AKT3 (NM_181690) Human Untagged Clone

CAT#: SC310362

AKT3 (untagged)-Human v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) (AKT3), transcript variant 2


  "NM_181690" in other vectors (6)

Reconstitution Protocol

SC310362 is the updated version of SC124741.

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol AKT3
Synonyms MPPH; MPPH2; PKB-GAMMA; PKBG; PRKBG; RAC-gamma; RAC-PK-gamma; STK-2
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_181690 edited
CCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGA
GTCATCATGAGCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGAGAATAT
ATAAAAAACTGGAGGCCAAGATACTTCCTTTTGAAGACAGATGGCTCATTCATAGGATAT
AAAGAGAAACCTCAAGATGTGGATTTACCTTATCCCCTCAACAACTTTTCAGTGGCAAAA
TGCCAGTTAATGAAAACAGAACGACCAAAGCCAAACACATTTATAATCAGATGTCTCCAG
TGGACTACTGTTATAGAGAGAACATTTCATGTAGATACTCCAGAGGAAAGGGAAGAATGG
ACAGAAGCTATCCAGGCTGTAGCAGACAGACTGCAGAGGCAAGAAGAGGAGAGAATGAAT
TGTAGTCCAACTTCACAAATTGATAATATAGGAGAGGAAGAGATGGATGCCTCTACAACC
CATCATAAAAGAAAGACAATGAATGATTTTGACTATTTGAAACTACTAGGTAAAGGCACT
TTTGGGAAAGTTATTTTGGTTCGAGAGAAGGCAAGTGGAAAATACTATGCTATGAAGATT
CTGAAGAAAGAAGTCATTATTGCAAAGGATGAAGTGGCACACACTCTAACTGAAAGCAGA
GTATTAAAGAACACTAGACATCCCTTTTTAACATCCTTGAAATATTCCTTCCAGACAAAA
GACCGTTTGTGTTTTGTGATGGAATATGTTAATGGGGGCGAGCTGTTTTTCCATTTGTCG
AGAGAGCGGGTGTTCTCTGAGGACCGCACACGTTTCTATGGTGCAGAAATTGTCTCTGCC
TTGGACTATCTACATTCCGGAAAGATTGTGTACCGTGATCTCAAGTTGGAGAATCTAATG
CTGGACAAAGATGGCCACATAAAAATTACAGATTTTGGACTTTGCAAAGAAGGGATCACA
GATGCAGCCACCATGAAGACATTCTGTGGCACTCCAGAATATCTGGCACCAGAGGTGTTA
GAAGATAATGACTATGGCCGAGCAGTAGACTGGTGGGGCCTAGGGGTTGTCATGTATGAA
ATGATGTGTGGGAGGTTACCTTTCTACAACCAGGACCATGAGAAACTTTTTGAATTAATA
TTAATGGAAGACATTAAATTTCCTCGAACACTCTCTTCAGATGCAAAATCATTGCTTTCA
GGGCTCTTGATAAAGGATCCAAATAAACGCCTTGGTGGAGGACCAGATGATGCAAAAGAA
ATTATGAGACACAGTTTCTTCTCTGGAGTAAACTGGCAAGATGTATATGATAAAAAGCTT
GTACCTCCTTTTAAACCTCAAGTAACATCTGAGACAGATACTAGATATTTTGATGAAGAA
TTTACAGCTCAGACTATTACAATAACACCACCTGAAAAATGTCAGCAATCAGATTGTGGC
ATGCTGGGTAACTGGAAAAAATAAT
>OriGene 5' read for NM_181690 unedited
NATTTGCATTTGTAAACGACTCATATAGGCGGCCGCGCAATTCGCACGAGGCCAAACCCT
AAAGCTGATATCACAAAGTACCATTTCTCCAATTGGGGGCTCAGAGGGGAGTCATCATGA
GCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGAGAATATATAAAAAACT
GGAGGCCAAGATACTTCCTTTTGAAGACAGATGGCTCATTCATAGGATATAAAGAGAAAC
CTCAAGATGTGGATTTACCTTATCCCCTCAACAACTTTTCAGTGGCAAAATGCCAGTTAA
TGAAAACAGAACGACCAAAGCCAAACACATTTATAATCAGATGTCTCCAGTGGACTACTG
TTATAGAGAGAACATTTCATGTAGATACTCCAGAGGAAAGGGAAGAATGGACAGAAGCTA
TCCAGGCTGTAGCAGACAGACTGCAGAGGCAAGAAGAGGAGAGAATGAATTGTAGTCCAA
CTTCACAAATTGATAATATAGGAGAGGAAGAGATGGATGCCTCTACAACCCATCATAAAA
GAAAGACAATGAATGATTTTGACTATTTGAAACTACTAGGTAAAGGCACTTTTGGGAAAG
TTATTTTGGTTCGAGAGAAGGCAAGTGGAAAATACTATGCTATGAAGATTCTGAAGAAAG
