Frizzled 6 (FZD6) (NM_003506) Human Untagged Clone

CAT#: SC316995

FZD6 (untagged)-Human frizzled family receptor 6 (FZD6), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: FZD6
• Synonyms: FZ-6; FZ6; HFZ6; NDNC10
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003506 edited
  AGGACTCATTTTCAGGAAAGCCTGAAAATGAGTAAAATAGTGAAATGAGGAATTTGAACA
  TTTTATCTTTGGATGGGGATCTTCTGAGGATGCAAAGAGTGATTCATCCAAGCCATGTGG
  TAAAATCAGGAATTTGAAGAAAATGGAGATGTTTACATTTTTGTTGACGTGTATTTTTCT
  ACCCCTCCTAAGAGGGCACAGTCTCTTCACCTGTGAACCAATTACTGTTCCCAGATGTAT
  GAAAATGGCCTACAACATGACGTTTTTCCCTAATCTGATGGGTCATTATGACCAGAGTAT
  TGCCGCGGTGGAAATGGAGCATTTTCTTCCTCTCGCAAATCTGGAATGTTCACCAAACAT
  TGAAACTTTCCTCTGCAAAGCATTTGTACCAACCTGCATAGAACAAATTCATGTGGTTCC
  ACCTTGTCGTAAACTTTGTGAGAAAGTATATTCTGATTGCAAAAAATTAATTGACACTTT
  TGGGATCCGATGGCCTGAGGAGCTTGAATGTGACAGATTACAATACTGTGATGAGACTGT
  TCCTGTAACTTTTGATCCACACACAGAATTTCTTGGTCCTCAGAAGAAAACAGAACAAGT
  CCAAAGAGACATTGGATTTTGGTGTCCAAGGCATCTTAAGACTTCTGGGGGACAAGGATA
  TAAGTTTCTGGGAATTGACCAGTGTGCGCCTCCATGCCCCAACATGTATTTTAAAAGTGA
  TGAGCTAGAGTTTGCAAAAAGTTTTATTGGAACAGTTTCAATATTTTGTCTTTGTGCAAC
  TCTGTTCACATTCCTTACTTTTTTAATTGATGTTAGAAGATTCAGATACCCAGAGAGACC
  AATTATATATTACTCTGTCTGTTACAGCATTGTATCTCTTATGTACTTCATTGGATTTTT
  GCTGGGCGATAGCACAGCCTGCAATAAGGCAGATGAGAAGCTAGAACTTGGTGACACTGT
  TGTCCTAGGCTCTCAAAATAAGGCTTGCACCGTTTTGTTCATGCTTTTGTATTTTTTCAC
  AATGGCTGGCACTGTGTGGTGGGTGATTCTTACCATTACTTGGTTCTTAGCTGCAGGAAG
  AAAATGGAGTTGTGAAGCCATCGAGCAAAAAGCAGTGTGGTTTCATGCTGTTGCATGGGG
  AACACCAGGTTTCCTGACTGTTATGCTTCTTGCTCTGAACAAAGTTGAAGGAGACAACAT
  TAGTGGAGTTTGCTTTGTTGGCCTTTATGACCTGGATGCTTCTCGCTACTTTGTACTCTT
  GCCACTGTGCCTTTGTGTGTTTGTTGGGCTCTCTCTTCTTTTAGCTGGCATTATTTCCTT
  AAATCATGTTCGACAAGTCATACAACATGATGGCCGGAACCAAGAAAAACTAAAGAAATT
  TATGATTCGAATTGGAGTCTTCAGCGGCTTGTATCTTGTGCCATTAGTGACACTTCTCGG
  ATGTTACGTCTATGAGCAAGTGAACAGGATTACCTGGGAGATAACTTGGGTCTCTGATCA
  TTGTCGTCAGTACCATATCCCATGTCCTTATCAGGCAAAAGCAAAAGCTCGACCAGAATT
  GGCTTTATTTATGATAAAATACCTGATGACATTAATTGTTGGCATCTCTGCTGTCTTCTG
  GGTTGGAAGCAAAAAGACATGCACAGAATGGGCTGGGTTTTTTAAACGAAATCGCAAGAG
  AGATCCAATCAGTGAAAGTCGAAGAGTACTACAGGAATCATGTGAGTTTTTCTTAAAGCA
  CAATTCTAAAGTTAAACACAAAAAGAAGCACTATAAACCAAGTTCACACAAGCTGAAGGT
