GRIA4 (NM_001077243) Human Untagged Clone

CAT#: SC315627

GRIA4 (untagged)-Human glutamate receptor, ionotrophic, AMPA 4 (GRIA4), transcript variant 2


  "NM_001077243" in other vectors (4)

Reconstitution Protocol

USD 1,790.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol GRIA4
Synonyms GluA4; GLUR4; GLUR4C; GLURD; NEDSGA
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_001077243, the custom clone sequence may differ by one or more nucleotides


GAAAGAGAGAGAGCGCGCGCCAGGGAGAGGAGAAAAGAAGATGAGGATTATTTCCAGACAGATTGTCTTG
TTATTTTCTGGATTTTGGGGACTCGCCATGGGAGCCTTTCCGAGCAGCGTGCAAATAGGTGGTCTCTTCA
TCCGAAACACAGATCAGGAATACACTGCTTTTCGATTAGCAATTTTTCTTCATAACACCAGCCCCAATGC
GTCGGAAGCTCCTTTTAATTTGGTACCTCATGTGGACAACATTGAGACAGCCAACAGTTTTGCTGTAACA
AACGCCTTCTGTTCCCAGTATTCTAGAGGAGTATTTGCCATTTTTGGACTCTATGATAAGAGGTCGGTAC
ATACCTTGACCTCATTCTGCAGCGCCTTACATATCTCCCTCATCACACCAAGTTTCCCTACTGAGGGGGA
GAGCCAGTTTGTGCTGCAACTAAGACCTTCGTTACGAGGAGCACTCTTGAGTTTGCTGGATCACTACGAA
TGGAACTGTTTTGTCTTCCTGTATGACACAGACAGGGGATACTCGATACTCCAAGCTATTATGGAAAAAG
CAGGACAAAATGGTTGGCATGTCAGCGCTATATGTGTGGAAAATTTTAATGATGTCAGCTATAGGCAACT
TCTAGAAGAACTTGACAGAAGACAAGAGAAGAAGTTTGTAATAGACTGTGAGATAGAGAGACTTCAAAAC
ATATTAGAACAGATTGTAAGTGTTGGAAAGCATGTTAAAGGCTACCATTATATCATTGCAAACTTGGGAT
TCAAGGATATTTCTCTTGAGAGGTTTATACATGGTGGAGCCAATGTTACTGGATTCCAGTTGGTGGATTT
TAATACACCTATGGTAATCAAACTAATGGATCGCTGGAAGAAACTAGATCAGAGAGAGTATCCAGGATCT
GAGACTCCTCCAAAGTACACCTCTGCTCTGACTTATGATGGAGTCCTTGTGATGGCTGAAACTTTCCGAA
GTCTTAGGAGGCAGAAAATTGATATCTCAAGGAGAGGAAATGCTGGGGATTGTCTGGCAAATCCTGCTGC
TCCATGGGGCCAGGGAATTGACATGGAGAGGACACTCAAACAGGTTCGAATTCAAGGGCTGACAGGGAAT
GTTCAGTTTGACCACTATGGACGTAGAGTCAATTACACAATGGATGTGTTTGAGCTGAAAAGCACAGGAC
CTAGAAAGGTTGGTTACTGGAATGATATGGATAAGTTAGTCTTGATTCAAGATGTACCAACTCTTGGCAA
TGACACAGCTGCTATTGAGAACAGAACAGTGGTTGTAACCACAATTATGGAATCCCCATATGTTATGTAC
AAGAAAAATCATGAAATGTTTGAAGGAAATGACAAGTATGAAGGATACTGTGTAGATTTGGCATCTGAAA
TTGCAAAACATATTGGTATCAAGTATAAAATTGCCATTGTCCCTGATGGAAAATATGGAGCAAGGGATGC
AGACACAAAAATCTGGAATGGGATGGTAGGAGAACTTGTTTATGGGAAAGCAGAGATTGCTATTGCCCCT
CTGACAATCACTTTGGTACGAGAGGAGGTCATTGACTTTTCTAAGCCCTTCATGAGTTTGGGCATATCTA
TCATGATCAAAAAGCCTCAGAAATCCAAACCAGGAGTGTTTTCCTTCTTGGATCCTCTGGCCTATGAGAT
TTGGATGTGCATAGTCTTTGCCTACATTGGTGTCAGCGTGGTCTTATTCCTAGTTAGTAGATTTAGTCCA
TATGAGTGGCACACAGAAGAGCCAGAGGACGGAAAGGAAGGACCCAGCGACCAGCCTCCCAATGAGTTTG
GCATCTTTAACAGCCTCTGGTTTTCCCTGGGTGCTTTTATGCAGCAAGGATGTGACATTTCACCCAGATC
CCTCTCAGGTCGAATTGTTGGAGGTGTTTGGTGGTTCTTTACACTCATCATTATATCATCTTATACTGCT
AACCTCGCTGCTTTCCTGACGGTTGAGCGAATGGTCTCTCCCATAGAAAGTGCAGAAGACCTGGCCAAAC
AAACAGAAATTGCCTATGGAACACTGGATTCAGGATCAACAAAAGAATTCTTCAGAAGATCAAAAATAGC
AGTGTATGAAAAGATGTGGACCTACATGCGATCAGCAGAGCCATCAGTATTCACTAGGACTACAGCTGAG
GGAGTAGCTCGTGTCCGCAAATCCAAGGGCAAATTTGCCTTTCTCCTGGAGTCCACTATGAATGAATACA
TTGAGCAGCGAAAGCCATGTGACACGATGAAAGTGGGAGGAAATCTGGATTCCAAAGGCTATGGAGTAGC
AACGCCCAAGGGTTCCTCATTGGGAAATGCTGTTAACCTCGCAGTTTTAAAACTGAATGAACAAGGCCTC
TTGGACAAATTGAAAAACAAATGGTGGTACGACAAAGGAGAATGTGGCAGCGGGGGAGGTGACTCCAAGG
ACAAGACGAGTGCCTTGAGCCTGAGCAATGTAGCAGGCGTCTTCTACATTCTGGTTGGCGGCTTGGGCTT
GGCAATGCTGGTGGCTTTGATAGAGTTCTGTTACAAGTCCAGGGCAGAAGCGAAGAGAATGAAGGTGGCA
AAGAGTGCACAGACTTTTAACCCAACTTCCTCGCAGAATACCCAGAATTTAGCAACCTATAGAGAAGGTT
ACAACGTATATGGAACCGAAAGTATTAAAATTTAG


Restriction Sites Please inquire     
ACCN NM_001077243
Insert Size 0
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_001077243.1, NP_001070711.1
RefSeq Size 5621 bp
RefSeq ORF 2655 bp
Locus ID 2893
Cytogenetics 11q22.3
Protein Families Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane
Protein Pathways Neuroactive ligand-receptor interaction
Gene Summary 'Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]'
Transcript Variant: This variant (2) contains an alternate in-frame coding exon, and uses a downstream donor splice site at the penultimate exon, compared to transcript variant 1. This results in a shorter isoform (2) with a different C-terminus compared to isoform 1. RNA editing (AGA->GGA) changes Arg765Gly. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.

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