MAML2 (NM_032427) Human Untagged Clone

CAT#: SC309968

MAML2 (untagged)-Human mastermind-like 2 (Drosophila) (MAML2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MAML2
• Synonyms: MAM-3; MAM2; MAM3; MLL-MAML2
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_032427 edited
  ATGGGGGACACAGCGCCCCCGCAGGCCCCCGCAGGAGGGCTAGGGGGGGCCTCTGGGGCG
  GGGCTCCTTGGAGGGGGCTCAGTCACCCCGAGAGTGCACAGTGCTATCGTGGAGCGCCTC
  CGGGCTCGGATCGCTGTCTGCCGCCAACACCACCTGAGCTGTGAAGGACGATATGAACGA
  GGTAGGGCCGAGAGCTCAGACCGGGAAAGAGAAAGCACCTTGCAGCTCCTGAGCCTTGTA
  CAGCATGGCCAGGGGGCAAGGAAAGCTGGCAAACACACCAAGGCCACCGCCACTGCTGCC
  ACCACTACAGCCCCTCCACCGCCCCCTGCTGCCCCTCCTGCGGCCTCCCAAGCAGCAGCA
  ACAGCAGCCCCACCGCCCCCACCAGACTATCACCATCACCACCAGCAGCACCTGCTGAAC
  AGTAGCAATAATGGTGGCAGTGGTGGGATAAACGGAGAGCAGCAGCCGCCCGCTTCAACC
  CCAGGGGACCAGAGGAACTCAGCCCTGATTGCGCTCCAGGGTTCCTTGAAAAGAAAACAG
  GTAGTTAACCTATCTCCTGCCAACAGCAAGCGACCCAATGGCTTTGTGGACAACTCATTT
  CTTGATATCAAAAGAATTCGTGTTGGGGAGAATCTCTCTGCAGGACAAGGTGGCCTCCAA
  ATAAACAATGGACAAAGTCAGATTATGTCAGGGACCTTGCCTATGAGCCAAGCACCCCTG
  CGAAAGACTAACACTCTGCCATCCCATACACATTCTCCTGGCAATGGCCTGTTTAACATG
  GGCTTAAAGGAGGTAAAGAAGGAGCCAGGAGAGACTCTGTCTTGCAGTAAGCACATGGAT
  GGCCAAATGACCCAAGAGAATATTTTTCCTAATAGGTACGGAGACGACCCTGGAGAACAA
  CTGATGGATCCTGAGCTGCAGGAACTGTTCAATGAACTGACCAACATATCTGTGCCTCCC
  ATGAGTGACCTTGAACTGGAGAACATGATCAATGCCACCATAAAGCAGGATGACCCATTT
  AACATTGACTTGGGTCAGCAAAGCCAGAGGAGCACACCTAGGCCCTCCTTACCCATGGAG
  AAAATAGTGATCAAAAGTGAATACTCACCGGGCTTGACTCAGGGCCCCTCAGGCTCTCCT
  CAGCTGAGGCCCCCATCAGCTGGCCCCGCATTCTCCATGGCCAACTCTGCCCTCTCCACT
  TCGTCTCCAATCCCTTCAGTCCCTCAGAGCCAGGCTCAGCCTCAGACAGGCTCCGGAGCA
  AGCCGGGCCTTGCCAAGCTGGCAGGAAGTATCCCATGCCCAGCAGCTCAAACAGATAGCT
  GCTAATCGTCAGCAGCATGCCCGGATGCAGCAGCACCAGCAGCAGCACCAGCCTACCAAC
  TGGTCAGCCTTGCCCTCCTCTGCTGGACCATCACCAGGTCCATTTGGGCAGGAGAAAATC
  CCCAGCCCTTCTTTTGGTCAGCAGACATTCAGCCCACAGAGCTCCCCCATGCCTGGGGTA
  GCTGGCGGCAGCGGCCAGTCGAAAGTAATGGCTAACTACATGTACAAGGCCGGCCCCTCA
  GCCCAGGGTGGGCACCTAGATGTCCTCATGCAGCAAAAGCCTCAGGATCTCAGTCGAAGT
  TTTATTAACAACCCGCACCCAGCCATGGAGCCCCGTCAGGGCAACACCAAGCCTTTGTTT
  CATTTTAACTCAGATCAAGCGAACCAGCAGATGCCTTCTGTTTTGCCTTCCCAGAACAAG
  CCTTCTCTCCTACACTACACCCAACAGCAACAGCAGCAACAGCAGCAGCAGCAGCAGCAG
