LRP6 (NM_002336) Human Untagged Clone

CAT#: SC315373

LRP6 (untagged)-Human low density lipoprotein receptor-related protein 6 (LRP6)


  "NM_002336" in other vectors (6)

Reconstitution Protocol

USD 1,100.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol LRP6
Synonyms ADCAD2; STHAG7
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_002336 edited
CTGGGAAGTATGAGCGTGCAGCCCTGCCGCTGCGGCGGCCGCCCCGGCTCCTCGCCTCCC
CCACTTCTGGCCACCCCTCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCC
GTCCTGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGCGGCCCCTTTGTTG
CTTTATGCAAACAGACGGGACTTGCGATTGGTTGATGCTACAAATGGCAAAGAGAATGCT
ACGATTGTAGTTGGAGGCTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGC
TTGATATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGAATTTAACAAAACT
GAGAGTGTGCAGAATGTTGTTGTTTCTGGATTATTGTCCCCCGATGGGCTGGCATGTGAT
TGGCTTGGAGAAAAATTGTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAAT
TTAGATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCAACCCAGAGCTATT
GCCTTAGATCCTTCAAGTGGGTTCATGTACTGGACAGACTGGGGAGAAGTGCCAAAGATA
GAACGTGCTGGAATGGATGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGG
CCAAATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGCAGATGCAAAACTT
AATTTCATCCACAAATCAAATCTGGATGGAACAAATCGGCAGGCAGTGGTTAAAGGTTCC
CTTCCACATCCTTTTGCCTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGC
ACACACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCGTGAAATCCATTCT
GACATCTTCTCTCCCATGGATATACATGCCTTCAGCCAACAGAGGCAGCCAAATGCCACA
AATCCATGTGGAATTGACAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAG
CCTTTTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAATGGAAAAACCTGC
AAAGATGGTGCCACAGAATTATTGCTTTTAGCTCGAAGGACAGACTTGAGACGCATTTCT
TTGGATACACCAGATTTTACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATT
GCCATAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGATGAAGTGAGGGCC
ATACGCCGTTCATTTATAGATGGATCTGGCAGTCAGTTTGTGGTCACTGCTCAAATTGCC
CATCCTGATGGTATTGCTGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGC
ACTGATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGATCTTGATTTCAGAG
GACTTAGAGGAACCCCGGGCTATTGTGTTAGATCCCATGGTTGGGTACATGTATTGGACT
GACTGGGGAGAAATTCCGAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTA
TTGGTTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTATGATGAAGGCAAA
ATATACTGGGGAGATGCCAAAACAGACAAGATTGAGGTTATGAATACTGATGGCACTGGG
AGACGAGTACTAGTGGAAGACAAAATTCCTCACATATTTGGATTTACTTTGTTGGGTGAC
TATGTTTACTGGACTGACTGGCAGAGGCGTAGCATTGAAAGAGTTCATAAACGAAGTGCA
GAGAGGGAAGTGATCATAGATCAGCTGCCTGACCTCATGGGCCTAAAGGCTACAAATGTT
CATCGAGTGATTGGTTCCAACCCCTGTGCTGAGGAAAACGGGGGATGTAGCCATCTCTGC
CTCTATAGACCTCAGGGCCTTCGCTGTGCTTGCCCTATTGGCTTTGAACTCATCAGTGAC
ATGAAGACCTGCATTGTCCCAGAGGCTTTCCTTTTGTTTTCACGGAGAGCAGATATCAGA
CGAATTTCTCTGGAAACAAACAATAATAATGTGGCTATTCCACTCACTGGTGTCAAAGAA
GCTTCTGCTTTGGATTTTGATGTGACAGACAACCGAATTTATTGGACTGATATATCACTC
AAGACCATCAGCAGAGCCTTTATGAATGGCAGTGCACTGGAACATGTGGTAGAATTCGGC
TTAGATTATCCAGAAGGCATGGCAGTAGACTGGCTTGGGAAGAACTTGTACTGGGCAGAC
ACAGGAACGAATCGAATTGAGGTGTCAAAGTTGGATGGGCAGCACCGACAAGTTTTGGTG
TGGAAAGACCTAGATAGTCCCAGAGCTCTCGCGTTGGACCCTGCCGAAGGATTTATGTAT
TGGACTGAATGGGGTGGAAAACCTAAGATAGACAGAGCTGCAATGGATGGAAGTGAACGT
ACTACCTTAGTTCCAAATGTGGGGCGGGCAAACGGCCTAACTATTGATTATGCTAAAAGG
AGGCTTTATTGGACAGACCTGGACACCAACTTAATAGAATCTTCAAATATGCTTGGGCTC
AACCGTGAAGTTATAGCAGATGACTTGCCTCATCCTTTTGGCTTAACTCAGTACCAAGAT
TATATCTACTGGACGGACTGGAGCCGACGCAGCATTGAGCGTGCCAACAAAACCAGTGGC
CAAAACCGCACCATCATTCAGGGCCATTTGGATTATGTGATGGACATCCTCGTCTTTCAC
TCATCTCGACAGTCAGGGTGGAATGAATGTGCTTCCAGCAATGGGCACTGCTCCCACCTC
TGCTTGGCTGTGCCAGTTGGGGGTTTTGTTTGTGGATGCCCTGCCCACTACTCTCTTAAT
GCTGACAACAGGACTTGTAGTGCTCCTACGACTTTCCTGCTCTTCAGTCAAAAGAGTGCC
ATCAACCGCATGGTGATTGATGAACAACAGAGCCCCGACATCATCCTTCCCATCCACAGC
CTTCGGAATGTCCGGGCCATTGACTATGACCCACTGGACAAGCAACTCTATTGGATTGAC
TCACGACAAAACATGATCCGAAAGGCACAAGAAGATGGCAGCCAGGGCTTTACTGTGGTT
GTGAGCTCAGTTCCGAGTCAGAACCTGGAAATACAACCCTATGACCTCAGCATTGATATT
TACAGCCGCTACATCTACTGGACTTGTGAGGCTACCAATGTCATTAATGTGACAAGATTA
GATGGGAGATCAGTTGGAGTGGTGCTGAAAGGCGAGCAGGACAGACCTCGAGCCATTGTG
GTAAACCCAGAGAAAGGGTATATGTATTTTACCAATCTTCAGGAAAGGTCTCCTAAAATT
GAACGGGCTGCTTTGGATGGGACAGAACGGGAGGTCCTCTTTTTCAGTGGCTTAAGTAAA
CCAATTGCTTTAGCCCTTGATAGCAGGCTGGGCAAGCTCTTTTGGGCTGATTCAGATCTC
CGGCGAATTGAAAGCAGTGATCTCTCAGGTGCTAACCGGATAGTATTAGAAGACTCCAAT
