KLHL24 (NM_017644) Human Untagged Clone

CAT#: SC314153

KLHL24 (untagged)-Human kelch-like 24 (Drosophila) (KLHL24)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: KLHL24
• Synonyms: DRE1; EBSSH; KRIP6
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_017644, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGTACTAATATTGGGACGCAGACTAAACAGAGAGGATCTTGGGGTGCGTGATTCCCCAGCAACTAAGC
  GAAAAGTTTTTGAAATGGACCCCAAATCTCTGACAGGTCATGAGTTTTTTGACTTCTCTTCAGGATCATC
  CCATGCCGAAAACATACTCCAGATATTTAATGAATTTCGTGATAGCCGCTTATTCACAGATGTTATCATT
  TGTGTGGAAGGAAAAGAATTTCCTTGCCATAGAGCTGTGCTCTCAGCCTGTAGCAGCTACTTCAGAGCTA
  TGTTTTGTAATGACCACAGGGAAAGCCGAGAAATGTTGGTTGAGATCAATGGTATTTTAGCTGAAGCTAT
  GGAATGTTTTTTGCAGTATGTTTATACTGGAAAGGTGAAGATCACTACAGAGAATGTACAGTATCTCTTT
  GAGACATCAAGCCTCTTTCAGATTAGTGTTCTCCGTGATGCATGTGCCAAGTTCTTGGAGGAGCAACTTG
  ATCCTTGTAATTGCTTAGGAATCCAGCGCTTTGCTGATACCCATTCACTCAAAACACTCTTCACAAAATG
  CAAAAATTTTGCGTTACAGACTTTTGAGGATGTATCCCAGCACGAAGAATTTCTTGAGCTTGACAAAGAT
  GAACTTATTGATTATATTTGTAGTGATGAACTTGTTATTGGTAAAGAGGAGATGGTTTTTGAAGCCGTCA
  TGCGTTGGGTCTATCGTGCCGTTGATCTGAGAAGACCACTGTTACACGAGCTCCTGACACATGTGAGACT
  CCCTCTGTTGCATCCCAACTACTTTGTTCAAACAGTTGAAGTGGACCAATTGATCCAGAATTCTCCTGAG
  TGTTATCAGTTGTTGCATGAAGCAAGACGGTACCACATACTTGGGAATGAAATGATGTCCCCAAGGACTA
  GGCCACGCAGGTCCACTGGCTATTCTGAGGTGATAGTTGTCGTTGGAGGATGTGAGCGAGTTGGAGGATT
  TAATCTTCCATACACTGAGTGCTACGATCCTGTAACAGGAGAATGGAAGTCTTTGGCTAAGCTTCCAGAA
  TTTACCAAATCAGAGTATGCAGTCTGTGCTCTAAGGAATGACATTCTTGTTTCAGGTGGAAGAATCAACA
  GCCGTGATGTCTGGATTTATAACTCACAGTTAAATATTTGGATCAGAGTTGCCTCTCTCAATAAAGGCAG
  ATGGCGTCACAAAATGGCTGTCCTCCTTGGTAAAGTATATGTTGTCGGTGGCTATGATGGGCAAAACAGA
  CTTAGCAGCGTAGAATGTTATGATTCCTTTTCAAATCGATGGACTGAAGTTGCTCCCCTTAAGGAAGCCG
  TGAGTTCTCCTGCAGTGACTAGCTGTGTAGGCAAACTGTTTGTGATTGGTGGAGGACCTGATGATAATAC
  TTGTTCTGATAAGGTTCAATCTTATGATCCAGAAACCAATTCTTGGCTACTTCGTGCAGCTATCCCAATT
  GCCAAAAGGTGTATAACAGCTGTATCCCTAAACAACCTGATCTATGTTGCCGGTGGACTGACCAAGGCAA
  TATACTGTTACGATCCAGTTGAAGATTACTGGATGCACGTACAGAATACATTCAGCCGTCAGGAAAACTG
  TGGTATGTCTGTGTGTAATGGTAAAATATATATCCTGGGCGGAAGACGGGAAAATGGAGAAGCCACAGAC
  ACTATTCTCTGTTATGATCCTGCAACAAGTATCATCACAGGGGTAGCTGCAATGCCCAGGCCAGTGTCCT
  ATCATGGCTGTGTGACTATTCATAGATACAATGAGAAATGCTTTAAACTCTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_017644
• ORF Size: 1803 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_017644.3, NP_060114.2
• RefSeq Size: 7331
• RefSeq ORF: 1803
• Locus ID: 54800
• Domains: Kelch
• Gene Summary: The protein encoded by this gene is a ubiquitin ligase substrate receptor and is regulated by autoubiquitination. Variations in the translation initiation codon of this gene have been found, which result in an N-terminally truncated but more stable protein due to loss of the autoubiquitination function. The more stable mutant protein causes an increased ubiquitin and degradation of keratin 14, which leads to skin fragility and the potentially life-threatening disease epidermolysis bullosa. The encoded protein is also involved in the regulation of kainate receptors. [provided by RefSeq, Mar 2017]
  Transcript Variant: This variant (7), as well as variants 8-15, encodes isoform b.