SEPTIN4 (NM_080415) Human Untagged Clone

CAT#: SC312764

41521 (untagged)-Human septin 4 (SEPT4), nuclear gene encoding mitochondrial protein, transcript variant 2


  "NM_080415" in other vectors (6)

Reconstitution Protocol

USD 660.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol SEPTIN4
Synonyms ARTS; BRADEION; C17orf47; CE5B3; H5; hCDCREL-2; hucep-7; MART; PNUTL2; SEP4; SEPT4
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_080415 edited
GGGTGACGGCGGTGCTGCGAGGTCGGCGCGCAGCTCCGCCGCGGGTCGCTCGGGCGCTGT
CCAGGCGGAGCCGGCCCCGCCCGGGCTGCAGCCATGATCAAGCGTTTCCTGGAGGACACC
ACGGATGATGGAGAACTGAGCAAGTTCGTGAAGGATTTCTCAGGAAATGCGAGCTGCCAC
CCACCAGAGGCTAAGACCTGGGCATCCAGGCCCCAAGTCCCGGAGCCAAGGCCCCAGGCC
CCGGACCTCTATGATGATGACCTGGAGTTCAGACCCCCCTCGCGGCCCCAGTCCTCTGAC
AACCAGCAGTACTTCTGTGCCCCAGCCCCTCTCAGCCCATCTGCCAGGCCCCGCAGCCCA
TGGGGCAAGCTTGATCCCTATGATTCCTCTGAGGATGACAAGGAGTATGTGGGCTTTGCA
ACCCTCCCCAACCAAGTCCACCGAAAGTCCGTGAAGAAAGGCTTTGACTTTACCCTCATG
GTGGCAGGAGAGTCTGGCCTGGGCAAATCCACACTTGTCAATAGCCTCTTCCTCACTGAT
CTGTACCGGGACCGGAAACTTCTTGGTGCTGAAGAGAGGATCATGCAAACTGTGGAGATC
ACTAAGCATGCAGTGGACATAGAAGAGAAGGGTGTGAGGCTGCGGCTCACCATTGTGGAC
ACACCAGGTTTTGGGGATGCAGTCAACAACACAGAGTGCTGGAAGCCTGTGGCAGAATAC
ATTGATCAGCAGTTTGAGCAGTATTTCCGAGACGAGAGTGGCCTGAACCGAAAGAACATC
CAAGACAACAGGGTGCACTGCTGCCTGTACTTTATCTCACCCTTCGGCCATGGGTATGGT
CCAAGCCTGAGGCTCCTGGCACCACCGGGTGCTGTCAAGGGAACAGGCCAAGAGCACCAG
GGGCAGGGCTGCCACTAGCAGGTGGTCACAGGTTCCTGTTCCCCAGGCTCCGGCCATTGG
ATGTTGAATTCATGAAGGCCCTGCATCAGCGGGTCAACATCGTGCCTATCCTGGCTAAGG
CAGACACACTGACACCTCCCGAAGTGGACCACAAGAAACGCAAAATCCGGGAGGAGATTG
AGCATTTTGGAATCAAGATCTATCAATTCCCAGACTGTGACTCTGATGAGGATGAGGACT
TCAAATTGCAGGACCAAGCCCTAAAGGAAAGCATCCCATTTGCAGTAATTGGCAGCAACA
CTGTAGTAGAGGCCAGAGGGCGGCGAGTTCGGGGTCGACTCTACCCCTGGGGCATCGTGG
AAGGACCTGAAGGATGTGACGCGGGAGACACATTATGAGAACTACCGGGCACAGTGCATC
CAGAGCATGACCCGCCTGGTGGTGAAGGAACGGAATCGCAACAAACTGACTCGGGAAAGT
GGTACCGACTTCCCCATCCCTGCTGTCCCACCAGGGACAGATCCAGAAACTGAGAAGCTT
ATCCGAGAGAAAGATGAGGAGCTGCGGCGGATGCAGGAGATGCTACACAAAATACAAAAA
CAGATGAAGGAGAACTATTAACTGGCTTTCAGCCCTGGATATTTAAATCTCCTCCTCTTC
TTCCTGTCCATGCCGGCCCCTCCCAGCACCAGCTCTGCTCAGGCCCCTTCAGCTACTGCC
ACTTCGCCTTACATCCCTGCTGACTGCCCAGAGACTCAGAGGAAATAAAGTTTAATAAAT
CTGTAGTGAGAATCCATCAGGCAACACAAAAAAAA
>OriGene 5' read for NM_080415 unedited
GTAGGACTTGTATACGACTCCTATAGGGCGGCCGCGAATTCGGCACGAGGCCTCGTGCCG
AATTCGGCACGAGGGGGTGACGGCGGTGCTGCGAGGTCGGCGCGCAGCTCCGCCGCGGGT
CGCTCGGGCGCTGTCCAGGCGGAGCCGGCCCCGCCCGGGCTGCAGCCATGATCAAGCGTT
TCCTGGAGGACACCACGGATGATGGAGAACTGAGCAAGTTCGTGAAGGATTTCTCAGGAA
ATGCGAGCTGCCACCCACCAGAGGCTAAGACCTGGGCATCCAGGCCCCAAGTCCCGGAGC