ATCTTGCAGCCTGTGGGACTTACTGTGTTTGAAAACTGGCTCTATTGGATTGATAAACAG
CAGCAAATGATTGAAAAAATTGACATGACAGGTCGAGAGGGTAGAACCAAAGTCCAAGCT
CGAATTGCCCAGCTTAGTGACATTCATGCAGTAAAGGAGCTGAACCTTCAAGAATACAGA
CAGCACCCTTGTGCTCAGGATAATGGTGGCTGTTCACATATTTGTCTTGTAAAGGGGGAT
GGTACTACAAGGTGTTCTTGCCCCATGCACCTGGTTCTACTTCAAGATGAGCTATCATGT
GGAGAACCTCCAACATGTTCTCCTCAGCAGTTTACTTGTTTCACGGGGGAAATTGACTGT
ATCCCTGTGGCTTGGCGGTGCGATGGGTTTACTGAATGTGAAGACCACAGTGATGAACTC
AATTGTCCTGTATGCTCAGAGTCCCAGTTCCAGTGTGCCAGTGGGCAGTGTATTGATGGT
GCCCTCCGATGCAATGGAGATGCAAACTGCCAGGACAAATCAGATGAGAAGAACTGTGAA
GTGCTTTGTTTAATTGATCAGTTCCGCTGTGCCAATGGTCAGTGCATTGGAAAGCACAAG
AAGTGTGATCATAATGTGGATTGCAGTGACAAGTCAGATGAACTGGATTGTTATCCGACT
GAAGAACCAGCACCACAGGCCACCAATACAGTTGGTTCTGTTATTGGCGTAATTGTCACC
ATTTTTGTGTCTGGAACTGTATACTTTATCTGCCAGAGGATGTTGTGTCCACGTATGAAG
GGAGATGGGGAAACTATGACTAATGACTATGTAGTTCATGGACCAGCTTCTGTGCCTCTT
GGTTATGTGCCACACCCAAGTTCTTTGTCAGGATCTCTTCCAGGAATGTCTCGAGGTAAA
TCAATGATCAGCTCCCTCAGTATCATGGGGGGAAGCAGTGGACCCCCCTATGACCGAGCC
CATGTTACAGGAGCATCATCAAGTAGTTCTTCAAGCACCAAAGGCACTTACTTCCCTGCA
ATTTTGAACCCTCCACCATCCCCAGCCACAGAGCGATCACATTACACTATGGAATTTGGA
TATTCTTCAAACAGTCCTTCCACTCATAGGTCATACAGCTACAGGCCATATAGCTACCGG
CACTTTGCACCCCCCACCACACCCTGCAGCACAGATGTTTGTGACAGTGACTATGCTCCT
AGTCGGAGAATGACCTCAGTGGCAACAGCCAAGGGCTATACCAGTGACTTGAACTATGAT
TCAGAACCTGTGCCCCCACCTCCCACACCCCGAAGCCAATACTTGTCAGCAGAGGAGAAC
TATGAAAGCTGCCCACCTTCTCCATACACAGAGAGGAGCTATTCTCATCACCTCTACCCA
CCGCCACCCTCTCCCTGTACAGACTCCTCCTGAGGAGGGGCCCTCCTCCTCTGACTGCCT
CCAACGTAAAAATGTAAATATAAATTTGGTTGAGATCTGGAGGGGGGGAGGGAGCTATTA
GAGAAGGATGAGGCAGACCATGTACAGTTAAAATTATAAAATGGGGTAGGGAATACTGGA
GATATTTGTACAGAAGAAAAGGATATTTATATATTTTCTTAAAACAGCAGATTTGCTGCT
TGTGCCATAAAAGTTTGTATAAAAAAAATTTGTACTAAAAGTTTTATTTTTGCAAACTAA
ATACACAAAGCATGCCTTAAACCCAGTGAAGCAACTGAGTACAAAGGAAACAGGAATAAT
AAAGGCATCACTGACCAGGAATATCTGGGCTTTATTGATACCAAAAATAAAAAAAAAAAA
AAAAAA
>Reverse primer walk for NM_002336 unedited
GCCTAGTTCATAAACTTTTCTAAACTCCTCTAATTAGAAACTTCATCCGATTAGTTTCAG
AATCTGTCCAGTACAATTTTTCTCCAAGCCAATCACATGCCAGCCCATCGGGGGACAATA
ATCCAGAAACAACAACATTCTGCACACTCTCAGTTTTGTTAAATTCTGTTCGTTTAATGG
CTTCTTCGCTGACATCACTCCAGTATATCAAGCCATGACTAAACACAAAGTCCACCGCAG