  CATTTCCAAATCCATGGGAACCAGCACAGGAGCTACAGCAAATCATGGCACTTCTGCAGT
  AGCAATTACTAGCCATGATTACCTAGGACAAGAAACTTTGACAGAAATCCAAACCTCACC
  AGAAACATCAATGAGAGAGGTGAAAGCGGACGGAGCTAGCACCCCCAGGTTAAGAGAACA
  GGACTGTGGTGAACCTGCCTCGCCAGCAGCATCCATCTCCAGACTCTCTGGGGAACAGGT
  CGACGGGAAGGGCCAGGCAGGCAGTGTATCTGAAAGTGCGCGGAGTGAAGGAAGGATTAG
  TCCAAAGAGTGATATTACTGACACTGGCCTGGCCCAGAGCAACAATTTGCAGGTCCCCAG
  TTCTTCAGAACCAAGCAGCCTCAAAGGTTCCACATCTCTGCTTGTTCACCCAGTTTCAGG
  AGTGAGAAAAGAGCAGGGAGGTGGTTGTCATTCAGATACTTGAAGAACATTTTCTCTCGT
  TACTCAGAAGCAAATTTGTGTTACACTGGAAGTGACCTATGCACTGTTTTGTAAGAATCA
  CTGTTACGTTCTTCTTTTGCACTTAAAGTTGCATTGCCTACTGTTATACTGGAAAAAATA
  GAGTTCAAGAATAATATGACTCATTTCACACAAAGGTTAATGACAACAATATACCTGAAA
  ACAGAAATGTGCAGGTTAATAATATTTTTTTAATAGTGTGGGAGGACAGAGTTAGAGGAA
  TCTTCCTTTTCTATTTATGAAGATTCTACTCTTGGTAAGAGTATTTTAAGATGTACTATG
  CTATTTTACTTTTTTGATATAAAATCAAGATATTTCTTTGCTGAAGTATTTAAATCTTAT
  CCTTGTATCTTTTTATACATATTTGAAAATAAGCTTATATGTATTTGAACTTTTTTGAAA
  TCCTATTCAAGTATTTTTATCATGCTATTGTGATATTTTAGCACTTTGGTAGCTTTTACA
  CTGAATTTCTAAGAAAATTGTAAAATAGTCTTCTTTTATACTGTAAAAAAAGATATACCA
  AAAAGTCTTATAATAGGAATTTAACTTTAAAAACCCACTTATTGATACCTTACCATCTAA
  AATGTGTGATTTTTATAGTCTCGTTTTAGGAATTTCACAGATCTAAATTATGTAACTGAA
  ATAAGGTGCTTACTCAAAGAGTGTCCACTATTGATTGTATTATGCTGCTCACTGATCCTT
  CTGCATATTTAAAATAAAATGTCCTAAAGGGTTAGTAGACAAAATGTTAGTCTTTTGTAT
  ATTAGGCCAAGTGCAATTGACTTCCCTTTTTTAATGTTTCATGACCACCCATTGATTGTA
  TTATAACCACTTACAGTTGCTTATATTTTTTGTTTTAACTTTTGTTTTTTAACATTTAGA
  ATATTACATTTTGTATTATACAGTACCTTTCTCAGACATTTTGTAGAATTCATTTCGGCA
  GCTCACTAGGATTTTGCTGAACATTAAAAAGTGTGATAGCGATATTAGTGCCAATCAAAT
  GGAAAAAAGGTAGTCTTAATAAACAAGACACAACGTTTTTATACAACATACTTTAAAATA
  TTAAGGAGTTTTCTTAATTTTGTTTCCTATTAAGTATTATTCTTTGGGCAAGATTTTCTG
  ATGCTTTTGATTTTCTCTCAATTTAGCATTTGCTTTTGGTTTTTTTCTCTATTTAGCATT
  CTGTTAAGGCACAAAAACTATGTACTGTATGGGAAATGTTGTAAATATTACCTTTTCCAC
  ATTTTAAACAGACAACTTTGAATACAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003506 unedited
  GACCGCCCCCCGAGTAATTGACCCAGGACTCATTTTCAGGAAAGCCTGAAAATGAGTAAA
  ATAGTGAAATGAGGAATTTGAACATTTTATCTTTGGATGGGGATCTTCTGAGGATGCAAA
  GAGTGATTCATCCAAGCCATGTGGTAAAATCAGGAATTTGAAGAAAATGGAGATGTTTAC
  ATTTTTGTTGACGTGTATTTTTCTACCCCTCCTAAGAGGGCACAGTCTCTTCACCTGTGA