CAAGGCCCCAGGCCCCGGACCTCTATGATGATGACCTGGAGTTCAGACCCCCCTCGCGGC
CCCAGTCCTCTGACAACCAGCAGTACTTCTGTGCCCCAGCCCCTCTCAGCCCATCTGCCA
GGCCCCGCAGCCCATGGGGCAAGCTTGATCCCTATGATTCCTCTGAGGATGACAAGGAGT
ATGTGGGCTTTGCAACCCTCCCCAACCAAGTCCACCGAAAGTCCGTGAAGAAAGGCTTTG
ACTTTACCCTCATGGTGGCAGGAGAGTCTGGCCTGGGCAAATCCACACTTGTCAATAGCC
TCTTCCTCACTGATCTGTACCGGGACCGGAAACTTCTTGGTGCTGAAGAGAGGATCATGC
AAACTGTGGAGATCACTAAGCATGCAGTGGACATAGAAGAGAAGGGTGTGAGGCTGCGGC
TCACCATTGTGGACACACCAGGTTTTGGGGATGCAGTCAACAACACAGAGTGCTGGAAGC
CTGTGGCAGATACATTGATCAGCAGTTTGAGCAGTATTTCCCGAGACGAGAGTGGCCTGA
ACCGAAAGACATCCAAGACACAGGTGCACTGCTGCCTGTACTTTATTCTCACCCTTCGGC
CATGGGTTATGGTTCCAGGCCTGAGGCTTCCTGGCAAC
>OriGene 3' read for NM_080415 unedited
CGTGATGCACCTTCAGGGCCGGAGAGGCACTGGGGAGGGGTCACAGGGATGCCACCCGGG
ATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCCCCCAACAAATTTAT
AAAATTTTATTTCCCCTAATTCTCGGGGCATTCCCCAGGGATGTAAGGCAAAGTGGCATT
ACCTAAAGGGGCCTGACCAAACCTGGGGCGGGGAGGGGCCGGCTTGGACAGAAAAAAAAG
AAAAAAATTTAAATTTCCGGGGCTAAAACCCATTTAAAATTTCCCCTTCATCGGTTTTTG
TTTTTGGGGAACCATCTCCGGCACCCCCCGCACCTCCTCATTTTTTTTTCGAATAACCTT
CTAATTTTCTGAATCTGCCCCGGGGGGAACACCGGGGATGGGAAATTCGGTCCCCTTTTC
CCAATTCATTTTGTTGCAATTCCTTTCTTTCACCACCAGGCGGGTCATGCTTTGAATGCA
TTGTCCCCGGTATTTCTAAAAATGTGTCTCCCGGTAAAACCTTAAGGTCCTTCCAAATGC
CCAGGGGTAAAGTCGACCCCGAACTCGCCGCCCTCTGGCCTTTATAAAGTGTGGCTGCCA
TTACTGAAATGGGGACGCTTTCCTTTAGGGCTTGGTCCGCATTTGAATTCCTCATCCTCA
TCAGAGTACAGTCTGGGAATTGATATATCTGATCAAAATGCTCATCTCTCCCGGATTTGC
GTTTCTTGGGTCACTTCGGGAGTGTCAGTGTGTCTGCCTTACCAGAAGCCATGTGACCCG
TGATGCGGCCTATGGAATCACATCCATGCCGAACCTGGAAACAGAACTGT
Restriction Sites Please inquire     
ACCN NM_080415
Insert Size 1700 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_080415.1, NP_536340.1
RefSeq Size 1911 bp
RefSeq ORF 825 bp
Locus ID 5414
Cytogenetics 17q22
Domains GTP_CDC
Gene Summary 'This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010]'
Transcript Variant: This variant (2) differs in the 5' UTR and coding region and initiates translation at an alternate start codon, compared to variant 7. This transcript contains an early translation termination site, rendering this transcript a candidate for nonsense-mediated mRNA decay (NMD). However, the encoded protein (isoform 2, also known as ARTS, SEPT4_i2), with distinct N- and C-termini compared to isoform 5, has been shown to be expressed in vivo, and characterized as a mitochondrial pro-apoptotic, tumor suppressor protein having a role in cancer (PMIDs: 11146656, 15254396).

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