ACMSD (NM_138326) Human Untagged Clone

CAT#: SC317515

ACMSD (untagged)-Human aminocarboxymuconate semialdehyde decarboxylase (ACMSD)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ACMSD
• Synonyms: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; aminocarboxymuconate semialdehyde decarboxylase; OTTHUMP00000162500
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_138326, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGAAAATTGACATCCATAGTCATATTCTACCAAAAGAATGGCCAGATCTAAAAAAGAGGTTTGGCTACG
  GAGGCTGGGTGCAGCTCCAACACCACAGCAAGGGAGAAGCAAAGTTGTTGAAAGATGGGAAAGTCTTCAG
  AGTGGTGCGAGAGAATTGCTGGGATCCAGAAGTTCGTATTAGAGAAATGGACCAAAAAGGAGTAACAGTG
  CAAGCCCTTTCCACAGTTCCTGTCATGTTTAGCTACTGGGCCAAACCTGAGGACACTTTAAACCTGTGCC
  AGCTTTTAAACAACGACCTTGCCAGCACCGTTGTGAGCTACCCCAGGAGGTTCGTGGGTCTGGGGACGTT
  GCCCATGCAGGCCCCTGAGCTGGCGGTCAAGGAGATGGAGCGCTGTGTGAAAGAGCTGGGCTTTCCCGGG
  GTCCAAATTGGCACCCACGTCAACGAGTGGGACCTGAACGCGCAGGAGCTCTTTCCTGTCTATGCGGCAG
  CCGAAAGGCTGAAGTGTTCCCTGTTCGTGCATCCCTGGGACATGCAGATGGATGGACGAATGGCCAAATA
  CTGGCTCCCTTGGCTTGTAGGAATGCCAGCAGAGACCACCATAGCCATTTGCTCCATGATCATGGGTGGA
  GTATTTGAGAAGTTTCCCAAACTGAAAGTGTGTTTCGCACATGGTGGTGGTGCCTTCCCCTTCACAGTGG
  GAAGAATCTCCCATGGATTCAGCATGCGCCCAGATCTGTGTGCCCAGGACAACCCCATGAACCCGAAGAA
  ATACCTTGGTTCCTTTTACACAGATGCTTTGGTTCATGATCCTCTGTCCCTCAAGCTGTTAACAGATGTC
  ATAGGAAAGGATAAAGTCATTTTGGGAACCGATTACCCCTTTCCACTAGGTGAGCTGGAACCTGGGAAAC
  TAATAGAGTCCATGGAAGAATTTGATGAAGAAACAAAGAATAAACTCAAAGCCGGCAATGCCCTGGCATT
  TTTGGGTCTTGAGAGAAAACAATTTGAATGA
  
  
• Restriction Sites: Please inquire
• ACCN: NM_138326
• ORF Size: 1011 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_138326.2, NP_612199.2
• RefSeq Size: 1278
• RefSeq ORF: 1011
• Locus ID: 130013
• Protein Families: Transmembrane
• Protein Pathways: Metabolic pathways, Tryptophan metabolism
• Gene Summary: The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS. [supplied by OMIM, Oct 2004]
  Transcript Variant: This variant (1) encodes the longer isoform (1).