SYT8 (NM_138567) Human Untagged Clone

CAT#: SC317636

SYT8 (untagged)-Human synaptotagmin VIII (SYT8)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SYT8
• Synonyms: DKFZp434K0322
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_138567, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGCTCCACCTGCATGGCTGGCAAACCATGCAGGGTAGAAAGATGGGGCACCCACCAGTCTCTCCCAGTG
  CCCCGGCCCCAGCTGGCACCACAGCTATACCTGGGCTTATTCCAGACCTTGTCGCCGGGACCCCCTGGCC
  CCGCTGGGCTCTCATTGCCGGCGCCCTTGCCGCGGGCGTCCTCCTCGTCTCCTGCCTCCTCTGTGCTGCC
  TGCTGCTGCTGCCGCCGCCACAGGAAGAAGCCCAGGGACAAGGAGTCCGTGGGTCTGGGCAGTGCCCGCG
  GCACCACCACCACCCACCTGGTGCAACCTGATGTGGATGGCCTGGAGTCCAGCCCGGGGGATGCTCAGCA
  ATGGGGGCGCCTGCAGCTCTCCCTGGAGTTCGACTTTGGAAGCCAGGAGATCAGGGTGGGCCTGAGGCAG
  GCAGCCGACCTGAGGCCTGGGGGCACCGTGGACCCCTATGCCCGGGTCAGCGTCTCCACCCAGGCCGGAC
  ACAGACATGAGACAAAAGTGCACCGAGGCACGCTCTGCCCCGTGTTTGACGAGACCTGCTGCTTCCACAT
  CCCGCAGGCGGAGCTGCCAGGGGCCACCCTGCAGGTGCAGCTTTTCAACTTCAAGCGCTTCTCGGGGCAT
  GAGCCCCTGGGTGAGCTCCGTCTGCCACTGGGCACCGTGGATCTGCAGCATGTTCTGGAGCACTGGTACC
  TGCTGGGCCCGCCGGCTGCCACTCAGCCCGAGCAGGTCGGGGAGCTGTGCTTCTCTCTCCGGTACGTGCC
  CAGCTCAGGCCGGCTGACCGTGGTGGTGCTGGAGGCTCGAGGCCTGCGTCCAGGACTTGCAGAGCCCTAC
  GTGAAGGTCCAGCTCATGCTGAACCAGAGGAAGTGGAAGAAGAGAAAGACAGCCACCAAAAAGGGCACGG
  CGGCCCCCTACTTCAATGAGGCCTTCACCTTCCTGGTGCCCTTCAGCCAGGTCCAGAATGTGGACCTGGT
  GCTGGCTGTCTGGGACCGCAGCCTGCCGCTCCGAACTGAGCCCGTAGGCAAGGTGCACCTGGGTGCCCGG
  GCCTCGGGGCAGCCCCTGCAGCACTGGGCAGACATGCTGGCCCACGCCCGGCGGCCCATTGCCCAGCGGC
  ACCCCCTGCGGCCAGCCAGGGAGGTGGACCGCATGCTGGCCCTGCAGCCCCGCCTTCGCCTGCGCCTGCC
  CTTGCCCCACTCCTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_138567
• ORF Size: 1206 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_138567.4, NP_612634.3
• RefSeq Size: 1558
• RefSeq ORF: 1206
• Locus ID: 90019
• Protein Families: Transmembrane
• Gene Summary: This gene encodes a member of the synaptotagmin protein family. Synaptotagmins are membrane proteins that are important in neurotransmission and hormone secretion, both of which involve regulated exocytosis. Expression of the encoded protein in human pancreatic islets has been connected to activity of the promoter for the insulin gene, on the same chromosome several hundred kilobases away (PMID: 21336277 and 22928559). This association would link response to gluclose to insulin secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
  Transcript Variant: This variant (2) uses an alternate in-frame splice site, and an alternate upstream translation start, compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct N-terminus, compared to isoform 1. CCDS Note: The coding region has been updated to represent an alternative 3' splice pattern, resulting in a longer and distinct C-terminus that is better supported by available transcript and homology data. The update adds two C2 domains (Ca2+-dependent membrane-targeting modules), which are hallmarks of synaptotagmin proteins.