGGCTAGGCAT
  GTCCAGGATGTCAGGGCGGGGCTCCGAGGACACAGACAGCAGGTCTAGAGCTGTGTGACA
  AGGTAGCAGGTGCGGTGGGAGGCGGAGAGAGTCTTGGTGACGGCACAGGGAGGGGTGGGA
  GGTCTGGGGCCCAGGCTGAGGTGGGGAACTTGGGTTCGATGGCTGCCCAGCCCTTCCTGA
  AGCAGATTGGTGCTGGAGTGCCTTTGGGAGTGCTGTCGGTTCCAGAAATATCCCAGGACC
  TTGTCTCGGAACACCTCACAGAGGTAGTCTAGGATCTCGAGGATGGTGAGCAGGCTGGCC
  CCGATGAACAGCCCCATCTGGCCCCCAATGTCACCAAGCAGCTCTGACATCTCATAGGCC
  TTCTTCTGCTCCACGGTCTCATAGTTGAGGGCCTCAAAGAAGATGTCCAGGGCCAGCACG
  TTCTCCGCGATGTAGGCCTCGCTGCGGTTGAGCTTCCGGGCCAGGAAGCGCGCGGCGGCG
  CGGCTCGGGATCCGCACCATGGAGAGCTCCTTGGCGTAGCGCGTGCTGGCGCACGGGTTG
  GGGCAGGCGCACGAGTCCTTGCGAAGCATGGCATCTATGGCCGGGTGGGCACAGTTCTTG
  TACTGCTGGGGGCTGCACACTGGCACGTCGCCTGGCATGTACACCATTCGGCAGCCGCAC
  TTCCGAGCCACGTAGCGGGTTTCGCAGGCCAGGCGACACCCCATAAGGGTATAGGGAGGG
  CTGGGGCTGGGGCTGGGGGAGCCTAAGGGATCAAAGGGCTCTGGCTCATAGTTTGGGGTT
  CAGAGATGCTGAACTGCAATCGCCCCCAGGCGGTGGCCAGAAGCTCAACTGCTGCTGCTG
  GCAAAC
  
• Restriction Sites: Please inquire
• ACCN: NM_004769
• ORF Size: 1596 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_004769.1, NP_004760.1
• RefSeq Size: 1746
• RefSeq ORF: 1596
• Locus ID: 9311
• Protein Families: Druggable Genome, Ion Channels: Other
• Gene Summary: This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
  Transcript Variant: This variant (1) uses an alternate splice site in the 3' coding region, compared to variant 2. The resulting protein (isoform a) has a shorter and distinct C-terminus, compared to isoform b.