HEXO (ERI1) (NM_153332) Human Untagged Clone

CAT#: SC317546

ERI1 (untagged)-Human exoribonuclease 1 (ERI1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ERI1
• Synonyms: 3'HEXO; HEXO; THEX1
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_153332, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGAGGATCCACAGAGTAAAGAGCCTGCCGGCGAGGCCGTGGCTCTCGCGCTGCTGGAGTCGCCGCGGC
  CGGAGGGCGGGGAGGAGCCGCCGCGTCCCAGTCCCGAGGAAACTCAACAGTGTAAATTTGATGGCCAGGA
  GACAAAAGGATCCAAGTTCATTACCTCCAGTGCGAGTGACTTCAGTGACCCGGTTTACAAAGAGATTGCC
  ATTACGAATGGCTGTATTAATAGAATGAGTAAGGAAGAACTCAGAGCTAAGCTTTCAGAATTCAAGCTTG
  AAACTAGAGGAGTAAAGGATGTTCTAAAGAAGAGACTGAAAAACTATTATAAGAAGCAGAAGCTGATGCT
  GAAAGAGAGCAATTTTGCTGACAGTTATTATGACTACATTTGTATTATTGACTTTGAAGCCACTTGTGAA
  GAAGGAAACCCACCTGAGTTTGTACATGAAATAATTGAATTTCCGGTTGTTTTACTGAATACGCATACTT
  TAGAAATAGAAGACACGTTTCAGCAGTATGTAAGACCAGAGATTAACACACAGCTGTCTGATTTCTGCAT
  CAGTCTAACTGGAATTACTCAGGATCAGGTAGACAGAGCTGATACCTTCCCTCAGGTACTAAAAAAAGTA
  ATTGACTGGATGAAATTGAAGGAATTAGGAACAAAGTATAAATACTCACTTTTAACAGATGGTTCTTGGG
  ATATGAGTAAGTTCTTGAACATTCAGTGTCAACTCAGCAGGCTCAAATACCCTCCTTTTGCGAAAAAGTG
  GATCAATATTCGGAAGTCATATGGAAATTTTTACAAGGTTCCTAGAAGCCAAACCAAACTGACAATAATG
  CTTGAAAAATTAGGAATGGATTATGATGGGCGGCCTCACTGTGGTCTTGATGACTCTAAGAATATCGCCC
  GAATAGCAGTTCGAATGCTTCAGGATGGGTGTGAACTCCGAATCAACGAGAAAATGCATGCAGGACAGCT
  AATGAGTGTGTCCTCTTCCTTACCAATAGAGGGCACTCCACCACCACAAATGCCACATTTTAGAAAGTAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_153332
• ORF Size: 1050 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_153332.3, NP_699163.2
• RefSeq Size: 4615
• RefSeq ORF: 1050
• Locus ID: 90459
• Gene Summary: RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs. [UniProtKB/Swiss-Prot Function]