  ACCAATTACTGTTCCCAGATGTATGAAAATGGCCTACAACATGACGTTTTTCCCTAATCT
  GATGGGTCATTATGACCAGAGTATTGCCGCGGTGGAAATGGAGCATTTTCTTCCTCTCGC
  AAATCTGGAATGTTCACCAAACATTGAAACTTTCCTCTGCAAGCATTTGTACCAACCTGC
  ATAGAACAAATTCATGTGGTTCCACCTTGTCGTAAACTTTGTGAGAAAGTATATTCTGAT
  TGCAAAAAATTAATTGACACTTTTGGGATCCCGATGGCCTGAGGAGCTTGAATGTGACAG
  ATTACAATACTGTGATGAGACTGTTCCTGGTACTTTTTGATCCACACACAGAATTTCTTG
  GGTTCTCAGAAGAAACAGAACAAGTCCAAAGAAAATTTGGATTTTTGGTGCCCAAGGATC
  TTAAGACTTCTGGGGGACAGGGTATATATGTTCTTGGGATTGACCAGTGGGCGCCTCCTT
  GCCCTACTTGTTTTTAAAAGTGATGAACTTAGTTGGCAAAGATTTATTGGACAATTCAAT
  ATTTGTGCTTTGGCAACTTTGTCCATTCTTCTTTTTTATGAGGTATAAAATCCATACC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003506 unedited
  GGGGTACGTGNACCGCGGCCCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTGTATTCA
  AAGTTGTCTGTTTAAAATGTGGAAAAGGTAATATTTACAACATTTCCCATACAGTACATA
  GTTTTTGTGCCTTAACAGAATGCTAAATAGAGAAAAAAACCAAAAGCAAATGCTAAATTG
  AGAGAAAATCAAAAGCATCAGAAAATCTTGCCCAAAGAATAATACTTAATAGGAAACAAA
  ATTAAGAAAACTCCTCAATATTTTAAAGTATGTTGTATAAAAACGTTGTGTCTTGTTTAT
  TAAGACTACCTTTTTTCCATTTGATTGGCACTAATATCGCTATCACACTTTTTAATGTTC
  AGCAAAATCCTAGTGAGCTGCCGAAATGAATTCTACAAAATGTCTGAGAAAGGTACTGTA
  TAATACAAAATGTAATATTCTAAATGTTAAAAAATCAAAAGTTAAAACAAAAAATATAAG
  CAACTGTAAGTGGTTATAATACAATCAATGGGTGGTCATGAAACATTAAAAAAGGGAAGT
  CAATTGCACTTGGCCTAATATACAAAAGACTAACATTTTGTCTACTAACCCTTTAGGACA
  TTTTATTTTAAATATGCAGAAGGATCAGTGAGCAGCATAATACAATCAATAGTGGACACT
  CTTTGAGTAAGCACCTTATTTCAGTTACATAATTTAGATCTGTGAAATTCCTAANACGAG
  ACTATAAAAATCACACATTNTAGATGGTAAGGTATCAATAAGTGGGTTTTTAAAGTTAAA
  TTCCTATTATAAGACTTTTTTGGTATATCTTTNTTTACAGTATAAAAGAAGACTATTTTA
  CAAATTTCTTAGAATTCAGTGTAAAAGCTACCAAAGTGCTAAAATATCACAATAGCATGA
  TAAAAAT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003506
• ORF Size: 2121 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.NA

Reference Data

• RefSeq: NM_003506.2, NP_003497.2
• RefSeq Size: 3768
• RefSeq ORF: 2121
• Locus ID: 8323
• Domains: FRI, Frizzled
• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway
• Gene Summary: This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide. [provided by RefSeq, Aug 2011]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.