Apc4 (ANAPC4) (NM_013367) Human Untagged Clone

CAT#: SC310100

ANAPC4 (untagged)-Human anaphase promoting complex subunit 4 (ANAPC4)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ANAPC4
• Synonyms: APC4
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_013367, the custom clone sequence may differ by one or more nucleotides
  ATGTTGCGTTTTCCGACCTGTTTCCCATCCTTCCGGGTGGTGGGAGAGAAGCAGCTCCCG
  CAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACACA
  GCTGGCGAGGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCA
  AATGAAAATACAGGAAAGGAGGTGACGTGTCTGGCATGGAGACCAGATGGCAAACTTTTG
  GCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGAGC
  TTACACTCTTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTA
  GAAAGCAGTGTTCTCACATCATTTTATAATGCTGAGGATGAATCAAATCTTCTCTTACCT
  AAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAAAT
  TCTGATGAAATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGA
  AGCTCTGGATTTATTGAGCTTTATGCTTATGGAATGTTTAAAATTGCTCGAGTCACAGGG
  ATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGGTC
  ACAGAAGTCTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTG
  TTGTACTCTTTCTTACCTGAAGTAACTCGGATGGCCAGAAAGTTTACTCATATTTCAGCT
  CTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATACTA
  ATGCAGATGGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTG
  CAAGATGAGTTCATGCACTTGCTATTATGGGGGAAAGCAAGTGCTGAACTTCAGACTCTC
  TTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCATCA
  TACTCCAGTATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTA
  TACCATTTGAGTGAATTGAAAGGAATGGCTTCATGGAAGCAAAAATATGAACCTCTTGGA
  CTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGGCA
  AATGAACTTCTTCAAGTTATAGATAGTAGTATGAAAAACTTCAAAGCATTTTTTCGGTGG
  CTTTATGTGGCAATGTTGAGAATGACAGAAGACCATGTGCTTCCCGAGCTGAATAAGATG
  ACTCAGAAAGATATCACATTTGTTGCTGAATTTCTTACTGAACATTTCAATGAGGCTCCA
  GACCTTTATAATCGAAAAGGAAAATACTTTAACGTTGAAAGAGTTGGTCAGTACTTGAAA
  GATGAAGATGATGATCTTGTGTCACCCCCTAACACAGAAGGAAACCAGTGGTATGACTTT
  CTTCAAAATAGCAGCCACCTTAAAGAAAGTCCTTTGCTGTTTCCTTATTATCCTCGAAAA
  TCATTGCATTTTGTGAAAAGGCGGATGGAGAATATTATTGATCAGTGTTTGCAAAAGCCA
  GCAGATGTAATTGGAAAATCGATGAATCAAGCAATCTGTATTCCATTGTATAGAGATACC
  AGAAGTGAGGATTCTACACGTAGATTGTTCAAATTTCCTTTTCTGTGGAATAATAAAACT
  TCAAATCTACATTATCTTCTTTTTACTATTCTAGAAGATTCACTTTATAAAATGTGCATC
  TTAAGGAGACATACTGATATTTCTCAATCTGTGAGTAATGGACTAATTGCTATTAAATTT
  GGGAGCTTTACATATGCCACAACAGAAAAAGTCAGAAGAAGCATCTACAGTTGTTTAGAT
  GCACAGTTTTATGATGATGAAACTGTAACAGTAGTTCTTAAAGACACTGTAGGACGTGAA
  GGAAGAGATAGACTCTTGGTCCAGCTGCCTTTGTCTTTAGTATATAACAGTGAAGATTCT
  GCAGAATATCAGTTCACTGGGACTTATTCTACAAGGCTAGATGAACAGTGTAGTGCTATT
  CCCACCCGTACCATGCATTTTGAGAAGCACTGGAGATTACTGGAAAGTATGAAAGCACAG
  TATGTTGCTGGGAATGGTTTTCGAAAAGTGTCCTGTGTGTTAAGCTCAAATCTTCGTCAT
  GTGAGAGTATTTGAAATGGACATAGATGATGAATGGGAGCTCGATGAGTCTTCAGATGAA
  GAGGAGGAGGCCAGTAATAAGCCTGTAAAAATAAAGGAAGAAGTGTTGTCGGAGTCAGAG
  GCAGAGAACCAACAAGCTGGTGCTGCCGCTTTAGCTCCAGAGATAGTCATTAAAGTGGAA
  AAACTTGACCCTGAGCTAGACTCCTAA
  
• Restriction Sites: Please inquire
• ACCN: NM_013367
• ORF Size: 2427 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_013367.2, NP_037499.2
• RefSeq Size: 2701
• RefSeq ORF: 2427
• Locus ID: 29945
• Protein Families: Druggable Genome
• Protein Pathways: Cell cycle, Oocyte meiosis, Progesterone-mediated oocyte maturation, Ubiquitin mediated proteolysis
• Gene Summary: A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
  Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.