KLHL24 (AK026326) Human Untagged Clone

CAT#: SC313316

(untagged)-Human cDNA: FLJ22673 fis, clone HSI10503

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: KLHL24
• Synonyms: DRE1|KRIP6
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for AK026326, the custom clone sequence may differ by one or more nucleotides
  ATGGTACTAATATTGGGACGCAGACTAAACAGAGAGGATCTTGGGGTGCGTGATTCCCCA
  GCAACTAAGCGAAAAGTTTTTGAAATGGACCCCAAATCTCTGACAGGTCATGAGTTTTTT
  GACTTCTCTTCAGGATCATCCCATGCCGAAAACATACTCCAGATATTTAATGAATTTCGT
  GATAGCCGCTTATTCACAGATGTTATCATTTGTGTGGAAGGAAAAGAATTTCCTTGCCAT
  AGAGCTGTGCTCTCAGCCTGTAGCAGCTACTTCAGAGCTATGTTTTGTAATGACCACAGG
  GAAAGCCGAGAAATGTTGGTTGAGATCAATGGTATTTTAGCTGAAGCTATGGAATGTTTT
  TTGCAGTATGTTTATACTGGAAAGGTGAAGATCACTACAGAGAATGTACAGTATCTCTTT
  GAGACATCAAGCCTCTTTCAGATTAGTGTTCTCCGTGATGCATGTGCCAAGTTCTTGGAG
  GAGCAACTTGATCCTTGTAATTGCTTAGGAATCCAGCGCTTTGCTGATACCCATTCACTC
  AAAACACTCTTCACAAAATGCAAAAATTTTGCGTTACAGACTTTTGAGGATGTATCCCAG
  CACGAAGAATTTCTTGAGCTTGACAAAGATGAACTTTATGTTGTCGGTGGCTATGATGGG
  CAAAACAGACTTAGCAGCGTAGAATGTTATGATTCCTTTTCAAATCGATGGACTGAAGTT
  GCTCCCCTTAAGGAAGCCGTGAGTTCTCCTGCAGTGACTAGCTGTGTAGGCAAACTGTTT
  GTGATTGGTGGAGGACCTGATGATAATACTTGTTCTGATAAGGTTCAATCTTATGATCCA
  GAAACCAATTCTTGGCTACTTCGTGCAGCTATCCCAATTGCCAAAAGGTGTATAACAGCT
  GTATCCCTAAACAACCTGATCTATGTTGCCGGTGGACTGACCAAGGCAATATGCTGTTAC
  GATCCAGTTGAAGATTACTGGATGCACGTACAGAATACATTCAGCCGTCAGGAAAACTGT
  GGTATGTCTGTGTGTAATGGTAAAATATATATCCTGGGCGGAAGACGGGAAAATGGAGAA
  GCCACAGACACTATTCTCTGTTATGATCCTGCAACAAGTATCATCACAGGGGTAGCTGCA
  ATGCCCAGGCCAGTGTCCTATCATGGCTGTGTGACTATTCATAGATACAATGAGAAATGC
  TTTAAACTC
  
• Restriction Sites: Please inquire
• ACCN: AK026326
• ORF Size: 1212 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: AK026326.1, BAB15447.1
• RefSeq Size: 1706
• RefSeq ORF: 1212
• Locus ID: 54800
• Domains: BTB, Kelch
• Gene Summary: The protein encoded by this gene is a ubiquitin ligase substrate receptor and is regulated by autoubiquitination. Variations in the translation initiation codon of this gene have been found, which result in an N-terminally truncated but more stable protein due to loss of the autoubiquitination function. The more stable mutant protein causes an increased ubiquitin and degradation of keratin 14, which leads to skin fragility and the potentially life-threatening disease epidermolysis bullosa. The encoded protein is also involved in the regulation of kainate receptors. [provided by RefSeq, Mar 2017]