AASS (NM_005763) Human Untagged Clone

CAT#: SC314936

AASS (untagged)-Human aminoadipate-semialdehyde synthase (AASS), nuclear gene encoding mitochondrial protein

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: AASS
• Synonyms: LKR/SDH; LKRSDH; LORSDH
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_005763, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGCTGCAAGTACATAGGACTGGACTGGGCAGGCTGGGGGTCAGCCTCTCCAAGGGTCTTCACCACAAAG
  CTGTGTTGGCCGTCCGGAGGGAGGATGTGAACGCCTGGGAGAGAAGGGCCCCGCTAGCTCCCAAGCACAT
  CAAAGGCATCACCAATCTGGGATACAAGGTCTTGATACAGCCTTCGAATCGGCGGGCCATTCATGATAAG
  GACTATGTCAAAGCTGGTGGCATTCTTCAGGAGGATATTTCTGAAGCTTGTCTAATTTTAGGAGTTAAAA
  GACCTCCAGAGGAAAAATTAATGTCCAGGAAGACTTATGCATTTTTCTCCCACACAATAAAAGCTCAGGA
  GGCCAATATGGGCTTGTTGGATGAGATTCTAAAACAGGAAATTCGCCTTATTGATTATGAGAAAATGGTG
  GATCATAGAGGAGTACGGGTAGTGGCATTTGGACAGTGGGCTGGTGTGGCAGGAATGATCAACATTTTAC
  ATGGAATGGGTTTAAGGCTCCTTGCTTTGGGACATCACACACCTTTTATGCACATTGGCATGGCTCATAA
  CTACAGGAATAGCAGTCAGGCTGTGCAAGCTGTCCGTGATGCTGGCTATGAAATATCTTTGGGTTTGATG
  CCTAAGTCAATAGGACCCTTAACATTTGTGTTCACAGGAACTGGTAATGTTTCTAAGGGAGCCCAAGCAA
  TCTTTAATGAGCTACCTTGTGAATATGTGGAGCCCCATGAATTAAAAGAAGTTTCCCAAACTGGAGACCT
  CAGAAAAGTGTATGGGACGGTGTTAAGTCGTCATCATCATCTTGTCAGGAAAACAGATGCTGTGTATGAT
  CCTGCAGAGTATGACAAACATCCGGAGCGCTACATAAGTCGTTTTAATACTGATATTGCACCCTATACAA
  CTTGCTTAATTAATGGAATCTACTGGGAACAAAACACTCCTCGCCTCCTAACCCGCCAAGATGCTCAGAG
  TCTCCTGGCTCCGGGCAAGTTCTCACCTGCTGGTGTGGAAGGCTGCCCTGCATTACCACACAAACTCGTG
  GCAATATGTGACATTTCAGCTGACACAGGAGGGTCTATAGAGTTTATGACTGAGTGTACAACAATAGAGC
  ATCCCTTTTGCATGTATGATGCAGACCAGCATATTATTCATGACAGTGTTGAAGGCTCGGGGATCCTGAT
  GTGTTCCATTGACAATTTGCCGGCACAGCTCCCAATTGAAGCTACAGAATGCTTTGGAGACATGCTTTAC
  CCTTATGTTGAAGAAATGATATTATCAGACGCGACACAGCCTCTTGAAAGTCAGAATTTTTCTCCTGTGG
  TGAGAGATGCAGTGATTACATCCAACGGTACATTACCTGATAAATATAAATATATCCAGACACTCCGGGA
  GAGCAGGGAACGTGCTCAGTCACTTTCAATGGGCACCAGGAGAAAGGTTTTGGTTCTTGGATCTGGCTAC
  ATATCTGAGCCTGTATTAGAATATTTATCAAGAGATGGCAATATAGAAATAACAGTAGGATCTGACATGA
  AGAATCAAATTGAACAGTTAGGCAAGAAATATAATATTAATCCTGTTAGCATGGACATTTGTAAACAAGA
  AGAGAAGCTGGGCTTCTTGGTGGCAAAACAGGATCTTGTCATCAGCTTGTTGCCTTATGTATTGCACCCT
  CTTGTGGCCAAGGCCTGCATCACAAACAAAGTTAACATGGTCACTGCAAGCTACATCACACCAGCACTAA
  AAGAATTGGAAAAGAGTGTGGAAGATGCTGGCATCACAATCATTGGTGAATTGGGATTGGACCCTGGTCT
  GGATCACATGTTAGCAATGGAAACAATAGATAAAGCCAAGGAAGTGGGAGCCACGATTGAATCATATATT
  TCCTACTGTGGTGGGCTTCCAGCCCCTGAACATTCAAACAATCCATTGAGATATAAATTTAGCTGGAGTC
  CAGTGGGAGTTTTGATGAATGTAATGCAGTCTGCCACCTATCTGCTCGATGGAAAGGTTGTGAATGTTGC
  AGGAGGCATCTCCTTTCTTGATGCCGTTACGTCCATGGATTTTTTTCCAGGATTAAATTTGGAAGGCTAT
  CCTAACAGAGACAGTACGAAATATGCTGAGATTTATGGCATTTCTTCTGCTCACACTTTGTTGCGGGGGA
  CACTGAGATATAAGGGATATATGAAAGCTTTGAATGGATTTGTAAAATTAGGTCTTATAAACAGAGAAGC
  GCTTCCTGCCTTTAGACCTGAGGCCAACCCTCTCACCTGGAAACAACTCCTCTGTGACCTAGTTGGGATT
  TCACCCTCCTCTGAGCATGATGTGTTGAAGGAAGCTGTTCTTAAGAAACTAGGAGGAGACAATACCCAGT
  TGGAGGCTGCTGAATGGTTGGGCTTACTTGGGGATGAACAAGTTCCTCAGGCAGAGTCCATTCTGGATGC
  CCTCTCCAAGCATTTGGTCATGAAGCTTTCCTATGGTCCTGAAGAAAAAGATATGATTGTGATGAGAGAC
  AGCTTTGGAATCAGACATCCTTCTGGACATTTAGAACATAAAACGATTGATCTTGTGGCTTATGGGGACA
  TCAATGGCTTTTCAGCCATGGCTAAAACCGTGGGGTTACCCACCGCCATGGCAGCCAAAATGTTGCTTGA
  TGGTGAAATTGGAGCCAAAGGCCTAATGGGGCCCTTTTCAAAGGAGATCTATGGACCAATATTGGAGCGA
  ATTAAAGCAGAAGGCATTATATATACTACACAGAGTACAATTAAACCATAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_005763
• ORF Size: 2781 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_005763.3, NP_005754.2
• RefSeq Size: 5887
• RefSeq ORF: 2781
• Locus ID: 10157
• Domains: Saccharop_dh, AlaDh_PNT_C, AlaDh_PNT_N
• Protein Families: Druggable Genome
• Protein Pathways: Lysine biosynthesis, Lysine degradation, Metabolic pathways
• Gene Summary: This gene encodes a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in this gene are associated with familial hyperlysinemia. [provided by RefSeq, Jul 2008]