NAIP (NM_022892) Human Untagged Clone

CAT#: SC315876

NAIP (untagged)-Human NLR family, apoptosis inhibitory protein (NAIP), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NAIP
• Synonyms: BIRC1; NLRB1; psiNAIP
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_022892, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGCCACTTCATATTGGGGACTTCGTCTGGGATTCCAAGGTGCATTCATTGCAAAGTTCCTTAAATATTT
  TCTCACTGCTTCCTACTAAAGGACGGACAGAGCATTTGTTCTTCAGCCACATACTTTCCTTCCACTGGCC
  AGCATTCTCCTCTATTAGACTAGAACTGTGGATAAACCTCAGATGTGAATTTCTTCGGAGTAAGAAATCC
  TCAGAGGAAATTACCCAGTATATTCAAAGCTACAAGGGATTTGTTGACATAACGGGAGAACATTTTGTGA
  ATTCCTGGGTCCAGAGAGAATTACCTATGGCATCAGCTTATTGCAATGACAGCATCTTTGCTTACGAAGA
  ACTACGGCTGGACTCTTTTAAGGACTGGCCCCGGGAATCAGCTGTGGGAGTTGCAGCACTGGCCAAAGCA
  GGTCTTTTCTACACAGGTATAAAGGACATCGTCCAGTGCTTTTCCTGTGGAGGGTGTTTAGAGAAATGGC
  AGGAAGGTGATGACCCATTAGACGATCACACCAGATGTTTTCCCAATTGTCCATTTCTCCAAAATATGAA
  GTCCTCTGCGGAAGTGACTCCAGACCTTCAGAGCCGTGGTGAACTTTGTGAATTACTGGAAACCACAAGT
  GAAAGCAATCTTGAAGATTCAATAGCAGTTGGTCCTATAGTGCCAGAAATGGCACAGGGTGAAGCCCAGT
  GGTTTCAAGAGGCAAAGAATCTGAATGAGCAGCTGAGAGCAGCTTATACCAGCGCCAGTTTCCGCCACAT
  GTCTTTGCTTGATATCTCTTCCGATCTGGCCACGGACCACTTGCTGGGCTGTGATCTGTCTATTGCTTCA
  AAACACATCAGCAAACCTGTGCAAGAACCTCTGGTGCTGCCTGAGGTCTTTGGCAACTTGAACTCTGTCA
  TGTGTGTGGAGGGTGAAGCTGGAAGTGGAAAGACGGTCCTCCTGAAGAAAATAGCTTTTCTGTGGGCATC
  TGGATGCTGTCCCCTGTTAAACAGGTTCCAGCTGGTTTTCTACCTCTCCCTTAGTTCCACCAGACCAGAC
  GAGGGGCTGGCCAGTATCATCTGTGACCAGCTCCTAGAGAAAGAAGGATCTGTTACTGAAATGTGCGTGA
  GGAACATTATCCAGCAGTTAAAGAATCAGGTCTTATTCCTTTTAGATGACTACAAAGAAATATGTTCAAT
  CCCTCAAGTCATAGGAAAACTGATTCAAAAAAACCACTTATCCCGGACCTGCCTATTGATTGCTGTCCGT
  ACAAACAGGGCCAGGGACATCCGCCGATACCTAGAGACCATTCTAGAGATCAAAGCATTTCCCTTTTATA
  ATACTGTCTGTATATTACGGAAGCTCTTTTCACATAATATGACTCGTCTGCGAAAGTTTATGGTTTACTT
  TGGAAAGAACCAAAGTTTGCAGAAGATACAGAAAACTCCTCTCTTTGTGGCGGCGATCTGTGCTCATTGG
  TTTCAGTATCCTTTTGACCCATCCTTTGATGATGTGGCTGTTTTCAAGTCCTATATGGAACGCCTTTCCT
  TAAGGAACAAAGCGACAGCTGAAATTCTCAAAGCAACTGTGTCCTCCTGTGGTGAGCTGGCCTTGAAAGG
  GTTTTTTTCATGTTGCTTTGAGTTTAATGATGATGATCTCGCAGAAGCAGGGGTTGATGAAGATGAAGAT
  CTAACCATGTGCTTGATGAGCAAATTTACAGCCCAGAGACTAAGACCATTCTACCGGTTTTTAAGTCCTG
  CCTTCCAAGAATTTCTTGCGGGGATGAGGCTGATTGAACTCCTGGATTCAGATAGGCAGGAACATCAAGA
  TTTGGGACTGTATCATTTGAAACAAATCAACTCACCCATGATGACTGTAAGCGCCTACAACAATTTTTTG
  AACTATGTCTCCAGCCTCCCTTCAACAAAAGCAGGGCCCAAAATTGTGTCTCATTTGCTCCATTTAGTGG
  ATAACAAAGAGTCATTGGAGAATATATCTGAAAATGATGACTACTTAAAGCACCAGCCAGAAATTTCACT
