MTGR1 (CBFA2T2) (NM_005093) Human Untagged Clone

CAT#: SC314164

CBFA2T2 (untagged)-Human core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (CBFA2T2), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CBFA2T2
• Synonyms: EHT; MTGR1; p85; ZMYND3
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_005093, the custom clone sequence may differ by one or more nucleotides
  ATGGCTAAAGAATCTGGAATAAGCTTGAAAGAAATACAGGTCCTGGCAAGGCAATGGAAA
  GTTGGTCCTGAGAAAAGGGTGCCAGCGATGCCTGGATCGCCTGTGGAAGTGAAGATACAG
  TCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGAGG
  CCAGTGTCCTTCACTCCTACTGCATTAAGCAATGGCATCAACCATTCTCCTCCTACCCTG
  AATGGTGCCCCATCACCGCCACAGAGATTCAGCAATGGTCCTGCCTCCTCCACATCATCT
  GCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGAAA
  CGCTTTCTTACCACTCTGCAACAGTTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAG
  GTGCGGACTCTTGTTCTTGCACTGGTGAACTCAACAGTGACAATTGAGGAATTCCACTGT
  AAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGGCC
  AACCTGCCCCTGCTGCAGCGGGAACTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCA
  TCCCAGTACCTGGCTCAGCACGAACACCTTCTGCTCAACACAAGCATTGCATCGCCTGCT
  GACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGAGG
  AGAGAAGAGAATAGTTTTGATAGAGACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTA
  TGTACCATCAGCCCTGCTCCTCGGCACAGTCCTGCTCTCACTGTGCCCCTCATGAATCCC
  GGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTGCA
  ACTTCTCACCTGTATCGGGAACCCAACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGA
  CACCACAGTCTTGGTCTAAATGGAGGCTATCAAGATGAGTTGGTAGATCATCGTTTGACA
  GAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGGAA
  ATGGTAGAGAAAACAAGGCGCTCTATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGT
  GAAGAACTCAACTACTGGAAAAGACGGTACAATGAAAACACAGAGCTGAGGAAAACGGGG
  ACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATTCT
  CAGAGAGAGTTCAACAGCAGGCCAGGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAA
  ACAGAAGAAGCTGTGAATAAGGTGAAAATTCAGGCCATGTCAGAAGTACAGAAGGCCGTC
  GCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGCAA
  ACCATAGCGGATGTCAAGCGGCAGGCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAA
  GAGGAGTCCACGGAGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACATGCAGTGGC
  TGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCAC
  CGCCTCTGTGGTCAGAACCTGCATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTT
  CCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGCCCAGCCCTC
  GACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGAC
  ACCAACGGACTC
  
• Restriction Sites: Please inquire
• ACCN: NM_005093
• ORF Size: 1815 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_005093.2, NP_005084.1
• RefSeq Size: 6920
• RefSeq ORF: 1815
• Locus ID: 9139
• Domains: zf-MYND, TAFH
• Protein Families: Transcription Factors
• Gene Summary: In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (MTGR1b).