Kv2.2 (KCNB2) (NM_004770) Human Untagged Clone

CAT#: SC310052

KCNB2 (untagged)-Human potassium voltage-gated channel, Shab-related subfamily, member 2 (KCNB2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: KCNB2
• Synonyms: KV2.2
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_004770, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCAGAAAAGGCTCCCCCGGGCTTAAACAGGAAGACTTCAAGGTCGACACTTTCCCTTCCTCCAGAGC
  CTGTGGACATTATCCGGAGCAAAACATGCTCCAGGAGAGTTAAGATCAATGTGGGGGGCCTCAACCACGA
  AGTCCTGTGGAGAACGCTGGACAGGCTGCCCAGGACGCGCCTGGGGAAGCTTCGAGACTGCAACACACAC
  GAGAGCCTCCTGGAAGTGTGCGACGACTATAATCTGAACGAGAACGAGTATTTCTTTGATCGGCATCCAG
  GAGCCTTCACTTCCATTTTAAATTTCTACCGGACCGGGAAACTCCATATGATGGAAGAAATGTGTGCACT
  TTCGTTTGGCCAAGAACTTGATTACTGGGGGATTGATGAGATCTACTTGGAGTCCTGCTGCCAGGCCAGA
  TATCATCAAAAAAAAGAACAAATGAACGAAGAACTGAGGCGAGAGGCAGAGACTATGCGAGAGCGAGAAG
  GAGAAGAGTTTGATAATACCTGCTGCCCTGATAAAAGGAAGAAACTGTGGGACTTGCTGGAGAAACCTAA
  CTCATCAGTGGCTGCAAAGATCCTGGCCATCGTGTCTATCCTGTTCATTGTGCTTTCCACCATTGCTTTG
  TCTCTCAATACGCTGCCGGAGCTGCAGGAAACGGACGAATTTGGACAACTCAATGACAACCGCCAATTAG
  CACACGTGGAGGCTGTGTGTATTGCATGGTTTACCATGGAGTACCTTTTGCGATTCTTATCCTCACCAAA
  TAAATGGAAGTTCTTCAAAGGCCCACTGAATGTCATTGATTTGCTGGCCATCTTGCCGTACTATGTCACC
  ATTTTTCTGACGGAGTCCAACAAGAGCGTGCTGCAGTTCCAAAACGTGAGGCGCGTGGTCCAGATCTTCC
  GAATCATGCGCATCCTCAGGATCCTGAAACTCGCCAGGCATTCGACAGGCCTGCAGTCTCTGGGTTTCAC
  CCTTAGGCGGAGTTACAATGAATTGGGCTTGTTGATATTGTTTCTGGCCATGGGGATAATGATATTTTCC
  AGCCTGGTATTTTTTGCTGAGAAGGATGAAGATGCTACCAAGTTCACCAGTATCCCTGCATCATTTTGGT
  GGGCCACCATCACCATGACCACTGTTGGCTATGGTGACATTTACCCTAAAACATTACTAGGGAAAATTGT
  GGGAGGTCTGTGCTGTATTGCTGGGGTTCTGGTTATTGCCCTTCCTATCCCAATTATTGTGAACAATTTT
  TCTGAGTTTTACAAGGAGCAGAAACGCCAAGAGAAAGCAATTAAAAGGAGGGAGGCTCTTGAGCGGGCCA
  AAAGGAACGGAAGCATCGTTTCTATGAACTTAAAAGATGCCTTCGCTCGAAGTATGGAACTGATAGATGT
  GGCTGTTGAGAAGGCCGGAGAGTCCGCCAACACAAAGGACTCCGCCGACGATAATCACCTGTCGCCAAGC
  CGGTGGAAGTGGGCCAGGAAGGCTCTGTCGGAAACAAGCTCCAACAAGTCTTTCGAGAATAAGTACCAGG
  AGGTTAGCCAAAAAGACTCCCACGAGCAGCTGAACAACACGTCTTCCTCCAGCCCACAGCATCTGAGTGC
  CCAGAAACTGGAGATGCTATACAATGAAATCACCAAGACACAGCCTCATTCTCACCCAAACCCAGACTGC
  CAAGAAAAGCCTGAGAGGCCATCTGCATATGAAGAAGAGATTGAAATGGAAGAAGTGGTGTGTCCACAGG
  AGCAGCTGGCCGTGGCACAGACCGAGGTCATTGTGGACATGAAGAGCACCTCCAGCATCGACAGCTTCAC
  CAGCTGTGCCACCGACTTCACAGAGACAGAGAGATCGCCGCTGCCGCCGCCCTCCGCCTCTCACTTGCAG
  ATGAAGTTCCCAACCGACCTCCCAGGGACAGAAGAGCACCAAAGAGCTAGGGGCCCCCCGTTTCTAACTC
  TATCCAGAGAGAAAGGACCTGCTGCCAGGGATGGCACGCTGGAGTATGCCCCAGTTGACATAACTGTGAA
  CCTCGATGCCAGTGGCTCCCAGTGTGGGCTACATAGTCCTTTGCAGTCTGACAATGCCACCGACAGTCCT
  AAGAGCTCTCTAAAAGGCAGCAACCCACTAAAGTCCAGATCCCTCAAAGTGAACTTTAAGGAAAATAGAG
  GCAGTGCACCACAGACCCCGCCCAGCACAGCCAGGCCACTGCCAGTCACCACAGCTGACTTTTCGCTCAC
  TACCCCGCAGCACATCAGTACCATCCTCTTAGAAGAAACCCCCTCCCAGGGAGACAGACCCTTGCTGGGC
  ACTGAGGTTTCAGCGCCTTGTCAGGGACCTTCCAAAGGGCTGTCCCCCAGGTTTCCCAAGCAGAAACTGT
  TCCCTTTCTCTTCAAGAGAGAGGAGGAGCTTCACTGAAATAGATACTGGTGACGACGAAGACTTCTTAGA
  GCTCCCAGGGGCAAGGGAGGAGAAGCAGGTGGACTCCAGCCCAAATTGCTTTGCAGATAAGCCTAGTGAT
  GGGAGAGACCCTTTAAGAGAAGAGGGCAGTGTGGGCTCTTCCTCCCCGCAGGACACAGGTCACAACTGTA
  GGCAAGACATTTACCATGCTGTGAGTGAAGTCAAAAAGGACAGTAGTCAAGAAGGGTGCAAGATGGAAAA
  TCACTTGTTTGCCCCAGAAATTCATTCCAACCCAGGAGACACAGGTTATTGTCCCACACGTGAAACCAGC
  ATGTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_004770
• ORF Size: 2736 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_004770.2, NP_004761.2
• RefSeq Size: 3597
• RefSeq ORF: 2736
• Locus ID: 9312
• Domains: BTB, K_tetra, Kv2channel, ion_trans
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008]