  CAGCAGCAGCAACAGCAGCAGCAGCAGCAACAGCAACAGCAACAGCAACAGCAGAGTTCA
  ATTTCAGCTCAACAACAGCAACAGCAGCAGAGCTCAATTTCAGCCCAACAGCAGCAGCAG
  CAGCAACAACAGCAGCAGCAGCAGCAACAACAACAGCAACAACAGCAGCAGCAGCAGCAG
  CAACAACCATCTTCTCAGCCTGCCCAATCTCTACCAAGCCAGCCTTTGCTAAGGTCACCT
  TTGCCACTTCAGCAAAAGCTCCTACTTCAGCAAATGCAGAATCAGCCCATTGCAGGAATG
  GGATACCAAGTCTCCCAACAACAGAGACAGGATCAACACTCTGTGGTAGGCCAGAACACA
  GGCCCCAGTCCAAGTCCTAACCCCTGCTCAAATCCAAACACTGGAAGTGGTTACATGAAC
  TCCCAGCAATCACTGTTGAATCAGCAATTGATGGGAAAGAAGCAGACTCTACAGAGGCAG
  ATCATGGAGCAGAAACAGCAACTTCTTCTCCAGCAGCAGATGCTGGCTGACGCGGAGAAA
  ATTGCTCCACAAGATCAGATAAACCGACATTTGTCAAGGCCACCTCCAGATTATAAAGAC
  CAAAGAAGAAATGTGGGCAATATGCAACCAACTGCTCAGTATTCTGGTGGCTCATCCACA
  ATAAGCTTAAACTCTAACCAGGCTTTGGCAAACCCAGTTTCAACACACACCATTTTAACT
  CCCAATTCCAGCCTCCTGTCTACTTCTCACGGGACAAGAATGCCATCATTATCTACAGCA
  GTTCAGAATATGGGGATGTATGGAAATCTGCCTTGTAATCAACCTAACACATACAGTGTC
  ACTTCAGGAATGAATCAATTGACCCAACAGAGAAACCCAAAGCAATTGTTAGCAAATCAA
  AACAACCCTATGATGCCACGGCCACCTACCTTAGGGCCAAGTAATAATAACAATGTAGCC
  ACTTTTGGAGCTGGATCTGTTGGTAATTCACAACAATTGAGACCAAATTTAACCCATAGT
  ATGGCAAGCATGCCACCACAGAGAACATCAAACGTAATGATCACATCCAACACAACTGCA
  CCAAACTGGGCCTCTCAAGAAGGAACAAGCAAACAGCAAGAAGCCCTGACGTCTGCAGGA
  GTCCGCTTCCCCACAGGTACACCTGCAGCCTATACCCCAAATCAGTCACTGCAACAGGCA
  GTAGGTAGCCAGCAATTTTCCCAGAGGGCAGTGGCTCCTCCTAACCAGTTAACACCAGCA
  GTGCAAATGAGACCCATGAACCAAATGAGCCAAACACTAAATGGGCAAACCATGGGTCCC
  CTCAGGGGTCTGAATCTCAGACCCAATCAGCTAAGCACACAGATTTTGCCTAATTTGAAT
  CAGTCAGGAACAGGGTTGAATCAGTCGAGGACGGGCATCAACCAGCCACCATCCCTGACG
  CCCAGCAATTTTCCTTCACCCAACCAAAGTTCCAGGGCTTTTCAAGGAACTGACCACAGC
  AGTGACTTAGCTTTTGACTTCCTCAGCCAACAAAATGATAACATGGGCCCTGCCCTAAAC
  AGTGATGCTGATTTCATTGATTCTTTATTGAAGACAGAGCCTGGTAATGATGACTGGATG
  AAAGACATCAATCTTGATGAAATCTTGGGGAACAATTCCTAA
  
• Restriction Sites: Please inquire
• ACCN: NM_032427
• ORF Size: 3471 bp
• Insert Size: 3500
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_032427.1, NP_115803.1
• RefSeq Size: 5428
• RefSeq ORF: 3471
• Locus ID: 84441
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Notch signaling pathway
• Gene Summary: The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]