MRVI1 (NM_001098579) Human Untagged Clone

CAT#: SC316432

MRVI1 (untagged)-Human murine retrovirus integration site 1 homolog (MRVI1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MRVI1
• Synonyms: IRAG; JAW1L
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001098579, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGGAATGGATTTGACTTGTCCTTTTGGCATCTCCCCAGCCTGTGGAGCCCAGGCCTCTTGGAGCATCT
  TTGGGGCTGACGCAGCGGAGGTTCCGGGCACACGTGGCCACTCCCAGCAGGAGGCTGCCATGCCCCACAT
  TCCCGAGGACGAGGAGCCCCCCGGAGAGCCACAGGCAGCCCAGAGCCCTGCCGGCCAAGGTCCTCCTGCC
  GCAGGAGTATCTTGCAGTCCAACTCCCACGATTGTCCTGACTGGGGATGCCACTTCACCAGAAGGAGAAA
  CCGACAAAAACCTGGCCAACAGAGTTCACAGTCCCCACAAGAGGCTTTCTCACCGACACTTGAAGGTGTC
  CACTGCCTCCCTGACATCTGTGGACCCCGCGGGGCACATCATTGACCTGGTGAATGACCAGCTGCCAGAC
  ATCAGCATCTCAGAGGAGGACAAGAAGAAAAACCTGGCGCTGCTGGAAGAAGCCAAGTTGGTGAGTGAGC
  GATTCCTGACCCGCCGTGGGAGGAAGTCCAGGAGCAGCCCCGGAGACTCCCCATCAGCTGTTTCCCCGAA
  CCTCAGCCCCAGCGCTTCTCCTACATCCTCTCGGAGCAACTCACTTACAGTCCCCACCCCGCCAGGTTTG
  GATGTGTGCAGTGGCCCGCCATCCCCTCTGCCTGGAGCACCACCACAGCAGAAGGGGGATGAGGCCGACG
  TCTCTTCACCTCACCCTGGCGAGCCTAACGTCCCCAAAGGGCTAGCTGACAGGAAGCAGAATGACCAGAG
  GAAAGTGTCTCAGGGCAGGCTGGCTCCTCGTCCTCCTCCAGTTGAGAAGTCCAAAGAGATTGCAATAGAA
  CAAAAGGAAAACTTCGATCCCCTCCAGTACCCCGAGACCACACCCAAAGGCCTAGCTCCTGTTACAAACA
  GCAGTGGGAAAATGGCCCTGAACAGCCCTCAGCCTGGCCCCGTGGAGAGCGAGCTGGGGAAGCAGCTCTT
  GAAAACGGGCTGGGAGGGCAGCCCTCTGCCGAGAAGTCCAACCCAGGATGCGGCAGGAGTGGGTCCCCCA
  GCCTCCCAGGGGAGAGGCCCAGCTGGAGAGCCGATGGGGCCCGAGGCTGGCTCCAAAGCTGAGCTTCCAC
  CCACTGTGTCCCGGCCCCCGCTGCTGCGAGGGCTCTCCTGGGACAGTGGCCCTGAAGAACCTGGCCCCCG
  GCTGCAGAAAGTGCTTGCCAAGCTGCCACTGGCAGAGGAAGAAAAGCGTTTTGCAGGCAAGGCCGGCGGC
  AAGCTGGCCAAGGCCCCTGGTCTCAAAGACTTTCAGATACAAGTGCAGCCCGTGCGGATGCAGAAACTGA
  CCAAGCTCCGAGAGGAGCACATCCTGATGAGAAATCAGAACTTAGTGGGGCTCAAGCTTCCAGACCTTAG
  TGAAGCAGCTGAGCAGGAAAAAGGGCTTCCTTCTGAACTCTCCCCAGCTATTGAGGAAGAAGAGTCAAAG
  AGTGGCTTAGATGTCATGCCTAATATTTCTGATGTGCTGCTGCGCAAACTGCGGGTCCACAGGAGTCTCC
  CTGGAAGTGCCCCTCCACTCACTGAAAAGGAAGTTGAGAACGTGTTTGTGCAACTGTCCTTGGCCTTTAG
  AAATGACAGCTACACTCTGGAATCTAGAATTAACCAGGCTGAAAGGGAACGCAACCTGACAGAGGAGAAC
  ACTGAGAAAGAACTGGAAAACTTCAAAGCTTCCATTACGTCCTCAGCTTCACTCTGGCACCACTGTGAGC
  ACCGGGAAACCTACCAGAAGTTGCTGGAGGACATCGCTGTCCTGCACCGCCTGGCTGCCCGCCTCTCCAG
  CCGAGCTGAGGTGGTAGGCGCCGTCCGCCAGGAAAAGCGCATGTCGAAAGCAACGGAAGTGATGATGCAG
  TATGTGGAGAATCTAAAGAGGACGTATGAGAAGGACCATGCGGAGCTCATGGAGTTTAAAAAGCTTGCAA
  ATCAGAATTCAAGCCGCAGCTGTGGCCCCTCTGAAGATGGGGTCCCTCGCACGGCACGGTCCATGTCCCT
  CACGCTGGGAAAGAATATGCCTCGCCGGAGGGTCAGCGTTGCTGTGGTTCCTAAGTTTAATGCCCTGAAT
  CTGCCTGGCCAAACTCCCAGCTCATCATCCATTCCCTCCTTACCAGCCTTGTCGGAATCACCCAATGGGA
  AAGGCAGCCTACCTGTCACTTCAGCACTGCCTGCACTTTTGGAAAATGGAAAGACAAATGGGGACCCAGA
  TTGTGAAGCCTCTGCTCCTGCGCTGACCCTGAGCTGCCTGGAGGAGCTTAGTCAGGAGACCAAGGCCAGG
  ATGGAGGAAGAAGCCTACAGCAAGGGATTCCAAGAAGGTCTAAAGAAGACCAAAGAACTTCAAGACCTGA
  AGGAGGAGGAGGAAGAACAGAAGAGTGAGAGTCCTGAGGAACCTGAAGAGGTAGAAGAAACTGAGGAAGA
  GGAAAAGGGCCCAAGAAGCAGCAAACTTGAAGAATTGGTCCATTTCTTACAAGTCATGTATCCCAAACTG
  TGTCAGCACTGGCAAGTGATCTGGATGATGGCTGCAGTGATGCTGGTCTTGACTGTTGTGCTGGGGCTCT
  ACAATTCCTATAACTCTTGTGCAGAGCAGGCTGATGGGCCCCTTGGAAGATCCACTTGCTCGGCAGCCCA
  GAGGGACTCCTGGTGGAGCTCAGGACTCCAGCATGAGCAGCCTACAGAGCAGTAG
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001098579
• ORF Size: 2715 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001098579.2, NP_001092049.2
• RefSeq Size: 6045
• RefSeq ORF: 2715
• Locus ID: 10335
• Protein Families: Transmembrane
• Protein Pathways: Vascular smooth muscle contraction
• Gene Summary: This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011]
  Transcript Variant: This variant (1) encodes isoform a, also known as MRVI1A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.