CTGCATCCTCCAAGCCTCCAACTACAATCGTAGCATTCTCTTTGCCATTTGTAGCATCAA
CCAATCGCAAGTCCCGTCTGTTTGCATAAAGCAACAAAGGGGCCGCTCTCAGGAGCACAC
AGAAGCTGCAGGCCAGGAGGCTCCTCAGGACGGCCCCCATCTTCCCTTCTCGCGTTCTCT
TCTCTCACCGGCGAGGGGTGGCCAGAAGTGGGGGAGGCGAGGAGCCGGGGCGGCCGCCGC
AGCGGCAGGGCTGCACGCTCATACTTCCCAGCCTCGTGCCGAATTCGCGGCCGCCCTATA
GTGAGTCGTATTACANAATTCTGACGGTTCACTAAACGAGCTCTGCTTATATAGACCTCC
CACCGTACACGCCTACCGCCCATTTGCGTCAACGGGGCGGGGTTATTACGACATTTTGGA
AGTCCNGTTGATTTTGGTGCCAAACANAACTCCATTGACGTCNAATGGGTGGAGACTTGG
AAATCCCCGTGAGTCAAACCGCTATCCACGCCCATTGGTGTACTGCCAAAACCGCATCAC
CATGGTAATAGCGATGACTAATACGTAGATGTACTGCCCAGTAAGAAAGTCCCGTAAGGT
CATGTACTGGGCATAATGCCAGGCGGGCCATTTACCGTCTTTGACGTAAC
>Reverse primer walk for NM_002336 unedited
GGATCTATTACTTTTTACCTGGTAGCATCANAGNAGGAGGCCCCTCCTCAGNAGAGTCTG
TACAGGGAGAGGGTGGCGGTGGGTAGAGGTGATGAGAATAGCTCCTCTCTGTGTATGGAG
AAGGTGGGCAGCTTTCATAGTTCTCCTCTGCTGACAAGTATTGGCTTCGGGGTGTGGGAG
GTGGGGGCACAGGTTCTGAATCATAGTTCAAGTCACTGGTATAGCCCTTGGCTGTTGCCA
CTGAGGTCATTCTCCGACTAGGAGCATAGTCACTGTCACAAACATCTGTGCTGCAGGGTG
TGGTGGGGGGTGCAAAGTGCCGGTAGCTATATGGCCTGTAGCTGTATGACCTATGAGTGG
AAGGACTGTTTGAAGAATATCCAAATTCCATAGTGTAATGTGATCGCTCTGTGGCTGGGG
ATGGTGGAGGGTTCAAAATTGCAGGGAAGTAAGTGCCTTTGGTGCTTGAAGAACTACTTG
ATGATGCTCCTGTAACATGGGCTCGGTCATAGGGGGGTCCACTGCTTCCCCCCATGATAC
TGAGGGAGCTGATCATTGATTTACCTCGAGACATTCCTGGAAGAGATCCTGACAAAGAAC
TTGNGTGTGGCACATAACCAAGAGGCACAGAAGCTGGTCCATGAACTACATAGTCATTAG
TCATAGTTTCCCCCTCTCCCTTCATACGTGGACACAACATCCTCTGNCAGATAAAGTATA
CAGTTCCAGACCCAAAAATGGTGACAATTACGCCAATACCGAACCAACTGTATTGGTGGC
CTGTGGTGCTTGGTTCTCCATCGGAAAACATCCCATTCAATCTGCCTGTCCCTGCAATCC
CCTTAAGATCCCCCTCCTGGGGCTTTCCATGCCCCTGCCATTGGCACCACGG
Restriction Sites Please inquire     
ACCN NM_002336
Insert Size 5300 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_002336.1, NP_002327.1
RefSeq Size 5301 bp
RefSeq ORF 4842 bp
Locus ID 4040
Cytogenetics 12p13.2
Domains ldl_recept_b, ldl_recept_a, EGF, EGF
Protein Families Druggable Genome, Transmembrane
Protein Pathways Wnt signaling pathway
Gene Summary 'This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]'

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