AAK1 (NM_014911) Human Untagged Clone

CAT#: SC316852

AAK1 (untagged)-Human AP2 associated kinase 1 (AAK1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: AAK1
• Synonyms: RP11-427H3.3
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_014911, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAG
  GGGGCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCAC
  AGTGGACGAGGTGTTGGCGGAAGGTGGATTTGCTATTGTATTTCTGGTGAGGACAAGCAATGGGATGAAA
  TGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCCAGGTGTGCAAGAGAGAAATCCAGATAA
  TGAGGGATCTTTCAGGGCACAAGAATATTGTGGGTTACATTGATTCTAGTATCAACAACGTGAGTAGCGG
  TGATGTATGGGAAGTGCTCATTCTGATGGACTTTTGTAGAGGTGGCCAGGTGGTAAACCTGATGAACCAG
  CGCCTGCAAACAGGCTTTACAGAGAATGAAGTGCTCCAGATATTTTGTGATACCTGTGAAGCTGTTGCCC
  GCCTGCATCAGTGCAAAACTCCTATTATCCACCGGGACCTGAAGGTTGAAAACATCCTCTTGCATGACCG
  AGGCCACTATGTCCTGTGTGACTTTGGAAGCGCCACCAACAAATTCCAGAATCCACAAACTGAGGGAGTC
  AATGCAGTAGAAGATGAGATTAAGAAATACACAACGCTGTCCTATCGAGCACCAGAAATGGTCAACCTGT
  ACAGTGGCAAAATCATCACTACGAAGGCAGACATTTGGGCTCTTGGATGTTTGTTGTATAAATTATGCTA
  CTTCACTTTGCCATTTGGGGAAAGTCAGGTGGCAATTTGTGATGGAAACTTCACAATTCCTGATAATTCT
  CGATATTCTCAAGACATGCACTGCCTAATTAGGTATATGTTGGAACCAGACCCTGACAAAAGGCCGGATA
  TTTACCAGGTGTCCTACTTCTCATTTAAGCTACTCAAGAAAGAGTGCCCAATTCCAAATGTACAGAACTC
  TCCCATTCCTGCAAAGCTTCCTGAACCAGTGAAAGCCAGTGAGGCAGCTGCAAAAAAGACCCAGCCAAAG
  GCCAGACTGACAGATCCCATTCCCACCACAGAGACTTCAATTGCACCCCGCCAGAGGCCTAAAGCTGGGC
  AGACTCAGCCGAACCCAGGAATCCTTCCCATCCAGCCAGCGCTGACACCCCGGAAGAGGGCCACTGTTCA
  GCCCCCACCTCAGGCTGCAGGATCCAGCAATCAGCCTGGCCTTTTAGCCAGTGTTCCCCAACCAAAACCC
  CAAGCCCCACCCAGCCAGCCTCTGCCGCAAACTCAGGCCAAGCAGCCACAGGCTCCTCCCACTCCACAGC
  AGACGCCTTCTACTCAGGCCCAGGGTCTGCCCGCTCAGGCCCAGGCCACACCCCAGCACCAGCAGCAACT
  CTTCCTCAAGCAGCAACAGCAGCAGCAACAGCCACCGCCAGCACAGCAGCAGCCGGCAGGCACGTTTTAC
  CAGCAGCAGCAGGCCCAGACTCAGCAGTTTCAGGCAGTACATCCAGCAACCCAGCAACCAGCAATTGCTC
  AGTTCCCTGTGGTGTCCCAAGGAGGCTCTCAACAGCAGCTAATGCAGAATTTCTACCAGCAGCAGCAGCA
  GCAGCAACAACAACAGCAACAGCAACAGCTGGCCACAGCCCTGCATCAACAACAGCTGATGACTCAGCAG
  GCTGCCTTGCAGCAAAAGCCCACTATGGCAGCAGGACAGCAGCCCCAGCCACAGCCAGCTGCAGCCCCAC
  AGCCAGCCCCTGCCCAGGAGCCAGCGATTCAAGCCCCAGTAAGACAACAGCCAAAGGTTCAGACAACCCC
  ACCTCCTGCCGTCCAGGGGCAGAAAGTTGGATCTCTCACTCCACCCTCATCCCCCAAAACCCAACGTGCT
  GGGCACAGGCGTATTCTCAGTGACGTAACCCACAGTGCAGTCTTTGGGGTCCCTGCCAGCAAATCAACCC
  AGCTGCTCCAGGCAGCTGCAGCTGAGGCCAGTCTCAATAAGTCCAAGTCTGCAACCACCACTCCATCAGG
  CTCTCCTCGGACCTCTCAACAAAACGTTTATAATCCTTCAGAAGGGTCTACGTGGAATCCCTTTGATGAC
  GATAATTTCTCCAAACTCACAGCTGAAGAACTGCTAAACAAGGACTTTGCCAAGCTTGGGGAAGGCAAAC
  ATCCCGAGAAGCTTGGAGGCTCAGCTGAGAGTTTGATCCCAGGCTTTCAATCAACCCAAGGTGATGCTTT
  TGCTACGACCTCATTTTCTGCTGGAACTGCTGAAAAAAGGAAGGGTGGGCAGACTGTGGACTCTGGCCTC
  CCGCTTCTAAGCGTGTCTGATCCTTTCATTCCTCTTCAAGTACCTGATGCACCAGAAAAACTAATTGAGG
  GACTCAAATCTCCTGACACTTCTCTTCTGCTCCCTGACCTCTTGCCTATGACAGATCCTTTTGGTAGCAC
  TTCTGATGCTGTAATTGAAAAAGCTGATGTTGCTGTTGAGAGTCTCATACCAGGACTGGAGCCCCCAGTT
  CCCCAGCGCCTCCCATCTCAGACGGAATCTGTGACCTCGAATCGCACAGATTCTCTCACCGGGGAAGATT
  CCCTGCTTGATTGCTCTCTGCTCTCTAACCCTACTACTGACCTTCTGGAAGAGTTTGCCCCCACAGCAAT
  CTCTGCTCCAGTCCATAAAGCTGCAGAAGATAGTAATCTCATCTCAGGTTTTGATGTCCCTGAGGGCTCG
  GACAAGGTGGCTGAAGATGAGTTTGACCCTATTCCTGTATTGATAACCAAAAACCCACAAGGTGGGCACT
  CTAGAAACAGCAGTGGGAGCTCTGAGTCCAGTCTTCCCAACCTAGCCAGGTCTTTACTGCTGGTGGATCA
  GCTCATAGACCTGTAG
  
  
• Restriction Sites: Please inquire
• ACCN: NM_014911
• ORF Size: 2886 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_014911.3, NP_055726.3
• RefSeq Size: 21283
• RefSeq ORF: 2886
• Locus ID: 22848
• Domains: pkinase, TyrKc, S_TKc
• Protein Families: Druggable Genome, Protein Kinase
• Gene Summary: Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]