AAGTCATTATTGCAAAGGATGAAGTGGCACACACTCTAACTGANAGCAGAGTATTAAAGA
ACACTAGACATCCCTTTTTAACATCCTTGAAATATTCCTTCCAGACAAAAGACCGTTTGT
GTTTTGTGATGGAATATGTTAATGNGGGGCGAGCTGTTTTTCCATTTG
>OriGene 3' read for NM_181690 unedited
CATGGGGAGGCACTTCAGGCCAGGAAGCACTGGGGAGGGTCACAGGAGCCCCCGGGATCT
GTTCAGAAACAGCTATGACCGCGGCCGCAATCTAGATTATTTTTTCCAGTTACCCAGCAT
GCCACAATCTGATTGCTGACATTTTTCAGGTGGTGTTATTGTAATAGTCTGAGCTGTAAA
TTCTTCATCAAAATATCTAGTATCTGTCTCAGATGTTACTTGAGGTTTAAAAGGAGGTAC
AAGCTTTTTATCATATACATCTTGCCAGTTTACTCCAGAGAAGAAACTGTGTCTCATAAT
TTCTTTTGCATCATCTGGTCCTCCACCAAGGCGTTTATTTGGATCCTTTATCAAGAGCCC
TGAAAGCAATGATTTTGCATCTGAAGAGAGTGTTCGAGGAAATTTAATGTCTTCCATTAA
TATTAATTCAAAAAGTTTCTCATGGTCCTGGTTGTAGAAAGGTAACCTCCCACACATCAT
TTCATACATGACAACCCCTAGGCCCCACCAGTCTACTGCTCGGCCATAGTCATTATCTTC
TAACACCTCTGGTGCCAGATATTCTGGAGTGCCACAGAATGTCTTCATGGTGGCTGCATC
TGTGATCCCTTCTTTGCAAAGTCCAAATCTGNTATTTTTATGTGGCCATCTTTGTCCAGC
ATTAGATTCTCCAACTTGAGATCACGGTACACAATCTTTCCGGAATGTAGATAGTCCCAA
GGCAGAAGACATTTCTGCACCATAGAAACGTGGTGCGGTCCTCAGAAGAACACCCGCTCT
CTCGACAAATGGAAAAACAGCTCGCCCCCCTTAACATATTTCATCACAAACACAAACGGT
CTTTTGTCCTGGGAAGGATATTTCAAGGATGTTAAAAAAGGAGGCCAAATGGTCCTTTAT
AACTCTGCTT
Restriction Sites Please inquire     
ACCN NM_181690
ORF Size 1398 bp
Insert Size 1500
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This TrueClone was found to represent an alternative form of the specific reference to which it is associated. Its Open Reading Frame (ORF) may represent a novel form or alternative splice variant. By virtue of it being a true transcript (cDNA clone not PCR product), it provides a biologically relevant copy of its mRNA template. For more details, please evaluate the sequence information provided on this website or contact our customer care specialists.
Reference Data
RefSeq NM_181690.1, NP_859029.1
RefSeq Size 1703
RefSeq ORF 1398
Locus ID 10000
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase
Protein Pathways Acute myeloid leukemia, Adipocytokine signaling pathway, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Glioma, Insulin signaling pathway, Jak-STAT signaling pathway, MAPK signaling pathway, Melanoma, mTOR signaling pathway, Neurotrophin signaling pathway, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer, Renal cell carcinoma, Small cell lung cancer, T cell receptor signaling pathway, Tight junction, Toll-like receptor signaling pathway, VEGF signaling pathway
Gene Summary The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Transcript Variant: This variant (2) differs in the 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (2) is shorter and has has a distinct C-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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