  GCAGATGCAGTTACTTAGGGGATTGTGGCAAATTTGTCCACAAGCTTACTTTTCAATGGTTTCAGAACAT
  TTACTGGTTCTTGCCCTGAAAACTGCTTATCAAAGCAACACTGTTGCTGCGTGTTCTCCATTTGTTTTGC
  AATTCCTTCAAGGGAGAACACTGACTTTGGGTGCGCTTAACTTACAGTACTTTTTCGACCACCCAGAAAG
  CTTGTCATTGTTGAGGAGCATCCACTTCCCAATACGAGGAAATAAGACATCACCCAGAGCACATTTTTCA
  GTTCTGGAAACATGTTTTGACAAATCACAGGTGCCAACTATAGATCAGGACTATGCTTCTGCCTTTGAAC
  CTATGAATGAATGGGAGCGAAATTTAGCTGAAAAAGAGGATAATGTAAAGAGCTATATGGATATGCAGCG
  CAGGGCATCACCAGACCTTAGTACTGGCTATTGGAAACTTTCTCCAAAGCAGTACAAGATTCCCTGTCTA
  GAAGTCGATGTGAATGATATTGATGTTGTAGGCCAGGATATGCTTGAGATTCTAATGACAGTTTTCTCAG
  CTTCACAGCGCATCGAACTCCATTTAAACCACAGCAGAGGCTTTATAGAAAGCATCCGCCCAGCTCTTGA
  GCTGTCTAAGGCCTCTGTCACCAAGTGCTCCATAAGCAAGTTGGAACTCAGCGCAGCCGAACAGGAACTG
  CTTCTCACCCTGCCTTCCCTGGAATCTCTTGAAGTCTCAGGGACAATCCAGTCACAAGACCAAATCTTTC
  CTAATCTGGATAAGTTCCTGTGCCTGAAAGAACTGTCTGTGGATCTGGAGGGCAATATAAATGTTTTTTC
  AGTCATTCCTGAAGAATTTCCAAACTTCCACCATATGGAGAAATTATTGATCCAAATTTCAGCTGAGTAT
  GATCCTTCCAAACTAGTAAAATTAATTCAAAATTCTCCAAACCTTCATGTTTTCCATCTGAAGTGTAACT
  TCTTTTCGGATTTTGGGTCTCTCATGACTATGCTTGTTTCCTGTAAGAAACTCACAGAAATTAAGTTTTC
  GGATTCATTTTTTCAAGCCGTCCCATTTGTTGCCAGTTTGCCAAATTTTATTTCTCTGAAGATATTAAAT
  CTTGAAGGCCAGCAATTTCCTGATGAGGAAACATCAGAAAAATTTGCCTACATTTTAGGTTCTCTTAGTA
  ACCTGGAAGAATTGATCCTTCCTACTGGGGATGGAATTTATCGAGTGGCCAAACTGATCATCCAGCAGTG
  TCAGCAGCTTCATTGTCTCCGAGTCCTCTCATTTTTCAAGACTTTGAATGATGACAGCGTGGTGGAAATT
  GCCAAAGTAGCAATCAGTGGAGGTTTCCAGAAACTTGAGAACCTAAAGCTTTCAATCAATCACAAGATTA
  CAGAGGAAGGATACAGAAATTTCTTTCAAGCACTGGACAACATGCCAAACTTGCAGGAGTTGGACATCTC
  CAGGCATTTCACAGAGTGTATCAAAGCTCAGGCCACAACAGTCAAGTCTTTGAGTCAATGTGTGTTACGA
  CTACCAAGGCTCATTAGACTGAACATGTTAAGTTGGCTCTTGGATGCAGATGATATTGCATTGCTTAATG
  TCATGAAAGAAAGACATCCTCAATCTAAGTACTTAACTATTCTCCAGAAATGGATACTGCCGTTCTCTCC
  AATCATTCAGAAATAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_022892
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_022892.1, NP_075043.1
• RefSeq Size: 5880 bp
• RefSeq ORF: 3726 bp
• Locus ID: 4671
• Cytogenetics: 5q13.2
• Protein Families: Druggable Genome
• Protein Pathways: NOD-like receptor signaling pathway
• Gene Summary: 'This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]'
  Transcript Variant: This variant (2), also known as psiNAIP, lacks two internal exons in the 5' coding region, as compared to variant 1. The resulting isoform (2) has an alternate and shorter N-terminus, as compared to isoform 1.